检索结果-南通市图书馆

Concise Synthesis of Lactococcus garvieae Lipoteichoic Acids Through an Additive-m.dulated Preactivation Protocol and the Im.unological Studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chem.stry 2024年第2期6卷 403-414页

作者： Tianlu Li Tong Li Yue Yang Haoru Zhuang Jianwu Lv Ning Zhou m.aom.ao Zhang Fengshan Wang Yiqun Geng Richard R.schmidt Peng Peng National Glycoengineering Research Center Shandong Key Laboratory of Carbohydrate Chemistry and GlycobiologyNMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate Based MedicineShandong UniversityQingdao 266237 State Key Laboratory of Bioactive Substance and Function of Natural m.dicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050 Departm.nt of Chem.stry University of KonstanzD-78457 Konstanz

Lipoteichoic acids(LTAs)are m.croam.hiphiles com.osed of alditol,lipid,phosphate,and carbohydrate *** to their inherent com.lexity,it is a severe challenge to access LTAs with structural integrity from.natural sources for biological or im.unological ***,we describe the first total synthesis of Lactococcus garvieae LTA(type II LTA),containing five distinct 1,2-cis gluco/galactopyranosidic linkages,via a novel additive-m.dulated O-glycosyl trichloroacetim.date preactivation glycosidation *** strategy features(1)high glycosidation yields and excellent 1,2-cis stereoselectivities independent of the donor anom.ric configuration,(2)com.on and inexpensive reagents as prom.ters and additives,(3)application to standard glycosyl im.date donors without resorting to participating protection,and(4)general application to reactive and less reactive glycosyl ***,via the precise stereocontrolled construction of three galactopyranosidic and two glucopyranosidic bonds on a m.ltigram.scale,a series of structurally well-defined LTA m.lecules were successfully *** evaluation of these type II synthetic LTAs showed a structure–activity relationship in the stim.lation of a proinflam.atory response.

关键词： 1,2-cis glycosidation stereoselectivity lipoteichoic acid total synthesis additive-m.dulated trichloroacetim.date glycosidation im.une response

Genom. and clonal hem.topoiesis stability contrasts with im.une,cfDNA,m.tochondrial,and telom.re length changes during short duration spaceflight

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Precision Clinical m.dicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-m.dina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon m.rissa Burke Jacqueline Proszynski Braden Tierney Caleb m.schmidt Nuria m.ncia-Trinchant Rem. Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina m.tei Irenaeus Chan Carlos Cruchaga Ashley Kleinm.n JangKeun Kim.Alexander Lucaci Conor Loy Om.ry m.ava Iwijn De Vlam.nck Anvita Singaraju Lynn E.Taylor Julian C.schmidt m.chael A.schmidt Kelly Blease Juan m.reno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altom.re Sem.on Kruglyak Shawn Levy m.n Yu Duane C.Hassane Susan m.Bailey Kelly Bolton Jaim. m.teus Christopher E.m.son Departm.nt of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Com.utational Biom.dicine Weill Cornell MedicineNew YorkNY 10021USA Departm.nt of Im.unology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Departm.nt of Stem.Cell Biology and Regenerative m.dicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Hum.n Perform.nce Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA m.yer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Departm.nt of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Departm.nt of System. Engineering Colorado State UniversityFort CollinsCO 80523USA Elem.nt Biosciences San DiegoCA 10055USA Departm.nt of Environm.ntal and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and m.lecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA m.inig School of Biom.dical Engineering Cornell UniversityIthacaNY 14853USA The Feil Fam.ly Brain and m.nd Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)m.ssion,the first all-civilian orbital flight m.ssion,investigated the physiological effects of short-duration spaceflight through a m.lti-om.c *** advances,there rem.ins m.ch to learn about hum.n adaptation to spaceflight's unique challenges,including m.crogravity,im.une system.perturbations,and radiation *** To provide a detailed genetics analysis of the m.ssion,we collected dried blood spots pre-,during,and post-flight for DNA *** length was m.asured by quantitative PCR,while whole genom. and cfDNA sequencing provided insight into genom.c stability and im.une adaptations.A robust bioinform.tic pipeline was used for data analysis,including variant calling to assess m.tational *** Telom.re elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased im.une cell signatures *** significant clonal hem.topoiesis of indeterm.nate potential(CHIP)or whole-genom. instability was *** long-term.gene expression changes across im.une cells suggested cellular adaptations to the space environm.nt persisting m.nths *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telom.re dynam.cs and im.une cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early developm.nt of CHIP in astronauts,an understudied phenom.non as previous studies have focused on career *** study will serve as a reference point for future com.ercial and non-com.ercial spaceflight,low Earth orbit(LEO)m.ssions,and deep-space exploration.

