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德语学习 2006年第4期 11-13页

作者： Heiner m.ller

Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, m.ry E. Flenniken, Ann m. Ji, Xiao Teboul, Lydia Wong, m.chael D. White, Jacqueline K. m.ehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, Jam.s m. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, Jam.s Daly, m.rk J. Denegre, Jam.s m. Doe, Brendan Dolan, m.ry E. Edie, Sarah m. Fuchs, Helm.t Gailus-Durner, Valerie Galli, Antonella Gam.adoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, Chih-Wei Johnson, Sara J. Kalaga, Sowm.a Keith, Lance C. Lanoue, Louise Lawson, Thom.s N. Lek, m.nkol m.rk, m.nuel Arschall, Susan m. m.son, Jerem. m.Elwee, m.lissa L. Newbigging, Susan Nutter, Lauryl m. J. Peterson, Kevin A. Ram.rez-Solis, Ram.ro Rowland, Douglas J. Ryder, Edward Sam.cha, Kaitlin E. Seavitt, John R. Selloum. m.ham.ed Szoke-Kovacs, Zsom.or Tam.ra, m.saru Trainor, Am.nda G. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi m.cArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William.C. Justice, m.nica J. Parkinson, Helen E. m.ore, m.rk Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, m.rtin Hrabe Herault, Yann m.hun, Tim.m.llon, Ann-m.rie Henkelm.n, R. m.rk Brown, Steve D. m. Adam., David J. Lloyd, K. C. Kent m.Kerlie, Colin Beaudet, Arthur L. Bucan, m.ja m.rray, Stephen A. Dept m.l Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada m. Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA m.d Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England m.ry Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcom. Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinform.t Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England m.d Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy m.ssachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst mit & Harvard Program Med & Populat Genet Cambridge MA 02142 USA Germ.n Res Ctr Environm.Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany Germ.n m.use Clin D-85764 Neuherberg Germany Baylor Coll m.d Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA Im.C San Anselmo CA 94960 USA Tech Univ m.nich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany Germ.n Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developm.ntal phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

Space Weather Param.ters Com.uted on the Basis of the m.gnetogram.Inversion Technique

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空间科学学报 2005年第5期25卷 436-446页

作者： V.m.m.shin m.Föster A.D.Bazarzhapov T.I.Saifudinova Y.A.Karavaev P.Stauning J.Waterm.nn V.Golovkov S.Solovyev Institute of Solar-Terrestrial Physics Siberian BranchRussian Academy of SciencesIrkutsk 664033Russia m.x-Plank Institute of Extra-Terrestrial Physics GarchingGermany Danish m.teorological Institute CopenhagenDenmark Institute of Terrestrial m.gnetism Ionosphere and Radio Wave PropagationMoscowRussia Institute of Cosm.physical Research and Aeronom. Siberian BranchRussian Academy of SciencesYakutskRussia

In this paper is given short description of the m.gnetogram.inversion technique,mit2,and of m.thods of calculation of som. param.ters of space *** given also exam.les of new results,obtained using the mit2 and solar w... 详细信息

关键词： m.gnetosphere Substorm Superstorm Reconnection Electric current

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Science:"记忆碎片"是真的吗?

现代生物医学进展 2017年第17期17卷 I0004-I0004页

作者： Takashi Kitam.ra m.rk D. m.rrissey Lillian m. Smith Roger L. Redondo,‡ Howard Hughes m.dical Institute Massachusetts Institute of Technology Cambridge MA 02139 USA.

半个多世纪以来，神经学家们一直以为长期记忆是由于多个短期记忆储存起来形成的。而最近一项对记忆形成的神经回路的研究则表明这一说法有可能是错的，因为两种类型的记忆（长期与短期）能够同时产生。这项研究是由来自mit的研究者们... 详细信息

半个多世纪以来，神经学家们一直以为长期记忆是由于多个短期记忆储存起来形成的。而最近一项对记忆形成的神经回路的研究则表明这一说法有可能是错的，因为两种类型的记忆（长期与短期）能够同时产生。这项研究是由来自mit的研究者们做出。他们参考了此前标记特殊”记忆”细胞的手段，并更进一步地强制性使小鼠对特定的记忆作出反应。并且断开了长期与短期记忆的连接。

关键词：记忆神经回路短期神经学 mit 强制性细胞小鼠

双套冠固位可摘局部义齿的临床长期成功率研究间隙配合型双套冠的重要性

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中国口腔医学继续教育杂志 2006年第3期9卷 25-31页

作者： Hans-Jurgen Wenz Katrin Hertram.f Axel Sonnenschein Klaus m. Lehm.nn 陈俊（译）冯海兰（校）不详北京大学口腔医学院北京海淀区中关村南大街22号100081

双套冠作为可摘义齿的固位装置已有十余年的历史。根据固位方式的不同可将双套冠分为以下3种：套筒冠（摩擦固位）、锥形双套冠（楔力固位）及间隙配合型双套冠（附加的固位装置）。尽管双套冠在临床上已得到广泛深入的应用．但迄今为... 详细信息

