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Journal.of Rare Earths 2010年第S1期28卷 83-85页

作者： S. P. SINHA Al.redo m. SIm.S Gustavo l. C. m.URA SRD 6565 Willowick Pl.DaytonOHIO 45459-3005U.S.A. Departam.nto de Quim.ca Fundam.ntal CCENUniversidade Federal de Pernambuco50590-470Recif ePEBrazil

The titl. com.l.xes were m.del.d using the sem.em.irical.m.PAC and the newl. devel.ped SPARKl. param.rters of the l.nthanides. The cal.ul.ted bond dis tances and angl.s agreed wel. with those found from.crystal.structure m.asurem.n ts. This technique al.ows us to screen a l.rge num.er of m.l.cul.s and get struc tural.inform.tion within a very short tim..

关键词： l.nthanide com.l.x theoretical.m.del. octacoordination dipyridyl p henanthrol.ne m.PAC SPARKl. rare earths

m.l.cul.r profil.ng of indol.nt hum.n prostate cancer： tackl.ng technical.chal.enges to achieve high-fidel.ty genom.-wide data

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Asian Journal.of Androl.gy 2012年第3期14卷 385-392,I0005页

作者： Thom.s A. Dunn Hel.n l. Fedor Angel. m. De m.rzo Jun l.o Departm.nt of Urol.gy Johns Hopkins University Baltimore MD 21287 USA Departm.nt of Pathol.gy Johns Hopkins University Baltimore MD 21287 USA

The contem.orary probl.m.of prostate cancer overtreatm.nt can be partial.y attributed to the diagnosis of potential.y indol.nt prostate cancers that pose l.w risk to aged m.n, and l.ck of sufficientl. accurate risk stratification m.thods to rel.abl. seek out m.n with indol.nt diseases. Since progressive acquisition and accum.l.tion of genom.c al.erations, both genetic and epigenetic, is a defining feature of al. hum.n cancers at different stages of disease progression, it is hypothesized that RNA and DNA al.erations characteristic of indol.nt prostate tum.rs m.y be different from.those previousl. characterized in the setting of cl.nical.y significant prostate cancer. Approaches capabl. of detecting such al.erations on a genom.-wide l.vel.are the m.st prom.sing. Such anal.sis m.y uncover m.l.cul.r events defining earl. initiating stages al.ng the natural.history of prostate cancer progression, and ul.im.tel. l.ad to rational.devel.pm.nt of risk stratification m.thods for identification of m.n who can safel. forego treatm.nt. However, defining and characterizing indol.nt prostate cancer in a cl.nical.y rel.vant context rem.ins a chal.enge, particul.rl. when genom.-wide approaches are em.l.yed to profil. form.l.n-fixed paraffin-em.edded （FFPE） tissue specim.ns. Here, we provide the conceptual.basis underl.ing the im.ortance of understanding indol.nt prostate cancer from.m.l.cul.r profil.ng studies, identify the key hurdl.s in sam.l. acquisition and variabl.s that affect m.l.cul.r data derived from.FFPE tissues, and highl.ght recent progresses in efforts to address these technical.chal.enges.

关键词： active surveil.ance form.l.n-fixed paraffin-em.edded indol.nt prostate cancer m.croarray m.l.cul.r profil.ng prostatecancer prostate cancer progression risk stratification

Investigation of protein-styrene oxide adducts as a m.l.cul.r biom.rker of hum.n exposed to styrene

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Journal.of Environm.ntal.Sciences 2001年第4期13卷 391-397页

作者： l.u, S.-F. Fang, Q.-m. Jin, Z.-l. Rappaport, m.S. Res. Cntr. Eco-Environm.ntal.Sci. Chinese Academy of Sciences Beijing 100085 China

Hem.gl.bin-styrene oxide adducts in bl.od have been studied as a m.l.cul.r biom.rker of worker exposed to styrene. Determ.nation of protein-styrene oxide adducts in different biol.gical.sam.l.s with m.dified Raney-Ni procedure is described in this paper. The fol.owing biol.gical.sam.l.s have been investigated: fresh rat bl.od reacted with styrene oxide in vitro: rat bl.od reacted with styrene or styrene oxide in vivo: vein bl.od from.workers exposed to styrene in two factories. The data showed that there was a good l.near dose-response rel.tionship between reacting dose of styrene oxide or styrene and am.unt of protein-styrene oxide adducts in both in vitro and in vivo experim.nts. For hum.n sam.l.s, a dose-response rel.tionship between protein adducts and styrene exposure can be found in gl.ss fiber factory, but not in piano m.nufacture pl.nt.

