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Association of the g.ycem.c backg.ound patterns and the diabetes m.nag.m.nt efficacy in poorly controlled type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 74-90页

作者： Ayşe n Erbakan m.zeyyen Arslan Bahadır Fatoşn Kaya Büşra g.leç m.raçVural Keskinler Üm.üg.lsüm.Aktem.rÇelik Özg. Faydalıel Banu m.sçi Aytekin Oğuz Departm.nt of Internal m.dicine Prof Dr Suleyman Yalcin City HospitalIstanbul Medeniyet UniversityIstanbul 34722Türkiye Departm.nt of Fam.ly m.dicine Istanbul Medeniyet UniversityIstanbul 34722Türkiye

BACKg.OUnD Inadequate g.ycem.c control in patients with type 2 diabetes(T2Dm.is a m.jor public health problem.and a sig.ificant risk factor for the prog.ession of diabetic *** To evaluate the effects of intensive and supportive g.ycem.c m.nag.m.nt strateg.es over a 12-m.nth period in individuals with T2Dm.with g.ycated hem.g.obin(HbA1c)≥10%and varying.backg.ounds of g.ycem.c *** This prospective observational study investig.ted g.ycem.c control in patients with poorly controlled T2Dm.over 12 *** were categ.rized into four g.oups based on prior g.ycem.c history:newly diag.osed,previously well controlled with recent worsening.previously off-targ.t but now worsening.and HbA1c consistently above 10%.HbA1c levels were m.nitored quarterly,and patients received m.dical,educational,and dietary support as *** analysis focused on the success rates of g.od g.ycem.c control and the associated factors within each *** The study showed sig.ificant im.rovem.nts in HbA1c levels in all *** m.st sig.ificant im.rovem.nt was observed in individuals newly diag.osed with diabetes:65%achieved an HbA1c targ.t of≤7%.The results varied between participants with different g.ycem.c control histories,followed by decreasing.success rates:39%in participants with previously g.od g.ycem.c control,21%in participants whose g.ycem.c control had deteriorated com.ared to before,and only 10%in participants with persistently poor control,with m.an HbA1c levels of 6.3%,7.7%,8.2%,and 9.7%,*** one year,65.2%of the“newly diag.osed patients”,39.3%in the“previously controlled g.oup”,21.9%in the“previously off-targ.t but now worsened'”g.oup and 10%in the“poorly controlled from.the start”g.oup had achieved HbA1c levels of 7 and *** In poorly controlled diabetes,the rate at which treatm.nt g.als are achieved is associated with the g.ycem.c backg.ound characteristics,em.hasizing.the need for tailored ***

关键词： Type 2 diabetes m.llitus g.ycated hem.g.obin g.ycem.c control Patient-centered care Diabetes m.nag.m.nt g.ycem.c backg.ound

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neurocircuit reg.neration by extracellular m.trix reprog.am.ing

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neural Reg.neration Research 2025年第8期20卷 2300-2301页

作者： Sheng.hang.Su Ian n.Levasseur Kim.erly m.Along. Departm.nt of m.dicinal Chem.stry University of WashingtonSeattleWAUSA Departm.nt of Chem.stry University of WashingtonSeattleWAUSA Departm.nt of m.dicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular m.trix(ECm.,which is com.rised of protein and g.ycosam.nog.ycan(g.g.scaffolds,constitutes 20%-40% of the hum.n brain and is considered one of the larg.st influencers on brain cell functioning.Soles et al.,2023).Synthesized by neural and g.ial cells,the brain's ECm.reg.lates a m.riad of hom.ostatic cellular processes,including.neuronal plasticity and firing.m.yata et al.,2012),cation buffering.m.raws ki et al.,2015),and g.ia-neuron interactions(Anderson et al.,2016).Considering.the diversity of functions,dynam.c rem.deling.of the brain's ECm.indicates that this understudied m.dium.is an active participant in both norm.l physiolog. and neurolog.cal diseases.

关键词： m.trix prog.am.ing

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Efficiency of a g.ass Buffer Strip for Lim.ting.Diuron Losses from.an Uphill Vineyard Towards Surface and Subsurface Waters

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Pedosphere 2012年第4期22卷 580-592页

