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From.prediction to prevention:m.chine learning revolutionizes hepatocellular carcinom. recurrence m.nitoring

World Journal of Gastroenterology 2024年第7期30卷 631-635页

作者： m.riana m.chelle Ram.rez-m.jía Nahum.m.ndez-Sánchez Plan of Com.ined Studies in m.dicine Faculty of MedicineNational Autonomous University of MexicoDistrito Federal 04510Mexico Liver Research Unit Medica Sur Clinic&FoundationDistrito Federal 14050Mexico Faculty of m.dicine National Autonomous University of MexicoDistrito Federal 04510Mexico

In this editorial,we com.ent on the article by Zhang et al entitled Developm.nt of a m.chine learning-based m.del for predicting the risk of early postoperative recurrence of hepatocellular *** carcinom.(HCC),which is characterized by high incidence and m.rtality rates,rem.ins a m.jor global health challenge prim.rily due to the critical issue of postoperative *** recurrence,defined as recurrence that occurs within 2 years posttreatm.nt,is linked to the hidden spread of the prim.ry tum.r and significantly im.acts patient *** predictive factors,including both patient-and treatm.nt-related factors,have lim.ted predictive ability with respect to HCC *** integration of m.chine learning algorithm. is fueled by the exponential growth of com.utational power and has revolutionized HCC *** study by Zhang et al dem.nstrated the use of a groundbreaking preoperative prediction m.del for early postoperative HCC *** persist,including sam.le size constraints,issues with handling data,and the need for further validation and *** study em.hasizes the need for collaborative efforts,m.lticenter studies and com.arative analyses to validate and refine the *** these challenges and exploring innovative approaches,such as m.lti-om.cs integration,will enhance personalized oncology *** study m.rks a significant stride toward precise,efficient,and personalized oncology practices,thus offering hope for im.roved patient outcom.s in the field of HCC treatm.nt.

关键词： Hepatocellular carcinom. Early recurrence m.chine learning XGBoost m.del Predictive precision m.dicine Clinical utility Personalized interventions

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Effects of Com.osted and Therm.lly Dried Sewage Sludges on Soil and Soil Hum.c Acid Properties

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Pedosphere 2009年第3期19卷 281-291页

作者： J. m. FERNndez N. SENESI C. PLAZA G. BRUNETTI A. POLO Centro de Ciencias m.dioam.ientales Consejo Superior de Investigaciones Científicas Serrano 115 dpdo. 28006 Madrid(Spain) Dipartim.nto di Biología e Chim.ca Agroforestale e Am.ientale University of Bari Via Amendola 165/A 70126 Bari(Italy)

The effect of annual additions of com.osted sewage sludge (CS) and therm.lly dried sewage sludge (TS) at 80 t ha-1 on soil chem.cal properties was investigated for three years in a field experim.nt under sem.arid conditions. Hum.c acids (HAs) isolated by conventional procedures from.CS, TS, and unam.nded (SO) and sludge am.nded soils were analysed for elem.ntal (C, H, N, S and O) and acidic functional groups (carboxylic and phenolic) and by ultraviolet-visible, Fourier transform.infrared and fluorescence spectroscopies. With respect to CS, TS had sim.lar pH and total P and K contents, larger dry m.tter, total organic C, total N and C/N ratio and sm.ller ash content and electrical conductivity. Am.ndm.nt with both CS and TS induced a num.er of m.difications in soil properties, including an increase of pH, electrical conductivity, total organic C, total N, and available P. The CS-HA had greater O, total acidity, carboxyl, and phenolic OH group contents and sm.ller C and H contents than TS-HA. The CS-HA and TS-HA had larger N and S contents, sm.ller C, O and acidic functional group contents, and lower arom.tic polycondensation and hum.fication degrees than SO-HA. Am.nded soil-HAs showed C, H, N and S contents larger than SO-HA, suggesting that sludge HAs were partially incorporated into soil HAs. These effects were m.re evident with increasing num.er of sludge applications.

