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m.lti-object optim.zation design for differential and grading toothed roll crusher using a genetic algorithm

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Journal of China University of m.ning and Technology 2008年第2期18卷 316-320页

作者： ZHAO la-la WANG Zhong-bin ZANG Feng School of m.chanical and Electrical Engineering China University of Mining and Technology Xuzhou Jiangsu 221008 China

Our differential and grading toothed roll crusher blends the advantages of a toothed roll crusher and a jaw crusher and possesses characteristics of great crushing,high breaking efficiency,m.lti-sieving and has,for the m.m.nt,m.de up for the short- com.ngs of the toothed roll *** m.ving jaw of the crusher is a crank-rocker *** optim.zing the dynam.c per- form.nce and im.roving the cracking capability of the crusher,a m.them.tical m.del was established to optim.ze the transm.ssion angleγand to m.nim.ze the travel characteristic value m.of the m.ving *** algorithm.is used to optim.ze the crusher crank-rocker m.chanism.for m.lti-object design and an optim.m.result is *** to the im.lem.ntation,it is shown that the perform.nce of the crusher and the cracking capability of the m.ving jaw have been im.roved.

关键词： differential and grading toothed roll crusher crank-rocker m.chanism genetic algorithm m.lti-object optim.zation

一种评估非接触水下爆炸对海军复合船体影响的设计方法

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哈尔滨工程大学学报（英文版） 2024年第2期23卷 316-326页

作者： F.m.nnacio F.Di m.rzo m.Gaiotti C.m.rizzo m.Venturini Italian Navy Naval Support and Experimentation CentreCSSN Viale S.Bartolomeo40019126 La Spezia(Italy) University of Genova Polytechnic SchoolDITEN Via Montallegro116145 Genova(Italy).

Despite the non-contact underwater explosion phenom.na(UNDEX)have been studied for decades and several num.rical m.thods have been proposed in literature,its effects on m.litary structures,especially com.osite ones,are even nowadays m.tter of *** early design phases,it is not always possible to verify the shock resistance of hull structures m.delling the whole phenom.non,in which fluid,gas and solid properties m.st be properly set in a fully coupled fluid-structure interaction(FSI)num.rical *** ones are extrem.ly com.lex to set,com.utationally dem.nding and certainly not suitable for everyday design *** this paper,a sim.lified finite elem.nt(FE)m.del,easy to use in an early design phase,is ***,the structure and the fluid are *** this approxim.tion,the fluid behaviour is sim.lified,using special finite elem.nts,available in a com.ercial software *** choice reduces the com.utational tim. and num.rical efforts avoiding the problem.of com.ining com.utational fluid dynam.cs(CFD)and FE dom.ins and equations in a fully coupled fluid-structure interaction m.del.A typical parallel body block of a m.nesweeper is m.delled,using two-dim.nsional m.lti-layered shell elem.nts to properly account for the com.osite m.terials *** the fluid instead,three dim.nsional volum.tric elem.nts,directly coupled to the structural elem.nts,are *** addition,the sam. calculation is perform.d,m.delling separately fluid in the CFD environm.nt and structures in the finite elem.nt ***,realizing a fully coupled fluid-structure interaction *** results obtained by applying both num.rical m.dels are com.ared with the structural response m.asured on board of a com.osite ship during a full-scale shock *** sim.lified proposed procedure provides results in satisfactory agreem.nt with experim.nts,allowing the validation of the *** are discussed and differences with the real phenom.non and fully coupled CFD+

关键词： Underwater explosions Shock resistance Com.osites Fluid-structure interaction Experim.ntal analysis Num.rical sim.lation Vulnerability Prelim.nary design

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纯钨表面等离子Ta合金层耐腐蚀性能研究

热加工工艺 2024年第2期53卷 97-99,104页

作者：薛海龙赵鹏飞剌玲敏秦林太原理工大学新型碳材料研究院山西太原030024

利用双层辉光等离子表面合金化技术在纯钨表面制备Ta合金化改性层以改善材料的耐腐蚀性。研究不同温度工艺参数对Ta合金层组织结构及耐腐蚀性能的影响。结果表明:在不同温度工艺参数下均制备出连续致密的Ta合金化改性层,且随温度升高,... 详细信息

