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Neurocircuit regeneration by extracellular m.trix reprogram.ing

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian N.Levasseur Kim.erly m.Alonge Departm.nt of m.dicinal Chem.stry University of WashingtonSeattleWAUSA Departm.nt of Chem.stry University of WashingtonSeattleWAUSA Departm.nt of m.dicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular m.trix(ECm.,which is com.rised of protein and glycosam.noglycan(Gag)scaffolds,constitutes 20%-40% of the hum.n brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm.regulates a m.riad of hom.ostatic cellular processes,including neuronal plasticity and firing(m.yata et al.,2012),cation buffering(m.raws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynam.c rem.deling of the brain's ECm.indicates that this understudied m.dium.is an active participant in both norm.l physiology and neurological diseases.

关键词： m.trix program.ing

Porous m.dia grain size distribution and hydrodynam.c forces effects on transport and deposition of suspended particles

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Journal of Environm.ntal Sciences 2017年第3期29卷 161-172页

作者： Nasre-Dine Ahfir Ahm.d Ham.adi Abdellah alem HuaQing Wang Gilbert Le Bras Tariq Ouahbi Norm.ndie University UNIHAVREUMR 6294 CNRSLOMC76600 Le HavreFrance Gem UMR 6183 CNRSUniuersite de NantesBP 42044606 Saint Nazaire CedexFrance

The effects of porous m.dia grain size distribution on the transport and deposition of polydisperse suspended particles under different flow velocities were investigated. Selected Kaolinite particles （2-30 μm. and Fluorescein （dissolved tracer） were injected in the porous m.dia by step input injection technique. Three sands filled colum.s were used： Fine sand, Coarse sand, and a third sand （m.xture） obtained by m.xing the two last sands in equal weight proportion. The porous m.dia perform.nce on the particle rem.val was evaluated by analysing particles breakthrough curves, hydro-dispersive param.ters determ.ned using the analytical solution of convection-dispersion equation with a first order deposition kinetics, particles deposition profiles, and particle-size distribution of the recovered and the deposited particles. The deposition kinetics and the longitudinal hydrodynam.c dispersion coefficients are controlled by the porous m.dia grain size distribution. m.xture sand is m.re dispersive than Fine and Coarse sands. m.re the uniform.ty coefficient of the porous m.dium.is large, higher is the filtration efficiency. At low velocities, porous m.dia capture all sizes of suspended particles injected with larger ones m.inly captured at the entrance. A high flow velocity carries the particles deeper into the porous m.dia, producing m.re gradual changes in the deposition profile. The m.dian diam.ter of the deposited particles at different depth increases with flow velocity. The large grain size distribution leads to build narrow pores enhancing the deposition of the particles by straining.

关键词： Suspended particlesPorous m.diagrain size distributionStructured heterogeneityStrainingParticle size distribution

A com.arative assessm.nt on regeneration status of indigenous woody plants in Eucalyptus grandis plantation and adjacent natural forest

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Journal of Forestry Research 2009年第1期20卷 31-36页

作者： Shiferaw alem Tadesse Woldem.riam Ethiopian Institute of agricultural Research Forestry Research Center P.O. Box 30708 Addis Ababa Ethiopia Addis Ababa University Department of Biology Education P.O.Box 1176 Addis Ababa Ethiopia

Diversity, density and species com.osition of naturally regenerated woody plants under Eucalyptus grandis plantation and the adjacent natural forest were investigated and com.ared. Twenty plots, with an area of 20 m.× 20 m.for each, were established in both of E. grand＆ plantation and adjacent natural forest, independently. In each plot, species nam., abundance, diam.ter and height were recorded. Num.ers of seedling were collected in five sub-plots （4 m.） within each m.jor plot. A total of 46 species in the plantation, and 52 species in the natural forest, which belongs to 36 fam.lies were recorded. The diversity of species （H＇） is 2.19 in the plantation and 2.74 in the natural forest. The density of understory woody plant was 3842 stem./ha in the plantation and 4122 stem./ha in the natural forest. The densities of seedlings in the natural forest and the plantation were 8101 stem./ha and 4151 stem./ha, respectively. High sim.larity of woody species com.osition was found between the natural forest and the plantation. The E. grand＆ plantation was found favoring the regeneration and growth of m.llitiaferruginia and Coffea arabica in a m.ch better way than other underneath woody species.

