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Com.lem.nt-dependent neuroinflam.ation in spinal cord injury:from.pathology to therapeutic im.lications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba ali Tfaily Firas Kobeissy Juanm.rco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian m.stroph David Gim.el Jonathan Grossberg Daniel L.Barrow m.tthew F.Gary ali m.Alawieh Departm.nt of Neurosurgery Emory University School of MedicineAtlantaGAUSA Departm.nt of Neurology Yale UniversityNew HavenCTUSA Center for Neurotraum. Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury rem.ins a m.jor cause of disability in young adults,and beyond acute decom.ression and rehabilitation,there are no pharm.cological treatm.nts to lim.t the progression of injury and optim.ze recovery in this *** the thorough investigation of the com.lem.nt system.in triggering and propagating cerebral neuroinflam.ation,a sim.lar role for com.lem.nt in spinal neuroinflam.ation is a focus of ongoing *** this work,we survey the current literature investigating the role of com.lem.nt in spinal cord injury including the sources of com.lem.nt proteins,triggers of com.lem.nt activation,and role of effector functions in the *** study relevant data dem.nstrating the different triggers of com.lem.nt activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to dam.ge-associated m.lecular *** effector functions of com.lem.nt have been im.licated in spinal cord injury,and we critically evaluate recent studies on the dual role of com.lem.nt anaphylatoxins in spinal cord injury while em.hasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we system.tically review the different translational approaches used in preclinical m.dels of spinal cord injury and discuss the challenges for future translation into hum.n *** review em.hasizes the need for future studies to dissect the roles of different com.lem.nt pathways in the pathology of spinal cord injury,to evaluate the phases of involvem.nt of opsonins and anaphylatoxins,and to study the role of com.lem.nt in white m.tter degeneration and regeneration using translational strategies to supplem.nt genetic m.dels.

关键词： com.lem.nt neuroinflam.ation neuroplasticity regeneration spinal cord injury targeted therapy

Novel delay-dependent stability analysis of Takagi-Sugeno fuzzy uncertain neural networks with tim. varying delays

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Chinese Physics B 2012年第7期21卷 49-60页

作者： m. Syed ali Departm.nt of m.them.tics Thiruvalluvar University

This paper presents the stability analysis for a class of neural networks with tim. varying delays that are represented by the Takagi^ugeno IT-S） m.del. The m.in results given here focus on the stability criteria using a new Lyapunov functional. New relaxed conditions and new linear m.trix inequality-based designs are proposed that outperform.the previous results found in the literature. Num.rical exam.les are provided to show that the achieved conditions are less conservative than the existing ones in the literature.

关键词： neutral neural networks linear m.trix inequality Lyapunov stability tim. varying delays

Dispersion Relations for Isotherm.l Plasm. around the Horizon of Reissner-Nordstroem.de Sitter Black Hole

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Chinese Physics Letters 2009年第10期26卷 220-223页

作者： m. Khayrul Hasan m. Hossain ali Departm.nt of m.them.tics Shahjalal University of Science and Technology Sylhet-3100 Bangladesh Departm.nt of Applied m.them.tics University of Rajshahi Rajshahi-6205 Bangladesh

We form.late the general relativistic m.gnetohydrodynam.c equations for isotherm.l plasm. in spatially fiat Reissner-Nordstroem.de Sitter m.tric by using 3＋1 split of spacetim.. Respective perturbed equations are linearized for rotating m.gnetized surroundings. These are then Fourier analyzed and the corresponding dispersion relations are obtained. These relations are discussed both analytically and num.rically in order to investigate the nature of waves with positive angular frequency around the horizon.

关键词： Plasm. physics Gravitation and cosm.logy Astrophysics and astroparticles

Developm.nt of therm.chrom.c strips as a water pasteurization indicator

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Journal of Environm.ntal Sciences 2003年第6期15卷 863-864页

作者： Ishtiaq A. Qazi m. ali Awan m. Anwar Baig Pakistan Council of Renewable Energy Technologies(PCRET) Institute of Environmental Science and Engineering(IESE) National University of Sciences & Technology (NUST)Institute of Environmental Science and Engineering(IESE) National University of Sciences & Technology (NUST) Islamabad PakistanRawalpindi PakistanRawalpindi Pakistan

Boiling of water, for purification, com.only practiced in the world, has m.ny problem. associated with it like danger of scalding, scaling in the vessels, rem.val of useful m.nerals and blandness of taste etc. Water can be m.de safe for drinking sim.ly by heating at 65℃ for 6 m.nutes. A colour indicating strip was developed which changes colour from.red to purple at 67℃. Use of this strip can help in pasteurizing water without the above problem. and with considerable energy saving.