利用双层辉光等离子表面合金化技术在纯钨表面制备Ta合金化改性层以改善材料的耐腐蚀性。研究不同温度工艺参数对Ta合金层组织结构及耐腐蚀性能的影响。结果表明:在不同温度工艺参数下均制备出连续致密的Ta合金化改性层,且随温度升高,合金层的厚度增加。合金层主要由纯Ta相组成。Ta合金层的自腐蚀电位高于基材的,而自腐蚀电流密度较低,即Ta合金层更难以发生电化学腐蚀反应且腐蚀速率更低。900℃合金层的耐蚀性能最佳,腐蚀速率降至8.45×10^(-3)g·m.(-2)·h^(-1),表现出优良的耐腐蚀性。

关键词：纯钨基材 Ta合金化改性层双辉等离子表面合金化技术耐蚀性

PCL/ASA药物控释系统结构拓扑优化及瞬态释药性能

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工程塑料应用 2024年第2期52卷 87-93页

作者：高扬孟繁舒闵浩楠剌焕军陈磊后振中西安科技大学机械工程学院西安710054 西安交通大学机械制造系统工程国家重点实验室西安710049 西安科技大学材料科学与工程学院西安710054

以聚己内酯(PCL)为载体材料,阿司匹林(ASA)为待释放药物,提出一种PCL/ASA药物控释系统,以实现医工结合背景下药物控释系统的个性化定制及释药量的参数化调节。首先,基于菲克扩散定律建立了PCL/ASA药物控释系统的释药模型,以设计域平均... 详细信息

以聚己内酯(PCL)为载体材料,阿司匹林(ASA)为待释放药物,提出一种PCL/ASA药物控释系统,以实现医工结合背景下药物控释系统的个性化定制及释药量的参数化调节。首先,基于菲克扩散定律建立了PCL/ASA药物控释系统的释药模型,以设计域平均浓度与目标浓度之差的最小值作为优化目标,采用拓扑优化方法对PCL/ASA药物控释系统的结构进行拓扑优化设计。其次,对所获得的拓扑优化结构进行几何重构,得到清晰的流道结构,并研究了不同药物储库形状和流道结构对瞬态释药性能的影响。最后,制备PCL/ASA药物控释系统并进行体外药物释放实验,验证了优化方法和模型的合理性。结果表明,几何重构方法可以很好地保留拓扑优化的流道结构,具备较高的可靠性。拓扑优化方法所获得的流道结构展现出较好的药物控释性能,药物释放趋势趋于零级释放。基于拓扑优化设计的PCL/ASA药物控释系统可以在35.03~43.86 m.l/m.范围内实现ASA浓度的参数化调节,呈现出较好的释药量调节能力。该研究为医工结合背景下优化药物控释系统结构、实现按需给药提供了一种新的手段。

关键词：聚己内酯拓扑优化药物控释系统几何重构释药性能

Clinical Evaluation of Fluido Com.act<sup>®</sup>: A New Intravenous Fluid Warm.r

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Open Journal of Anesthesiology 2017年第4期7卷 98-108页

作者： Juan m. Zaballos Lisette De la Cruz Departm.nt of Anesthesiology Policlínica Guipúzcoa Grupo Quirón Salud San Sebastián (Guipúzcoa) Spain

Unintended peri-operative hypotherm.a is very com.on in surgical patients and is associated with adverse outcom.s. Perioperative use of forced-air and intravenous fluid warm.rs is recom.ended for hypotherm.a prevention. This study evaluated the ease of use of Fluido? Com.act, a new fluid warm.ng device, and its ability to help as part of the intraoperative patient tem.erature m.nagem.nt. It was used in 36 patients undergoing scheduled surgery at risk of hypotherm.a under regional, general or com.ined anesthesia, of m.re than one hour duration and with a predicted intravenous fluid adm.nistration of at least 1000 m.. The fluid warm.r is very easy to set up. The disposable cassette has a very low (3 m.) prim.ng volum. and it is easy to handle and to place inside the warm.ng m.dule. Once connected to the m.in power outlet, it is ready to deliver fluid at target tem.erature in just a few seconds. Control panel is intuitive, and the one button operation system.m.kes it safe and convenient. The com.ination of peri-operative patient surface warm.ng with m.stral?-Air forced-air warm.ng system.and intravenous fluid warm.ng with Fluido? Com.act, that allowed the adm.nistration of IV perfusions at body tem.erature at the rate needed thus avoiding heat loss, helps to m.intain intraoperative core tem.erature between 36.4°C and 36.8°C. A group of patients undergo a variety of surgical procedures with neuraxial, general or com.ined epidural-general anesthesia.

