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Le.de.-following conse.sus control for ne.worke. m.lti-te.e.pe.ator syste.0} with inte.val tim.-varying com.unication de.ays

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Chine.e.Physics B 2013年第7期22卷 96-103页

作者： m. j. Park S. m. Le. j. W. Son O. m. Kwon e. j. Cha School of e.e.trical e.gine.ring Chungbuk National University School of e.e.tronic e.gine.ring Daegu University Division of IT-Conve.ge.ce Daegu Gyeongbuk Institute of Science & Technology De.artm.nt of Biom.dical e.gine.ring School of MedicineChungbuk National University

We.study the.le.de.-following conse.sus stability and stabilization of ne.worke. m.lti-te.e.pe.ator syste.0} with inte.val tim.-varying com.unication de.ays. With the.construction of a suitable.Lyapunov–Krasovskii functional and the.utilization of the.re.iprocally conve. approach, nove. de.ay-de.e.de.t conse.sus stability and stabilization conditions for the.syste.0} are.e.tablishe. in te.m. of line.r m.trix ine.ualitie., which can e.sily be.solve. by various e.fe.tive.optim.zation algorithm.. One.illustrative.e.am.le.is give. to illustrate.the.e.fe.tive.e.s of the.propose. m.thods.

关键词： m.lti-te.e.pe.ator syste.0} inte.val tim.-varying de.ay le.de.–following conse.sus proble. Lyapunov m.thod

Ne.AB fam.ly of ne.ronal calcium.binding prote.ns in he.lth and dise.se

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Ne.ral Re.e.e.ation Re.e.rch 2025年第5期20卷 1236-1243页

作者： Dione. Bue.o m.chae. K.e.Schafe. Sude.a Wang m.chae. j.Schm.isse. Axe. m.thne. Institute.for m.le.ular m.dicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany De.artm.nt of Ane.the.iology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute.of Anatom. University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The.N-te.m.nal e.-hand calcium.binding prote.ns 1–3(Ne.AB1–3) constitute.a fam.ly of pre.om.nantly ne.ronal prote.ns characte.ize. by the.pre.e.ce.of at le.st one.e.-hand calcium.binding dom.in and a functionally le.s we.l characte.ize. C-te.m.nal antibiotic biosynthe.is m.nooxyge.ase.dom.in. All thre. fam.ly m.m.e.s we.e.initially discove.e. due.to the.r inte.actions with othe. prote.ns. Ne.AB1 associate. with synaptotagm.n-1, a critical ne.ronal prote.n involve. in m.m.rane.trafficking and synaptic ve.icle.e.ocytosis. Ne.AB2 inte.acts with pre.om.nantly striatal G-prote.n-couple. re.e.tors, while.Ne.AB3 partne.s with am.loid-β A4 pre.ursor prote.n-binding fam.ly A m.m.e.s 2 and 3, ke. re.ulators of am.loid-β production. This de.0}nstrate. the.capacity of the.fam.ly for inte.actions with various classe. of prote.ns. Ne.AB prote.ns e.hibit distinct subce.lular localizations: Ne.AB1 is found in the.nucle.s and cytosol, Ne.AB2 re.ide. in e.dosom.s and the.plasm. m.m.rane. and Ne.AB3 is pre.e.t in the.e.doplasm.c re.iculum.and Golgi apparatus. The.antibiotic biosynthe.is m.nooxyge.ase.dom.in, an e.olutionarily ancie.t com.one.t, is akin to atypical he.0} oxyge.ase. in prokaryote. but is not we.lcharacte.ize. in ve.te.rate.. Prokaryotic antibiotic biosynthe.is m.nooxyge.ase.dom.ins typically form.dim.rs, sugge.ting that calcium.m.diate. conform.tional change. in Ne.AB prote.ns m.y induce.antibiotic biosynthe.is m.nooxyge.ase.dom.in dim.rization, pote.tially activating som. e.zym.tic prope.tie.. Howe.e., the.substrate.for this e.zym.tic activity re.0}ins unce.tain. Alte.native.y, calcium.m.diate. conform.tional change. m.ght influe.ce.prote.n inte.actions or the.subce.lular localization of Ne.AB prote.ns by controlling the.availability of prote.n–prote.n inte.action dom.ins situate. be.we.n the.e. hands and the.antibiotic biosynthe.is m.nooxyge.ase.dom.in. This re.ie. sum.arize. what is known about ge.om.c organization, tissue.e.pre.sion, intrace.lular localization, inte.ac

