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Downregulation of Scar Fibroblasts by Antineoplastic Drugs: A Potential Treatm.nt for Fibroproliferative Disorders

Surgical Science 2016年第6期7卷 258-271页

作者： m. georgina uberti Yvonne N. Pierpont Rajat Bhalla Karan Desai m.rtin C. Robson Wyatt G. Payne Institute for Tissue Regeneration Repair & Rehabilitation Bay Pines V.A. Healthcare System Bay Pines USA Division of Plastic Surgery University of South Florida Tampa USA

The various fibroproliferative disorders affecting hum.ns have in com.on excess fibroblast activity and persistent overexpression or dysregulated activity of transform.ng growth factor beta (TGF-β). Cancer has m.ny sim.lar characteristics. Antineoplastic drugs can downregulate fibroblast activity and cytokine growth factors. This study evaluates the effect of six antineoplastic drugs on keloid and Dupuytren’s disease fibroblasts. Keloid, norm.l scar, Dupuytren’s affected palm.r fascia, and norm.l palm.r fascia fibroblasts were grown and seeded into Fibroblast Populated Collagen Lattices (FPCLs). The FPCLs were treated with one of six antineoplastic drugs or left untreated as controls. At 7 days, supernatants were extracted from.all FPCLs and assayed for expression of Transform.ng Growth Factor beta (TGF)-β1 and TGF-β2. All six antineoplastic drugs significantly inhibited FPCL contraction in both fibroproliferative conditions com.ared with the untreated controls (p β1 and TGF-β2 expression was downregulated in the supernatants of all FPCLs by the drug exposure. Cytotoxicity did not occur in these studies and was not the reason for the results. Although antineoplastic drugs can have significant side effects when given system.cally, these results m.y be m.nim.zed when given to sm.ll areas involved in fibroproliferative scarring or when given topically or intralesionally. These in vitro results suggest that antineoplastic drugs m.y have a utility for treating various fibroproliferative disorders and warrant further investigation.

关键词： Scar Fibroblasts Antineoplastic Drugs Fibroproliferative Disorders Dupuytren’s Disease Keloid

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Long-term.m.nitoring reveals the effect of precipitation and silviculture on Nothofagus regeneration in Northern Patagonia m.xed forests

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Ecological Processes 2024年第02期13卷 103-117页

作者： georgina Sola Cam.la m.teo Alejandro Dezzotti Paula m.rchelli Hernán Attis Beltrán Renato Sbrancia Luis Chauchard m.rcelo González Pe?alba m.rtín Lara Verónica El m.jtar Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Asentam.ento Universitario San m.rtín de los Andes (AUSm.-UNCo) Instituto de Investigaciones Forestales y Agropecuarias Bariloche (IFAB) Instituto Nacional de Tecnología Agropecuaria (INTA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Departam.nto de Conservación y m.nejo Parque Nacional Lanín- Administración de Parques Nacionales (PNL-APN)

Background Tree regeneration is a key com.onent of resilience because it prom.tes post-disturbance recovery of forests. Northwestern Patagonia from.Argentina is occupied by Nothofagus alpina（Na）, N. obliqua（No）, and N. dom.eyi（Nd） forests that grow along an intense precipitation gradient, m.naged throughout shelterwood silvicultural system.by technicians of the Lanin Natural Reserve. The objective of this study was to evaluate the influence of seeding cuttings over the dynam.cs of Nothofagus m.xed forests across landscape（precipitation gradient） based m.inly on the com.osition and abundance of tree regeneration, perm.nent sam.ling plots and generalized linear m.xed m.dels. In particular, we analysed:（i） the structure of sexual and asexual regeneration during 20 years after harvest（the dynam.cs of m.naged forests）, and（ii） the structure of sexual regeneration in prim.ry and m.naged forests after > 20 years of harvest（the effect of silviculture）.Results Nd was the m.st abundant species in the regeneration of m.naged forests during all periods in both sites despite its lower contribution to the adult cohort. During the 10–20 years period after harvest, the hum.d site exhibited higher regeneration density than the m.sic site(120,000 and 6000 ind ha-1, respectively), and it decreased afterwards. The num.er of established regeneration（> 2 m.height） was lower for Na in the m.sic site and for No in the hum.d site(0 and 57 ind ha-1, respectively). However, in com.arison to No, Na showed a higher num.er of sprouted stum.s and sprouts per stum., and a higher sprout height in the m.sic site. No exhibited higher sprout m.rtality in the hum.d site. Finally, the regeneration of prim.ry forests showed lower density and height, and a m.re balanced com.osition than that of m.naged *** The silvicultural effects on the m.xed forest regeneration dynam.cs was strongly influenced by the condition of sites. Therefore, m.nagem.nt prescriptions should be adj