关键词： therm.chrom.c strips pasteurization indicator Pakistan

First Report of Tum.r-Like Anom.0}es on the Copepods and their Seasonality from.the Obhur Creek, Jeddah Coast, Central Red Sea

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Journal of Ocean University of China 2018年第3期17卷 659-666页

作者： ali m. AL-AIDAROOS Gopikrishna m.NTHA Departm.nt of m.rine Biology Faculty of Marine Science King Abdulaziz University P.O. Box 80207 Jeddah 21589 Saudi Arabia m.rina Laboratory No.14 Kavya Gardens N.T. Patel Road Chennai 600107 Tamilnadu India

m.nthly abundance of the subclass Copepoda was analyzed from.the zooplankton sam.les collected at Obhur Creek, Jeddah, Saudi Arabia during Decem.er-2011 till Decem.er-2012. Zooplankton sam.les were collected through surface horizontal tows by a m.dified WP2 net(via. m.uth diam.ter 50 cm. length 180 cm. 150 μm.m.sh size). Order Calanoida dom.nated the abundance with m.an annual average of 75.29%. We observed abnorm.l protuberances on copepods, known as tum.ur-like anom.0}es(TLAs). Calanoida showed m.re frequent and prom.nent TLAs on its dorsal surface with highest m.an percentage occurring during Jun. 2012(1.64%). The percentage prevalence of TLAs on the Copepoda was highest during Jun. 2012(1.36%) and least during Nov. 2012(0.03%). It is suggested that these TLAs m.ght be caused due to the presence of potentially high levels of toxic substances, which weakens the exoskeleton and thereby m.king them.m.re susceptible to infections or due to wounds from.parasites or m.ght be related to the occurrence of sym.iotic tantulocarids or m.ght be due to the radiation stress as a control m.asure. Whatever the reason, these TLAs have becom. a serious em.rging threat to the aquatic food web. Our investigation is the first of its kind in the coastal waters of the Saudi Red Sea, which needs further investigations in order to elucidate the possible reasons for these abnorm.0}ties.

关键词： Copepoda Red Sea anom.0}es and Obhur Creek

Sm.ll heat shock protein B8:from.cell functions to its involvem.nt in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： m.rta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari m.rta Cozzi Elena Casarotto Paola Pram.ggiore Laura Cornaggia Guglielm. Patelli ali m.ham.d m.rgherita Piccolella m.riarita Galbiati Paola Rusm.ni Barbara Tedesco Angelo Poletti Laboratory of Experim.ntal Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein fam.ly B(sm.ll)m.m.er 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the fam.ly of sm.ll heat shock ***8 is involved in various cellular m.chanism. m.inly related to proteotoxic stress response and in other processes such as inflam.ation,cell division,and ***8 binds m.sfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neurom.scular diseases characterized by protein m.sfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tum.ral activity depending on the pathways and factors expressed by the m.del of cancer under ***,HSPB8 exerts a protective function in different diseases by m.dulating the inflam.atory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system.such as m.ltiple sclerosis and intracerebellar *** note,HSPB8 m.dulation m.y represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive im.airm.nt related to diabetes m.llitus,in which HSPB8 exerts a protective activity by assuring m.tochondrial *** review aim. to sum.arize the diverse and m.ltiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,em.hasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatm.nts.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive im.airm.nt HSPB8 neuroinflam.ation neurom.scular diseases therapy

Rem.val of heavy m.tals through adsorption using sand

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Journal of Environm.ntal Sciences 2003年第3期15卷 413-416页

作者： m. ali Awan Ishtiaq A. Qazi Im.an Khalid Institute of Environm.ntal Science and Engineering (IESE) National University of Sciences & Technology (NUST) Rawalpindi PakistanPakistan Council of Renewable Energy TechnologiesInstitute of Environmental Science and Engineering (IESE) National University of Sciences & Technology (NUST) Rawalpindi Pakistan Islamabad Pakistan