作者： J.-g. LACAS n. CARLUER m. VOLTZ IRSTEA UR Qualité des Eaux et Prévention des Pollutions 3 bis quai Chauveau 69 336 Lyon Cedex 09 (France) InRA UMR L.I.S.A.H. INRA-IRD-SupAgro 2 place Viala 34060 Montpellier Cedex 1 (France)

g.ass buffer strips lim.t the transfer of pesticides from.cultivated fields to rivers. These solutions are g.nerally efficient at reducing.polluted surface flows, m.inly by infiltration of the soil, raising.the question of the fate of the infiltrated pollutants. An environm.ntal evaluation was conducted on the efficiency of a g.ass strip receiving.diuron-contam.nated water from.an uphill vineyard in France. During.two runoff events, the following.m.asurem.nts were taken: surface inflow and outflow with Venturi flum.s, vertical percolated flow below the root layer (0-50 cm., and variations in water and solute content of the root layer. One runoff event occurred under natural rainfall conditions, while the other runoff event was artificially provoked with water doped by diuron and brom.de. For the natural runoff event, representative of m.dium.intensity events, 94% of the diuron was retained in the root layer, whereas 2% left the g.ass strip by surface runoff and 4% left the g.ass strip in the water percolating.under the root zone. For the artificial event, representative of intense runoff events, m.re than half of the incom.ng.diuron was retained by the g.ass strip, whereas 24% and 18% of it were transferred by surface runoff and percolation, respectively. These results showed that the capacity of the root layer to retain diuron was hig.ly sig.ificant despite a larg. percolation flux. However, for larg. runoff events, surface and subsurface losses can still be considerable, up to 40% of the pesticide load entering.the strip.

关键词： infiltration percolation pesticide sorption surface runoff

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Analytical and sim.lation studies for diode and triode ion beam.extraction system.

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Chinese Physics C 2012年第4期36卷 344-349页

作者： m. m. Abdelrahm.n n. I. Basal S. g. Zakhary Accelerators & Ion Sources Departm.nt Nuclear Research Center Atomic Energy Authority P.O. Box: 13759 Inchas Atomic Energy Authority

This work is concerned with ion beam.dynam.cs and com.ares the em.ttance to aberration ratios of two-and three-electrode extraction system.. The study is conducted with the aid of Version 7 of SIm.On 3D ray-tracing.software. The beam.dependence on various param.ters of the extraction system. is studied and the num.rical results lead to qualitative conclusions. Ion beam.characteristics using.diode and triode extraction system. are investig.ted with the aid of the com.uter code SIm.On 3 D, Version 7.0. The diode （two electrode extraction system. and triode （three- electrode extraction, acceleration-deceleration system. extraction system. are desig.ed and optim.zed with different g.om.tric param.ters of the electrode system. voltag. applied to the extraction electrode, and plasm. param.ters inside the ion source cham.er, as well as by the ion beam.space charg.. This work attem.ts to describe the im.ortance of the acceleration-deceleration extraction system. It shows that besides an increase of the beam.energ., the ion beam.has lower em.ttance than the two-electrode extraction system. Ion beam. of the hig.est quality are extracted whenever the half-ang.lar diverg.nce is m.nim.m.for which the perveance current intensity and the extraction g.p have optim.m.value. Knowing.the electron tem.erature of the plasm. is necessary to determ.ne plasm. potential and the exact beam.energ..

关键词： ion beam.em.ttance plasm. m.niscus space charg. ion beam SIm.On com.uter prog.am

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Sim.lified approach for desig. of raft foundations ag.inst fault *** I:free-field

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Earthquake Eng.neering.and Eng.neering.Vibration 2008年第2期7卷 147-163页

作者： I. Anastasopoulos n. g.rolym.s g. g.zetas m. F. Bransb School of Civil Eng.neering National Technical University of AthensGreece Civil LecturerEngineeringUniversity of DundeeScotlandUK School of Civil Eng.neering National Technical University of AthensGreece Civil Eng.neering University of DundeeScotlandUK

Over the past few decades, earthquake eng.neering.research m.inly focused on the effects of strong.seism.c shaking. After the 1999 earthquakes in Turkey and Taiwan, and thanks to num.rous cases where fault rupture caused substantial dam.g. to structures, the im.ortance of faulting.induced deform.tion has re-em.rg.d. This paper, along.with its com.anion （Part Ⅱ）, exploits param.tric results of finite elem.nt analyses and centrifug. m.del testing.in developing.a four-step sem.-analytical approach for analysis of dip-slip （norm.l and thrust） fault rupture propag.tion throug. sand, its em.rg.nce on the g.ound surface, and its interaction with raft foundations. The present paper （Part Ⅰ） focuses on the effects of faulting.in the absence of a structure （i.e., in the free-field）. The sem.-analytical approach com.rises two-steps： the first deals with the rupture path and the estim.tion of the location of fault outcropping. and the second with the tectonically- induced displacem.nt profile at the g.ound surface. In both cases, sim.le m.chanical analog.es are used to derive sim.lified sem.-analytical expressions. Centrifug. m.del test data, in com.ination with param.tric results from.nonlinear finite elem.nt analyses, are utilized for m.del calibration. The derived sem.-analytical expressions are shown to com.are reasonably well with m.re rig.rous experim.ntal and theoretical data, thus providing.a useful tool for a first estim.tion of near-fault seism.c hazard.

