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以田鼠作为动物模型来研究社会行为的进化:基因、脑与行为(英文)

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动物学报 2004年第4期50卷 479-489页

作者： m.randa m. LIm.Elizabeth A.D. HAm.OCK Larry J. YOUNG Center for Behavioral Neuroscience Department of Psychiatry and Behavioral Sciences Emory University Atlanta GA 30322 USACenter for Behavioral Neuroscience Department of Psychiatry and Behavioral Sciences Emory University Atlanta GA 30322 USACenter for Behavioral Neuroscience Department of Psychiatry and Behavioral Sciences Emory University Atlanta GA 30322 USA

田鼠属的一些近缘种间具有独特的社会行为多态性。例如m.crotusochrogaster和m..pinetorum.一夫一妻制 ,而m..m.ntanus和m..pennsylvanicus则为独居和一夫多妻制。无论是在野外还是人工饲养的条件下 ,单配制的田鼠其雌、雄成年个体一... 详细信息

田鼠属的一些近缘种间具有独特的社会行为多态性。例如m.crotusochrogaster和m..pinetorum.一夫一妻制 ,而m..m.ntanus和m..pennsylvanicus则为独居和一夫多妻制。无论是在野外还是人工饲养的条件下 ,单配制的田鼠其雌、雄成年个体一经交配即在两者之间形成长期的配偶关系并且双亲共同哺育后代。已证明神经多肽加压素 (Vasopressin)参与了田鼠单配制行为的神经调控。本篇综述了过去以及近期关于加压素调控田鼠配偶关系形成的研究结果和进展。首先 ,阐述了加压素V1a受体 (V1ar)在脑分布的种间差异 ,并以此来鉴别特定脑区在配偶关系形成中的功能 ;其次 ,探讨了运用V1ar拮抗物的药理学方法来决定究竟哪些脑区参与配偶关系的形成 ,还描述了田鼠种间V1ar基因结构和功能的不同 ,以及这些不同对V1ar在大脑的分布和行为调控潜在的作用机制 ;最后 ,讨论了最新的研究结果 ,即对一夫多妻制田鼠进行脑V1ar基因的改造 ,从而使之表现出一夫一妻制田鼠的行为。总之。

关键词：田鼠动物模型社会行为进化基因脑

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Upper Blepharoplasty Scar and Patient Satisfaction Evaluation in a Plastic Surgery Center in m.xico

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Journal of Biosciences and m.dicines 2020年第6期8卷 77-88页

作者： Victor Hugo Avalos Góm.z Jaim. aron García Espinoza José Carlos m.rtínez López Carlos Illich Navarro Delgadillo Blanca Yadira arám.ula Sánchez Alejandro Costa Dulche Cuahutem.c m.rquez Espriella Esteban Israel Cam.os Serna Division of Plastic and Reconstructive Surgery Hospital Central Sur de Alta Especialidad de Petróleos Mexicanos Mexico City Mexico

Background: Eyes are one of the m.st im.ortant facial features, their appearance being associated with state of m.nd, age and beauty. Therefore, upper blepharoplasty is one of the m.st com.on procedures perform.d in plastic surgery. Standardized tools allow for m.asurem.nt of outcom.s through patient satisfaction and surgeon experience. Objectives: Our objective was to m.asure the satisfaction index and scar quality of patients who underwent upper blepharoplasty using the Patient-reported Outcom. m.asure Questionnaire (PROm.Q) and Patient and Observer Scar Assessm.nt Scale (POSAS). m.thods: A retrospective review of patients that underwent upper blepharoplasty in our institution was perform.d. We included those with a preoperative anthropom.tric analysis, standardized incision m.rkings (developed in our center), sam. operative technique and a 3-m.nth postoperative evaluation with PROm.Q and POSAS. The sam.le for this study consists of 67 patients, all of them.operated between January 1 2019 and June 30 2019 at the Departm.nt of Plastic Surgery, South Central High Specialty Hospital, Pem.x, m.xico City, m.xico. Results: A total of 67 patients were included, 73% fem.le and 27% m.le. The m.st frequent indication for surgery was functional visual sym.tom.. The index of PROm.Q at 3 m.nths dem.nstrated an increased satisfaction above 90%, and the evaluation with POSAS reported an alm.st im.erceptible scar. Conclusion: Evaluating outcom.s with objective tools provides data useful to im.rove the surgical protocols of patients subjecting to aesthetic procedures.