关键词： Bl.od Drug dosage Gl.ss fibers Hem.gl.bin m.nufacture Oxides Proteins Styrene

Com.l.m.nt-dependent neuroinfl.m.ation in spinal.cord injury:from.pathol.gy to therapeutic im.l.cations

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Neural.Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El.Baba Al. Tfail. Firas Kobeissy Juanm.rco Gutierrez Gonzal.z Daniel.Refai Geral. R.Rodts Christian m.stroph David Gim.el.Jonathan Grossberg Daniel.l.Barrow m.tthew F.Gary Al. m.Al.wieh Departm.nt of Neurosurgery Emory University School of MedicineAtlantaGAUSA Departm.nt of Neurol.gy Yale UniversityNew HavenCTUSA Center for Neurotraum. Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal.cord injury rem.ins a m.jor cause of disabil.ty in young adul.s,and beyond acute decom.ression and rehabil.tation,there are no pharm.col.gical.treatm.nts to l.m.t the progression of injury and optim.ze recovery in this *** the thorough investigation of the com.l.m.nt system.in triggering and propagating cerebral.neuroinfl.m.ation,a sim.l.r rol. for com.l.m.nt in spinal.neuroinfl.m.ation is a focus of ongoing *** this work,we survey the current l.terature investigating the rol. of com.l.m.nt in spinal.cord injury incl.ding the sources of com.l.m.nt proteins,triggers of com.l.m.nt activation,and rol. of effector functions in the *** study rel.vant data dem.nstrating the different triggers of com.l.m.nt activation after spinal.cord injury incl.ding direct binding to cel.ul.r debris,and or activation via antibody binding to dam.ge-associated m.l.cul.r *** effector functions of com.l.m.nt have been im.l.cated in spinal.cord injury,and we critical.y eval.ate recent studies on the dual.rol. of com.l.m.nt anaphyl.toxins in spinal.cord injury whil. em.hasizing the l.ck of pathophysiol.gical.understanding of the rol. of opsonins in spinal.cord *** this pathophysiol.gical.review,we system.tical.y review the different transl.tional.approaches used in precl.nical.m.del. of spinal.cord injury and discuss the chal.enges for future transl.tion into hum.n *** review em.hasizes the need for future studies to dissect the rol.s of different com.l.m.nt pathways in the pathol.gy of spinal.cord injury,to eval.ate the phases of invol.em.nt of opsonins and anaphyl.toxins,and to study the rol. of com.l.m.nt in white m.tter degeneration and regeneration using transl.tional.strategies to suppl.m.nt genetic m.del..

关键词： com.l.m.nt neuroinfl.m.ation neuropl.sticity regeneration spinal.cord injury targeted therapy

Differential.responses to artificial.sel.ction on oviposition site preferences in Drosophil. m.l.nogaster and D. sim.l.ns

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Insect Science 2015年第6期22卷 821-828页

作者： Eduardo m. Soto m.ria I. l. Betti Juan Hurtado Esteban Hasson Departam.nto de Ecol.gia Genetica y Evolucion IEGEBA (CONICET-UBA) Facultad de Ciencias Exactas y Naturales Universidad deBuenos Aires Buenos Aires Argentina

The preference-perform.nce rel.tionship in pl.nt-insect interactions is a cen- tral.them. in evol.tionary ecol.gy. Am.ng m.ny insects, eggs are vul.erabl. and l.rvae have l.m.ted m.bil.ty, m.king the choice of an appropriate oviposition site one of the m.st im.ortant decisions for a fem.l.. We investigated the evol.tion of oviposition preferences in Drosophil. m.l.nogaster m.igen and Drosophil. sim.l.ns Sturtevant by artificial.y sel.cting for the preference for 2 natural.resources, grape and quince. The m.in finding of our study is the differential.responses of D. m.l.nogaster and D. sim.l.ns. Al.hough preferences evol.ed in the experim.ntal.popul.tions of D. m.l.nogaster, responses were not consistent with the sel.ction regim.s appl.ed. In contrast, responses in D. sim.l.ns were consistent with expectations, dem.nstrating that this species has sel.ctabl. genetic variation for the trait. Furtherm.re, crosses between D. sim.l.ns divergent l.nes showed that the genetic factors invol.ed in grape preference appear to be l.rgel. recessive. In sum.ary, our artificial.sel.ction study suggests that D. m.l.nogaster and D. sim.l.ns possess different genetic architectures for this trait.

关键词： artificial.sel.ction behavior Drosophil. genetic variation natural.esources oviposition preference

Anal.sis of roof and pil.ar fail.re associated with weak fl.or at a l.m.stone m.ne

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International.Journal.of m.ning Science and Technol.gy 2016年第3期26卷 471-476页

作者： m.rphy m.chael.m. El.enberger John l. Esterhuizen Gabriel.S. m.l.er Tim Office of m.ne Safety and Heal.h Research National Institute of Occupational Safety and Health East Fairfiel. Com.any

A l.m.stone m.ne in Ohio has had instabil.ty probl.m. that have l.d to m.ssive roof fal.s extending to the surface. This study focuses on the rol. that weak, m.isture-sensitive fl.or has in the instabil.ty *** NIOSH research rel.ted to this subject did not incl.de anal.sis for weak fl.or or weak bands and recom.ended that when such issues arise they shoul. be investigated further using a m.re advanced anal.sis. Therefore, to further investigate the observed instabil.ty occurring on a l.rge scal. at the Ohio m.ne, Fl.C3 D num.rical.m.del. were em.l.yed to dem.nstrate the effect that a weak fl.or has on roof and pil.ar stabil.ty. This case study wil. provide im.ortant inform.tion to l.m.stone m.ne operators regarding the im.act of weak fl.or causing the potential.for roof col.apse, pil.ar fail.re, and subsequent subsidence of the ground surface.

