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Neurogenesis dyna.0}cs in the olfa.tory bulb:deciphering circuitry orga.iza.ion, function, a.d a.a.tive pla.ticity

Neura. Regenera.ion Resea.ch 2025年第6期20卷 1565-1581页

作者： m.a.ia. m.Na.fa. Depa.tm.nt of Psychology a.d Neuroscience Duke UniversityDurhamNCUSA Depa.tm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

a.ult neurogenesis persists a.ter birth in the subventricula. zone, with new neurons m.gra.ing to the gra.ule cell la.er a.d glom.rula. la.ers of the olfa.tory bulb, where they integra.e into existing circuitry a. inhibitory interneurons. The genera.ion of these new neurons in the olfa.tory bulb supports both structura. a.d functiona. pla.ticity, a.ding in circuit rem.deling triggered by m.m.ry a.d lea.ning processes. however, the presence of these neurons, coupled with the cellula. diversity within the olfa.tory bulb, presents a. ongoing cha.lenge in understa.ding its network orga.iza.ion a.d function. m.reover,the continuous integra.ion of new neurons in the olfa.tory bulb pla.s a.pivota. role in regula.ing olfa.tory inform.tion processing. This a.a.tive process responds to cha.ges in epithelia. com.osition a.d contributes to the form.tion of olfa.tory m.m.ries by m.dula.ing cellula. connectivity within the olfa.tory bulb a.d intera.ting intrica.ely with higher-order bra.n regions. The role of a.ult neurogenesis in olfa.tory bulb functions rem.ins a.topic of deba.e. Nevertheless, the functiona.ity of the olfa.tory bulb is intrica.ely linked to the orga.iza.ion of gra.ule cells a.ound m.tra. a.d tufted cells. This orga.iza.iona. pa.tern significa.tly im.a.ts output, network beha.ior, a.d syna.tic pla.ticity, which a.e crucia. for olfa.tory perception a.d m.m.ry. a.ditiona.ly, this orga.iza.ion is further sha.ed by a.on term.na.s origina.ing from.cortica. a.d subcortica. regions. Despite the crucia. role of olfa.tory bulb in bra.n functions a.d beha.iors rela.ed to olfa.tion, these com.lex a.d highly interconnected processes ha.e not been com.rehensively studied a. a.whole. Therefore, this m.nuscript a.m. to discuss our current understa.ding a.d explore how neura. pla.ticity a.d olfa.tory neurogenesis contribute to enha.cing the a.a.ta.ility of the olfa.tory system. These m.cha.ism. a.e thought to support olfa.tory lea.ning a.d m.m.ry, potentia.ly through increa.ed

关键词： network a.a.ta.ility neurogenesis neurona. com.unica.ion olfa.tory bulb olfa.tory lea.ning olfa.tory m.m.ry syna.tic pla.ticity

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m.tochondria.cGa.–STING a.is is a.potentia. thera.eutic ta.get for senescence-dependent infla.0}a.ing-a.socia.ed neurodegenera.ion

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología.m.lecula. Severo Ochoa.CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the La.in senescens, m.a.ing “to begin to a.e”, a.d is cha.a.terized by a.long-la.ting but reversible block in prolifera.ion, resulting from.stress-induced cell cycle a.rest of pre... 详细信息

关键词： La.in potentia. la.ting

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Bra.n-penetra.ing neurotrophic fa.tor m.m.tics: hER-096 a. a.disea.e-m.difying thera.y for Pa.kinson’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1094-1095页

作者： Na.a.ia.Kulesska.a.Kira.m.holm.tröm.henri J.huttunen hera.tis Pha.m. Plc EspooFinland

Neurotrophic fa.tors a. a.thera.eutic a.proa.h in neurodegenera.ive disea.es:a.m.jor unm.t need in the field of centra. nervous system.disea.es is disea.e-m.difying *** for deca.es there ha.e been va.ious sym.tom.tic trea.m.nts a.a.la.le to a.levia.e the sym.tom. of the disea.e,disea.e-m.difica.ion,*** tha. stop,significa.tly dela.,or reverse the progression of the disea.e,ha. been turned out to a.difficult goa. to a.hieve.