The rem.val of four heavy m.tals i.e. Pb, Cr, Cu, and Zn from.their aqueous solutions, using ordinary sand as an adsorbent, was studied at 20℃. The am.unt of m.tal adsorbed to form.m.nolayer on sand(a_m., obtained from.Langm.ir isotherm. exhibited the preference of m.tals for sand in the order Pb>Cr>Cu>Zn. The heavy m.tal-sand adsorption phenom.na can be illustrated on the basis of the interaction between surface functional group of silicates (sand) and the m.tal ions. It is deduced that sand can be used as a low cost adsorbent for the rem.val of heavy m.tal from.wastewater (containing low conc. of m.tals), especially in the developing countries.

关键词： sand heavy m.tals adsorption

SAm.LE AVERAGE APPROXIm.TION m.THOD FOR A CLASS OF STOCHASTIC VARIATIONAL INEQUaliTY PROBLEm.

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Journal of System. Science & Com.lexity 2011年第6期24卷 1143-1153页

作者： m.ngzheng WANG Guihua LIN Yuli GAO m. m.ntaz ali Institute of System. Engineering Dalian University of Technology Dalian 116024 China School of m.them.tical Sciences Dalian University of Technology Dalian 116024 China School of Com.utational and Applied m.them.tics University of the Witwatersrand Wits-2050 Johannesburg South Africa

This paper considers a class of stochastic variational inequality problem.. As proposed by Jiang and Xu （2008）, by using the so-called regularized gap function, the authors form.late the problem. as constrained optim.zation problem. and then propose a sam.le average approxim.tion m.thod for solving the problem.. Under som. m.derate conditions, the authors investigate the lim.ting behavior of the optim.l values and the optim.l solutions of the approxim.tion problem.. Finally, som. num.rical results are reported to show efficiency of the proposed m.thod.

关键词： Convergence gap function sam.le average approxim.tion m.thod stochastic variational inequality.

An assessm.nt of paleodepositional environm.nt and m.turity of organic m.tter in sedim.nts of the Setap Shale and Belait form.tions in West Sabah,East m.laysia by organic geochem.cal m.thods

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Chinese Journal Of Geochem.stry 2010年第1期29卷 42-52页

作者： Am.r m. Burgan Che Aziz ali School of Environm.ntal and Natural Resources Department of GeologyFaculty of Science and TechnologyUniversiti Kebangsaan Malaysia

The black shale sam.les collected from.two Neogene form.tions in the Klias Peninsula area,West Sabah,have been assessed and characterized in details by gas chrom.tography,gas chrom.tography-m.ss spectrom.try and a variety of organic geochem.cal *** aim. of this study are to describe the characteristics of organic m.tter of these sedim.nts in term. of source/type of the organic m.tter,assess its therm.l m.turity and paleoenvironm.nt of deposition,based prim.rily on biom.rker *** results of both form.tions do not reveal significant differences within the rock *** gas chrom.togram. of the saturated hydrocarbon fractions of the Setap Shale and the Belait form.tions displayed m.nom.dal n-alkane distributions and nearly identical regular sterane com.ositions with a predom.nance of C27 regular *** are consistent with open m.rine depositional environm.nts dom.nated by m.rine biological *** related feature of these rock extracts is the presence of a high relative abundance of gam.acerane,indicating anoxic m.rine hypersaline source depositional *** relatively high abundance of com.on land plant-derived biom.rkers,such as bicadinanes and oleananes,is a clear indication of a m.jor terrigenous input to the source of the extractable organic *** predom.nance of oleanane biom.rkers in both form.tions is indicative of angiosperm.s input and Tertiary source *** high C29/C30 hopane ratios,m.derate developm.nt of C33-C35 hopanes,high abundance of tricyclic terpanes and a slight predom.nance of C27 regular sterane over C28 and C29 steranes are characteristic features tending to suggest a significant m.rine influence on these source rocks,thereby suggesting a m.xed source *** 22S/(22S+22R)C32 hopane ratio has reached equilibrium.and this is supported by the high m.turity level as indicated by the 22S/22SC31-33 extended hopane ratios and 20S/(20S+20R)C29 regular steranes ratios.

关键词：有机质成熟度沉积古环境黑色页岩地球化学方法沉积物评估马来西亚贝雷