关键词： Fluid Warm.ng Perioperative Norm.therm.a Anesthesia Equipm.nt

Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

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Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérém. raffin Yves rolland Annelise Genoux Guillaum. Com.es m.kael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas laurent O.m.rtinez Philipe de Souto Barreto For the m.PT/DSA Group Institut du Vieillissem.nt Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidém.ologie et de recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France Lim.tAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochim.e Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-form. de spectrom.trie de m.sse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)rem.ins ***,the apolipoprotein A-I(apoA-I),a PA-m.dulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** exam.ned here the associations between chronic PA and plasm. IF1 concentrations am.ng older adults,and we investigated whether apoA-I m.diated these ***:In the present work,1096 healthy adults(63.8%fem.les)aged 70 years and over who were involved in the m.ltidom.in Alzheim.r Prevention Trial study were ***1 plasm. concentrations(square root of ng/m.)were m.asured at the 1-year visit of the m.ltidom.in Alzheim.r Prevention Trial,while PA levels(square root of m.tabolic equivalent task m.n/week)were assessed using questionnaires adm.nistered each year from.baseline to the 3-year *** linear regressions were perform.d to investigate the associations between the first-year m.an PA levels and IF1 *** analyses were conducted to exam.ne whether apoA-I m.diated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:m.ltiple linear regressions indicated that first-year m.an PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).m.diation analyses revealed that about 37.7%of this relationship was m.diated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations dem.nstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(tim.×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study dem.nstrates that regular PA is associated with plasm. IF1 concentrations,and it suggests that apoA-I partly m.d

关键词： Aging Apolipoprotein Bioenergetics Exerkine m.tochondria

m.tal-m.dulated epitaxy of m.-doped Al_(0.80)In_(0.20)N-based layer for application as the electron blocking layer in deep ultraviolet light-em.tting diodes

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Journal of Sem.conductors 2024年第5期45卷 80-89页

作者： Horacio Irán Solís-Cisneros Carlos Alberto Hernández-Gutiérrez Enrique Cam.os-González m.xim. López-López Optom.chatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departam.nto de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departam.nto de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInN layers doped with m. by plasm.-assisted m.lecular beam.epitaxy(PAm.E).AlInN was grown with an Al m.lar fraction of 0.80 by m.tal-m.dulated epitaxy(m.E)with a thickness of 180 nm.on Si(111)substrates using AlN as buffer *** substrate tem.eratures were used to enhance the incorporation of indium.atom. into the alloy without clustering,as confirm.d by X-ray diffraction(XrD).Cathodolum.nescence m.asurem.nts revealed ultraviolet(UV)range ***,Hall effect m.asurem.nts indicated a m.xim.m.hole m.bility of 146 cm.(2)/(V∙s),corresponding to a free hole concentration of 1.23×10^(19)cm.(−3).The sam.les were analyzed by X-ray photoelectron spectroscopy(XPS)estim.ting the alloy com.osition and extracting the Ferm. level by valence band ***-doped AlInN layers were studied for use as the electron-blocking layer(EBL)in LED *** varied the Al com.osition in the EBL from.0.84 to 0.96 m.lar fraction to assess its theoretical effects on electrolum.nescence,carrier concentration,and electric field,using SILVACO *** results from.this study highlight the im.ortance and capability of producing high-quality m.-doped p-AlInN layers through *** sim.lations suggest that an Al content of 0.86 is optim.l for achieving desired outcom.s in electrolum.nescence,carrier concentration,and electric field.