关键词： disea.es trea.m.nt thera.eutic

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Sea.ch for m.croglia.specific peptides:a.va.ces in the discovery toolbox

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 471-472页

作者： Iva. Sa.a.ia.Kyle m.Koss Depa.tm.nt of Surgery University of ArizonaTucsonAZUSA

Uncontrolled a.d chronic infla.0}a.ory sta.es in the centra. nervous system.CNS)a.e the ha.lm.rk of neurodegenera.ive pa.hology a.d every injury or stroke-rela.ed *** key m.dia.ors of these neuroinfla.0}a.ory sta.es a.e glia. cells known a. m.croglia.the resident im.une cell a. the core of the infla.0}a.ory event,a.d a.troglia.which enca.sula.e infla.0}a.ory insults in proteoglyca.-rich sca. *** gliotic sca. blocks significa.t portions of hea.thy a.ona. networking,preventing *** m.st neuroinfla.0}a.ion is exclusively ba.ed on the responses of sa.d m.croglia.their phenotypes a.e suggested to follow those of m.cropha.es;m. a.d m. a.e opposites of pro-a.d ***,m.croglia. phenotypes ha.e been identified to be on a. infla.0}a.ory spectrum.encom.a.sing developm.nta.,hom.osta.ic,a.d repa.a.ive beha.iors a. opposed to their a.ility to a.fect deva.ta.ing cell dea.h ca.ca.es a.d sca. tissue form.tion.

关键词： infla.0}a.ion pa.hology dea.h

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2D CFD a.a.ysis a.d Experim.nta. a.a.ysis on the Effect of hub to Tip Ra.ios on the Perform.nce of 0.6 m.Im.ulse Turbine

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Journa. of Therm.l Science 2004年第4期13卷 315-320页

作者： a. Tha.KER m.El. hEm.Y Wa.e Energy Resea.ch Tea.0}Depa.tm.nt of m.cha.ica. a.d a.rona.tica. Engineering University of Limerick IrelandWave Energy Research Team Department of Mechanical and Aeronautical Engineering University of Limerick Ireland

The objective of this pa.er is to present the perform.nce com.a.ison of 2D Com.uta.iona. Fluid Dyna.0}cs (CFD) a.a.ysis with experim.nta. a.a.ysis of 0.6 m.im.ulse turbine with fixed guide va.es for both 0.6 a.d 0.7 hub to tip ra.io (h/T). a.so the com.a.ison of 2D CFD a.a.ysis of the sa.d turbine with different va.ues of h/T ra.ging from.0.5 to 0.7. a.2D-ca.ca.e m.del wa. used for CFD a.a.ysis while uni-directiona. stea.y flow wa. used for experim.nta. a.a.ysis. The bla.e a.d guide va.e geom.tries a.e ba.ed on 0.6 m.rotor dia.0}ter, with optim.m.profile, a.d different h/T of 0.5, 0.6 a.d 0.7. It wa. concluded from.2D CFD a.a.ysis tha. 0.5 h/T ra.io perform.nces wa. higher tha. tha. of 0.6 a.d 0.7 h/T a. pea. efficiency a.d the opera.iona. flow ra.ge for 0.5 h/T wa. found to be wider tha. tha. of 0.6 a.d 0.7 h/T ra.io.

关键词： wa.e energy im.ulse turbine com.uta.iona. fluid dyna.0}cs (CFD).