关键词： fault rupture sem.-analytical expression soil-structure interaction earthquake

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Hig. nym.hal host density and m.rtality neg.tively im.act parasitoid com.lex during.an insect herbivore outbreak

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Insect Science 2019年第2期26卷 351-365页

作者： Aidan A. g. Hall Scott n. Johnson Jam.s m. Cook m.rkus Rieg.er Hawkesbury Institute for the Environm.nt Western Sydney University NSW Australia

Insect herbivore outbreaks frequently occur and this m.y be due to factors that restrict top-down control by parasitoids, for exam.le, host-parasitoid asynchrony, hyperparasitization, resource lim.tation and clim.te. Few studies have exam.ned hostparasitoid density relationships during.an in sect herbivore outbreak in a n atural ecosystem.with diverse parasitoids. We studied parasitization patterns of Cardiaspina psyllids during.an outbreak in a Eucalyptus woodland. First, we established the trophic roles of the parasitoids throug. a species-specific m.ltiplex PCR approach on m.m.ies from.which parasitoids em.rg.d. Then, we assessed host-parasitoid density relationships across three spatial scales (leaf, tree and site) over one yeas We detected four endoparasitoid species of the fam.ly Encyrtidae (Hym.noptera);two prim.ry parasitoid and one heteronom.us hyperparasitoid Psyllaephag.s species (the latter with fem.le developm.nt as a prim.ry parasitoid and m.le developm.nt as a hyperparasitoid), and the hyperparasitoid Coccidoctonuspsyllae. Parasitoid developm.nt was host-synchronized, althoug. synchrony between sites appeared constrained during.winter (due to tem.erature differences). Parasitization was predom.nantly driven by one prim.ry parasitoid species and was m.stly inversely host-density dependent across the spatial scales. Hyperparasitization by C. psyllae was psyllid-density dependent at the site scale, however, this only im.acted the rarer prim.ry parasitoid. Hig. larval parasitoid m.rtality due to density-dependent nym.hal psyllid m.rtality (a consequence of resource lim.tation) com.ounded by a sum.er heat wave was incorporated in the assessm.nt and resulted in density independence of host-parasitoid relationships. As such, hig. larval parasitoid m.rtality during.insect herbivore outbreaks m.y contribute to the absence of host density-dependent parasitization during.outbreak events.

关键词： density-dependent m.rtality insect outbreak psyllid synchronization tem.erature trophic interactions

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Electron Param.g.etic Resonance and Optical Absorption Studies on Copper Ions in m.xed Alkali Cadm.um.Phosphate g.asses

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Journal of m.terials Science & Technolog. 2009年第4期25卷 531-534页

作者： g. g.ridhar m. Rang.charyulu R.V.S.S.n. Ravikum.r P. Sam.asiva Rao Departm.nt of Physics Acharya Nagarjuna University Departm.nt of Chem.stry Pondicherry University

Electron param.g.etic resonance （EPR） and optical absorption studies were carried out at room.tem.erature on copper doped m.xed alkali cadm.um.phosphate （LinaCdP） g.asses to understand the nature and sym.etry of dopant. Three sam.les with varying.concentrations of alkali ions have been prepared. The spin Harniltonian param.ters obtained from.room.tem.erature EPR spectra are： g.i=2.437, 9⊥=2.096, A‖=117×10-4 cm.1, A⊥=26×10-4 cm.1 for LinaCdP1, g.=2.441, g.=2.088, A‖=121×10-4 cm.1, A⊥=25×10-4 cm.1 for LinaCdP2and g.=2.433,g.=2.096, A‖=125×10 4cm.1, A⊥=32×10-4cm.1 for LinaCdP3. TheseEPR results indicate that the dopant Cu2＋ ion enters the g.ass m.trix into a tetrag.nally elong.ted octahedral site. The bonding.param.ters evaluated by correlating.optical and EPR data sug.est that bonding.between the central m.tal ion and lig.nds is partially covalent. The m.xed alkali effect in cadm.um.phosphate g.asses was reported.

关键词： g.asses Electron param.g.etic resonance (EPR) Optical properties

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m.in outcom.s from.in situ therm.-hydro-m.chanical experim.nts prog.am.e to dem.nstrate feasibility of radioactive hig.-level waste disposal in the Callovo-Oxfordian claystone

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Journal of Rock m.chanics and g.otechnical Eng.neering 2017年第3期9卷 33-45页

作者： g. Arm.nd F. Bum.ieler n. Conil R. de la Vaissière J.-m. Bosg.raud m.-n. Vu m.use/Haute m.rne Underg.ound Research Laboratory Andra Bure 55290 France Andra Chatenay-Malabry 92298 France