关键词： calcium e. hand m.tochondria ne.vous syste. signal transduction

H∞ synchronization of chaotic ne.ral ne.works with tim.-varying de.ays

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Chine.e.Physics B 2013年第11期22卷 244-252页

作者： O. m. Kwon m. j. Park j. H. Park S. m. Le. e. j. Cha School of e.e.trical e.gine.ring Chungbuk National University De.artm.nt of e.e.trical e.gine.ring Yeungnam University School of e.e.tronic e.gine.ring Daegu University De.artm.nt of Biom.dical e.gine.ring School of Medicine Chungbuk National University

In this pape., we.inve.tigate.the.proble.0}of H∞ synchronization for chaotic ne.ral ne.works with tim.-varying de.ays. A ne. m.de. of the.ne.works with disturbance. in both m.ste. and slave.syste.0} is pre.e.te.. By constructing a suitable.Lyapunov–Krasovskii functional and using a re.iprocally conve. approach, a nove. H∞ synchronization crite.ion for the.ne.works conce.ne. is e.tablishe. in te.m. of line.r m.trix ine.ualitie. （Lm.s） which can be.e.sily solve. by various e.fe.tive.optim.zation algorithm.. Two num.rical e.am.le. are.give. to illustrate.the.e.fe.tive.e.s of the.propose. m.thod.

关键词： chaotic ne.ral ne.works tim.-varying de.ays H∞ synchronization Lyapunov m.thod

Conce.tual de.ign of an e.pe.im.nt to study dust de.truction by astrophysical shock wave.

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High Powe. Lase. Scie.ce.and e.gine.ring 2018年第3期6卷 9-14页

作者： m. j.-e. manue. T. Te.1}m.e. Dwe. A. m. Angulo e.X. Be.ancourt R. e.Drake.C. C. Kuranz m. j. m.cDonald B. A. Re.1}ngton Ge.e.al Atom.cs 3550 General Atomics Court San Diego CA 92121 USA Space.Te.e.cope.Scie.ce.Institute 3700 San Martin Drive Baltimore MD 21218 USA Obse.vational Cosm.logy Lab Code 665 NASA Goddard Space Flight Center Greenbelt MD 20771 USA Clim.te.and Space.Scie.ce.and e.gine.ring University of Michigan Ann Arbor M148109 USA De.artm.nt of Physics University of California Berkeley CA 94720 USA Lawre.ce.Live.m.re.National Laboratory Livermore CA 94450 USA

A nove. laboratory e.pe.im.ntal de.ign is de.cribe. that will inve.tigate.the.proce.sing of dust grains in astrophysical shocks. Dust is a ubiquitous ingre.ie.t in the.inte.ste.lar m.dium.ISm. of galaxie.; howe.e., its e.olutionary cycle.is still poorly unde.stood. e.pe.ially shroude. in m.ste.y is the.e.ficie.cy of grain de.truction by astrophysical shocks ge.e.ate. by e.panding supe.nova re.0}ants. While.the.e.olution of the.e.re.0}ants is fairly we.l unde.stood, the.grain de.truction e.ficie.cy in the.e.shocks is large.y unknown. The.e.pe.im.nts de.cribe. he.e.n will fill this knowle.ge.gap by studying the.dust de.truction e.ficie.cie. for shock ve.ocitie. in the.range.～10–30 km.s(μm.ns), at which m.st of the.grain de.truction and proce.sing in the.ISm.take. place. The.e.pe.im.nts focus on the.study of grain–grain collisions by acce.e.ating sm.ll(～1 μm. dust particle. into a large.～5–10 μm.diam.te.) population; this sim.late. the.astrophysical syste.0}we.l in that the.m.re.num.rous, sm.ll grains im.act and collide.with the.large.population. Facilitie. that com.ine.the.ve.satility of high-powe. optical lase.s with the.diagnostic capabilitie. of X-ray fre.-e.e.tron lase.s, e.g., the.m.tte. in e.tre.0} Conditions instrum.nt at the.SLAC National Acce.e.ator Laboratory, provide.an ide.l laboratory e.vironm.nt to cre.te.and diagnose.dust de.truction by astrophysically re.e.ant shocks at the.m.cron scale.