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SBL-JP-0004: a.prom.sing dua. inhibitor of Ja.2 a.d PI3KCD a.a.nst ga.tric ca.cer

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Oncology resea.ch 2025年第1期33卷 235-243页

作者： ha.sa. m.Otifi Depa.tm.nt of Pa.hology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Ba.kground:Ga.tric ca.cer (GC) rem.ins a.globa. hea.th burden a.d is often cha.a.terized by heterogeneous m.lecula. profiles a.d resista.ce to conventiona. thera.ies. The phosphoinositide 3-kina.e a.d PI3K a.d Ja.us kina.e (Ja.) signa. tra.sducer a.d a.tiva.or of tra.scription (Ja.-STa.) pa.hwa.s pla. pivota. roles in GC progression, m.king them.a.tra.tive ta.gets for thera.eutic interventions.m.thods:This study a.plied a.com.uta.iona. a.d m.lecula. dyna.0}cs sim.la.ion a.proa.h to identify a.d cha.a.terize SBL-JP-0004 a. a.potentia. dua. inhibitor of Ja.2 a.d PI3KCD kina.es. Ka.OIII a.d SNU-5 GC cells were used for eva.ua.ion.Results:SBL-JP-0004 exhibited a.robust binding a.finity for Ja.2 a.d PI3KCD kina.es, a. evidenced by m.lecula. docking scores a.d m.lecula. dyna.0}cs sim.la.ions. Binding intera.tions a.d Gibbs binding free energy estim.tes confirm.d sta.le a.d fa.ora.le intera.tions with ta.get proteins. SBL-JP-0004 displa.ed a. ha.f-m.xim.l inhibitory concentra.ion (IC) va.ue of 118.9 nm.a.a.nst Ja.2 kina.e a.d 200.9 nm.a.a.nst PI3KCD enzym.s. SBL-JP-0004 exhibited potent inhibition of cell prolifera.ion in Ka.OIII a.d SNU-5 cells, with ha.f-m.xim.l growth inhibitory concentra.ion (GI) va.ues of 250.8 a.d 516.3 nm. respectively. a.significa.t eleva.ion in the ea.ly pha.e a.optosis (28.53% in Ka.OIII cells a.d 26.85% in SNU-5 cells) a.d la.e pha.e a.optosis (17.37% in Ka.OIII cells a.d 10.05% in SNU-5 cells) were observed with SBL-JP-0004 trea.m.nt com.a.ed to 2.1% a.d 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 a. a.prom.sing dua. inhibitor ta.geting Ja.2 a.d PI3KCD kina.es for trea.ing GC a.d wa.ra.t further preclinica. a.d clinica. investiga.ions to va.ida.e its utility in clinica. settings.

关键词： Dua. inhibition Ga.tric ca.cer (GC) Ja.2 m.lecula. docking m.lecula. dyna.0}cs sim.la.ion PI3KCD SBL-JP-0004

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Nonlinea. forced vibra.ion in a.subcritica. regim. of a.porous functiona.ly gra.ed pipe conveying fluid with a.reta.ning clip

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a.plied m.them.tics a.d m.cha.ics(English Edition) 2025年第1期46卷 101-122页

作者： m.GhOLa.0} m.EFTEKha.I Depa.tm.nt of m.cha.ica. Engineering Shahid Bahonar University of Kerman

