检索结果-南通市图书馆

Prelim.nary Application of High-Frequency Ultrasound in the Differentiation of Pem.higus and Bullous Pem.higoid: An Observational Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Derm.tology and Venereology 2024年第3期7卷 155-159页

作者： Liu Y.-A. Cao R. Da m.-H. Dong Z.-B. Wang F. Departm.nt of Derm.tology Taizhou Central Hospital (Taizhou University Hospital) Zhejiang Taizhou 318000 China Departm.nt of Derm.tology Children's Hospital of Soochow University Jiangsu Suzhou 215025 China Departm.nt of Derm.tology Zhongda Hospital Southeast University Jiangsu Nanjing 210009 China

Objective: Ultrasonography is a diagnostic im.ging technique used to visualize subcutaneous body structures for identification of possible pathologies. In this study, we aim.d to explore the clinical significance of high-frequency ultrasound in differentiating the location of blisters between pem.higus and bullous pem.higoid. m.thods: Eighteen patients were recruited in Departm.nt of Derm.tology, Zhongda Hospital from.2020 to 2021 and divided into a pem.higus group (n = 8) and a bullous pem.higoid group (n = 10) according to the diagnostic criteria for each. Ultrasonographic im.ges were collected using a 50-m.z high-frequency ultrasound system. The indexes of ultrasonic evaluation were the layer (epiderm.s or derm.s), size, shape, internal echo, and boundary of the blister. Categorical variables are expressed as n (%), and differences were com.ared using Fisher's exact test. Results: The ultrasonographic im.ges in the pem.higus group showed an intraepiderm.l sem.-arc or irregular anechoic or hypoechoic areas. The inferior borders were situated above the characteristic thin linear hyperechoic bands of the epiderm.s. A linear hypoechoic band was present at the derm.epiderm.l junction in som. cases. In the ultrasonographic im.ges of the bullous pem.higoid group, the linear hyperechoic bands of the epiderm.s were continuous and intact. An oval fluid anechoic area (subepiderm.l blister) was present im.ediately below the bands. The location of the blisters in the ultrasonographic im.ges was significantly different between the 2 groups (P m.ans to differentiate the location of blisters between pem.higus and bullous pem.higoid. © 2022 Hospital for Skin Diseases (Institute of Derm.tology), Chinese Academ. of m.dical Sciences, and Chinese m.dical Association, published by Wolters Kluwer, Inc.

关键词： bullous pem.higoid high-frequency ultrasound pem.higus

Enhancing Pneum.nia Detection in Pediatric Chest X-Rays Using CGAN-Augm.nted Datasets and Lightweight Deep Transfer Learning m.dels

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Data Analysis and Inform.tion Processing 2024年第1期12卷 1-23页

作者： Coulibaly m.ham.d Ronald Waweru m.angi John m. Kihoro Departm.nt of m.them.tics Pan African University Institute for Basic Sciences Technology and Innovation (PAUSTI) Nairobi Kenya Departm.nt of Com.uting Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya School of Com.uting and m.them.tics The Cooperative University of Kenya Nairobi Kenya

Pneum.nia ranks as a leading cause of m.rtality, particularly in children aged five and under. Detecting this disease typically requires radiologists to exam.ne chest X-rays and report their findings to physicians, a task susceptible to hum.n error. The application of Deep Transfer Learning (DTL) for the identification of pneum.nia through chest X-rays is hindered by a shortage of available im.ges, which has led to less than optim.l DTL perform.nce and issues with overfitting. Overfitting is characterized by a m.del’s learning that is too closely fitted to the training data, reducing its effectiveness on unseen data. The problem.of overfitting is especially prevalent in m.dical im.ge processing due to the high costs and extensive tim. required for im.ge annotation, as well as the challenge of collecting substantial datasets that also respect patient privacy concerning infectious diseases such as pneum.nia. To m.tigate these challenges, this paper introduces the use of conditional generative adversarial networks (CGAN) to enrich the pneum.nia dataset with 2690 synthesized X-ray im.ges of the m.nority class, aim.ng to even out the dataset distribution for im.roved diagnostic perform.nce. Subsequently, we applied four m.dified lightweight deep transfer learning m.dels such as Xception, m.bileNetV2, m.bileNet, and EfficientNetB0. These m.dels have been fine-tuned and evaluated, dem.nstrating rem.rkable detection accuracies of 99.26%, 98.23%, 97.06%, and 94.55%, respectively, across fifty epochs. The experim.ntal results validate that the m.dels we have proposed achieve high detection accuracy rates, with the best m.del reaching up to 99.26% effectiveness, outperform.ng other m.dels in the diagnosis of pneum.nia from.X-ray im.ges.

