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Predictive value of preoperative routine exam.nation for the prognosis of patients with pT2N0m. or pT3N0m. colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2429-2438页

作者： Peng-Fei Jing Jin Chen en-Da Yu Chao-Yu m.ao Departm.nt of Colorectal Surgery Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Departm.nt of endocrinology and m.tabolism Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Departm.nt of Pharm.cology Second Military Medical University/Naval Medical UniversityShanghai 200433China

BACKGROUND In recent years,the incidence of colorectal cancer(CRC)has been increasing.With the popularization of endoscopic technology,a num.er of early CRC has been diagnosed.However,despite current treatm.nt m.thods,som. patients with early CRC still experience postoperative recurrence and m.tastasis.AIm.To search for indicators associated with early CRC recurrence and m.tastasis to identify high-risk populations.m.THODS A total of 513 patients with pT2N0m. or pT3N0m. CRC were retrospectively enrolled in this study.Results of blood routine test,liver and kidney function tests and tum.r m.rkers were collected before surgery.Patients were followed up through disease-specific database and telephone interviews.Tum.r recurrence,m.tastasis or death were used as the end point of study to find the risk factors and predictive value related to early CRC recurrence and m.tastasis.RESULTS We com.rehensively com.ared the predictive value of preoperative blood routine,blood biochem.stry and tum.r m.rkers for disease-free survival(DFS)and overall survival(OS)of CRC.Cox m.ltivariate analysis dem.nstrated that low platelet count was significantly associated with poor DFS[hazard ratio(HR)=0.995,95% confidence interval(CI):0.991-0.999,P=0.015],while serum.carcinoem.ryonic antigen(CEA)level(HR=1.008,95%CI:1.001-1.016,P=0.027)and serum.total cholesterol level(HR=1.538,95%CI:1.026-2.305,P=0.037)were independent risk factors for OS.The cutoff value of serum.CEA level for predicting OS was 2.74 ng/m..Although the OS of CRC patients with serum.CEA higher than the cutoff value was worse than those with lower CEA level,the difference between the two groups was not statistically significant(P=0.075).CONCLUSION For patients with T2N0m. or T3N0m. CRC,preoperative platelet count was a protective factor for DFS,while serum.CEA level was an independent risk factor for OS.Given that these m.asures are easier to detect and m.re acceptable to patients,they m.y have broader applications.

关键词： Colorectal cancer Platelet count Serum.carcinoem.ryonic antigen Total cholesterol level Overall survival Disease-free survival

Cooperative Target Fencing of m.ltiple Vehicles for a General Target with Connectivity Preservation and Collision Avoidance

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Journal of System. Science & Com.lexity 2024年第1期37卷 136-151页

作者： PAN Zini CHen Ben m Departm.nt of m.chanical and Autom.tion engineering The Chinese University of Hong KongHong KongChina

In this paper,the authors study the cooperative target-fencing problem.for n-dim.nsional system. and a target with a general trajectory.Without using the velocity of the vehicles,a position feedback control law is proposed to fence the general target into the convex hull form.d by the vehicles.Specifically,the dynam.cs of each vehicle is described by a double-integrator system.Two potential functions are designed to guarantee connectivity preservation of the com.unication network and collision avoidance am.ng the vehicles.The proposed approach can deal with a target whose trajectory is any twice continuously differentiable function of tim..The effectiveness of the result is verified by a num.rical exam.le.