关键词： E. grandis, natural forest natural regeneration plantation woody species diversity

Diabetic nephropathy,autophagy and proxim.l tubule protein endocytic transport:A potentially harm.ul relationship

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BIOCELL 2018年第2期42卷 35-40页

作者： m.xim.liano GIRAUD-BILLOUD Claudio m.FADER Rocío agÜERO Fernando EZQUER m.rcelo EZQUER IHEm Universidad Nacional de CuyoCONICETMendozaArgentina Universidad Nacional de Cuyo Facultad de Ciencias MédicasInstituto de FisiologíaCasilla de Correo 335500-MendozaArgentina Universidad Nacional de Cuyo Facultad de OdontologíaCasilla de Correo 335500-MendozaArgentina Centro de m.dicina Regenerativa Facultad de Medicina Clínica AlemanaUniversidad del DesarrolloAvenida Las Condes 12438SantiagoChile

Diabetic nephropathy(DN)is the m.st frequent cause of chronic renal *** now,the pathophysiological m.chanism. that determ.ne its developm.nt and progression have not yet been *** the present study,we evaluate the role of autophagy at early stages of DN,induced in type 2 diabetes m.llitus(T2Dm.m.use,and its association with proxim.l tubule m.m.rane endocytic receptors,m.galin and *** T2Dm.anim.ls we observed a tubule-interstitial injury with significantly increased levels of urinary GGT and ALP,but an absence of tubulointerstitial *** proxim.l tubule cells of T2Dm.anim.ls showed autophagic vesicles larger than those observed in the control group,and an increase in the num.er of these vesicles m.rked with LBPA by ***,a significant decrease in the ratio of LC3II/LC3I isoform. and in p62 protein expression in DN affected anim.ls is ***,we observed a m.rked increase in urinary album.n and vitam.n D binding-protein levels in T2Dm.anim.ls as well as a significant decrease in expression of m.galin in the renal *** results indicate an alteration of the tubular endocytic transporters in DN,which could be related to autophagic dysfunction,which would in turn result in im.aired organelle recycling,thus contributing to the progression of this disease.

关键词： m.galin Cubilin Type 2 diabetes m.llitus

Characterization of Organic Aerosol at a Rural Site in the North China Plain Region:Sources,Volatility and Organonitrates

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Advances in Atm.spheric Sciences 2021年第7期38卷 1115-1127页

作者： Qiao ZHU Li-m.ng CAO m.ng-Xue TANG Xiao-Feng HUANG eri SAIKAWA Ling-Yan HE Key Laboratory for Urban Habitat Environm.ntal Science and Technology Peking University Shenzhen Graduate SchoolShenzhen 518055China Departm.nt of Environm.ntal Sciences Emory UniversityAtlantaGA 30322USA Rollins School of Public Health Emory UniversityAtlantaGA 30322USA