关键词： Pneum.nia Detection Pediatric Radiology CGAN (Conditional Generative Adversarial Networks) Deep Transfer Learning m.dical Im.ge Analysis

The Protective Effect of m.ringa oleifera Leaves Extract on Paracetam.l Hepatotoxicity in m.le Rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biom.dical Science and Engineering 2024年第3期17卷 72-82页

作者： Reham.m. Al-Sultan Noorah Saleh Al-Sowayan Departm.nt of Biology College of Science Qassim University Buraydah Saudi Arabia

In recent years, there has been an increase in concern regarding the effects of paracetam.l poisoning on liver tissues, particularly when consum.d in large am.unts. Som. studies have estim.ted that paracetam.l is involved in 56% of acute liver diseases, whereas 0.4% of paracetam.l overdose cases result in fatal-ity. In this study, the effects of m.ringa oleifera on paracetam.l toxicity in the liver were explored. It has been dem.nstrated that m.ringa oleifera is highly nu-tritious, contains bioactive m.lecules, and is therapeutically beneficial. m.ny studies have shown that m.ringa oleifera leaves possess a wide range of biologi-cal properties, including antioxidant, tissue protection, analgesic, antihyperten-sive, and im.unom.dulatory activities. This study highlights the protective role of m.ringa oleifera on handling possible paracetam.l hepatotoxicity in m.le rats. .

关键词： m.ringa oleifera Paracetam.l Hepatotoxicity Oxidative Stress

A Study of Radiation-Induced Telom.re Instability Using m.ltiplex Ligation-Dependent Probe Am.lification (m.PA)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Biological Chem.stry 2024年第3期14卷 73-85页

作者： Alan Chant Ahm.d Chaudary Christina m. Kraem.r-Chant Departm.nt of m.crobiology and m.lecular Genetics University of Vermont Burlington VT USA Departm.nt of Public and Allied Health Bowling Green State University Bowling Green OH USA Departm.nt of Chem.stry Saint Michaels College Colchester VT USA

The integrity of the chrom.som.s for two WIL2-derived lym.hoblastoid cell lines (TK6 and WTK1) in the presence and absence of ionizing radiation was analyzed by m.ltiplex Ligation-Dependent Probe Am.lification (m.PA). The TK6 cell line has the native p53 tum.r-suppressor gene, whereas WTK1 cells contain a p53 m.tation. Each cell line was isolated pre- and post-irradiation (2 and 3 Gy) and analyzed by m.PA. The im.act of irradiation on these two cell lines was investigated using probes that target specific regions on chrom.som.s associated with subtelom.ric regions. Results indicate that WTK1 and TK6 are im.acted differently after irradiation, and that each cell line presents its own unique m.PA profile. The m.st notable differences are the appearance of a num.er of probes in the post-irradiated m.PA profile that are not present in the controls, and two unique probe signals only seen in WTK1 cells. These results build on our previous studies that indicate how different hum.n cell lines can be affected by radiation in significantly different ways depending on the presence or absence of wild type p53.

关键词： Ionizing Radiation m.ltiplex Ligation-Dependent Probe Am.lification (m.PA) p53 Tum.r Suppressor Telom.re Instability

Analysis and Review of Downregulated Actin Cytoskeletal Proteins in Non-Sm.ll Cell Lung Cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biosciences and m.dicines 2024年第4期12卷 89-115页

作者： Hala m. Abdel m.geed Praveen Sahu Raji Sundararajan School of Engineering Technology Purdue University West Lafayette USA National Institute of Standards Al Haram Egypt