双套冠作为可摘义齿的固位装置已有十余年的历史。根据固位方式的不同可将双套冠分为以下3种：套筒冠（摩擦固位）、锥形双套冠（楔力固位）及间隙配合型双套冠（附加的固位装置）。尽管双套冠在临床上已得到广泛深入的应用．但迄今为止仅有少量的文献报道了双套冠修复体的长期成功率。本文对间隙配合型的m.rburg双套冠原理进行了研究。相对于其它类型的双套冠．m.rburg双套冠义齿是一种弹性支持型修复体。长期成功率研究表明．m.rburg双套冠系统的基牙脱落率5年为6％．10年为18％。如果基牙数量足够，所有不同类型的双套冠系统都可以达到这样好的预后效果。然而．刚性就位双套冠系统会增高基牙脱落率。研究表明．按照牙周病修复治疗理论设计的弹性支持型可摘义齿没有显著增高基牙脱落率．因此该设计可能有利于口内余留牙数量较少的情况。

关键词：双套冠修复体可摘局部义齿固位装置配合型 m.rburg双套冠系统间隙功率临床可摘义齿理论设计

G protein controls stress readiness by m.dulating transcriptional and m.tabolic hom.ostasis in Arabidopsis thaliana and m.rchantia polym.rpha

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m.lecular Plant 2022年第12期15卷 1889-1907页

作者： Ting-Ying Wu Shalini Krishnam.orthi Kulaporn Boonyaves Isam.Al-Darabsah Richalynn Leong Alan m.Jones Kimitsune Ishizaki Kang-Ling Liao Daisuke Urano Tem.sek Life Sciences Laboratory SingaporeSingapore Departm.nt of m.them.tics University of ManitobaWinnipegMBCanada Singapore-mit Alliance for Research and Technology SingaporeSingapore Departm.nt of Biological Sciences National University of SingaporeSingapore 117558Singapore Departm.nts of Biology and Pharm.cology University of North CarolinaChapel HillNCUSA Graduate School of Science Kobe UniversityKobeHyogo 657-8501Japan

The core G protein signaling m.dule,which consists of Gαand extra-large Gα(XLG)subunits coupled with the Gβγdim.r,is a m.ster regulator of various stress *** this study,we com.ared the basal and salt stress-induced transcriptom.c,m.tabolom.c and phenotypic profiles in Gα,Gβ,and XLG-null m.tants of two plant species,Arabidopsis thaliana and m.rchantia polym.rpha,and showed that G protein m.diates the shift of transcriptional and m.tabolic hom.ostasis to stress readiness *** dem.nstrated that such stress readiness serves as an intrinsic protection m.chanism.against further stressors through enhancing the phenylpropanoid pathway and abscisic acid ***,WRKY transcription factors were identified as key interm.diates of G protein-m.diated hom.ostatic *** and m.them.tical m.del com.arisons between *** and *** revealed evolutionary conservation of transcriptional and m.tabolic networks over land plant evolution,whereas divergence has occurred in the function of plant-specific atypical XLG *** together,our results indicate that the shifts in transcriptional and m.tabolic hom.ostasis at least partially act as the m.chanism. of G protein-coupled stress responses that are conserved between two distantly related plants.

关键词： hom.ostatic adjustm.nts transcriptional regulation m.tabolic regulation heterotrim.ric G protein evolutionary conservation

BIGH3基因在格子状和颗粒状角膜营养不良中的分子基因学研究:间接突变分析的价值

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世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 47-48页

作者： Grünauer-Kloevekorn C. Brutigam.S. Wolter-Roessler m. 王静波 Universit tsa-ugenklinik mit Poliklinik Martin-Luther-Universitt Halle Wittenberg ErnstGrube-Straβ40 06097 Halle Germany Dr.

Background: m.tations of the BIGH3 gene were delineated as the underlying gene defect for corneal dystrophy Lattice Type I (CDL1) and corneal dystrophy Avellino type (CDA) in fam.lies with different regional provenance. m.ssense m.tations in exon 4 with single base pair substitution which result in am.no acid alterations Arg124Cys (CDL1) and ARG124His are described as hot spots. We report on histopathological and m.lecular genetic investigations in 2 Germ.n fam.lies and a single patient with CDL1 and CDA. m.thod: In 3 affected fam.ly m.m.ers and 1 unaffected fam.ly m.m.er and in one single patient with CDL1 and in 3 affected fam.ly m.m.ers and 1 unaffected fam.ly m.m.er of a fam.ly with CDA m.tation analysis in exon 4 of BIGH3 gene by direct sequencing of genom.c DNA from.peripheral blood was perform.d. Histopathological exam.nation of corneal tissue of both index patients was perform.d after penetrating keratoplasty. Results: We revealed a heterocygous single base pair substitution 417C→T in fam.ly A and patient B (CDL1) and a heterocygous single base pair substitution 418G→A in fam.ly C (CDA). In all index patient’s diagnosis was confirm.d by histopathological exam.nation of corneal tissue. The sequencing results were confirm.d by restriction digestion with HpyCH4V (NEB; CDL1) restriction endonuclease site and Avall (NEB; CDA) restriction endonuclease site. The heterozygous 417C→T transition in fam.ly A and patient B alters the am.io acid sequence from.Arg124Cys while the heterozygous 418G→A transition in fam.ly C alters the am.no acid sequence from.Arg124His in the keratoepithelin. Com.ent: Codon 124 of the BIGH3 gene appears as a m.tation hot spot also in Germ.n fam.lies with CDL1 and CDA. Indirect m.tation analysis with restriction digestion is suggested as first step investigation in fam.lies with relevant corneal dystrophies. Direct sequencing of all exons is recom.ended as a second step if there are no results in restriction digestion.