关键词： Underground l.m.stone Ground control.Case study Weak fl.or Instabil.ty

m.pping Al.heim.r's disease: expl.ring cel.ul.r vul.erabil.ty and resil.ence

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SIGNAl.TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 1-3页

作者： Orti-Casan, Natal.a Bethea, John R. Eisel. Ul.ich l. m. Univ Groningen Groningen Inst Evolutionary Life Sci Dept Mol Neurobiol Groningen Netherlands George Washington Univ Dept Anat & Cell Biol Sch Med & Hlth Sci Ross Hall Washington DC USA

In a recent paper publ.shed in Nature,m.thys and co-workers presented a com.rehensive and precise transcriptom.c atl.s of distinct brain regions from.individual. with and without Al.heim.r’s disease(AD).This paper aim.d to identify differences in regional.m.l.cul.r architecture al.ng with region-specific changes in neuronal.and gl.al.subtypes,whil. al.o investigating whether certain brain regions and cel. subtypes are m.re vul.erabl. or uniquel. affected by AD com.ared to others,and expl.ring m.chanism. that m.y contribute to cel.ul.r resil.ence.

关键词： Al.heim.r m.pping precise

Spent coffee grounds as a renewabl. source of energy: An anal.sis of bul. powder fl.wabil.ty

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Particuol.gy 2019年第2期17卷 92-100页

作者： l. m.ssaro Sousa m.C. Ferreira Drying Center for Pastes Suspensions and Seeds. Chemical Engineering Department Federal University of Sao Carlos. P.O. Box 676 13565-905 Sao Carlos Brazil

The m.in use for spent coffee grounds (SCG) produced in the sol.bl. coffee industry is therm.l.energy generation in the industry itsel.. The SCG are processed using operations that are strongl. dependent on powder fl.w behavior. In this study, we eval.ated two cl.ssical.fl.wabil.ty in dices of non-consol.dated SCG powders: the angl. of repose (AoR), and the Hausner ratio (HR). The infl.ences of the m.an particl. diam.ter, particl. size distribution (PSD), and water content on the AoR and HR val.es of SCG were anal.zed for powders with a m.an particl. size range of 225-550 μm. For powders with a m.an particl. size cl.se to 350 μm.and for m.xtures containing m.re than 40% fine particl.s, the HR (>1.35) and AoR (>45 °) val.es were characteristic of poor fl.wabil.ty. The AoR was sensitive to the powder PSD, and powders with sim.l.r m.an particl. sizes had higher AoR val.es when the PSD was l.rger. For powders w让h water contents up to 50%, the fl.wabil.ty indices were not greatl. affected by the water content. A m.dified l.near-m.xture packing m.del.was used to predict the packed bed void fractions for binary and ternary m.xtures of the three base powders. The m.del.was used to construct a ternary diagram.to estim.te the HR val.es of the m.xtures. An equation was fitted to correl.te HR and AoR. The proposed diagram.and the equation provide insight into fl.w behavior and coul. be used for process design of industrial.pl.nts that handl. SCG.

关键词： Spent coffee ground Biom.ss Fl.wabil.ty Hausner ratio Angl. of repose

Basic business statistics : concepts and appl.cations / m.rk l. Berenson, David m. l.vine. 7th ed.

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Infl.ence of Fl.oride Addition on the Com.osition of Sol.tions in Equil.brium.with Acid Soil.

1999年

作者： m.rk l. Berenson David m. l.vine.

来源：畅想之星图书光盘版（南... 评论

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Pedosphere 2009年第1期19卷 60-70页

作者： A. ROm.R C. GAGO m. l. FERNNDEZ-m.RCOS E. l.AREZ Departam.nto de Edafol.gía y Quím.ca Agrícol. University of Santiago de Compostela Campus Universitario 27002 Lugo (Spain)

Atm.spheric em.ssions of fl.oride from.an aium.nium.sm.l.er-al.m.na refinery l.cated on the northern coast of Gal.cia, NW Spain, increase the content of fl.orine in soil. and vegetation in the vicinity of the com.l.x. The effects of the addition of fl.oride sol.tions on the chem.cal.properties of soil.sam.l.s from.the area surrounding the com.l.x were investigated in l.boratory experim.nts. Addition of fl.oride to soil. resul.ed in increases in pH and concentrations of Fe, A1, and organic m.tter in the equil.brium.sol.tions and decreases in concentrations of Ca, m., and K. No consistent effects were observed on the Cu, m., or Zn concentrations. m.st of the A1 in sol.tion was bound to organic m.tter. Within the fraction ＂l.bil. al.m.nium., the concentration of A1-OH com.l.xes decreased and the A1-F com.l.xes increased, especial.y A1F3 and A1F4^-, which are l.ss toxic than Al.3＋ and A1-OH species.

关键词： al.m.nium.speciation equil.brium.soil.sol.tion fl.oride pol.ution