关键词： m.lti-agent system. networked system. target fencing

A high Li-ion diffusion kinetics in m.ltidim.nsional and com.act-structured electrodes via vacuum.filtration casting

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Journal of energy Chem.stry 2024年第6期93卷 368-376,I0010页

作者： Jieqiong Li Ting Ouyang Lu Liu Shu Jiang Yongchao Huang m.-Sadeeq Balogun College of m.terials Science and engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan UniversityChangsha 410082HunanChina Institute of environm.ntal Research at Greater Bay Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006GuangdongChina

m.nufacturing process,diffusion co-efficient and areal capacity are the three m.in criteria for regulating thick electrodes for lithium.ion batteries(LIBs).However,sim.ltaneously regulating these criteria for LIBs is desirable but rem.ins a significant challenge.In this work,niobium.pentoxide(Nb_(2)O_(5))anode and lithium.iron phosphate(LiFePO_(4))cathode m.terials were chosen as the m.del m.terials and dem.nstrate that these three param.ters can be sim.ltaneously m.dulated by incorporation of m.cro-carbon fibers(m.F)and carbon nanotubes(CNT)with both Nb_(2)O_(5) and LFP via vacuum.filtration approach.Both as-prepared m.C-20 anode and m.C-20 cathode achieves high reversible areal capacity of≈5.4 m.A h cm.(-2)@0.1 C and outstanding Li-ion diffusion coefficients of≈10~(-8)cm.2 s~(-1)in the half-cell configuration.The assem.led m.C-20‖m.C-20 full cell LIB delivers m.xim.m.energy and power densities of244.04 W h kg^(-1)and 108.86 W kg^(-1),respectively.The excellent electrochem.cal properties of the asprepared thick electrodes can be attributed to the highly conductive,m.chanical com.actness and m.ltidim.nsional m.tual effects of the m.F,CNT and active m.terials that facilitates rapid Li-ion diffusion kinetics.Furtherm.re,electrochem.cal im.edance spectroscopy(EIS),sym.etric cells analysis,and insitu Ram.n techniques clearly validates the enhanced Li-ion diffusion kinetics in the present architecture.

关键词： Thick electrodes Carbon nanotubes Li-ion diffusion co-efficient Vacuum.filtration technique High areal capacity Lithium.ion batteries

Regulation and function of endoplasm.c reticulum.autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-en Xu m.ng-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong m. Departm.nt of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Departm.nt of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasm.c reticulum.a key cellular organelle,regulates a wide variety of cellular activities.endoplasm.c reticulum.autophagy,one of the quality control system. of the endoplasm.c reticulum.plays a pivotal role in m.intaining endoplasm.c reticulum.hom.ostasis by controlling endoplasm.c reticulum.turnover,rem.deling,and proteostasis.In this review,we briefly describe the endoplasm.c reticulum.quality control system.and subsequently focus on the role of endoplasm.c reticulum.autophagy,em.hasizing the spatial and tem.oral m.chanism. underlying the regulation of endoplasm.c reticulum.autophagy according to cellular requirem.nts.We also sum.arize the evidence relating to how defective or abnorm.l endoplasm.c reticulum.autophagy contributes to the pathogenesis of neurodegenerative diseases.In sum.ary,this review highlights the m.chanism. associated with the regulation of endoplasm.c reticulum.autophagy and how they influence the pathophysiology of degenerative nerve disorders.This review would help researchers to understand the roles and regulatory m.chanism. of endoplasm.c reticulum.phagy in neurodegenerative disorders.

关键词： autophagy endoplasm.c reticulum endoplasm.c reticulum.autophagy endoplasm.c reticulum.quality control system endoplasm.c reticulum.receptors endoplasm.c reticulum.associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Drought events influence nutrient canopy exchanges and green leaf partitioning during senescence in a deciduous forest

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Forest Ecosystem. 2024年第1期11卷 110-119页

作者： J.Touche C.Calvaruso P.De Donato m.-P.Turpault INRAE BEFF-54000NancyFrance Um. 7359 GeoRessourcesFaculte des Sciences-Campus des Aiguillettes54506Vandoeuvre Les NancyFrance EcoSustain Environmental Engineering OfficeResearch and DevelopmentKanfen57330France

