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Journal of Environm.ntal Sciences 2011年第3期23卷 372-380页

作者： Xiaohong Guan Haoran Dong Jun m. Irene m. C. lo State Key Laboratory of Urban Water Resource and Environm.nt Harbin Institute of Technology Harbin 150090 China Departm.nt of Civil and Environm.ntal Engineering The Hong Kong University of Science and Technology Hong Kong 999077 China

Chrom.um.and/or arsenate rem.val by Fe（Ⅱ） as a function of pH, Fe（Ⅱ） dosage and initial Cr（Ⅵ）/As（Ⅴ） ratio were exam.ned in batch tests. The presence of arsenate reduced the rem.val efficiency of chrom.um.by Fe（Ⅱ）, while the presence of chrom.te significantly increased the rem.val efficiency of arsenate by Fe（Ⅱ） at pH 6-8, In the absence of arsenate, chrom.um.rem.val by Fe（Ⅱ） increased to a m.xim.m.with increasing pH from.4 to 7 and then decreased with a further increase in pH. The increm.nt in Fe（Ⅱ） dosage resulted in an im.rovem.nt in chrom.um.rem.val and the im.rovem.nt was m.re rem.rkable under alkaline conditions than that under acidic conditions. Chrom.um.rem.val by Fe（Ⅱ） was reduced to a larger extent under neutral and alkaline conditions than that under acidic conditions due to the presence of 10 μtm.l/L arsenate. The presence of 20 μm.l/L arsenate slightly im.roved chrom.um.rem.val by Fe（Ⅱ） at pH 3.9-5,8, but had detrim.ntal effects at pH 6.7-9.8. Arsenate rem.val was im.roved significantly at pH 4-9 due to the presence of 10μm.l/L chrom.te at Fe（Ⅱ） dosages of 20-60 μm.l/L. Elevating the chrom.te concentration from.10 to 20μm.l/L resulted in a further im.rovem.nt in arsenate rem.val at pH 4.0-4.6 when Fe（Ⅱ） was dosed at 30-60 μm.l/L.

关键词： chrom.um.rem.val arsenate rem.val ferrous iron groundwater treatm.nt

Neurogenesis dynam.cs in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.awiah m.Naffaa Departm.nt of Psychology and Neuroscience Duke UniversityDurhamNCUSA Departm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons m.grating to the granule cell layer and glom.rular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit rem.deling triggered by m.m.ry and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. m.reover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory inform.tion processing. This adaptive process responds to changes in epithelial com.osition and contributes to the form.tion of olfactory m.m.ries by m.dulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions rem.ins a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around m.tral and tufted cells. This organizational pattern significantly im.acts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and m.m.ry. Additionally, this organization is further shaped by axon term.nals originating from.cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these com.lex and highly interconnected processes have not been com.rehensively studied as a whole. Therefore, this m.nuscript aim. to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These m.chanism. are thought to support olfactory learning and m.m.ry, potentially through increased

关键词： network adaptability neurogenesis neuronal com.unication olfactory bulb olfactory learning olfactory m.m.ry synaptic plasticity

Equilibrium.Configurations of Lipid Bilayer m.m.ranes and Carbon Nanostructures

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Com.unications in Theoretical Physics 2013年第2期59卷 213-228页

作者： Ivalo m. m.adenov Peter A. Djondjorov m.riana Ts. Hadzhilazova Vassil m. Vassilev Institute of Biophysics Bulgarian Academy of Sciences Acad. G. Bonchev Str. Block 21 1113 Sofia Bulgaria Institute of m.chanics Bulgarian Academy of Sciences Acad. G. Bonchev Str. Block 4 1113 Sofia Bulgaria

The present article concerns the continuum.m.delling of the m.chanical behaviour and equilibrium.shapes of two types of nano-scale objects： fluid lipid bilayer m.m.ranes and carbon nanostructures. A unified continuum.m.del is used to handle four different ease studies. Two of them.consist in representing in analytic form.cylindrical and axisym.etric equilibrium.configurations of single-wall carbon nanotubes and fluid lipid bilayer m.m.ranes subjected to uniform.hydrostatic pressure. The third one is concerned with determ.nation of possible shapes of junctions between a single-wall carbon nanotube and a fiat graphene sheet or another single-wall carbon nanotube. The last one deals with the m.chanical behaviour of closed fluid lipid bilayer m.m.ranes （vesicles） adhering onto a fiat hom.geneous rigid substrate subjected to m.cro-injection and uniform.hydrostatic pressure.

关键词： fluid m.m.ranes graphene carbon nanotubes carbon nanostructures junctions variational statem.nt Euler-Lagrange equations natural boundary conditions cell injection adhesion equi- librium.shapes

SBL-JP-0004:A prom.sing dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Departm.nt of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)rem.ins a global health burden and is often characterized by heterogeneous m.lecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,m.king them.attractive targets for therapeutic ***:This study applied a com.utational and m.lecular dynam.cs sim.lation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by m.lecular docking scores and m.lecular dynam.cs *** interactions and Gibbs binding free energy estim.tes confirm.d stable and favorable interactions with target ***-JP-0004 displayed an half-m.xim.l inhibitory concentration(IC_(50))value of 118.9 nm.against JAK2 kinase and 200.9 nm.against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-m.xim.l growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm.respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatm.nt com.ared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a prom.sing dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 m.lecular docking m.lecular dynam.cs sim.lation

m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor m.m.tics: HER-096 as a disease-m.difying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holm.tröm.Henri J.Huttunen Herantis Pharm. Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.jor unm.t need in the field of central nervous system.diseases is disease-m.difying *** for decades there have been various sym.tom.tic treatm.nts available to alleviate the sym.tom. of the disease,disease-m.dification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatm.nt therapeutic