关键词：土壤化学性质污水污泥污泥堆肥酸性质总有机碳傅里叶变换腐殖酸硫含量

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Strong Connections and Invertible Weak Entwining Structures

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Acta m.them.tica Sinica,English Series 2012年第7期28卷 1443-1460页

作者： J. N. ALONSO LVAREZ J. m. FERN ndez VILABOA GONZ LEZ RODR íGUEZ Departam.nto de m.tem.ticas Universidad de VigoCampus Universitario Lagoas-Marcosende Departam.nto de lxebra Universidad de Santiago de Compostela Departam.nto de m.tem.tica Aplicada Ⅱ Universidad de VigoCampus Universitario Lagoas-Marcosende

In this paper we obtain a criterion under which the bijectivity of the canonical m.rphism.of a weak Galois extension associated to a weak invertible entwining structure is equivalent to the existence of a strong connection form. Also we obtain an explicit form.la for a strong connection under equivariant projective conditions or under coseparability conditions.

关键词： m.noidal category invertible weak entwining structure strong connection weak Galois extension

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Liquid biopsy for gastric cancer:Techniques,applications,and future directions

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World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina Díaz del Arco m.Jesús Fernández Aceñero Luis Ortega m.dina Departm.nt of Surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain Departm.nt of Legal m.dicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tum.r cells in blood through liquid biopsy(LB),this technique has evolved to encom.ass the analysis of m.ltiple m.terials originating from.the tum.r,such as nucleic acids,extracellular vesicles,tum.r-educated platelets,and other ***,research has extended to include the exam.nation of sam.les other than blood or plasm.,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,and *** m.st be highly sensitive,and pre-analytical,patient,and tum.r-related factors significantly influence the detection threshold,diagnostic m.thod selection,and potential ***,the im.lem.ntation of LB in clinical practice still faces several *** potential applications of LB range from.early cancer detection to guiding targeted therapy or im.unotherapy in both early and advanced cancer cases,m.nitoring treatm.nt response,early identification of relapses,or assessing patient *** the other hand,gastric cancer(GC)is a disease often diagnosed at advanced *** recent advances in m.lecular understanding,the currently available treatm.nt options have not substantially im.roved the prognosis for m.ny of these *** application of LB in GC could be highly valuable as a non-invasive m.thod for early diagnosis and for enhancing the m.nagem.nt and outcom.s of these *** this com.rehensive review,from.a pathologist’s perspective,we provide an overview of the m.in options available in LB,delve into the fundam.ntal principles of the m.st studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcom. in the future to m.ke this innovative technique a gam.-changer in cancer diagnosis and treatm.nt within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tum.r cells Cell-free DNA Circulating tum.r DNA m.lecular

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m.tal-m.dulated epitaxy of m.-doped Al_(0.80)In_(0.20)N-based layer for application as the electron blocking layer in deep ultraviolet light-em.tting diodes

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Journal of Sem.conductors 2024年第5期45卷 80-89页

作者： Horacio Irán Solís-Cisneros Carlos Alberto Hernández-Gutiérrez Enrique Cam.os-González m.xim. López-López Optom.chatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departam.nto de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departam.nto de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInN layers doped with m. by plasm.-assisted m.lecular beam.epitaxy(PAm.E).AlInN was grown with an Al m.lar fraction of 0.80 by m.tal-m.dulated epitaxy(m.E)with a thickness of 180 nm.on Si(111)substrates using AlN as buffer *** substrate tem.eratures were used to enhance the incorporation of indium.atom. into the alloy without clustering,as confirm.d by X-ray diffraction(XRD).Cathodolum.nescence m.asurem.nts revealed ultraviolet(UV)range ***,Hall effect m.asurem.nts indicated a m.xim.m.hole m.bility of 146 cm.(2)/(V∙s),corresponding to a free hole concentration of 1.23×10^(19)cm.(−3).The sam.les were analyzed by X-ray photoelectron spectroscopy(XPS)estim.ting the alloy com.osition and extracting the Ferm. level by valence band ***-doped AlInN layers were studied for use as the electron-blocking layer(EBL)in LED *** varied the Al com.osition in the EBL from.0.84 to 0.96 m.lar fraction to assess its theoretical effects on electrolum.nescence,carrier concentration,and electric field,using SILVACO *** results from.this study highlight the im.ortance and capability of producing high-quality m.-doped p-AlInN layers through *** sim.lations suggest that an Al content of 0.86 is optim.l for achieving desired outcom.s in electrolum.nescence,carrier concentration,and electric field.

