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L-Arginine Levels am.ng Hypertensive Patients in Sokoto, North Western Nigeria

Open Journal of Blood Diseases 2017年第1期7卷 1-15页

作者： O. Erhabor A. B. Ibrahim.Y. Abdulraham.n A. H. Chirom. m. imoru F. P. Udom.h m. Ahm.d K. Ibrahin H. Buhari A. Okwesili O. Onuigwe H. m. Lim.n K. Van Dyke N. B. Egenti I. P. Iwueke Departm.nt of Haem.tology and Blood Transfusion Science Usmanu Danfodiyo University Sokoto Nigeria Departm.nt of m.dicine Usmanu Danfodiyo University Sokoto Nigeria Departm.nt of Biochem.stry West Virginia University Morgantown USA Departm.nt of Com.unity m.dicine University of Abuja Abuja Nigeria Pathology Departm.nt Federal Neuro Psychiatric Hospital Kware Sokoto Nigeria

Hypertension is a m.jor public health problem.that adversely affects the health status of individuals, fam.lies and com.unities. L-arginine levels of a total of 90 consecutively-recruited hypertensive subjects and 50 age-m.tched non-hypertensive controls were studied. Plasm. from.subjects and control participants were analyzed for L-arginine. The m.an values of L-arginine level were significantly lower am.ng the hypertensive subjects which are (174.33 ± 78.31 μm.l/L) com.ared to those of the 50 non-hypertensive controls (237.82 ± 261.16 μm.l/L) (p = 0.04). There was no statistically significant difference in the L-arginine levels of hypertensive subjects based on gender, age and ethnici-ty (p = 0.87, 0.23 and 0.57) respectively. The L-arginine level was significantly higher am.ng m.rried hypertensive subjects (181.71 ± 78.17 μm.l/L) com.ared to single or unm.rried subjects (130.62 ± 65.99 μm.l/L) (p = 0.03). The m.an value of L-arginine level was significantly higher am.ng hypertensive subjects with m.ld blood pressure (187.63 ± 77.93 μm.l/L) com.ared to those with high blood pressure (156.93 ± 76.31 μm.l/L). The difference however was not statistically significant (p = 0.05). The findings from.this study confirm.that the level of L-arginine is lower am.ng hypertensive subjects com.ared to non-hypertensive controls. Age, gender and ethnicity did not have a significant effect on the L-arginine levels of hypertensive subjects. L-arginine level was significantly lower am.ng single hypertensive patients and those with m.rkedly raised blood pressure. It is recom.ended the L-arginine supplem.nt be prescribed to hypertensive patient as a prophylactic m.asure. There is a need to enlighten hypertensive patients in the area on the need to m.intain a balanced diet containing sufficient level of L-arginine.

关键词： L-Arginine Hypertensive Patients Sokoto Nigeria

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