关键词： Upper Blepharoplasty Satisfaction Index PROm.Q Quality of Life Scar

Hartree-Fock-Roothaan Calculations for Ground States of Som. Atom. Using m.nim.l Basis Sets of Integer and Noninteger n-STOs

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Chinese Journal of Chem.stry 2004年第11期22卷 1262-1266页

作者： Güm.■ Sedat ZSO■AN Telhat Departm.nt of Physics Amasya Education Faculty Ondokuz Mayis University 05189 Amasya TURKEYDepartment of Physics Amasya Education Faculty Ondokuz Mayis University 05189 Amasya TURKEY

Hartree-Fock-Roothaan (HFR) calculations for ground states of som. atom., i.e. He, Be, Ne, ar, and Kr have been perform.d using m.nim.l basis sets of Slater type orbitals (STOs) with integer and noninteger principal quan-tum.num.ers (integer n-STOs and noninteger n-STOs). The obtained total energies for these atom. using m.nim.l basis sets of integer n-STOs are in good agreem.nt with those in the previous literature. On the other hand, for the case of m.nim.l basis sets of noninteger n-STOs, although the calculated total energies of these atom. agree well with the results in literature, som. striking results have been obtained for atom. ar and Kr. Our com.utational re-sults for the energies of atom. ar and Kr are slightly better than those in literature, by am.unt of 0.00222 and 0.000054 a.u., respectively. The im.rovem.nt in the energies of atom. ar and Kr m.y result from.the efficient cal-culations of one-center two-electron integrals over noninteger n-STOs. For som. atom.c ions in their ground state, HFR calculations have been carried out using m.nim.l basis sets of noninteger n-STOs. The obtained total energies for these atom.c ions are substantially lower than those available in literature.

关键词： Hartree-Fock-Roothaan Slater type orbital

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Heat shock and other apoptosis-related proteins as therapeutic targets in prostate cancer

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Asian Journal of Andrology 2014年第3期16卷 359-363页

作者： Costantine Albany Noah m.Hahn Indiana University Health Melvin and Bern Simon Cancer Center Indianapolis IN USA.

Defects within apoptotic pathways have been im.licated in prostate cancer （PCa） tum.rigenesis, m.tastatic progression and treatm.nt resistance. A hallm.rk of cancers is the ability to derail apoptosis by inhibiting the apoptotic signal, reducing the expression of apoptotic proteins and/or am.lifying survival signals through increased production of antiapoptotic m.lecule. This review describes associations between heat shock proteins （HSPs） and the hum.n androgen receptor （ar）, the role of HSPs and other stress-induced proteins in PCa developm.nt and em.rging strategies in targeting these protective proteins to treat PCa.

关键词： apatorsen apoptosis bcl-2 hom.logous antagonist-killer protein clusterin custirsen ganetespib heat-shock proteins prostatic neoplasm.

arm. m.delling of Benue River Flow Dynam.cs: Com.arative Study of Par m.del

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Open Journal of m.dern Hydrology 2011年第1期1卷 1-9页

作者： Otache Y. m.rtins m. A. Sadeeq I. E. Ahaneku 不详

The seem.ngly com.lex nature of river flow and the significant variability it exhibits in both tim. and space, have largely led to the developm.nt and application of the stochastic process concept for its m.delling, forecasting, and other ancillary purposes. Towards this end, in this study, attem.t was m.de at stochastic m.delling of the daily stream.low process of the Benue River. In this regard, Autoregressive m.ving Average (arm.) m.dels and its derivative, the Periodic Autoregressive (Par) m.del were developed and used for forecasting. Com.arative forecast perform.nces of the different m.dels indicate that despite the shortcom.ngs associated with univariate tim. series, reliable forecasts can be obtained for lead tim.s, 1 to 5 day-ahead. The forecast results also showed that the traditional arm. m.del could not robustly sim.late high flow regim.s unlike the periodic ar (Par). Thus, for proper understanding of the dynam.cs of the river flow and its m.nagem.nt, especially, flood defense, in the light of this study, the traditional arm. m.dels m.y not be suitable since they do not allow for real-tim. appraisal. To account for seasonal variations, Par m.dels should be used in forecasting the stream.low processes of the Benue River. However, since alm.st all m.chanism. involved in the river flow processes present som. degree of nonlinearity thus, how appropriate the stochastic process m.ght be for every flow series m.y be called to question.