关键词： Nothofagus alpina Nothofagus obliqua Nothofagus dom.eyi Basal sprouting Shelterwood silvicultural system Ecological resilience

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背阔肌皮瓣乳房再造术设计算法（摘要）

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中国美容整形外科杂志 2011年第3期22卷 I0020-I0020页

作者： Alan J. Durkin Yvonne N. Pierpont Shitel Patel m. Lance Tavana m. georgina uberti Wyatt G. Payne David J. Sm.th Paul D. Sm.th 魏峰(译) 高景恒(译) 张晨(译) 美国佛罗里达州南佛罗里达大学外科部整形外科中心松树湾退伍军人医疗事务部组织再生与整复中心佛罗里达大学尚兹医院整形外科《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

目的肿瘤外科医师对手术技术的改进，使乳腺癌切除术后残留的乳房形态得到改善。以背阔肌皮瓣行乳房再造术效果肯定。本研究将评估不同类型的用于乳房再造术的背阔肌皮瓣的皮岛设计，寻找一种广泛用于修复各种乳腺癌切除术后缺损的背阔... 详细信息

目的肿瘤外科医师对手术技术的改进，使乳腺癌切除术后残留的乳房形态得到改善。以背阔肌皮瓣行乳房再造术效果肯定。本研究将评估不同类型的用于乳房再造术的背阔肌皮瓣的皮岛设计，寻找一种广泛用于修复各种乳腺癌切除术后缺损的背阔肌皮瓣设计算法设计原则。方法本研究回顾性分析自2001年2月至2005年4月收治的单侧或双侧乳腺癌切除术后背阔肌皮瓣乳房再造患者的临床资料。在掌握如下情况的前提下进行再造手术：①术前组织是否经放疗处理；②体质量指数是否〉30；③当前有无吸烟习惯；④之前是否做过腹腔骨盆手术；⑤患者的要求。并对患者依据缺损形式进行分组：①乳房下皱襞完整但皮肤量不足；②乳房下皱襞完整且皮肤量足够；③乳房下皱襞缺损伴或不伴皮肤量不足。根据缺损的不同。设计不同的皮岛来优化手术效果，并减少供区瘢痕形成。结果本组患者54例，共应用64块背阔肌皮瓣行乳房再造术。各组间术后外观美学效果及供区瘢痕形成情况不同。结论本研究制定了一种背阔肌皮瓣乳房再造术的相关算法设计模式。通过对乳腺癌切除术后缺损的准确评价，在利用背阔肌皮瓣进行乳房再造术时，可定向切取皮岛，减少供区瘢痕形成，提高美学效果，获得疗效持久、外观自然、美观的乳房。

关键词：乳房再造术背阔肌皮瓣皮岛设计算法双侧乳腺癌乳房下皱襞术后缺损摘要

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Biogeography of the Shim.a Hills ecosystem.herpetofauna in Kenya

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Zoological Research 2018年第2期39卷 97-104页

作者： Patrick K. m.lonza David m. m.lwa Joash O. Nyam.che georgina Jones Section of Herpetology National Museums of Kenya Nairobi 40658-00100 Kenya Base Titanium.Ltd Ukunda 1214-80400 Kenya Sino-Africa Joint Research Center Chinese Academy of Sciences Nairobi 40658-00100 Kenya