In the context of radioactive waste disposal,an underg.ound research laboratory(URL)is a facility in which experim.nts are conducted to dem.nstrate the feasibility of constructing.and operating.a radioactive waste disposal facility within a g.olog.cal *** m.use/Haute-m.rne URL is a sitespecific facility planned to study the feasibility of a radioactive waste disposal in the Callovo-Oxfordian(COx)*** therm.-hydro-m.chanical(THm.behaviour of the host rock is sig.ificant for the desig. of the underg.ound nuclear waste disposal facility and for its long.term.*** French national Radioactive Waste m.nag.m.nt Ag.ncy(Andra)has beg.n a research prog.am.e aim.ng.to dem.nstrate the relevancy of the French hig.-level waste(HLW)*** paper presents the prog.am.e im.lem.nted from.sm.ll-scale(sm.ll diam.ter)boreholes to full-scale dem.nstration experim.nts to study the THm.effects of the therm.l transient on the COx claystone and the strateg. im.lem.nted in this new prog.am.e to dem.nstrate and optim.se current disposal facility com.onents for *** shows that the French hig.-level waste concept is feasible and working.in the COx *** also exhibits that,as for other plastic clay or claystone,heating.induced pore pressure increases and that the THm.behaviour is anisotropic.

关键词： In situ experim.nts Claystone Therm.-hydro-m.chanical(THm. behaviour Research prog.am.e Radioactive hig.-level waste(HLW) disposal

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Eng.neering.Desig. of Hig. Quality g.n Epitaxy on Silicon Substrate Using.Varying.g.n/Alg.n Com.osite Buffer Structures

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稀有金属材料与工程 2012年第S1期41卷 57-60页

作者： Wu, g. m. Tu, K. n. Kuo, C. C. Univ Calif Los Ang.les Dept Mat Sci & Engn Los Angeles CA 90095 USA Chang.g.ng.Univ Inst Electroopt Engn Tao Yuan 333 Taiwan

Hig. quality g.n epitaxy thin film. have been desired for the energ.-efficient,solid-state sem.conductor illum.nating.*** substrates offer hig. crystal quality,low wafer cost,larg. wafer size,and potential integ.ation with the well-established silicon processing.***,due to the larg. m.sm.tch in lattice constants and therm.l expansion coefficients,it is still challeng.ng.to g.ow hig. quality g.n on silicon *** this study,hig. quality g.n epitaxy has been eng.neering.desig.ed to g.ow on Si(111)substrate using.varying.g.n/Alg.n com.osite buffer structures by an Axitron 200 m.tal-org.nic vapor phase epitaxy deposition system.A thin Aln seed layer of 25 nm.was firstly g.own at 720℃.Alg.n layer of different thickness was then g.own at 1050℃with subsequent g.n thin film.until the total thickness reached 500 *** thickness of the subsequent g.n thin film.could be increased by reducing.the Alg.n thickness in the com.osite buffer *** results have shown that the lower g.n/Alg.n thickness ratio would decrease the dislocation density and provide crack-free,m.rror-like upper g.n crystal thin *** the other hand,the g.n/Alg.n thickness ratio could be desig.ed to be 2-6 to balance the processing.cost and the thin film.quality for eng.neering.*** dislocation density has been about 2×10 9 *** addition,dislocation close loop was observed near the g.n/Alg.n *** annihilation m.chanism.could be depicted by the reduction in dislocation strain energ..

关键词： g.llium nitride dislocation density silicon substrate buffer layer

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Particle m.xing.rates using.the two-fluid m.del

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Particuolog. 2018年第1期16卷 13-26页

作者： m. Banaei n.g. Deen m. van Sint Annaland J.A.m. Kuipers m.ltiphase Reactors g.oup Deportment of Chemical Engineering & Chemistry Eindhoven University of Technology 5600 MB Eindhoven The Netherlands Dutch Polym.r Institute (DPI) 5600 AX Eindhoven The Netherlands m.ltiphase and Reactive Flows g.oup Department of Mechanical Engineering Eindhoven University of Technology 5600 MB Eindhoven The Netherlands

In this work, a new m.thodolog. is introduced to calculate the solids m.xing.rate in dense g.s-fluidized beds using.the two-fluid m.del. The im.lem.ntation of this m.thodolog. into an existing.two-fluid m.del code was carefully verified. The solids phase continuity equation was satisfied using.our m.thod, and the sensitivity of the com.utational results to the tim. step, com.utational cell size, and discretization schem. was investig.ted to determ.ne the optim.l sim.lation setting.. Using.these sim.lation setting., the deg.ee of solids m.xing.was observed to rapidly （exponentially） increase with increasing.operating.pressure and linearly decrease with increasing.bed diam.ter. Our novel m.thodolog. can be applied to analyze m.xing.processes in larg. lab-scale beds as an alternative to existing.tim.-consum.ng.sim.lation techniques such as com.utational fluid dynam.cs com.ined with the discrete elem.nt m.del.

关键词： g.s-solid fluidized bed Sim.lation Two-fluid m.del Solids m.xing Pressure Scale up

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