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血清钙结合S100蛋白A8和A9的水平升高可以反映银屑病角质形成细胞的异常分化和疾病的活动性

世界核心医学期刊文摘（皮肤病学分册） 2006年第9期2卷 29-30页

作者： Benoit S. Toksoy A. Ahlm.nn m. m. goebeler 李晓莉 Departm.nt of Derm.tology University of Wü rzburgWü rzburg Germany

Background: The expression of calcium.binding S100 m.lecules organized within the epiderm.l differentiation com.lex on chrom.som. 1q21 is disturbed in hyperproliferative skin diseases such as psoriasis. Objectives: We studied whether serum.levels of S100 proteins A8 (S100A8) and A9 (S100A9) are elevated in psoriasis, correlated their am.unts with disease activity and identified potential cellular sources. m.thods: Serum.obtained from.psoriasis patients or from.healthy individuals was studied for S100A8 and S100A9 levels by enzym.-linked im.unosorbent assay. Data were correlated to disease activity as reflected by the Psoriasis Area and Severity Index (PASI). Cellular sources of S100A8 and S100A9 were identified by in situ hybridization and im.unohistochem.stry of lesional psoriatic and nonlesional, nonpsoriatic skin. Results: A significant increase of S100A8/S100A9 serum.levels was found in patients with psoriasis com.ared with healthy controls. Grading the patients into two groups of severity, individuals with a PASI of m.levels of 705 ± 120 ng m.- 1 (m.an ± SEm. n = 18), those with a PASI of ≥ 15 showed levels of 1315 ± 150 ng m.- 1 (n = 32) while controls presentedwith 365± 50 ng m.- 1. Perform.ng in situ hybridization of lesional psoriatic skin we detected a dram.tic induction of both S100A8 and S100A9 m.NA and protein prim.rily in the suprabasal layers of the epiderm.s while expression was negligible in nonlesional,nonpsoriatic interfollicular epiderm.s. Conclusions: Our data dem.nstrate that hyperproliferation and abnorm.l differentiation of psoriatic skin is associated with a m.ssive upregulation and secretion of S100A8 and S100A9, suggesting not only a prom.nent role of these m.lecules during intracellular calcium.dependent signalling but also im.lying distinct extracellular functions.

关键词：银屑病患者 S100蛋白疾病活动性血清水平表皮分化表达异常血清钙角质形成细胞

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先天性角化不良患者1例(德语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 52-52页

作者： Benoit S. Kraem.r D. Brcker E.-B. goebeler m. 周少娜 Klinik für Derm.tologie Venerologie und Allergologie Klinikum Mannheim-Universittsklinikum Ruprecht-Karls-Universitt Heidelberg Theodor-Kutzer Ufer 1-3 68135 Mannheim Dr.

A 40-year-old patient with a 3-year history of throm.ocytopenia was adm.tted with reticulated and speckled hyper and hypopigm.ntations especially on the upper trunk. Aplasia or dystrophy of the fingernails and toe-nails as well as atresia of the lacrim.l ducts were noted. Exam.nation of the oropharynx revealed m.ltiple m.cosal leukoplakias and loss of alm.st all teeth. Based on these observations the diagnosis of X-linked dyskeratosis congenita (Zinsser-Cole- Engm.n syndrom., Om.m.305000) was m.de and confirm.d by sequencing of the dyskerin 1 (DKC1) gene which revealed a m.ssense m.tation in exon 11.

关键词：先天性角化不良患者德语咽部检查基因测序血小板减少指(趾)甲色素沉着营养不良发育不全

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