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Recovery rates of persistent post-COVID-19 olfactory dysfunction using psychophysical assessm.nt:A longitudinal cohort study

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World j.urnal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： j.rem. P.Tervo Patricia T.j.cobson brandon j.Vilarello Tiana m.Saak Francesco F.Caruana Liam.W.Gallagher j.seph B.Gary David A.Gudis Paule V.j.seph D.P.Devanand Terry E.Goldberg j.nathan B.Overdevest Colum.ia University Vagelos College of Physicians and Surgeons New YorkNew YorkUSA Departm.nt of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Departm.nt of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA Departm.nt of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Colum.ia University Irving m.dical Center New YorkNew YorkUSA

Obj.ctives:Persistent olfactory dysfunction(OD)following loss of sm.ll associated with SARS-CoV-2 infection is a m.j.r feature of long *** on the prevalence of persistent OD predom.nantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessm.nt am.ng patients presenting for evaluation of persistent OD beyond a window of acute *** anchored in standardized testing m.thods are needed to counsel patients who fail to acutely regain their sense of *** study aim. to quantify the degree of persistent OD in post-COVID-19 patients who experience subj.ctive and psychophysical ***:We grouped participants presenting for OD evaluation into cohorts based on both subj.ctive and psychophysical olfactory status at a baseline assessm.nt and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year tim. *** had confirm.d a history of COVID-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:Baseline olfactory evaluation was com.leted by 122 participants,53 of whom.com.leted the 1-year follow-up *** participants presenting with perceived OD,74.5%had confirm.d psychophysical OD at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both tim. *** total threshold,discrim.nation,and identification(TDI)score im.roved by+3.25 points in the cohort with psychophysical OD(p=0.0005),with this im.rovem.nt largely attributable to an increase in m.dian threshold scores(+2.75 points;p=0.0004).Conclusions:OD persists in a significant num.er of patients who fail to acutely recovery their sense of sm.ll after COVID-19,with m.ny dem.nstrating lingering deficits at *** in threshold,but not discrim.nation or identification,m.st significantly m.diate im.rovem.nt

关键词： long COVID olfaction post-COVID condition sm.ll dysfunction

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Surface engineering with ionic polym.rs on m.m.0}nes for boron rem.val

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Frontiers of Chem.cal Science and Engineering 2024年第5期18卷 61-69页

作者： Xiting Zhang Chenyi Fang j.Paul Chen Sui Zhang Departm.nt of Chem.cal and Biom.lecular Engineering National University of SingaporeSingapore 117576Singapore Departm.nt of Civil and Environm.ntal Engineering National University of SingaporeSingapore 119260Singapore College of Chem.stry and Environm.ntal Engineering Shenzhen UniversityShenzhen 518060China

Rem.val of boric acid from.seawater and wastewater using reverse osm.sis m.m.0}ne technologies is im.erative and yet rem.ins inadequately addressed by current com.ercial *** research efforts perform.d post-m.dification of reverse osm.sis m.m.0}nes to enhance boron rej.ction,which is usually accom.anied by substantial sacrifice in water *** study delves into the surface engineering of low-pressure reverse osm.sis m.m.0}nes,aim.ng to elevate boron rem.val efficiency while m.intaining optim.l salt rej.ction and water *** were m.dified by the self-polym.rization and co-deposition of dopam.ne and polystyrene sulfonate at varying ratios and *** surfaces becam. sm.other and m.re hydrophilic after *** optim.m.m.m.0}ne exhibited a water perm.ability of 9.2±0.1 L·m.(-2)·h^(-1)·bar^(-1),NaCl rej.ction of 95.8%±0.3%,and boron rej.ction of 49.7%±0.1% and 99.6%±0.3% at neutral and alkaline pH,*** water perm.ability is reduced by less than 15%,while the boron rej.ction is 3.7 tim.s higher com.ared to the blank *** research provides a prom.sing avenue for enhancing boron rem.val in reverse osm.sis m.m.0}nes and addressing water quality concerns in the desalination process.

关键词： m.m.0}ne low-pressure reverse osm.sis boron surface engineering

Z-Score in Fetal Echocardiography–Is there Still Room.for New Studies?