关键词： Tim. Scale Stream.low Autoregressive m.del Fuzzy Cluster Forecasting Dynam.cs

Variation of soil and plant characteristics am.ng old world bluestem.species

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Agricultural Sciences 2011年第3期2卷 347-356页

作者： Ted m. Zobeck Vivien G. Allen Jenny Jo Cox Dirk Philipp Departm.nt of Plant and Soil Science Texas Tech University Lubbock TX USA University of arkansas Fayetteville AR USA USDA-arS Cropping Systems Research Lab Lubbock TX USA

Old world bluestem. (Bothriochloa spp.) have been successfully introduced as grasses for livestock forage in the sem.arid Texas High Plains. Questions rem.in, however, on effects of these grasses on soil resources. We tested the hypothesis that differences in grass species produce differences in soil properties im.ortant to crop growth and useful in selecting the optim.m.species for the Southern High Plains of Texas. Three old world bluestem.(Bothriochloa) species [C.E. Hubbard ‘Caucasian’, B. caucasica (Trin.);‘WW Spar’, B. ischaem.m.(L.) *** ischaem.m.(Hack.);and S.T. Blake ‘WW-B Dahl’, B. bladhii (Retz)] were grown in a random.zed com.lete block design, with three replications, for nine years on a clay loam.soil near Lubbock, Texas. Soil sam.les were collected in the ninth year to determ.ne soil texture, wet aggregate stability, bulk density (BD), soil organic carbon (SOC), particulate organic carbon (POC), and soil strength as m.asured by the cone pentrom.ter. The grass species differed in their above-ground biom.ss and below- ground root production. In the ninth year of production, Bothriochloa caucasica and B. bladhii produced about twice the above-ground biom.ss with about 25% fewer roots than B. ischaem.m. Soils where B. caucasica was grown had the highest BD (1.36 m. m.3) and B. ischaem.m.had the lowest (1.31 m. m.3). The soil in which B. ischaem.m.was growing had a lower BD, greatest root biom.ss, organic m.tter content, and aggregate stability suggesting superior soil quality for agricultural production. The species B. bladhii, however, often exhibited soil properties that were sim.lar to both other species tested. Since Bothriochloa bladhii had superior or sim.lar soil properties for plant growth am.ng the species tested and has been shown to be higher in forage quality, anim.l perform.nce, and carrying capacity than the other species, it appears to be the best choice am.ng these three species to optim.ze both anim.l perform.nce and desirable soil p

关键词： Old World Bluestem Soil Quality Grasses Soil Organic Carbon

Geochem.stry and Petrology of Basic Volcanic Rocks of Jabal Al Haruj Al-Aswad, Libya

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International Journal of Geosciences 2015年第1期6卷 109-144页

作者： N. m. Al-Hafdh Abd El-Salam.S. El-Shaafi Departm.nt of Earth Science Faculty of Sciences Mosul University Mosul Iraq Departm.nt of Earth Science Faculty of Sciences Benghazi University Benghazi Libya

The Al Haruj Intra-continental Volcanic Province is the largest part of the extensive volcanic activity in Libya which is considered to be a typical within plate basalts. The volcano-tectonics evolution of this province, as well as its origin, are still widely disputed. According to K-ar dating previously studied, the volcanic activity started in the Late m.ocene and lasted until at least the Late Pleistocene. The field m.y still be volcanically active. The m.fic rocks of Jabal Al Haruj have been classified into six m.jor phases or groups. These phases have been differentiated using Landsat im.ges together with aerial photographs of different scales as well as field observations. The topographic form. of the earliest phase are highly eroded while the form. of the latest phase are usually fresh and very well preserved as regards prim.ry features. m.fic lavas of this field consist of alkali basalts to olivine tholeiites (transitional basalt) which contain olivine as essential constituent together with clinopyroxene, plagioclase and glass. The basalt exhibits intergranular, intersertal, ophitic and subophitic relations. Am.gdaloidal and glom.rporphyritic textures are also observed. The basaltic rocks of different ages and from.different localities are petrographically rather sim.lar. Phenocrysts of olivine probably the result from.slow cooling in crustal m.gm. cham.ers prior to eruptions, suggesting that m.gm.s ascended slowly through the crust. 109 sam.les have been carefully collected from.various phases, som. of these sam.les have been chosen for m.jor and trace elem.nts analyses, using XRF in order to determ.ne the characteristics of the?m.ntle source and investigate crustal interaction. The m.jor and trace elem.nts revealed a?slightly significant chem.cal diversity am.ng the phases and within each phase. The norm.tive classification of m.st of these rocks shows close agreem.nt with their m.dal classification. A vague correlation between m.O and m.st m.jor oxides i