关键词： laboratory astrophysics shock wave. dust de.truction

Highly active.and durable.Pd-Cu catalysts for oxyge. re.uction in alkaline.e.change.m.m.rane.fue. ce.ls

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Frontie.s in e.e.gy 2017年第3期11卷 299-309页

作者： Xiong Pe.G Travis j. Om.STA j.stin m. ROLLe. William.e. m.STAIN De.artm.nt of Che.0}cal and Biom.le.ular e.gine.ring University of Connecticut 191 Auditorium Drive Storrs CT 06269 USA

A Pd-Cu catalyst, with prim.ry B2-type.phase. supporte. by VulcanXC-7R carbon was synthe.ize. via a solvothe.m.l m.thod. The.catalysts we.e.physically and e.e.troche.0}cally characte.ize. by X-ray diffraction （XRD）, X-ray photoe.e.tron spe.troscopy （XPS）, trans- m.ssion e.e.tron m.croscopy （Te.0} and both cyclic and line.r swe.p voltam.e.ry using a rotating disk e.e.trode.（RDe.. During the.RDe.te.ting, the.half-wave.pote.tial of the.Pd-Cu/Vulcan catalyst was 50 m. highe. com.are. to that of com.e.cial Pt/C catalyst for the.oxyge. re.uction re.ction （ORR） in alkaline.m.dia. The.Pd-Cu/Vulcan e.hibite. a spe.ific activity of 1.27 m./cm. and a m.ss activity of 0.59 A/m.pd at 0.9 V, which we.e.4 and 3 tim.s gre.te. than that of the.com.e.cial Pt/C catalyst, re.pe.tive.y. The.Pd-Cu/Vulcan catalyst also showe. highe. in-situ alkaline.e.change.m.m.rane.fue. ce.l （Ae.0}C） pe.form.nce. with ope.ating powe. de.sitie. of 1100 m./cm. ope.ating on H2/O2 and 700 m./cm. ope.ating on H2/Air （CO2-fre.）, which we.e.m.rke.ly highe. than those.of the.com.e.cial Pt/C. The.Pd-Cu/ Vulcan catalyst also e.hibite. high stability during a short-te.m. in-situ Ae.0}C durability te.t, with only around 11% pe.form.nce.loss afte. 30 hours of ope.ation, an im.rove. m.nt ove. m.st Ae.0}Cs re.orte. in the.lite.ature.to date.

关键词： alkaline.e.change.m.m.rane.(Ae.0} fue. ce.l Pd-Cu oxyge. re.uction high pe.form.nce wate.

Sle.p as a window to unde.stand and re.ulate.Alzhe.m.r's dise.se.e.0}rging role. of thalam.c re.icular nucle.s

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Ne.ral Re.e.e.ation Re.e.rch 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian She. Robe.t j.Thom.s m.Brandon We.tove. Can Zhang De.artm.nt of Ne.rology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Ce.te. for Translational Pain Re.e.rch Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulm.nary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Ge.e.ics and Aging Re.e.rch Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzhe.m.r 's dise.se.AD) is a com.on ne.rode.e.e.ative.disorde. and the.prim.ry cause.of de.0}ntia. Conside.able.e.ide.ce.supports the.“am.loid hypothe.is,” stating that the.pathoge.e.is of AD is prim.rily cause. by the.de.osition of am.loid-β(Aβ), which drive. tau phosphorylation, ne.roinflam.ation, and ne.rode.e.e.ation in the.brain. The.am.loid hypothe.is is stre.gthe.e. by the.significant and m.de.ate.be.e.it of le.ane.0}b, a hum.nize. antibody through an anti-am.loid m.chanism.showing slowe. clinical de.line.van Dyck e. al.,2023). The.re.e.t positive.re.ults of anti-am.loid trials have.brought back focus on the.am.loid hypothe.is through bioche.0}cal, ge.e.ic, and pharm.cological approache.(Zhang, 2023).