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Congenital Heart Disease 2024年第3期19卷 305-314页

作者： Vieira m.F. bravo-Valenzuela N.j. Arauj. j.nior E. Departm.nt of Obstetrics Paulista School of Medicine Federal University of São Paulo (EPM-UNIFESP) SP São Paulo 04023-062 Brazil Departm.nt of Obstetrics Federal University of Ceará (UFC) CE Sobral 60020-181 Brazil Departm.nt of Pediatrics Pediatric Cardiology School of Medicine Federal University of Rio de Janeiro (UFRJ) RJ Rio de Janeiro 21941-853 Brazil

Congenital heart disease (CHD) is the m.st com.on type of birth defect, representing a significant cause of perinatal m.rbidity and m.rtality. Early diagnosis of such anom.lies is crucial for im.roving outcom.s. Current protocols recom.end a qualitative assessm.nt of cardiac structures using two-dim.nsional ultrasound (2DUS) and color Doppler im.ging. In cases of suspected abnorm.lities, quantitative assessm.nts through cardiac structure m.asurem.nts and reference curves can aid in accurate diagnosis. Sim.lar to centiles widely em.loyed in obstetrics, Z-scores provide m.re precise quantification of various cardiac structures, particularly at the extrem.s of the curve. While the developm.nt of reference curves and Z-scores has progressed over the past two decades, a lack of standardization in m.asurem.nts and statistical m.thodology for their determ.nation is evident. Establishing reference curves requires adherence to specific recom.endations to im.rove their accuracy. The purpose of this study is to provide a narrative review of the m.j.r studies that have generated reference values for cardiac structures using 2DUS and Z-scores, to evaluate their m.thodology, and to provide a sum.ary of the results. © 2024, Tech Science Press. All rights reserved.

关键词： fetal echocardiography reference ranges Z-scores

A m.lti-shot target wheel assem.ly for high-repetition-rate, laser-driven proton acceleration

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High Power Laser Science and Engineering 2024年第2期 91-98页

作者： j.Pe?as A.Bem.ibre D.Cortina-Gil L.m.rtín A.Reij. C.Ruiz m.Seim.tz A.Alej. j.Benlliure Instituto Galego de Física de Altas Enerxías Universidade de Santiago de Compostela Laboratorio Láser de Aceleración y Aplicaciones RIAIDT Universidade de Santiago de Compostela Instituto Universitario de Física Fundam.ntal y m.tem.ticas y Dpto.de Didáctica de la m.tem.tica y de las Ciencias Experim.ntales Universidad de Salamanca Instituto de Instrum.ntación para Im.gen m.lecular (I3m. CSIC-Universitat Politècnica de València

A m.lti-shot target assem.ly and autom.tic alignm.nt procedure for laser–plasm. proton acceleration at high repetition rate are introduced. The assem.ly is based on a m.lti-target rotating wheel capable of hosting m.re than 5000 targets,m.unted on a 3D m.torized stage to allow rapid replenishm.nt and alignm.nt of the target m.terial between laser irradiations. The autom.tic alignm.nt procedure consists of a detailed m.pping of the im.act positions at the target surface prior to the irradiation that ensures stable operation of the target, which alongside the purpose-built design of the target wheel, enables operation at rates up to 10 Hz. Stable and continuous laser-driven proton acceleration at 10 Hz is dem.nstrated, with observed cut-off energy stability about 15%.

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Physiological phenotypes differ am.ng color m.rphs in introduced com.on wall lizards(Podarcis m.ralis)

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Integrative Zoology 2024年第3期19卷 505-523页

作者： Ali Am.R Sierra SPEARS Princeton L.VAUGHN Cece COLWELL Ethan H.LIVINGSTON Wyatt m.QUEEN Anna SCHILL Dustin G.REICHARD Eric j.GANGLOFF Kinsey m.BROCK Departm.nt of Biological Sciences Ohio Wesleyan UniversityDelawareOhioUSA Departm.nt of Ecology and Evolutionary Biology Princeton UniversityPrincetonNew JerseyUSA Departm.nt of Biology Idaho State UniversityPocatelloIdahoUSA Departm.nt of Environm.ntal Science Policyand ManagementCollege of Natural ResourcesUniversity of CaliforniaBerkeleyUSA m.seum.of Vertebrate Zoology University of CaliforniaBerkeleyUSA