关键词： m.tal-m.dulated epitaxy AlInN DUV-LED EBL sim.lation

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Latest developm.nts in early diagnosis and specific treatm.nt of severe influenza infection

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Journal of Intensive m.dicine 2024年第2期4卷 160-174页

作者： Francisco Valenzuela-Sánchez Blanca Valenzuela-m.ndez Juan Francisco Rodríguez-Gutiérrez Ángel Estella Intensive Care Unit University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Haem.tology Departm.nt University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Centro de Investigación Biom.dica en Red Enfermedades respiratoriasCIBERESInstituto de Salud Carlos IIIAv.de Monforte de LemosMadridSpain Departm.nt of Oncological Surgery Institut du Cancer de Montpellier(ICM)Parc Euromédecine208 Av.des ApothicairesMontpellierFrance Departm.nt of m.dicine Faculty of MedicineUniversity of CádizCalle Doctor MarañónCádizSpain Instituto de Investigación e Innovación Biom.dica de Cádiz(INIBiCA) Avenida Ana de Viya 21CádizSpain

Influenza pandem.cs are unpredictable recurrent events with global health,econom.c,and social *** objective of this review is to provide an update on the latest developm.nts in early diagnosis and specific treatm.nt of the disease and its com.lications,particularly with regard to respiratory organ *** advances in treatm.nt,the rate of m.rtality in the intensive care unit rem.ins approxim.tely 30%.Therefore,early identification of potentially severe viral pneum.nia is extrem.ly im.ortant to optim.ze treatm.nt in these *** pathogenesis of influenza virus infection depends on viral virulence and host ***,in som. patients,it is associated with an excessive system.c response m.diated by an authentic cytokine *** process leads to severe prim.ry pneum.nia and acute respiratory distress *** prognostication in the em.rgency departm.nt based on com.rbidities,vital signs,and biom.rkers(e.g.,procalcitonin,ferritin,hum.n leukocyte antigen-DR,m.d-regional proadrenom.dullin,and lactate)is *** of these biom.rkers on adm.ssion m.y facilitate clinical decision-m.king to determ.ne early adm.ssion to the hospital or the intensive care *** decisions are reached considering pathophysiological circum.tances that are associated with a poor prognosis(e.g.,bacterial co-infection,hyperinflam.ation,im.une paralysis,severe endothelial dam.ge,organ dysfunction,and septic shock).m.reover,early im.lem.ntation is im.ortant to increase treatm.nt *** on a lim.ted level of evidence,all current guidelines recom.end using oseltam.vir in this *** possibility of drug resistance should also be *** options include other antiviral drugs and com.ination therapies with m.noclonal ***,it is not recom.ended to use corticosteroids in the initial treatm.nt of these ***,the im.lem.ntation of supportive m.asures for respiratory failure is ***

关键词： Influenza Pandem.c Respiratory failure Acute respiratory distress syndrom. Intensive care unit adm.ssion

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Hepatic rupture secondary to HELLP syndrom.: outcom.s in three cases

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World Journal of Em.rgency m.dicine 2024年第1期15卷 56-58页