Actin, a highly conserved protein, plays a dom.nant role in Non-sm.ll cell lung cancer (NSCLC). Late diagnosis and the aggressive nature of NSCLC pose a significant threat. Studying the clinic pathological properties of NSCLC proteins is a potential alternative for developing treatm.nt strategies. Towards this, 35 downregulated actin cytoskeletal proteins on NSCLC prognosis and treatm.nt were studied by exam.ning their protein-protein interactions, gene ontology enrichm.nt term., and signaling pathways. Using Pubm.d, various proteins in NSCLC were identified. The protein-protein interactions and functional associations of these proteins were exam.ned using the STRING database. The focal adhesion signaling pathway was selected from.all available KEGG and Wiki pathways because of its role in regulating gene expression, facilitating cell m.vem.nt and reproduction, and significantly im.acting NSCLC. The protein-protein interaction network of the 35 downregulated actin cytoskeleton proteins revealed that ACTG1, ACTR2, ACTR3, ANXA2, ARPC4, FLNA, TLN1, CALD1, m.L6, m.H9, m.H10, TPm., TPm., TPm., PFN1, IQGAP1, m.N, and ZXY exhibited the highest num.er of interactions. Whereas HSPB1, CTNNA1, KRT17, KRT7, FLNB, SEPT2, and TUBA1B displayed m.dium.interactions, while UTRN, TUBA1B, and DUSP23 had relatively fewer interactions. It was discovered that focal adhesions are critical in connecting m.m.rane receptors with the actin cytoskeleton. In addition, protein kinases, phosphatases, and adapter proteins were identified as key signaling m.lecules in this process, greatly influencing cell shape, m.tility, and gene expression. Our analysis shows that the focal adhesion pathway plays a crucial role in NSCLC and is essential for developing effective treatm.nt strategies and im.roving patient outcom.s.

关键词： Non-Sm.ll Cell Lung Cancer NSCLC Actin Actin Cytoskeletal Proteins Focal Adhesion KEEG Pathway

Advancem.nts in Polym.r Science: Synthesis, Characterization, and Biom.dical Applications of Hom.polym.rs and Copolym.rs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Polym.r Chem.stry 2024年第3期14卷 167-198页

作者： Anaif m. Alhewaitey Ishrat Khan Em.anuel Ram.ey Buabeng Departm.nt of Chem.stry Clark Atlanta University Atlanta USA Departm.nt of Chem.stry University of Tabuk Tabuk Saudi Arabia Departm.nt of Chem.stry Georgia State University Atlanta GA USA

Polym.r science encom.asses a different range of m.terials critical to industries spanning from.packaging to biom.dicine. Understanding the synthesis, characterization, and applications of com.on hom.polym.rs and copolym.rs is fundam.ntal to advancing polym.r research and developm.nt. In this com.rehensive review, we explore various preparation m.thods, including free radical, anionic, and cationic polym.rization, utilized for synthesizing hom.polym.rs and copolym.rs. Furtherm.re, we investigate solvent choices com.only em.loyed for polym.r characterization, ranging from.neat conditions, polar protic and polar aprotic solvents. We also explored characterization techniques, including Fourier Transform.Infrared Spectroscopy (FTIR), Nuclear m.gnetic Resonance (Nm.), Atom.c Force m.croscopy (AFm., Differential Scanning Calorim.try (DSC), and Therm.gravim.tric Analysis (TGA). In addition to industrial applications, we highlight the diverse biological applications of hom.polym.rs, poly(2-hydroxyethyl m.thacrylate) (pHEm.) and polystyrene, which find its extensive use in biom.dicine. By synthesizing and analyzing this wealth of inform.tion, this review aim. to provide a com.rehensive understanding of the synthesis, characterization, and applications of hom.polym.rs and copolym.rs, with a particular focus on their biological applications. This holistic approach not only contributes to advancem.nts in polym.r science and technology but also fosters innovation in biom.dicine, ultim.tely benefiting hum.n health and well-being.

关键词： Hom.polym.r Copolym.r Poly(2-hydroxyethyl m.thacrylate) (pHEm.) Polystyrene Free Radical Polym.rization Atom.c Force m.croscopy Solvent Polarity

Braneworld black holes with m.dm.x electrodynam.cs on the brane

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Com.unications in Theoretical Physics 2024年第6期76卷 120-128页

作者： Haryanto m.Siahaan Jurusan Fisika Universitas Katolik ParahyanganJalan Ciumbuleuit 94Bandung 40141Indonesia

In this study,we investigate m.dm.x electrodynam.cs localized within the Randall-Sundrum.Ⅱ and Dvali-Gabadadze-Porrati branes,deriving corresponding 3-brane spacetim. solutions that conform.to the effective Einstein equations in each specific *** construct solutions for charged black holes within the effective Einstein equation fram.work in both braneworld *** exam.nation explores the trajectories of charged objects in this spacetim.,underscoring the significance of the nonlinear *** analysis uncovers the fact that,sim.lar to the prior m.dm.x black hole investigation,the nonlinear param.ter plays a pivotal role in suppressing the effective charge of the black hole,due to its definite positive value.

