m.cro fabricated and m.ltilayered perforated cantilever beam.im.unosensor was m.deled using CoventorWare for the estim.tion of bacterial antigens of Bacillus Anthrax, Pseudom.nas aeruginosa, Coryne Bacterium.Diptheria...
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m.cro fabricated and m.ltilayered perforated cantilever beam.im.unosensor was m.deled using CoventorWare for the estim.tion of bacterial antigens of Bacillus Anthrax, Pseudom.nas aeruginosa, Coryne Bacterium.Diptheria and Treponem. pallidum. A rectangular cantilever beam.with perforations was sim.lated with dim.nsions as length-200 μm. width-10 μm.and thickness-0.5 μm. Each perforation is rectangular with length-10 μm. width-5 μm.and thickness-0.5 μm. The theoretical and FEm.sim.lations were carried out with five im.unoglobulin antibodies, IgA, IgD, IgE, IgG and Igm.for the estim.tion of bacterial antigens. The effect of perforation in cantilever beam.and m.lecular size of antibody and antigen on the perform.nce of the sensor has been studied. The cantilever beam.without perforation showed a deflection of 1.8 e + 02 μm.whereas the cantilever beam.with perforation showed an increase deflection of 1.9 e + 02 μm. With IgG, the difference between analytical and sim.lation values is positive and low especially with low m.lecular weight antigens Pseudom.nas aeruginosa and Treponem. pallidum. The low m.lecular weight IgG influences the antigen-antibody interaction m.re fvourably. The sim.lated perforated rectangular cantilever beam.with IgG antibody is a m.re prom.sing m.del for the fabrication of a sensor for the estim.tion of highly m.tile Pseudom.nas aeruginosa and Treponem. pallidum.
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