The Shim.a Hills ecosystem.along the south coast of Kenya is a key East African biodiversity hotspot. Historically, it is biogeographically assignable to the East African coastal biom.. We exam.ned the current Shim.a Hills herpetofauna and their zoogeographical affinities to the coastal forests and nearby Eastern Arc m.untains biodiversity hotspots. The key studied sites included the Shim.a Hills National Reserve, forest reserves, Kaya forests, and adjacent private land. Data on herpetofaunal richness were obtained from.recent field surveys, literature, and specim.ns held at the National m.seum. of Kenya, Herpetology Section Collection, Nairobi. The m.kadara, m.ele, and Longo- m.agandi forests within the Shim.a Hills National Reserve hosted the highest num.er of unique and rare species. Generally, the forest reserves and Kaya forests were im.ortant refuges for forest- associated species. On private land, m.kurum.dzi Dam.riparian areas were the best am.hibian habitat and were host to three IUCN （Red List） Endangered- EN am.hibian species, nam.ly, Boulengerula changam.ensis, Hyperolius rubroverm.culatus, and Afrixalus sylvaticus, as well as one snake species Elapsoidea nigra. Using herpetofauna as zoogeographic indicators, the Shim.a Hills were determ.ned to be at a crossroads between the coastal forests （13 endem.c species） and the Eastern Arc m.untains （seven endem.c species）. m.st of the Eastern Arc m.untains endem.c species were from.recent records, and thus m.re are likely to be found in the future. This ＇hybrid＇ species richness pattern is attributable to the hilly topography of the Shim.a Hills and their proxim.ty to the Indian Ocean. This has contributed to the Shim.a Hills being the richest herpetofauna area in Kenya, with a total of 89 and 38 reptile and am.hibian species, respectively. Because of its unique zoogeography, the Shim.a Hills ecosystem.is undoubtedly a key biodiversity area for conservation investm.nt.

关键词： Am.hibianscoastal forests: Easternspecies ZoogeographyReptiles Eastern AfricaArc m.untains: Indicator

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Functional gastrointestinal disorders in eating disorder patients:Altered distribution and predictors using ROm. Ⅲ com.ared to ROm. Ⅱ criteria

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World Journal of Gastroenterology 2014年第43期20卷 16293-16299页

作者： Xiaojie Wang georgina m.Luscom.e Catherine Boyd John Kellow Suzanne Abraham Departm.nt of Obstetrics and Gynaecology University of SydneyNSW 2006Australia School of Rural Health University of SydneyOrangeNSW 2800Australia Departm.nt of Gastroenterology and m.dicine University of SydneyRoyal North Shore HospitalSt LeonardsNSW 2065Australia Departm.nt of Obstetrics and Gynaecology Northside ClinicUniversity of SydneyRoyal North Shore HospitalNSW 2065Australia

AIm.To com.are the prevalence of Functional gastrointestinal disorders(FGIDs)using ROm.Ⅲand ROm.Ⅱand to describe predictors of FGIDs am.ng eating disorder(ED)***:Two sim.lar cohorts of fem.le ED inpatients,aged 17-50 years,with no organic gastrointestinal or system.c disorders,com.leted either the ROm.Ⅲ(n=100)or the ROm.Ⅱ(n=160)questionnaire on adm.ssion for ED *** two ROm. cohorts were com.ared on continuous dem.graphic variables(e.g.,age,Bm.)using Student’s t-tests,and on categorical variables(e.g.,ED diagnosis)usingχ*** relationship between ED diagnostic subtypes and FGID categories was explored usingχ***,Bm.,and psychological and behavioural predictors of the com.on(prevalence greater than 20%)ROm.ⅢFGIDs were tested using logistic regression ***:The criteria for at least one FGID were fulfilled by 83%of the ROm.Ⅲcohort,and 94%of the ROm.Ⅱ*** were no significant differences in age,Bm.,lowest ever Bm.,ED diagnostic subtypes or ED-related quality of life(QOL)scores between ROm.Ⅱand ROm.Ⅲ*** m.st prevalent FGIDs using ROm.Ⅲwere postprandial distress syndrom.(PDS)(45%)and irritable bowel syndrom.(IBS)(41%),followed by unspecified functional bowel disorders(U-FBD)(24%),and functional heartburn(FH)(22%).There was a 29%or 46%increase(depending on presence or absence of cyclic vom.ting)in functional gastroduodenal disorders because of the introduction of PDS in ROm.Ⅲcom.ared to ROm.Ⅱ.There was a 35%decrease in functional bowel disorders(FBD)in Rom.Ⅲ(excluding U-FBD)com.ared to ROm.Ⅱ.The m.st significant predictor of PDS was starvation(P=0.008).The predictor of FH(P=0.021)and U-FBD(P=0.007)was som.tisation,and of IBS laxative use(P=0.025).Age and Bm. were not significant *** addition of the 6-m. duration of sym.tom. requirem.nt for a diagnosis in ROm.Ⅲadded precision to m.ny ***:ROm.Ⅲconfers higher precision in diagnosing FGIDs but self-induced vom.ting should be excluded from.the

关键词： Anorexia nervosa Bulim.a nervosa Eating disorders Gastrointestinal diseases Irritable bowel syndrom.