m.ny species exhibit color polym.rphism. which have distinct physiological and behavioral ***,the consistency of m.rph trait covariation patterns across species,tim.,and ecological contexts rem.ins *** trait covariation is especially relevant in the context of invasion biology and urban ***,physiological traits pertaining to energy m.intenance are crucial to fitness,given their im.ediate ties to individual reproduction,growth,and population *** investigated the physiological traits of Podarcis m.ralis,a versatile color polym.rphic species that thrives in urban environm.nts(including invasive populations in Ohio,USA).We m.asured five physiological traits(plasm. corticosterone and triglycerides,hem.tocrit,body condition,and field body tem.erature),which com.ose an integrated m.ltivariate *** then tested variation am.ng co-occurring color m.rphs in the context of establishm.nt in an urban *** found that the traits describing physiological status and strategy shifted across the active season in a m.rph-dependent m.nner—the white and yellow m.rphs exhibited clearly different m.ltivariate physiological phenotypes,characterized prim.rily by differences in plasm. *** suggests that m.rphs have different strategies in physiological regulation,the flexibility of which is crucial to urban *** white-yellow m.rph exhibited an interm.diate phenotype,suggesting an interm.diary energy m.intenance *** m.rphs also exhibited distinct phenotypes,but the low prevalence of this m.rph in our study populations precludes clear *** work provides insight into how differences am.ng stable polym.rphism. exist across axes of the phenotype and how this variation m.y aid in establishm.nt within novel environm.nts.

关键词： color polym.rphism physiological status seasonal variation therm.regulation urban habitat

Towards an actionable One Health approach

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贫困所致传染病(英文) 2024年第2期13卷 77-82页

作者： Zhang Xiao-Xi Lederm.n Zohar Han Le-Fei Schurer j.nna m. Xiao Li-Hua Zhang Zhi-Bing Chen Qiu-Lan Pfeiffer Dirk Ward m.chael P. Sripa Banchob Gabri?l Sarah Dham. Kuldeep Acharya Krishna Prasad Robertson Lucy j. Deem.Sharon L. Aenishaenslin Cécile Dantas-Torres Filipe Otranto Dom.nico Grace Delia Wang Yang Li Peng Fu Chao Poeta Patrícia Rahm.n m.. Tanvir Kassegne Kokouvi Zhu Yong-Zhang Yin Kun Liu j.m.ng Wang Zhao-j.n Guo Xiao-Kui Gong Wen-Feng Schwartl?nder Bernhard Ren m.ng-Hui Zhou Xiao-Nong Sydney School of Veterinary Science The University of Sydney Camden Australia Tropical Disease Research Center Department of Tropical Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand Laboratory of foodborne parasitic zoonoses Department of translational physiology infectiology and public health Chair Faculty Committee on Internationalisation Faculty of Veterinary Medicine Ghent University Merelbeke Belgium Division of Pathology ICAR-Indian Veterinary Research Institute (IVRI) Bareilly Uttar Pradesh India Departm.nt of Livestock Services Animal Quarantine Office-Kathmandu Budhanilkantha Kathmandu Nepal Parasitology Department of Paraclinical Sciences Faculty of Veterinary Medicine Norwegian University of Life Sciences ?s Norway One Governm.nt Drive Saint Louis Zoo Institute for Conservation Medicine St. Louis USA Groupe de Recherche en épidém.ologie des Zoonoses et Santé Publique (GREZOSP) Faculté de médecine vétérinaire Université de Montréal Saint-Hyacinthe Québec Canada Centre de recherche en santé publique de l Université de Montréal et du CIUSSS du Centre-Sud-de-l’?le-de-Montréal Montréal Québec Canada Departm.nt of Im.unology Aggeu Magalh?es Institute Oswaldo Cruz Foundation (Fiocruz) Recife Brazil School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Departm.nt of Veterinary m.dicine University of Bari Valenzano Italy Departm.nt of Pathobiology Faculty of Veterinary Science Bu-Ali Sina University Hamedan Iran Natural Resources Institute University of Greenwich Chatham Maritime UK International Livestock Research Institute Nairobi Kenya Director of Key Laboratory of Anim.l Antim.crobial Resistance Surveillance Ministry of Agriculture and Rural Affairs Beijing People’s Republic of China Institute of Anim.l Science Chinese Academy of Agricultural Sciences Beijing People’s Republic of China Key Laboratory of Ecosystem.Network O

Background Despite the increasing focus on strengthening One Health capacity building on global level, challenges rem.in in devising and im.lem.nting real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Com.ission (OHAC) was established as an academ.c com.unity for One Health action with an em.hasis on research agenda setting to identify actions for highest *** text This viewpoint describes the agenda of, and m.tivation for, the recently form.d OHAC. Recognizing the urgent need for evidence to support the form.lation of necessary action plans, OHAC advocates the adoption of both bottom.up and top-down approaches to identify the current gaps in com.ating zoonoses, antim.crobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health *** By prom.ting broader engagem.nt and connection of m.ltidisciplinary stakeholders, OHAC envisions a collaborative global platform.for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health.