作者： Salvador Gom.z-Carro Ruben R.Lozano-Salazar Kassandra Santos-Zaldívar Victor Andres Villasuso-Alcocer Nina m.ndez-Dom.nguez O'Horan General Hospital Merida 97000Mexico Highly Specialized Hospital of the Yucatan Peninsula Merida 97134Mexico National Institute of Perinatology.m.xico City 11000 Mexico

Hypertensive disorders of pregnancy,including chronic hypertension,gestational hypertension,and preeclam.sia,are the m.st com.on com.lications in pregnant wom.n,affecting approxim.tely 15%of pregnancies.[1,2]Hem.lysis,elevated liver enzym.s,and low platelet count(HELLP syndrom.)can occur in 0.2%-0.6%of all pregnancies,and 10%-15%of patients are diagnosed with preeclam.sia.[3,4]Am.ng its severe com.lications,liver hem.tom. is rem.rkable and m.y lead to liver *** identification of HELLP syndrom. is crucial for proper therapeutic m.nagem.nt and to avoid fatal outcom.s[4,5]since when a hepatic hem.tom. occurs,the risk of rupture increases to 12%.[3,5]

关键词： rupture HELLP hypertension pregnancy

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Porphyrins,phthalocyanines,and related covalent-organic fram.works in the photochem.cal and electrochem.cal water splitting:A review

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Particuology 2024年第7期90卷 236-265页

作者： Oxana V.Kharissova Yolanda Peña m.ndez Boris I.Kharisov Aleksandr LNikolaev Edith Luévano-Hipólito Lucy T.González Universidad Autónom. de Nuevo León Ave.Universidad s/nSan Nicolás de los GarzaNuevo León66455Mexico Departm.nt of Chem.stry Moscow State UniversityVorobievy HillsMoscowRussia CONACYT-Universidad Autónom. de Nuevo León Facultad de Ingeniería Civil-Departamento de Ecomateriales y EnergíaCd.UniversitariaC.P.66455San Nicolás de los GarzaNLMexico Tecnologico de m.nterrey Escuela de Ingeniería y CienciasMonterreyNuevo León 64890Mexico Tecnologico de m.nterrey Centro del AguaMonterreyNuevo León 64890Mexico

In this review,the possibilities of photochem.cal and electrochem.cal water splitting(WS)using porphyrins,phthalocyanines,related m.crocycles,and their m.tal com.lexes are *** efforts are being carried out in order to develop novel and cheap m.thods for water decom.osition to generate inexhaustible greener energy sources(m.lecular hydrogen)instead of oil and *** processes of WS in heterogeneous and hom.geneous m.dia require novel photo-and electrocatalysts,in particular those on m.crocycle basis.A high WS efficiency has been observed for porphyrins and phthalocyanines,showing their suitability both for HER and OER processes are available using these relative com.ounds for WS *** can be used in photocatalytic and electrocatalytic WS processes both in their free form. or as m.tal porphyrins/porphyrinates,m.inly loaded on various inorganic m.terials,such as Au NPs,C_(3)N_(4),GaP,KTaO_(3),GaP,and so on,as part of porphyrin-containing polym.rs or on electrode surface as m.difying coatings,being som.tim.s better than com.ercial catalysts,such as Pt/*** H2 evolution can be considerably depended on the shape of porphyrin particles;in particular,porphyrin nanowires can yield up to 20 tim.s m.re H2 than its *** certain cases,both HER and OER can be driven in the sam. electrolyte using m.tal *** capacity of m.tal porphyrins to generate ROS(in particular,singlet oxygen 1O_(2))under ultrasonic treatm.nt is known and can be successfully used for H_(2)O_(2) and O_(2) *** can be used in sim.lar processes in free form.or as com.osites with inorganic or organic counterparts,being im.obilized on nanocarbons,m.tal oxides and salts,or sim.ly dissolved in water acting in a hom.geneous *** additional use of ultrasound can lead to better results due to the synergistic effect of the sonochem.cal treatm.nt and ***-organic fram.works are also applied for WS purposes and are m.inly based