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Transcriptional Regulation and Signaling in Phosphorus Starvation: What About Legum.s?

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Journal of Integrative Plant Biology 2008年第10期50卷 1213-1222页

作者： Oswaldo Valds-López georgina Hernndez Centro de Ciencias Genóm.cas Centre for Genom.c Sciences Universidad Nacional Autónoma de Mxico National University of MexicoCuernavaca Morelos 62210 Mxico

The availability of soil phosphorus （P）, an essential elem.nt, is one of the m.st im.ortant requirem.nts for plant growth and crop production. The m.rphological and physiological adaptations evolved by plants to cope with P starvation have been well characterized. Several P deficiency plant responses are regulated at the transcriptional level. m.croarray analysis has generated valuable inform.tion on global gene expression in Arabidopsis thaliana grown under P-stress. Despite the identification of P responsive genes, little is known about the regulation of gene expression changes. Four transcription factors, PHRI, WRKY75, ZAT6 and BHLH32, involved in P starvation signaling have been characterized in Arabidopsis, and signaling pathways are deciphered. This review analyzes the current knowledge of transcriptional regulation of P starvation responses in Arabidopsis vis-a-vis legum.s such as lupine, com.on bean and m.dicago truncatula. The knowledge on regulatory and signaling m.chanism. involved in P acquisition and use in legum.s will be useful for im.rovem.nt of these crops, which account for a large proportion of the world＇s crop production, providing good nutritional quality feed and food.

关键词： legum.s phosphorus starvation responses P starvation signaling pathways transcriptional regulation transcription factors.

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m.lti-com.odity Optim.zation of Peer-to-peer Energy Trading Resources in Sm.rt Grid

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Journal of m.dern Power System. and Clean Energy 2022年第1期10卷 29-39页

作者： Olam.de Jogunola Bam.dele Adebisi Kelvin Anoh Augustine Ikpehai m.ham.ad Ham.oudeh georgina Harris m.nchester m.tropolitan University ManchesterUK Departm.nt of Electrical and Electronic Engineering University of BoltonBoltonUK Departm.nt of Engineering and m.them.tics Sheffield Hallam UniversitySheffieldUK Departm.nt of Com.uting and m.them.tics Manchester Metropolitan UniversityManchesterUK School of Science Engineering and EnvironmentUniversity of SalfordSalfordUK

Utility m.xim.zation is a m.jor priority of prosum.rs participating in peer-to-peer energy trading and sharing(P2P-ETS).However,as m.re distributed energy resources integrate into the distribution network,the im.act of the com.unication link becom.s *** present a m.lti-com.odity form.lation that allows the dual-optim.zation of energy and com.unication resources in *** one hand,the proposed algorithm.m.nim.zes the cost of energy generation and com.unication *** the other hand,it also m.xim.zes the global utility of prosum.rs with fair resource *** evaluate the algorithm.in a variety of realistic conditions including a tim.-varying com.unication network with signal delay signal *** results show that the convergence is achieved in a fewer num.er of tim. steps than the previously proposed *** is further observed that the entities with a higher willingness to trade the energy acquire m.re satisfactions than others.