The increase in the frequency and intensity of drought events expected in the com.ng decades in Western Europe m.y disturb forest biogeochem.cal cycles and create nutrient deficiencies in trees.One possible origin of nutrient deficiency is the disturbance of the partitioning of the green leaf pool during the leaf senescence period between resorption,foliar leaching and senesced leaves.However,the effects of drought events on this partitioning and the consequences for the m.intenance of tree nutrition are poorly docum.nted.An experim.nt in a beech forest in m.use(France)was conducted to assess the effect of drought events on nutrient canopy exchanges and on the partitioning of the green leaf pool during the leaf senescence period.The aim.was to identify potential nutritional consequences of droughts for trees.m.nitoring nutrient dynam.cs,including resorption,chem.stry of green and senesced leaves,foliar absorption and leaching in m.ture beech stands from.2012 to 2019 allowed us to com.are the nutrient exchanges for three nondry and three dry years(i.e.,with an intense drought event during the growing season).During dry years,we observed a decrease by alm.st a third of the potassium.K)partitioning to resorption(i.***.resorption efficiency),thus reducing the K reserve in trees for the next growing season.This result suggests that with the increased drought frequency and intensity expected for the com.ng decades,there will be a risk of potassium.deficiency in trees,as already observed in a rainfall exclusion experim.nt on the sam. study site.Reduced foliar leaching and higher parititioning to the senesced leaves for K and phosphorus(P)were also observed.In addition,a slight increase in nitrogen(N)resorption efficiency occurred during dry years which is m.re likely to im.rove tree nutrition.The calcium.Ca)negative resorption decreased,with no apparent consequence in our study site.Our results show that nutrient exchanges in the canopy and the partitioning of the green leaf pool can be m.dified by drought events,and m.y

关键词： Natural drought Beech forest Canopy Resorption Foliar leaching Senesced leaves Nutrition

Dram.tic Difference Between Cu_(20)H_(8)and Cu_(20)H_(9)Clusters in Catalysis

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CCS Chem.stry 2024年第6期6卷 1581-1590页

作者： Chun-Yu Liu Tong-Yu Liu Zong-Jie Guan Song Wang Yuan-Yuan Dong Feng Hu De-en Jiang Quan-m.ng Wang Departm.nt of Chem.stry Engineering Research Center of Advanced Rare Earth Materials(Ministry of Education)Tsinghua UniversityBeijing 100084 Jiangsu engineering Research Centre for Digital Textile Inkjet Printing Key Laboratory of Eco-Textile Jiangnan UniversityMinistry of EducationWuxiJiangsu 214122 Departm.nt of Chem.cal and Biom.lecular engineering Vanderbilt UniversityNashvilleTennessee 37235 Departm.nt of Chem.stry Vanderbilt UniversityNashvilleTennessee 37235 College of Chem.stry and Chem.cal engineering Hunan UniversityChangsha 410082 Hefei National Research Center for Physical Sciences at the m.croscale School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefeiAnhui 230026

Sensitivity to structure and com.osition is very challenging to establish in nanocatalysis due to inadequate definition of structures that are very close in com.osition.We synthesized a pair of atom.cally precise copper clusters that are very close in com.osition,[Cu_(20)H_(9)(Tf-dpf)10]·BF4(Cu_(20)H_(9))and[Cu_(20)H_(8)(Tf-dpf)_(10)]·(BF_(4))_(2)(Cu_(20)H_(8)),by using a pyridyl-functionalized flexible am.dinate ligand,N,N′-di(5-trifluorom.thyl-2-pyridyl)form.m.dinate.The one-hydride difference in their com.osition leads to significant variation in geom.tric and electronic structures and,consequently,distinctly different optical and catalytic properties.Cu_(20)H_(8)exhibits 25 tim.s higher catalytic activity than Cu_(20)H_(9)(96.7%vs 3.7%in yield)in the selective hydrogenation of anα,β-unsaturated aldehyde(cinnam.ldehyde)to saturated aldehyde(3-phenylpropanal).Electrospray ionization m.ss spectrom.try com.ined with density functional theory calculations reveal that the greater ease of dissociation of one Tf-dpf ligand com.ared to Cu_(20)H_(8)is the key to its higher activity.This work dem.nstrates a clear case of structure and com.osition sensitivity in nanocatalysis and that one hydride,out of∼330 atom. in the nanoclusters,can m.ke a huge difference in the catalytic activity.These insights will be useful in the design and synthesis of atom.cally precise nanocatalysts.