关键词： genom.s clonal hem.topoiesis stability im.une m.tochondria ribosom.s spaceflight

Rifaxim.n on epigenetics and autophagy in anim.l m.del of hepatocellular carcinom. secondary to m.tabolic-dysfunction associated steatotic liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第1期16卷 75-90页

作者： m.theus Truccolo m.chalczuk Larisse Longo m.lina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu schmidt Cerski Eduardo Filippi-Chiela m.rio ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program.in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experim.ntal Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflam.atory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Departm.nt of Gastroenterology(LIm.7) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Departm.nt of m.rphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvim.nto Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND Prevalence of hepatocellular carcinom.(HCC)is increasing,especially in patients with m.tabolic dysfunctionassociated steatotic liver disease(m.SLD).AIm.To investigate rifaxim.n(RIF)effects on epigenetic/autophagy m.rkers in *** Adult Sprague-Dawley rats were random.y assigned(n=8,each)and treated from.5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosam.ne(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 m./kg/d)gavage].Gene expression of epigenetic/autophagy m.rkers and circulating m.RNAs were *** All HCC and RIF anim.ls developed m.tabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** anim.ls who developed HCC with those who did not,m.R-122,m.R-34a,tubulin alpha-1c(Tuba-1c),m.talloproteinases-2(m.p2),and m.talloproteinases-9(m.p9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine m.thyltransferase-1(Carm.),enhancer of zeste hom.log-2(Ezh2),autophagy-related factor LC3A/B(m.p1 Lc3b),and p62/sequestosom.-1(p62/SQSTm.)-*** with controls,m.p1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(Pm. was lower in HCC com.ared to RIF(Pm.p9 was higher in HCC in relation to the control;the opposite was observed for p62/Sqstm.(Pm. protein was lower in the RIF-group com.ared to the control(P=0.024).There was no difference am.ng groups for Tuba-1c,Aldolase-B,alpha-fetoprotein,and m.p2(P>0.05).m.R-122 was higher in HCC,and m.R-34a in RIF com.ared to controls(Pm.R-26b was lower in HCC com.ared to RIF,and the inverse was observed for m.R-224(Pm.ng groups regarding m.R-33a,m.R-143,m.R-155,m.R-375 and m.R-21(P>0.05).CONCLUSION RIF m.ght have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Anim.l m.del Autophagy Epigenetic Hepatocellular carcinom. m.tabolic dysfunction-associated steatotic liver disease Rifaxim.n

Ethernet-APL推动流程工业现场网络的升级

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

流程工业 2024年第3期 24-25页

作者： Friederike schmidt Lapp缆普电缆公司

Ethernet-APL改变了之前现场级网络连接的固有规定,尤其适用于流程工业。它采用单一协议实现端到端联网,可在长达1000 m.电缆长度线路上实现高速传输,同时也具备本质安全性,适用于潜在爆炸区域。

关键词： Ethernet 网络连接电缆长度本质安全性爆炸区域流程工业高速传输 APL

Num.rical m.deling of m.ss Transfer in the Interaction between River Biofilm.and a Turbulent Boundary Layer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Fluid Dynam.cs 2024年第1期14卷 1-23页

作者： Falilou Coundoul Evrad m. D. Ngom.Frédéric Y. m.ulin Institut Polytechnique de Saint-Louis Université Gaston Berger Saint-Louis Senegal Institut de m.canique des Fluides de Toulouse UMR 5502-Université de Toulouse Occitanie France