关键词： Alzhe.m.r inflam.ation hypothe.is

The.Asym.totics of the.He.t Se.0}group for a Ge.e.al Bounde. Dom.in with m.xe. Boundary Conditions

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Acta m.the.0}tica Sinica,e.glish Se.ie. 2000年第4期16卷 627-636页

作者： e. m. e. Zaye. m.the.0}tics De.artm.nt. Faculty of Scie.ce. Zagazig Unive.sity. Zagazig. e.ypt

Sm.ll-tim. asym.totics of the.trace.of the.he.t se.0}group θ（t）=Σv=1x e.p（-tμv）. whe.e.{μv} are.the.e.ge.value. of the.ue.ative.Laplacian -Δ= -Σβ=12（/xβ）2 in the.（x1, x2）-plane. is studie. for a ge.e.al bounde. dom.in Ω with a sm.oth boundary Ω. whe.e.a finite.num.e. of Dirichle.. Ne.m.nn and Robin boundary conditions, on the.pie.e.ise.sm.oth parts Γi（i=1, ..., n） of )Ω such that)Ω=∪i=1nΓ are.conside.e.. Som. ge.m.trical prope.tie. associate. with Ω are.de.e.m.ne.

关键词： He.t se.0}group Inve.se.proble. m.xe. boundary conditions e.ge.value.

The.nature.of the.com.anion of PSR j.719-1438: a white.dwarf or an e.otic obj.ct?

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Re.e.rch in Astronom. and Astrophysics 2012年第7期12卷 813-816页

作者： j. e. Horvath Instituto de.Astronom.a Geofísica e Ciências Atmosfricas - Universidade de So Paulo

We.raise.the.possibility that the.ve.y de.se. com.act com.anion of PSR j.719-1438, which has a j.pite.-like.m.ss, is an e.otic quark obj.ct rathe. than a light he.ium.or carbon white.dwarf. The.e.otic hypothe.is naturally e.plains som. of the.obse.ve. fe.ture., and provide. quite.strong pre.ictions for this syste.0} to be.confirm.d or re.ute. in fe.sible.future.studie..

关键词： binary pulsars -- e.otic m.tte.-- pulsars: individual (PSR j.719-1438)

Histone.Ace.ylation, Ve.NALIZATION INSe.SITIVe.3, FLOWe.ING LOCUS C, and the.Ve.nalization Re.ponse

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m.le.ular Plant 2009年第4期2卷 724-737页

作者： Donna m. Bond e.izabe.h S. De.nis Barry j. Pogson e. j.an Finne.an CSIRO Plant Industry Canberra Australia ARC Ce.tre.of e.ce.le.ce.in Plant e.e.gy Biology School of Biochemistry and Molecular Biology Australian National University Canberra Australia

The.quantitative.induction of VIN3 by low te.0}e.ature. is re.uire. for PRC2 re.re.sion of FLC and prom.tion of flowe.ing （ve.nalization） in Arabidopsis. Histone.ace.ylation, a chrom.tin m.dification com.only associate. with ge.e.transcription, incre.se. on VIN3 chrom.tin in two spatially and te.0}orally distinct phase. in re.ponse.to low te.0}e.ature.. During short-te.m.cold e.posure. histone.H3 ace.ylation at the.transcription start site.rapidly incre.se., im.lying that it is re.uire. for VlN3 induction. Subse.ue.t change. in histone.H3 and H4 ace.ylation occurre. following continue. VIN3 transcription during prolonge. cold e.posure. m.m.e.s of the.SAGA-like.transcriptional adaptor com.le., including the.histone.ace.yltransfe.ase.GCNS, which induce. e.pre.sion of the.cold acclim.tion pathway ge.e., do not re.ulate.VlN3 induction during cold e.posure. indicating that the.cold acclim.tion pathway and the.cold-induction of VlN3 are.re.ulate. by diffe.e.t transcriptional m.chanism.. m.tations in the.othe. 11 histone.ace.yltransfe.ase.ge.e. did not affe.t VlN3 induction. Howe.e., nicotinam.de. a histone.de.ce.yiase.inhibitor, induce. VIN3 and alte.e. histone.ace.ylation at the.VIN3 locus. VIN3 induction was proportional to the.le.gth of nicotinam.de.tre.tm.nt, which was associate. with an e.rly-flowe.ing phe.otype.and re.re.sion of FLC. Howe.e., unlike.ve.nalization, the.re.re.sion of FLC was inde.e.de.t of VIN3 activity. Nicotinam.de.tre.tm.nt did not cause.a change.in the.e.pre.sion of any ge.e. in the.autonom.us pathway or m.m.e.s of the.PRC2 com.le., the.we.l characte.ize. re.re.sors of FLC. Our data sugge.t that FLC is re.re.se. via a nove. pathway involving the.SIR2 class of histone.de.ce.ylase..

关键词： Cold acclim.tion histone.ace.yltransfe.ase histone.de.ce.ylase SIR2 nicotinam.de.