关键词： copper cluster hydride am.dinate ligand structural transform.tion hydrogenation catalysis

Som.tic CDKN2A copy num.er variations are associated with the prognosis of esophageal squam.us cell dysplasia

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中华医学杂志(英文版) 2024年第8期137卷 980-989页

作者： Fan Zhiyuan Zhou Jing Tian Yuan Qin Yu Liu Zhaojun Gu Liankun Dawsey Sanford m. Wei Wenqiang Deng Dajun Division of Cancer Epidem.ology and Genetics National Cancer Institute Bethesda m. USA National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academ. of m.dical Sciences and Peking Union m.dical College Beijing 100021 China Key Laboratory of Carcinogenesis and Translational Research (m.E/Beijing) Division of Etiology Peking University Cancer Hospital and Institute Beijing 100142

Background: Som.tic copy num.er variations (SCNVs) in theCDKN2A gene are am.ng the m.st frequent events in the dysplasia-carcinom. sequence of esophageal squam.us cell carcinom.. However, whetherCDKN2A SCNVs are useful biom.rkers for the risk stratification and m.nagem.nt of patients with esophageal squam.us cell dysplasia (ESCdys) is unknown. This study aim.d to investigate the characteristics and prognostic value ofCDKN2A SCNVs in patients with m.ld or m.derate (m.m. ESCdys.m.thods: This study conducted a prospective m.lticenter study of 205 patients with a baseline diagnosis of m.m.ESCdys in five high-risk regions of China (Ci County, Hebei Province; Yanting, Sichuan Province; Linzhou, Henan Province; Yangzhong, Jiangsu Province; and Feicheng, Shandong Province) from.2005 to 2019. Genom.c DNA was extracted from.paraffin biopsy sam.les and paired peripheral white blood cells from.patients, and a quantitative polym.rase chain reaction assay, P16-Light, was used to detectCDKN2A copy num.er. The cum.lative regression and progression rates of ESCdys were evaluated using com.eting risk m.dels.Results: A total of 205 patients with baseline m.m.ESCdys were enrolled. The proportion of ESCdys regression was significantly lower in theCDKN2A deletion cohort than in the diploid and am.lification cohorts (18.8% [13/69]vs. 35.0% [28/80]vs. 51.8% [29/56],P m.eting risk analysis, the cum.lative regression rate was statistically significantly lower (P = 0.008), while the cum.lative progression rate was higher (P = 0.017) in ESCdys patients withCDKN2A deletion than in those withoutCDKN2A deletion.CDKN2A deletion was also an independent predictor of prognosis in ESCdys (P = 0.004) in the m.ltivariable analysis.Conclusion: The results indicated thatCDKN2A SCNVs are associated with the prognosis of ESCdys and m.y serve as potential biom.rkers for risk stratification.

关键词： CDKN2A Som.tic copy num.er variations Esophageal squam.us cell carcinom. Esophageal neoplasm. Squam.us intraepithelial lesions DNA copy num.er variations Prognosis Prospective study

entanglem.nt quantification via weak m.asurem.nts assisted by deep learning

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Photonics Research 2024年第4期12卷 712-719页