In this article dedicated to the m.deling of vertical m.ss transfers between the biofilm.and the bulk flow, we have, in the first instance, presented the m.thodology used, followed by the presentation of various results obtained through analyses conducted on velocity fields, different fluxes, and overall transfer coefficients. Due to num.rical constraints (resolution of relevant spatial scales), we have restricted the analysis to low schmidt num.ers (Sc=0.1, Sc=1, and Sc=10) and a single roughness Reynolds num.er (Re*=150). The analysis of instantaneous concentration fields from.various sim.lations revealed logarithm.c concentration profiles above the canopy. In this zone, the concentration is relatively hom.geneous for longer tim.s. The analysis of results also showed that the contribution of m.lecular diffusion to the total flux depends on the schmidt num.er. This contribution is negligible for schmidt num.ers Sc≥0.1, but nearly balances the turbulent flux for Sc=0.1. In the canopy, the local Sherwood num.er, given by the ratio of the total flux (within or above the canopy) to the m.lecular diffusion flux at the wall, also depends on the schmidt num.er and varies significantly between the canopy and the region above. The exchange velocity, a purely hydrodynam.c param.ter, is independent of the schmidt num.er and is on the order of 10% of in the present case. This study also reveals that nutrient absorption by organism. near the wall depends on the schmidt num.er. Such absorption is facilitated by lower schmidt num.ers.

关键词： Epilithic Biofilm Passive Scalar Transport Direct Num.rical Sim.lation Navier-Stokes

Suppression of Soybean Oleosin Produces m.cro-Oil Bodies that Aggregate into Oil Body/ER Com.lexes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

m.lecular Plant 2008年第6期1卷 910-924页

作者： m.nica A. schmidt Eliot m. Herm.n Donald Danforth Plant Science Center 975 N Warson Rd St Louis MO 63132 USA Plant Genetics Research Unit USDA/ARS Donald Danforth Plant Science Center 975 N. Warson Rd St Louis MO 63132 USA

Using RNAi, the seed oil body protein 24-kDa oleosin has been suppressed in transgenic soybeans. The endoplasm.c reticulum.（ER） form. m.cro-oil bodies about 50 nm.in diam.ter that coalesce with adjacent oil bodies form.ng a hierarchy of oil body sizes. The oil bodies in the oleosin knockdown form.large oil body-ER com.lexes with the interior dom.nated by m.cro-oil bodies and interm.diate-sized oil bodies, while the peripheral areas of the com.lex are dom.nated by large oil bodies. The com.lex m.rges to form.giant oil bodies with onset of seed dorm.ncy that disrupts cell structure. The transcriptom. of the oleosin knockdown shows few changes com.ared to wild-type. Proteom.c analysis of the isolated oil bodies of the 24-kDa oleosin knockdown shows the absence of the 24-kDa oleosin and the presence of abundant caleosin and lipoxygenase. The form.tion of the m.cro-oil bodies in the oleosin knockdown is interpreted to indicate a function of the oleosin as a surfactant.

关键词： RNAi protein soybean en-doplasm.c reticulum

Hadron and light nucleus radii from.electron scattering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2022年第12期46卷 1-15页

作者： Zhu-Fang Cui Daniele Binosi Craig D.Roberts Sebastian m.schmidt School of Physics Nanjing UniversityNanjing 210093China Institute for Nonperturbative Physics Nanjing UniversityNanjing 210093China European Centre for Theoretical Studies in Nuclear Physics and Related Areas Villa Tam.osi Strada delle Tabarelle 286I-38123 Villazzano(TN)Italy Helm.oltz-Zentrum.Dresden-Rossendorf Dresden D-01314Germany RWTH Aachen University Ⅲ.Physikalisches Institut BAachen D-52074Germany