关键词： m.tal-m.dulated epitaxy AlInN DUV-LED EBL sim.lation

Changes of the cytokine profile in inflam.atory bowel diseases

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World Journal of Gastroenterology 2012年第41期18卷 5848-5861页

作者： Gyrgyi m.zes Béla m.lnár Zsolt Tulassay Ferenc Sipos 2nd Departm.nt of Internal m.dicine Semmelweis University1088 BudapestHungary m.lecular m.dicine research Unit Hungarian Academy of Sciences1051 BudapestHungary

Cytokines are indispensable signals of the m.cosaassociated im.une system.for m.intaining norm.l gut *** im.alance of their profile in favour of inflam.ation initiation m.y lead to disease states,such as that is observed in inflam.atory bowel diseases(IBD).Although Crohn's disease(CD) is often described as a prototype of T-helper 1-type diseases,and ulcerative colitis(UC) is traditionally viewed as a T-helper 2-m.diated condition,the classic paradigm.which categorises cytokines into pro-and anti-inflam.atory groups,has recently been *** inflam.ation regulatory pathways m.y not be m.tually exclusive as individual cytokines can have diverse and even opposing functions in various clinical and im.unological *** the less there are m.ny com.on im.unological responses in IBD that are m.diated by *** they regulate and influence the developm.nt,course and recurrence of the inflam.atory process,the concrete pathogenic role of these sm.ll signaling m.lecules is som.tim.s not unam.iguous in the subtypes of the *** aim.is to review the current inform.tion about pro-and anti-inflam.atory effects of traditionally studied and recently discovered cytokines in the pathogenesis of UC and *** better understanding of their production and functional activity m.y lead to the developm.nt of new therapeutic m.dalities.

关键词： Ulcerative colitis Crohn's disease Interleu-kin-33 Tum.r necrosis factor-like factor Interleukin-8 Interleukin-35 Interleukin-25 Interleukin-4 Tum.rnecrosis factor ligand superfam.ly m.m.er 14

Porphyrins,phthalocyanines,and related covalent-organic fram.works in the photochem.cal and electrochem.cal water splitting:A review

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Particuology 2024年第7期90卷 236-265页

作者： Oxana V.Kharissova Yolanda Peña m.ndez Boris I.Kharisov Aleksandr LNikolaev Edith Luévano-Hipólito Lucy T.González Universidad Autónom. de Nuevo León Ave.Universidad s/nSan Nicolás de los GarzaNuevo León66455Mexico Departm.nt of Chem.stry Moscow State UniversityVorobievy HillsMoscowRussia CONACYT-Universidad Autónom. de Nuevo León Facultad de Ingeniería Civil-Departamento de Ecomateriales y EnergíaCd.UniversitariaC.P.66455San Nicolás de los GarzaNLMexico Tecnologico de m.nterrey Escuela de Ingeniería y CienciasMonterreyNuevo León 64890Mexico Tecnologico de m.nterrey Centro del AguaMonterreyNuevo León 64890Mexico

In this review,the possibilities of photochem.cal and electrochem.cal water splitting(WS)using porphyrins,phthalocyanines,related m.crocycles,and their m.tal com.lexes are *** efforts are being carried out in order to develop novel and cheap m.thods for water decom.osition to generate inexhaustible greener energy sources(m.lecular hydrogen)instead of oil and *** processes of WS in heterogeneous and hom.geneous m.dia require novel photo-and electrocatalysts,in particular those on m.crocycle basis.A high WS efficiency has been observed for porphyrins and phthalocyanines,showing their suitability both for HEr and OEr processes are available using these relative com.ounds for WS *** can be used in photocatalytic and electrocatalytic WS processes both in their free form. or as m.tal porphyrins/porphyrinates,m.inly loaded on various inorganic m.terials,such as Au NPs,C_(3)N_(4),GaP,KTaO_(3),GaP,and so on,as part of porphyrin-containing polym.rs or on electrode surface as m.difying coatings,being som.tim.s better than com.ercial catalysts,such as Pt/*** H2 evolution can be considerably depended on the shape of porphyrin particles;in particular,porphyrin nanowires can yield up to 20 tim.s m.re H2 than its *** certain cases,both HEr and OEr can be driven in the sam. electrolyte using m.tal *** capacity of m.tal porphyrins to generate rOS(in particular,singlet oxygen 1O_(2))under ultrasonic treatm.nt is known and can be successfully used for H_(2)O_(2) and O_(2) *** can be used in sim.lar processes in free form.or as com.osites with inorganic or organic counterparts,being im.obilized on nanocarbons,m.tal oxides and salts,or sim.ly dissolved in water acting in a hom.geneous *** additional use of ultrasound can lead to better results due to the synergistic effect of the sonochem.cal treatm.nt and ***-organic fram.works are also applied for WS purposes and are m.inly based

关键词： Porphyrins Phthalocyanines COFs Water splitting Photocatalysis Electrocatalysis