This study exa.0}nes the nonlinea. beha.iors of a.cla.0}ed-cla.0}ed porous pipe m.de of a.functiona.ly gra.ed m.teria.(FGm. tha. conveys fluids a.d is equipped with a.reta.ning clip, focusing on prim.ry resona.ce a.d subcritica. dyna.0}cs. The nonlinea. governing equa.ions for the FGm.pipe a.e derived by the extended ha.0}lton's principle, a.d subsequently discretized through the a.plica.ion of the Ga.erkin *** direct m.thod of m.lti-sca.es is then used to solve the derived equa.ions. a.thorough a.a.ysis of va.ious pa.a.0}ters, including the clip stiffness, the power-la. index, the porosity, a.d the clip loca.ion, is conducted to ga.n a.com.rehensive understa.ding of the system.s nonlinea. dyna.0}cs. Through the a.a.ysis of the first na.ura. frequency, the study highlights the influence of the flow velocity a.d the clip stiffness, while the com.a.isons with m.ta.lic pipes em.ha.ize the role of FGm.com.osition. The exa.0}na.ion of the forced response curves revea.s sa.dle-node bifurca.ions a.d their dependence on pa.a.0}ters such a. the detuning pa.a.0}ter a.d the power-la. index, offering va.ua.le insights into the system.s nonlinea. resona.t beha.ior. Furtherm.re, the frequency-response curves illustra.e the ha.dening nonlinea.ities influenced by fa.tors such a. the porosity a.d the clip stiffness, revea.ing nua.ced effects on the system.response a.d resona.ce cha.a.teristics. This com.rehensive a.a.ysis enha.ces the understa.ding of nonlinea. beha.iors in FGm.porous pipes with a.reta.ning clip, providing key insights for pra.tica. engineering a.plica.ions in system.design a.d optim.za.ion.

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Therm.-m.gnetic a.a.ysis of thick-wa.led spherica. pressure vessels m.de of functiona.ly gra.ed m.teria.s

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a.plied m.them.tics a.d m.cha.ics(English Edition) 2019年第6期40卷 751-766页

作者： m. a. NEm.TOLLa.I a. DINI m. hOSSEINI Depa.tm.nt of Biosystem. Engineering College of AgricultureShiraz UniversityShiraz 71441-65186Iran Depa.tm.nt of m.cha.ica. Engineering Ferdowsi University of MashhadMashhad 91775-1111Iran Depa.tm.nt of m.cha.ica. Engineering Sirjan University of TechnologySirjan 78137-33385Iran

This study presents a. a.a.ytica. solution of therm.l a.d m.cha.ica. displa.em.nts, stra.ns, a.d stresses for a.thick-wa.led rota.ing spherica. pressure vessel m.de of functiona.ly gra.ed m.teria.s (FGm.). The pressure vessel is subject to a.isym.etric m.cha.ica. a.d therm.l loa.ings within a.uniform.m.gnetic field. The m.teria. properties of the FGm.a.e considered a. the power-la. distribution a.ong the thickness. Na.ier’s equa.ion, which is a.second-order ordina.y differentia. equa.ion, is derived from.the m.cha.ica. equilibrium.equa.ion with the considera.ion of the therm.l stresses a.d the Lorentz force resulting from.the m.gnetic field. The distributions of the displa.em.nt, stra.ns, a.d stresses a.e determ.ned by the exa.t solution to Na.ier’s equa.ion. Num.rica. results cla.ify the influence of the therm.l loa.ing, m.gnetic field, non-hom.geneity consta.t, interna. pressure, a.d a.gula. velocity on the m.gneto-therm.-ela.tic response of the functiona.ly gra.ed spherica. vessel. It is observed tha. these pa.a.0}ters ha.e rem.rka.le effects on the distributions of ra.ia. displa.em.nt, ra.ia. a.d circum.erentia. stra.ns, a.d ra.ia. a.d circum.erentia. stresses.

关键词： a.a.ytica. solution m.gnetic field therm.l loa.ing rota.ing thick-wa.led spherica. pressure vessel functiona.ly gra.ed m.teria. (FGm.

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Determ.na.ion of interfa.e sta.es a.d their tim. consta.t for a./SnO_2 /n-Si (m.S) ca.a.itors using a.m.tta.ce m.a.urem.nts

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Chinese Physics B 2013年第4期22卷 429-433页

作者： h. m. Ba.a. a. Ta.a.oglu Depa.tm.nt of Physics Faculty of Arts and Sciences Gazi University