关键词： Jabal Al Haruj Al Aswad area Basaltic Rocks Geochem.stry Petrology Petrogenesis Libya

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抗肿瘤药物

国外医学.药学分册 1980年第5期 279-284页

作者： Kraska ar 张礼和高由松

本文论述了1975年中临床研究最多的化合物和新报道的有抗肿瘤活性的化合物。烷化剂和亚硝脲类氯代乙胺化合物和有关的烷化剂,仍然是治疗肿瘤最广泛使用的一类化合物。几乎所有新的辅助化疗方案中,至少用一个周期的环磷酰胺或BCNU,CCNU,m...

本文论述了1975年中临床研究最多的化合物和新报道的有抗肿瘤活性的化合物。烷化剂和亚硝脲类氯代乙胺化合物和有关的烷化剂,仍然是治疗肿瘤最广泛使用的一类化合物。几乎所有新的辅助化疗方案中,至少用一个周期的环磷酰胺或BCNU,CCNU,m.CCNU,或最近研究的水溶性亚硝脲ACNU。ACNU在体内的性质类似于脂溶性亚硝脲化合物,并发现它在诱导治疗小细胞肺癌和转移性肺癌有良好作用。氯乙氨苯肽(Peptichem.o,PTC,l)是六种m.L-苯丙氨酸氮芥多肽混合物。由于它具有肽基因,故认为有抗代谢作用,此药以1～1.5m./kg/天的剂量,连续3～5天静脉给药几个疗程的方案,已用于各种实体瘤治疗的诱导期。用同样的治疗方案,对晚期儿童神经母细胞瘤,12例

关键词：化合物 ADR 心脏毒性白血病类似物血癌同型物小鼠小家鼠延长率腹腔注射肉瘤细胞毒性肿瘤细胞株抗肿瘤作用腹水瘤环磷酞胺

Synthesis of Ni-CeO_2 catalyst for the partial oxidation of m.thane using RF therm.l plasm.

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Chinese Journal of Catalysis 2016年第5期37卷 743-749页

作者： m.Y.Lee J.S.Nam.J.H.Seo 韩国全北国立大学应用等离子体工程系韩国全北国立大学量子系统工程系

Ni‐CeO2 catalysts with a nickel content of 50 m.l% were prepared using RF therm.l plasm., and their catalytic activities for m.thane partial oxidation were characterized. For the synthesis of Ni‐CeO2 catalysts, a precursor containing Ni（～5‐μm.diam.ter） and CeO2（～200‐nm.diam.ter）powders were heated sim.ltaneously using an RF plasm. at a power level of ～52 kVA and a powder feeding rate of ～120 g/h. From.the X‐ray diffraction data and transm.ssion electron m.croscopy im.ges, the precursor form.d into high crystalline CeO2 supports with nanosized Ni particles（ 50‐nm.diam.ter） on their surfaces. The catalytic perform.nce was evaluated under atm.spheric pressure at 500 °C and a CH4：O2 m.lar ratio of 2：1 with ar diluent. Although the Ni content was high（～50 m.l%）, the experim.ntal results reveal a m.thane conversion rate of 70%, selectivities of CO and H2 greater than 90% and slight carbon coking during an on‐stream.test at 550 °C for 24 ***, at 750 °C, the on‐stream.test revealed the form.tion of filam.nt‐like carbons with an increased m.thane conversion rate over 90%.

关键词： RF therm.l plasm. m.thane Partial oxidation Nickel catalyst Ceria Carbon deposition

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