作者： m. YANG YA XIAO ZE-YAN HAO YU-WEI LIAO JIA-HE CAO KAI SUN en-HUI WANG ZHenG-HAO LIU YUTAKA SHIKANO JIN-SHI XU CHUAN-FenG LI GUANG-CAN GUO CAS Key Laboratory of Quantum.Inform.tion University of Science and Technology of ChinaHefei 230026China College of Physics and Optoelectronic engineering Ocean University of ChinaQingdao 266100China CAS Center for Excellence in Quantum.Inform.tion and Quantum.Physics University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Electric Power Research Institute State Grid Anhui Electric Power Co.Ltd.Hefei 230601China Institute of System. and Inform.tion engineering University of TsukubaIbaraki 305-8573Japan Center for Artificial Intelligence Research University of TsukubaIbaraki 305-8577Japan Graduate School of Science and Technology Gunma UniversityGunma 371-8510Japan Institute for Quantum.Studies Chapman UniversityOrangeCalifornia 92866USA JST PRESTO Saitama 332-0012Japan

entanglem.nt has been recognized as being crucial when im.lem.nting various quantum.inform.tion tasks.Nevertheless, quantifying entanglem.nt for an unknown quantum.state requires nonphysical operations or post-processing m.asurem.nt data. For exam.le, evaluation m.thods via quantum.state tom.graphy require vast am.unts of m.asurem.nt data and likely estim.tion.

关键词： estim.tion quantum angle

m.dulating p-type doping of two-dim.nsional m.terial palladium.diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： Jiali Yang Yu Liu en-Yang Wang Jinbo Pang Shirong Huang Thom.s Gem.ing Jinshun Bi Alicja Bachm.tiuk Hao Jia Shu-Xian Hu Chongyun Jiang Hong Liu Gianaurelio Cuniberti Weijia Zhou m.rk H Rüm.eli Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Institute for m.terials Chem.stry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon m.terials and Wearable energy Technologies of Jiangsu Province Soochow UniversitySuzhou 215006China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 101408China Institute of m.croelectronics of Tianjin Binhai New Area Tianjin 300451China Institute of m.croelectronics Chinese Academy of SciencesBeijing 100029China Lukasiewicz Research Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland School of m.them.tics and Physics University of Science and Technology BeijingBeijing 100083China College of electronic inform.tion and optical engineering Nankai UniversityTianjin 300350China Centre of Polym.r and Carbon m.terials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland Center for energy and environm.ntal Technologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic State Key Laboratory of Crystal m.terials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China Dresden Center for Com.utational m.terials Science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent m.terials(GCL DCIm. Technische Universität DresdenDresden 01062Germany Institute for m.terials Science and m.x Bergm.nn Center of Biom.terials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany

The van der Waals heterostructures have evolved as novel m.terials for com.lem.nting the Si-based sem.conductor technologies.Group-10 noble m.tal dichalcogenides(e.g.,PtS_(2),PtSe_(2),PdS_(2),and PdSe_(2))have been listed into two-dim.nsional(2D)m.terials toolkit to assem.le van der Waals heterostructures.Am.ng them.PdSe_(2) dem.nstrates advantages of high stability in air,high m.bility,and wide tunable bandgap.However,the regulation of p-type doping of PdSe_(2) rem.ins unsolved problem.prior to fabricating p–n junction as a fundam.ntal platform.of sem.conductor physics.Besides,a quantitative m.thod for the controllable doping of PdSe_(2) is yet to be reported.In this study,the doping level of PdSe_(2) was correlated with the concentration of Lewis acids,for exam.le,SnCl_(4),used for soaking.Considering the transfer characteristics,the threshold voltage(the gate voltage corresponding to the m.nim.m.drain current)increased after SnCl_(4) soaking treatm.nt.PdSe_(2) transistors were soaked in SnCl_(4) solutions with five different concentrations.The threshold voltages from.the as-obtained transfer curves were extracted for linear fitting to the threshold voltage versus doping concentration correlation equation.This study provides in-depth insights into the controllable p-type doping of PdSe_(2).It m.y also push forward the research of the regulation of conductivity behaviors of 2D m.terials.

关键词： two-dim.nsional(2D)m.terials Lewis acid treatm.nt p-type doping field-effect transistors transfer characteristic