关键词： RS-II DGP m.dm.x brane

Higgs-like(pseudo)scalars in AdS_(4),m.rginal and irrelevant deform.tions in CFT_(3),and instantons on S^(3)

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第4期48卷 68-81页

作者： m.Naghdi Departm.nt of Physics Faculty of Basic SciencesUniversity of IlamIlamIran

Em.loying a 4-form.ansatz of 11-dim.nsional supergravity over a non-dynam.cal AdS_(4)×S^(7)/Z_(k)background and setting the internal space as an S1 Hopf fibration on CP3,we obtain a consistent ***(pseudo)scalars,in the resulting scalar equations in Euclidean AdS_(4)space,m.y be considered to arise from.anti)m.branes wrapping around the internal directions in the(Wick-rotated)skew-whiffed m.-brane background(as the resulting theory is for anti-m.-branes),thus realizing the m.des after swapping the three fundam.ntal representations 8_(s),8_(c),and 8_(v) of SO(8).Taking the backreaction on the external and internal spaces,we obtain the m.ssless and m.ssive m.des,corresponding to exactly m.rginal and m.rginally irrelevant deform.tions on the boundary CFT3,***,we obtain a closed solution for the bulk equation and com.ute its correction with respect to the background ***,considering the Higgs-like(breathing)m.de m.(2)=18,having all supersym.etries as well as parity and scale-invariance broken,solving the associated bulk equation with m.them.tical m.thods,specifically the Adom.an decom.osition m.thod,and analyzing the behavior near the boundary of the solutions,we realize the boundary duals in the SU(4)×U(1)-singlet sectors of the ABJm.***,introducing the new dual deform.tionΔ_(+)=3,6 operators m.de of bi-fundam.ntal scalars,ferm.ons,and U(1)gauge fields,we obtain the SO(4)-invariant solutions as sm.ll instantons on a three-sphere with the radius at infinity,which correspond to collapsing bulk bubbles leading to big-crunch singularities.

关键词： AdS_(4)/CFT_(3)correspondence scalar equations in AdS_(4) instantons m.rginal and irrelevant operators (anti)m.branes

Optim.zation and Characterization of Cellulose Extraction from.Grevillea robusta (Silky Oak) Leaves by Soda-Anthraquinone Pulping Using Response Surface m.thodology

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Green and Sustainable Chem.stry 2024年第3期14卷 43-65页

作者： Catherine N. m.ya John m. Onyari Lydia W. Njenga Joab O. Onyango Wilson m. Gitari Departm.nt of Chem.stry The University of Nairobi Nairobi Kenya School of Chem.cal and m.terial Science The Technical University of Kenya Nairobi Kenya

Response surface m.thodology (RSm. using the central com.osite design (CCD) was applied to exam.ne the im.act of soda-anthraquinone pulping conditions on Grevillea robusta fall leaves. The pulping factors studied were: NaOH charge 5% to 20% w/v, pulping tim. 30 to 180 m.nutes, and the anthraquinone charge 0.1 to 0.5% w/w based on the oven-dried leaves. The responses evaluated were the pulp yield, cellulose content, and the degree of delignification. Various regression m.dels were used to evaluate the effects of varying the pulping conditions. The optim.m.conditions attained were;NaOH charge of 14.63%, 0.1% anthraquinone, and a pulping period of 154 m.nutes, corresponding to 20.68% pulp yield, 80.56% cellulose content, and 70.34% lignin rem.val. Analysis of variance (ANOVA), was used to determ.ne the m.st im.ortant variables that im.rove the extraction process of cellulose. The experim.nt outcom.s m.tched those predicted by the m.del (Predicted R2 = 0.9980, Adjusted R2 = 0.9994), dem.nstrating the adequacy of the m.del used. FTIR analysis confirm.d the elim.nation of the non-cellulosic fiber constituents. The lignin and hem.cellulose-related bands (around 1514 cm.1, 1604 cm.1, 1239 cm.1, and 1734 cm.1) decreased with chem.cal treatm.nt, indicating effective cellulose extraction by the soda-anthraquinone m.thod. Sim.lar results were obtained by XRD, SEm.and therm.gravim.tric analysis of the extracted cellulose. Therefore, Grevillea robusta fall leaves are suitable renewable, cost-effective, and environm.ntally friendly non-wood biom.ss for cellulose extraction.

关键词： Cellulose Extraction Response Surface m.thodology Central Com.osite Design Delignification