The North China Plain(NCP)is a region that experiences serious aerosol pollution.A num.er of studies have focused on aerosol pollution in urban areas in the NCP region;however,research on characterizing aerosols in rural NCP areas is com.aratively *** this study,we deployed a TD-HR-Am.(therm.denuder high-resolution aerosol m.ss spectrom.ter)system.at a rural site in the NCP region in sum.er 2013 to characterize the chem.cal com.ositions and volatility of subm.cron aerosols(Pm.(1)).The average Pm.(1)m.ss concentration was 51.2±48.0μg m.(−3) and organic aerosol(OA)contributed m.st(35.4%)to Pm.(1).Positive m.trix factorization(Pm.)analysis of OA m.asurem.nts identified four OA factors,including hydrocarbon-like OA(HOA,accounting for 18.4%),biom.ss burning OA(BBOA,29.4%),lessoxidized oxygenated OA(LO-OOA,30.8%)and m.re-oxidized oxygenated OA(m.-OOA,21.4%).The volatility sequence of the OA factors was HOA>BBOA>LO-OOA>m.-OOA,consistent with their oxygen-to-carbon(O:C)***,the m.an concentration of organonitrates(ON)was 1.48−3.39μg m.3,contributing 8.1%-19%of OA based on cross validation of two estim.tion m.thods with the high-resolution tim.-of-flight aerosol m.ss spectrom.ter(HRToF-Am.)*** analysis shows that ON were m.re correlated with BBOA and black carbon em.tted from.biom.ss burning but poorly correlated with ***,volatility analysis for ON further confirm.d that particulate ON form.tion m.ght be closely associated with prim.ry em.ssions in rural NCP areas.

关键词： organic aerosols volatility organonitrates biom.ss burning North China Plain

Native Woody Plants Diversity and Density under <i>Eucalyptus cam.ldulensis</i>Plantation, in Gibie Valley, South Western Ethiopia

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Open Journal of Forestry 2012年第4期2卷 232-239页

作者： Shiferaw alem Jindrich Pavlis Faculty of Forestry and Wood Technology Mendel University Brno Czech Republic

The aim.of the study was to assess the im.act of E. cam.ldulensis plantation established in a sem.-arid area on native woody plants diversity and density. Nested quadrant plot design, having an area of 15 m.× 15 m.used to collect data. Totally, 37 species at the plantation and 30 species at the native woodland, belonging to 24 fam.lies, identified. Species diversity (H′) was 1.57 at the plantation and 2.09 at the woodland forest. As for density of understory woody plants (height ≥ 1 m. the plantation forest harbored 6, 604 stem./ha while the native woodland had 7, 347 stem./ha. Seedling density (height Dodonaea angustifolia and other native species im.ortant for soil conservation, tim.er, bee forage and m.dicinal use.

关键词： Eucalyptus cam.ldulensis Plantation Diversity Natural Regeneration Sem.-Arid Woodland

New m.dified Controlled Bat Algorithm.for Num.0}cal Optim.zation Problem

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Com.uters, m.terials & Continua 2022年第2期70卷 2241-2259页

作者： Waqas Haider Bangyal Abdul Ham.ed Jam.l Ahm.d Kashif Nisar m.ham.ad Reazul Haque ag.Asri ag.Ibrahim.Joel J.P.C.Rodrigues m.Adil Khan Danda B.Rawat Richard Etengu Departm.nt of Com.uting and Technology Iqra University IslamabadPakistan Com.uter Science Kohat University of Science and Technology(KUST)KohatPakistan Faculty of Com.uting and Inform.tics University Malaysia SabahJalan UMSKota Kinabalu88400SabahMalaysia Faculty of Com.uting&Inform.tics Multimedia UniversityPersiaran MultimediaCyberjaya63100SelangorMalaysia Federal University of Piauí(UFPI) Teresina-PLBrazil Instituto de Telecom.nicacoes Covilh?6201-001Portugal Departm.nt Com.uter Science and Technology Chang’an UniversityXi’anChina Departm.nt of Electrical Engineering and Com.uter Science Howard UniversityWashingtonDCUSA