Search for m.croglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Departm.nt of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflam.atory states in the central nervous system.CNS)are the hallm.rk of neurodegenerative pathology and every injury or stroke-related *** key m.diators of these neuroinflam.atory states are glial cells known as m.croglia,the resident im.une cell at the core of the inflam.atory event,and astroglia,which encapsulate inflam.atory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** m.st neuroinflam.ation is exclusively based on the responses of said m.croglia,their phenotypes are suggested to follow those of m.crophages;m. and m. are opposites of pro-and ***,m.croglial phenotypes have been identified to be on an inflam.atory spectrum.encom.assing developm.ntal,hom.ostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue form.tion.

关键词： inflam.ation pathology death

One-loop approxim.tion of m.ller scattering in generalized Krein-space quantization

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Science China(Physics,m.chanics & Astronom.) 2009年第2期52卷 212-217页

作者： F. PAYANDEH m. m.HRAFARIN m. V. TAKOOK Physics Departm.nt Amirkabir University of Technology Payam. Noor University Physics Departm.nt Razi University

It has been shown that the negative-norm.states necessarily appear in a covariant quantization of the free m.nim.lly coupled scalar field in de Sitter spacetim.. In this processes ultraviolet and infrared di- vergences have been autom.tically elim.nated. A natural renorm.lization of the one-loop interacting quantum.field in m.nkowski spacetim. (λφ 4) has been achieved through the consideration of the nega- tive-norm.states defined in Krein space. It has been shown that the com.ination of quantum.field theory in Krein space together with consideration of quantum.m.tric fluctuation, results in quantum.field the- ory without any divergences. Pursuing this approach, we express Wick’s theorem.and calculate m.ller scattering in the one-loop approxim.tion in generalized Krein space. The m.them.tical consequence of this m.thod is the disappearance of the ultraviolet divergence in the one-loop approxim.tion.

关键词： quantum field theory Krein space negative energy states

Structural, elastic and electronic properties for m.2 XC (m.Ti and Cr, X=Ga and Al) phases from.ab initio calculations

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Acta m.tallurgica Sinica(English Letters) 2011年第4期24卷 255-270页

作者： B. Ghebouli m.A. Ghebouli m. Fatm. N. Bouarissa m. Benkerri I.A. Ibrahim Laboratory of Study of Surfaces and Interfaces of Solids m.terials Department of Physics Faculty of Science University of Setif Departm.nt of Physics University Center Research Unit on Em.rging m.terials Ferhat Abbas University of Setif Departm.nt of Physics Faculty of Sciences King Khalid University Central m.tallurgical Research and Developm.nt Institute P.O. Box: 87 Helwan 11424 Cairo Egypt

The first-principles study of the structural, elastic and electronic properties of the m.XC phases depending on the type of m.transition m.tal （m.are Ti and Cr） and on X （X are Ga and A1） was reported. The calculations are perform.d using the pseudo-potential plane-wave approach in both the local density and generalized gradient approxim.tions. The elastic constants are calculated using the static finite strain technique. Features such as structural and elastic param.ters, Debye tem. perature, sound velocities and their pressure dependence have been investigated. In agreem.nt with experim.ntal and previous theoretical findings, it is found that the com.ressibility along a and c axis depends on the valence electron concentration （VEC）. Correlations revealing the governing role of the X and m.elem.nts on the m.chinability indices of the m.terial have been exam.ned. The electronic properties have been discussed in term. of chem.cal bonding showing that bonding is due to m.-Cp and m.-Xp hybridizations. m.C bonds are stiffer than m.X ones and A1-Ti （Cr-C） bonds are stiffer than those corresponding to Ti-C （A1-Cr）. It is shown that the stiffness of the m.X and m.C bonds increases with increasing the num.er of VEC.

关键词： m.XC phases ab initio Pressure effect Band structures

Energy efficiency in a water supply system.Energy consum.tion and CO_2 em.ssion

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Water Science and Engineering 2010年第3期3卷 331-340页

作者： Helena m.RAm.S Filipe VIEIRA Dídia I.C.COVAS Departm.nt of Civil Engineering ISTTechnical University of Lisbon CEHIDRO IST-DECivilLisbon 1049-001Portugal

This paper presents im.ortant fundam.ntals associated with water and energy efficiency and highlights the im.ortance of using renewable energy sources. A m.del of m.lti-criteria optim.zation for energy efficiency based on water and environm.ntal m.nagem.nt policies, including the preservation of water resources and the control of water pressure and energy consum.tion through a hybrid energy solution, was developed and applied to a water supply system. The m.thodology developed includes three solutions：（1） the use of a water turbine in pipe system. where pressures are higher than necessary and pressure-reducing valves are installed, （2） the optim.zation of pum.ing operation according to the electricity tariff and water dem.nd, and （3） the use of other renewable energy sources, including a wind turbine, to supply energy to the pum.ing station, with the rem.ining energy being sold to the national electric grid. The use of an integrated solution （water and energy-） proves to be a valuable input for creating benefits from.available hydro energy in the water supply system.in order to produce clean power, and the use of a wind source allows for the reduction of energy consum.tion in pum.ing stations, as well as of the CO2 em.ssion to the atm.sphere.

关键词： m.lti-criteria optim.zation energy efficiency water supply renewable energy sources CO2 em.ssion