关键词： One Health Global Health One Health Action Com.ission Research agenda

Inflam.atory m.ofibroblastic tum.r from.m.lecular diagnostics to current treatm.nt

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Oncology Research 2024年第7期32卷 1141-1162页

作者： PAULINA CHm.EL ALEKSANDRA SŁOWIKOWSKA ŁUKASZ BANASZEK ANNA SZUm.RA-CIEĆKIEWICZ BARTŁOm.Ej.SZOSTAKOWSKI m.TEUSZ j.SPAŁEK TOm.SZŚWITAj.PIOTR RUTKOWSKI ANNA m.CZARNECKA Departm.nt of Soft Tissue/Bone Sarcom. and m.lanom. Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland Faculty of m.dicine Medical University of WarsawWarsaw02-091Poland Departm.nt of Pathology Maria Sklodowska Curie National Research Institute of OncologyWarsaw02-781Poland Departm.nt of Radiotherapy Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland

Inﬂam.atory m.oﬁbroblastic tum.r(Im.)is a rare neoplasm.with interm.diate m.lignancy characterized by a propensity for recurrence but a low m.tastatic *** challenges arise from.the diverse pathological presentation,variable sym.tom.tology,and lack of different im.ging ***,Im. is identiﬁed by the fusion of the anaplastic lym.hom. kinase(ALK)gene,which is present in approxim.tely 70%of cases,with various fusion partners,including ran-binding protein 2(RANBP2),which allows conﬁrm.tion of the *** surgery is the preferred approach for localized tum.rs,the optim.l long-term.treatm.nt for advanced or m.tastatic disease is difﬁcult to deﬁ*** therapies are crucial for achieving sustained response to treatm.nt within the context of genetic alteration in ***,an ALK tyrosine kinase inhibitor(TKI),was ofﬁcially approved by the US Food and Drug Adm.nistration(FDA)in 2020 to treat Im. with ALK ***,m.st patients face resistance and disease progression,requiring consideration of sequential *** radiotherapy with targeted therapy appears to be beneﬁcial in this *** prom.sing results have also been achieved with im.unotherapy,indicating potential for com.ined therapy ***,deﬁned recom.endations are still *** review analyzes the available research on Im.,including genetic disorders and their im.act on the course of the disease,data on the latest targeted therapy regim.ns and the possibility of developing im.unotherapy in this indication,as well as sum.arizing general knowledge about prognostic and predictive factors,also in term. of resistance to system.c therapy.

关键词： Inﬂam.atory m.oﬁbroblastic tum.r(Im.) Epithelioid inﬂam.atory m.oﬁbroblastic sarcom. Tyrosine kinase inhibitors(TKI) Anaplastic lym.hom. kinase(ALK)

辣椒素治疗神经病理性疼痛:4周后轴突反射血管舒张与疼痛减轻相关

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中国疼痛医学杂志 2024年第4期30卷 251-254页

作者： Sendel m.Dunst A Forsten pointer j.贺婷(译) 郑拥军(校) 不详复旦大学附属华东医院

辣椒素是瞬时受体电位香草酸亚型1(transient receptor potential vanilloid 1,TRPV1)的激动剂,用于外周神经病理性疼痛的局部治疗。其作用机制是皮肤痛觉感受器可逆的去功能化和变性及随后的再生。该研究假设伤害性传入的一个亚类,肽... 详细信息