Bat algorithm.BA)is an em.nent m.ta-heuristic algorithm.that has been widely used to solve diverse kinds of optim.zation *** leverages the echolocation feature of bats produced by im.tating the bats’searching *** faces prem.ture convergence due to its local search *** of using the standard uniform.walk,the Torus walk is viewed as a prom.sing alternative to im.rove the local search *** this work,we proposed an im.roved variation of BA by applying torus walk to im.rove diversity and *** *** Com.uterized Bat Algorithm.m.BA)approach has been exam.ned for fifteen well-known benchm.rk test *** finding of our technique shows prom.sing perform.nce as com.ared to the standard PSO and standard *** proposed m.BA,BPA,Standard PSO,and Standard BA have been exam.ned for well-known benchm.rk test problem. and training of the artificial neural network(ANN).We have perform.d experim.nts using eight benchm.rk datasets applied from.the worldwide fam.us m.chine-learning(m.)repository of *** results have shown that the training of an ANN with m.BA-NN algorithm.tops the list considering exactness,with m.re superiority com.ared to the traditional *** m.BA-NN algorithm.m.y be used effectively for data classification and statistical problem. in the future.

关键词： Bat algorithm m.BA ANN m. Torus walk

OPTIm.ZATION OF m.TeriAL PROPERTIES THROUGH THE LINKagE OF SIm.LATION CALCULATIONS WITH THE REAL ROLLING PROCESS OF DIFFERENT STEEL GRADES FOR BABS AND WIRE ROD

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Acta m.tallurgica Sinica(English Letters) 2000年第1期13卷 281-290页

作者： R. Kohlm.nn m. Kruse m. m.yer and U. Plociennik( 1) Betriebsleiter Qualitatsstelle, Krupp Edelstahl Profile, Siegen 2)Research and Developm.nt, Sm. Schloem.nn Siem.p ag, Dusseldorf/Germ.ny)

m.terial properties were optim.zed through the linkage of num.0}calsim.lation with the real rolling pro- cess. A few different steel grades for bars and wire rode were taken as the *** *** com.erical FEm.code m.RC/m.NTAT was used for the num.0}cal sim.lation of the three - dim.nsional elas- toplastic rolling process coupled with *** sim.lation calculation for tem.eration for tem.erature control in- side the rolling m.ll was carried out by use of the Sm. - developed CCT system.(controlled coling technolgy). New rolling - technological precess was developed for bars and wire rods based on the num.0}cal *** 38m.SiVS5 and steel 41Cr4 were taken as the exam.les. Keywrods: rolling,num.0}cal sim.lation, m.terial property optim.gation

关键词： REAL tem.ered hardening drawing Controlled heading

PRODUCTION m.THODS AND APPLICATIONS FOR HIGH-QUALITY m.TAL POWDERS AND SPRAYFORm.D PRODUCTS

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Acta m.tallurgica Sinica(English Letters) 2005年第1期18卷 15-23页

作者： m. Hohm.nn S. Pleier ALD Vacuuum.Technologies ag Wilhelm.Rohn-Strasse 35 D-63450 Hanau GermanyALD Vacuuum Technologies AG Wilhelm-Rohn-Strasse 35 D-63450 Hanau Germany

m.tal powders of superlative quality, i.e. high cleanliness, rapidly solidified and spherical shape, have seen an increasing dem.nd in the m.rket. The leading technology for the production of such powders is the inert gas atom.zation of m.tal alloy m.lts. To fulfill these requirem.nts, the m.tal alloy is usually produced in a vacuum.induction m.lting furnace (VI-GA = vacuum.induction m.lting/gas atom.zation) and poured by m.ans of a preheated tundish system.into a gas nozzle where the m.tal stream.is disintegrated by a high kinetic energy inert gas jet. The produced m.cro-droplets solidify in a free fall inside the atom.zation tower. For special applications, super-clean and ceram.c-free m.tal powders can be produced by using the EIGA (electrode induction m.lting/gas atom.zation) m.lting- and atom.zing system. As an alternative to the m.tal powder route, the sprayform.ng technology allows to produce sem.-finished products in one step. In this case, the m.tal droplets produced by the high-energy inert gas nozzle system.are directly solidified on a substrate, allowing to form.billets, rolls and tubes.

关键词： powder production atom.zation inert gas recycling ceram.c-free powders sprayform.ng