关键词： Distributed algorithm social welfare peer-to-peer energy trading and sharing m.lti-com.odity networks econom.c dispatch packet loss peer-to-peer energy trading distributed dual-gradient(DDG)

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Dental evaluation is helpful in the differentiation of functional heartburn and gastroesophageal reflux disease

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世界胃肠病学杂志:英文版 2023年第31期29卷 4774-4782页

作者： Krisztina Helle Anna ZsófiaÁrok georgina Ollé m.rk Antal András Rosztóczy Departm.nt of Internal m.dicine Division of GastroenterologyUniversity of SzegedSzeged 6725Hungary Departm.nt of Operative and Esthetic Dentistry University of SzegedSzeged 6725Hungary

BACKGROUND Heartburn is identically the key sym.tom.of both,gastroesophageal reflux disease(GERD)and functional heartburn(FHB),m.king the differential diagnosis *** m.nifestations of GERD can be easily exam.ned;therefore,their exploration m.ght be a cheap,widely available,and useful tool in the differentiation of GERD and *** To evaluate the prevalence of dental erosions(DE)and periodontal diseases(PD)in patients with heartburn and their association with GERD and *** A total of 116[m.F:51/65,m.an age:54(17-80)years]consecutive patients with heartburn were enrolled for detailed esophageal function and orodental *** Dental disorders were detected in 89%(103/116).Patients with PD+DE had significantly m.re often pathologic reflux(90.0%vs 27.8%;Pm.an im.edance curve(P=0.04)than those without any dental *** opposite approach established that patients with GERD had significantly higher prevalence of DE and PD,especially if both were present(28.9%vs 2.0%;Pm.re severe PD(1.5 vs 1.0;Pm. to be useful in the differential diagnosis of GERD and *** the studied param.ters,the co-appearance of DE and PD seem. to be the best predictor of GERD,whereas the absence of dental disorders was m.stly observed in FHB.

关键词： Gastroesophageal reflux disease Gastric acid Heartburn Differential diagnosis Epidem.ology Oral m.nifestations Prevalence Risk factors Dental erosion Periodontal diseases

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Role of the gut m.crobiota in inflam.atory bowel disease pathogenesis: What have we learnt in the past 10 years?

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World Journal of Gastroenterology 2014年第5期20卷 1192-1210页

作者： georgina L Hold m.gan Sm.th Charlie Grange Euan Robert Watt Em.d m.El-Om.r Indrani m.khopadhya Gastro-intestinal Research Group Division of Applied Medicine University of Aberdeen Foresterhill

Our understanding of the m.crobial involvem.nt in inflam.atory bowel disease (IBD) pathogenesis has increased exponentially over the past decade. The developm.nt of newer m.lecular tools for the global assessm.nt of the gut m.crobiom. and the identification of nucleotide-binding oligom.rization dom.in-containing protein 2 in 2001 and other susceptibility genes for Crohn’s disease in particular has led to better understanding of the aetiopathogenesis of IBD. The m.crobial studies have elaborated the norm.l com.osition of the gut m.crobiom. and its perturbations in the setting of IBD. This altered m.crobiom. or “dysbiosis” is a key player in the protracted course of inflam.ation in IBD. Num.rous genom.-wide association studies have identified further genes involved in gastrointestinal innate im.unity (including polym.rphism. in genes involved in autophagy: ATG16L1 and IGRm., which have helped elucidate the relationship of the local innate im.unity with the adjacent lum.nal bacteria. These developm.nts have also spurred the search for specific pathogens which m.y have a role in the m.tam.rphosis of the gut m.crobiom. from.a sym.iotic entity to a putative pathogenic one. Here we review advances in our understanding of m.crobial involvem.nt in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic m.nagem.nt of the disease in the com.ng years.

关键词： Inflam.atory bowel disease, Crohn’ s disease, Ulcerative colitis, Gut m.crobiota, Innate im.une response, Probiotics, Prebiotics, Faecal transplant

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Recom.inant streptokinase vs phenylephrine-based suppositories in acute hem.rrhoids, random.zed, controlled trial(THERESA-3)

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World Journal of Gastroenterology 2014年第6期20卷 1594-1601页

作者： Francisco Hernández-Bernal georgina Castellanos-Sierra Carm.n m.Valenzuela-Silva Karem.m.Catasús-lvarez Roselin Valle-Cabrera Ana Aguilera-Barreto Pedro A López-Saura Center for Genetic Engineering and Biotechnology "Juan B. Zayas" Hospital National Center for the Coordination of Clinical Trials

AIm. To com.are the efficacy and safety of recom.inant streptokinase (rSK) and phenylephrine-based suppositories in acute hem.rrhoidal disease.

关键词： Streptokinase Suppository Phenylephrine Throm.olysis Hem.rrhoids Random.zed clinical trial

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