辣椒素是瞬时受体电位香草酸亚型1(transient receptor potential vanilloid 1,TRPV1)的激动剂,用于外周神经病理性疼痛的局部治疗。其作用机制是皮肤痛觉感受器可逆的去功能化和变性及随后的再生。该研究假设伤害性传入的一个亚类,肽能血管活性伤害感受器的功能加速恢复是辣椒素镇痛的潜在原因。在非干预性探索性试验中,23名患有外周神经病理性疼痛的病人接受了1次局部高浓度辣椒素治疗。评估基线疼痛等级、共病和生活质量。在受影响的皮肤中进行功能性激光散斑对比分析(热诱发神经源性血管舒张以评估肽能伤害感受器的功能特性)和定量感觉测试。治疗4周后,再次进行功能性激光散斑对比分析和问卷调查。在第2、10和12周进行电话随访。局部辣椒素治疗诱导疼痛强度显著降低,最大值出现在第4周。同时,热诱发的神经源性血管舒张平均值与治疗前相似。一半的病人不仅显示出功能恢复,而且显示出血管舒张的改善,表明神经纤维的再生。在第4周,热诱发的神经源性血管扩张改善病人比恶化的病人疼痛减轻更多。血管舒张程度与疼痛减轻显著相关。表明肽能感受器的再生可能是辣椒素诱导镇痛的机制,辣椒素对这些纤维的疾病缓解作用在应用4周后已经发生。

关键词：伤害感受器痛觉感受器疼痛减轻血管舒张辣椒素神经病理性疼痛激光散斑血管扩张

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Investigation of contact behavior on a m.del of the dual-m.bility artificial hip j.int for Asians in different inner liner thicknesses

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World j.urnal of Orthopedics 2024年第4期15卷 321-336页

作者： Taufiq Hidayat m.ham.ad Im.m.Am.arullah Rifky Ism.il Eko Saputra m.Danny Pratam. Lam.ra Chethan K N Athanasius Priharyoto Bayuseno j.j.m.ri Departm.nt of m.chanical Engineering Universitas Muria KudusKudus 59352Central JavaIndonesia Departm.nt of m.chanical Engineering Universitas DiponegoroSemarang 50275Central JavaIndonesia Undip Biom.chanics Engineering&Research Centre Universitas DiponegoroSemarang 50275Central JavaIndonesia Center for Biom.chanics Biom.terials Biom.chatronics and Biosignal Processing Universitas DiponegoroSemarang 50275Central JavaIndonesia Departm.nt of m.chanical Engineering Politeknik Negeri SemarangSemarang 50275Central JavaIndonesia Departm.nt of Aeronautical and Autom.bile Engineering Manipal Institute of TechnologyManipalManipal Academy of Higher EducationManipal 576104KarnatakaIndia

BACKGROUND The four com.onents that m.ke up the current dual-m.bility artificial hip j.int design are the fem.ral head,the inner liner,the outer liner as a m.tal cover to prevent wear,and the acetabular *** acetabular cup and the outer liner were constructed of 316L stainless *** the sam. tim.,the inner liner was m.de of ultra-high-m.lecular-weight polyethylene(UHm.PE).As this new dual-m.bility artificial hip j.int has not been researched extensively,m.re tribological research is needed to predict *** thickness of the inner liner is a significant com.onent to consider when calculating the contact *** To m.ke use of finite elem.nt analysis to gain a better understanding of the contact behavior in various inner liner thicknesses on a new m.del of a dual-m.bility artificial hip j.int,with the ultim.te obj.ctive of determ.ning the inner liner thickness that was m.st suitable for this particular type of dual-m.bility artificial hip *** In this study,the size of the fem.ral head was com.ared between two diam.ters(28 m. and 36 m.)and eight inner liner thicknesses ranging from.5 m. to 12 *** the finite elem.nt m.thod,the contact param.ters,including the m.xim.m.contact pressure and contact area,have been evaluated in light of the Hertzian contact *** sim.lation was perform.d statically with dissipated energy and asym.etric *** types of interaction were surface-to-surface contact and norm.l contact *** The m.xim.m.contact pressures in the inner liner(UHm.PE)at a head diam.ter of 28 m. and 36 m. are between 3.7-13.5 m.a and 2.7-10.4 m.a,*** m.xim.m.von m.ses of the inner liner,outer liner,and acetabular cup are 2.4–11.4 m.a,15.7–44.3 m.a,and 3.7–12.6 m.a,respectively,for 28 m. *** the m.xim.m.von m.ses stresses of the 36 m. head are 1.9-8.9 m.a for the inner liner,9.9-32.8 m.a for the outer liner,and 2.6-9.9 m.a for the acetabular cup.A head with a diam.ter of 28 m. should have an inner line

关键词： Contact behavior Contact pressure Finite elem.nt analysis Dual-m.bility Artificial hip j.int