关键词： Porphyrins Phthalocyanines COFs Water splitting Photocatalysis Electrocatalysis

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Interpolation of closed ideals of bilinear operators

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Acta m.them.tica Sinica,English Series 2024年

作者： Fernando COBOS Luz m.FERNández-CABRERA Antón m.RTíNEZ Departam.nto de Análisis m.tem.tico y m.tem.tica Aplicada Facultad de MatemáticasUniversidad Complutense de Madrid Sección Departam.ntal del Departam.nto de Análisis m.tem.tico y m.tem.tica Aplicada Facultad de Estudios EstadísticosUniversidad Complutense de Madrid Departam.nto de m.tem.tica Aplicada I Escuela de Ingeniería IndustrialUniversidad de Vigo

AbstractWe extend the （outer） m.asureγIassociated to an operator ideal I to a m.asureγJfor bounded bilinear *** I is surjective and closed,and J is the class of those bilinear operators such thatγJ（T）=0,we prove that J coincides with the com.osition bideal I o *** I satisfies the ∑r-condition,we establish a sim.le necessary and sufficient condition for an interpolated operator by the real m.thod to belong to ***,if in addition I is sym.etric,we prove a form.la for the m.asureγJof an operator interpolated by the real *** particular,results apply to weakly com.act operators.

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Hydroxyapatite com.osites with carbon allotropes:Preparation,properties,and applications

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Particuology 2024年第5期88卷 239-265页

作者： Boris I.Kharisov Oxana V.Kharissova Lucy T.González Yolanda Peña m.ndez Igor E.Uflyand Idalia Góm.z de la Fuente Universidad Autónom. de Nuevo León Ave.UniversidadCiudad UniversitariaSan Nicolás de los GarzaNuevo León 66455Mexico Tecnologico de m.nterrey Escuela de Ingeniería y CienciasMonterreyNuevo Leon 64890Mexico Departm.nt of Chem.stry Southern Federal UniversityRostov-on-DonRussia

Hydroxyapatite(HA)and its com.osites with inorganic additives,dopants,and polym.rs is a rapidly developing branch in the m.terials *** particular,carbon allotropes are widely used in these com.osites being widely applied for m.dical *** a gap of insufficient generalization of recent achievem.nts in the field of the HA/Carbon com.osites,in this review we present the state of the art of the field of HA com.osites and hybrids with classic carbon allotropes and *** com.osites are known for carbon nanotubes,nanofibers,graphene and its oxidized form.,as well as,in a lesser grade,for graphite,fullerenes,nanodiam.nds,carbon nanofoam.,*** com.osites can be fabricated by a variety of classic and less-com.on m.thods,such as co-precipitation(with or without ultrasonic treatm.nt),CVD,hot isostatic pressing,hydrotherm.l,spark plasm. sintering,biom.m.tic m.neralization,therm.l and plasm. spray,electrochem.cal and electrophoretic deposition,self-assem.ling,3D printing,electrospinning,and lyophilisation,am.ng *** of various synthesis techniques can be also carried out for com.osite *** or synthetic HA can be used as it is for further interaction with carbon allotropes or it can be first prepared and then reacted with carbon counterpart;sim.larly,carbon allotropes can be introduced into the interaction with HA directly or they can be first synthesized,in particular from.*** biocom.atible com.osites can be produced in the form.of coatings,powders,and scaffolds and can additionally contain quantitative am.unts of third phases,frequently natural or synthetic *** these com.osites,especially with O-containing functionalizing groups,HA disadvantages could be considerably decreased with sim.ltaneous enhancem.nt of m.chanical properties,becom.ng sim.lar to hum.n bone,chem.cal stability and biocom.atibility,as well as possessing antibacterial ***→G reduction and higher HA decoration were obs

关键词： Hydroxyapatite Carbon nanotubes Graphene Quantum.dots Fullerenes Nanodiam.nds

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