Conceptually,radii are am.ngst the sim.lest Poincaré-invariant properties that can be associated with hadrons and light *** values of these quantities are necessary so that one m.y judge the character of putative solutions to the strong interaction problem.within the Standard ***,lim.ting their ability to serve in this role,recent m.asurem.nts and new analyses of older data have revealed uncertainties and im.recisions in the radii of the proton,pion,kaon,and *** the context of radius m.asurem.nt using electron+hadron elastic scattering,the past decade has shown that reliable extraction requires m.nim.sation of bias associated with practitioner-dependent choices of data fitting *** answers to that challenge have been offered;and this perspective describes the statistical Schlessinger point m.thod(SPm.,in unifying applications to proton,pion,kaon,and deuteron *** in analytic function theory,independent of assum.tions about underlying dynam.cs,free from.practitioner-induced bias,and applicable in the sam. form.to diverse system. and observables,the SPm.returns an objective expression of the inform.tion contained in any data under *** robust nature and versatility m.ke it suitable for use in m.ny branches of experim.nt and theory.

关键词： elastic electrom.gnetic form.factors lepton scattering from.hadrons and light nuclei em.rgence of m.ss m.onic atom. proton Nam.u-Goldstone m.des-pion and kaon deuteron strong interactions in the standard m.del of particle physics

Bayesian m.deling of dynam.c behavioral change during an epidem.c

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Infectious Disease m.delling 2023年第4期8卷 947-963页

作者： Caitlin Ward Rob Deardon Alexandra m.schmidt Division of Biostatistics University of MinnesotaMinneapolisMNUSA Faculty of Veterinary m.dicine University of CalgaryCalgaryABCanada Departm.nt of m.them.tics and Statistics University of CalgaryCalgaryABCanada Departm.nt of Epidem.ology Biostatisticsand Occupational HealthMontrealQCCanada

For m.ny infectious disease outbreaks,the at-risk population changes their behavior in response to the outbreak severity,causing the transm.ssion dynam.cs to change in *** change is often ignored in epidem.c m.deling efforts,m.king these m.dels less useful than they could *** address this by introducing a novel class of datadriven epidem.c m.dels which characterize and accurately estim.te behavioral *** proposed m.del allows tim.-varying transm.ssion to be captured by the level of“alarm.in the population,with alarm.specified as a function of the past epidem.c *** investigate the estim.bility of the population alarm.across a wide range of scenarios,applying both param.tric functions and non-param.tric functions using splines and Gaussian *** m.del is set in the data-augm.nted Bayesian fram.work to allow estim.tion on partially observed epidem.c *** benefit and utility of the proposed approach is illustrated through applications to data from.real epidem.cs.

关键词： Bayesian inference Com.artm.ntal m.del SIR SEIR Transm.ssion m.deling

Valence Quark Ratio in the Proton

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2022年第4期39卷 1-6页

作者： Zhu-Fang Cui Fei Gao Daniele Binosi Lei Chang Craig D.Roberts Sebastian m.schmidt School of Physics Nanjing UniversityNanjing 210093China Institute for Nonperturbative Physics Nanjing UniversityNanjing 210093China Centre for High Energy Physics Peking UniversityBeijing 100871China European Centre for Theoretical Studies in Nuclear Physics and Related Areas Villa TambosiStrada delle Tabarelle 286I-38123 Villazzano(TN)Italy School of Physics Nankai UniversityTianjin 300071China Helm.oltz-Zentrum.Dresden-Rossendorf Dresden D-01314Germany RWTH Aachen University III.Physikalisches Institut BAachen D-52074Germany

Beginning with precise data on the ratio of structure functions in deep inelastic scattering(DIS)from.^3He and ^3H,collected on the dom.in 0.19≤xB≤0.83,where xBis the Bjorken scaling variable,we em.loy a robust m.thod for extrapolating such data to arrive at a m.del-independent result for the xB=1 value of the ratio of neutron and proton structure *** this with inform.tion obtained in analyses of DIS from.nuclei,corrected for target-structure dependence,we arrive at a prediction for the proton valence-quark ratio:d_(v)/u_(v)|_(xB→1)=0.230(57).Requiring consistency with this result presents a challenge to m.ny descriptions of proton structure.

关键词： structure functions precise