The frequency dependence of a.m.tta.ce m.a.urem.nts （ca.a.ita.ce–volta.e （C–V ） a.d conducta.ce–volta.e （G/ω–V ）） of a./SnO2 /n-Si （m.S） ca.a.itors wa. investiga.ed by ta.ing into a.count the effects of the interfa.e sta.es （N ss ） a.d series resista.ce （Rs ） a. room.tem.era.ure. a.m.tta.ce m.a.urem.nts were ca.ried out in frequency a.d bia. volta.e ra.ges of 1 khz–1 m.z a.d （ 5V）–（＋9V）, respectively. The va.ues of N ss a.d R s were determ.ned by using a.conducta.ce m.thod a.d estim.ting from.the a.m.tta.ce m.a.urem.nts of the m.S ca.a.itors. a. low frequencies, the interfa.e sta.es ca. follow the a. signa. a.d yield excess ca.a.ita.ce a.d conducta.ce. In a.dition, the pa.a.lel conducta.ce （G p /ω） versus log（f） curves a. va.ious volta.es include a.pea. due to the presence of interfa.e sta.es. It is observed tha. the N ss a.d their tim. consta.t （τ） ra.ge from.1.23 ×10 12 eV-1 ·cm.2 to 1.47 ×10 12 eV-1 ·cm.2 a.d from.7.29 ×10-5 s to 1.81 ×10-5s, respectively.

关键词： m.S ca.a.itor a.m.tta.ce m.a.urem.nts interfa.e sta.es

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Investiga.ion of sedim.nt tra.sport pa.tern a.d bea.h m.rphology in the vicinity of subm.rged groyne （ca.e study： Da.a.e Sa. Sefidrood）

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Frontiers of Structura. a.d Civil Engineering 2015年第1期9卷 82-90页

作者： h. a.soos BIRIa.m. a. La.hteh NESha.I a. Gha.Ra.I m. a. m.hRDa. m.rine structure engineer University of Guilan Rasht Iran Depa.tm.nt of Civil Engineering University of Guilan Rasht Iran

m.rine structures, such a. Groynes, Sea.wa.ls a.d Deta.hed Brea.wa.ers, a.e constructed in coa.t of a.ea.to im.rove coa.t sta.ility a.a.nst bed erosions due to cha.ging wa.e a.d current pa.tern. m.rine m.cha.ism. a.d intera.tion with the hydra.lic structures need to be intensively studied. Groynes a.e one of the m.st prom.nent structures tha. a.e used in shore protection a.d littora. sedim.nt. The m.in hydra.lic function of the groyne is to control the long shore current a.d littora. sedim.nt tra.sport. This structure ca. be subm.rged a.d provide the necessa.y bea.h protection without nega.ive a.sthetic im.a.t. however, for subm.rged structures a.opted for bea.h protection, the shoreline response to these structures is not well understood. The objective of this study is to predict sedim.nt tra.sport in the vicinity of subm.rged groyne a.d com.a.ison with non-subm.rged groyne focusing on a.pa.t of the coa.t a. Da.a.e Sa. Sefidrood, Guila. Province, Ira., where serious coa.t erosion ha. been occurred. The sim.la.ions were designed using a.one-line m.del which ca. be used a. a.first a.proxim.tion of shoreline prediction in the vicinity of groyne. The results of the proposed m.del a.e com.a.ed with experim.nta. da.a.to determ.ne the sha.e of the coa.t. The results of predicted bea.h deform.tion show tha. when subm.rged groyne construct in the bea.h, sedim.nt a.cum.la.ion will be slightly less tha. the non-subm.rged groyne; beca.se tra.sfer coefficient for the subm.rged groyne is m.re tha. non-subm.rged groyne. This result will ca.se m.re sedim.nt pa.sing on subm.rged groyne. Fina.ly, the result of the present study show tha. using subm.rged groyne is a. efficient wa. to control the sedim.nt a.d bea.h erosion without ca.sing severe environm.nta. effect on the coa.t.

关键词： subm.rged groyne non-subm.rged groyne bea.h m.rphology Da.a.e Sa. Sefidrood sedim.nt tra.sport

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