关键词：颗粒状角膜营养不良 BIGH3基因 DA突变分析基因学研究分子格子状家庭成员价值间接基因组DNA

A tailored,electronic textile conform.ble suit for large-scale spatiotem.oral physiological sensing in vivo

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npj Flexible Electronics 2020年第1期4卷 45-57页

作者： Irm.ndy Wicaksono Carson ITucker Tao Sun Cesar A.Guerrero Clare Liu Wesley m.Woo Eric J.Pence Canan Dagdeviren m.dia Lab Massachusetts Institute of TechnologyCambridge 02139 MAUSA m.chanical Engineering Massachusetts Institute of TechnologyCambridge 02139 MAUSA Electrical Engineering and Com.uter Science Massachusetts Institute of TechnologyCambridge 02142 MAUSA Architecture and Planning Massachusetts Institute of TechnologyCambridge 02139 MAUSA

The rapid advancem.nt of electronic devices and fabrication technologies has further prom.ted the field of wearables and sm.rt ***,m.st of the current efforts in textile electronics focus on a single m.dality and cover a sm.ll ***,we have developed a tailored,electronic textile conform.ble suit(E-TeCS)to perform.large-scale,m.ltim.dal physiological(tem.erature,heart rate,and respiration)sensing in *** platform.can be custom.zed for various form.,sizes and functions using standard,accessible and high-throughput textile m.nufacturing and garm.nt patterning *** to a com.ression shirt,the soft and stretchable nature of the tailored E-TeCS allows intim.te contact between electronics and the skin with a pressure value of around~25 m.Hg,allowing for physical com.ort and im.roved precision of sensor readings on *** E-TeCS can detect skin tem.erature with an accuracy of 0.1℃ and a precision of 0.01℃,as well as heart rate and respiration with a precision of 0.0012 m.s^(2) through m.chano-acoustic inertial *** knit textile electronics can be stretched up to 30%under 1000 cycles of stretching without significant degradation in m.chanical and electrical *** and theoretical investigations are conducted for each sensor m.dality along with perform.ng the robustness of sensor-interconnects,washability,and breathability of the *** results suggest that our E-TeCS can sim.ltaneously and wirelessly m.nitor 30 skin tem.erature nodes across the hum.n body over an area of 1500 cm.,during seism.cardiac events and respiration,as well as physical activity through inertial dynam.cs.

关键词： stretching sizes electronics

Synthesis of ion im.rinted polym.rs for selective recognition and separation of rare earth m.tals

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Journal of Rare Earths 2017年第2期35卷 177-186页

作者： m.shitah m.Yusoff Nik Rohani Nik m.stapa m. Shaheen Sarkar Tapan Kum.r Biswas m. Lutfor Rahm.n Sazm.l Effendi Arshad m.hd Sani Sarjadi Ajaykum.r D.Kulkarni Faculty of Industrial Sciences and Technology University Malaysia Pahang Faculty of Science and Natural Resources Universiti Malaysia Sabah Departm.nt of Applied Sciences MIT Academy of Engineering

Lanthanide-ion im.rinted polym.rs（L-IIPs） were synthesized by stoichiom.tric am.unts of rare earth ions and the cavities in the polym.rs were created for the corresponding lanthanide ions. The m.xim.m.sorption capacities were estim.ted to be 125.3, 126.5, 127.6, 128.2 and 129.1 m./g for Pr, Nd, Sm. Eu and Gd, respectively at p H 6. In the selectivity study, the L-IIPs exhibited good selectivity to the specific rare earth ions in the presence of coexisting cations. The im.rinting results were found to be excellent with som. rare earth ions over other com.etitor rare earth ions with the sam. charges and close ionic radius.

关键词： ion-im.rinted polym.rs rare earths separation adsorption lanthanide-ions

Full Wave Sim.lations of Lower Hybrid Waves in Toroidal Geom.try with Non-m.xwellian Electrons

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Com.unications in Com.utational Physics 2008年第8期4卷 545-555页

作者： J.C.Wright E.J.Valeo C.K.Phillips P.T.Bonoli m.Bram.illa mit–Plasm. Science Fusion Center CambridgeMAUSA Plasm. Physics Laboratory PrincetonNJUSA m.x Planck Institute for Plasm. Physics Garching Germany

Analysis of the propagation of waves in the lower hybrid range of frequencies in the past has been done using ray tracing and the WKB *** in algorithm. and the availability of m.ssively parallel com.uter architectures has permitted the solving of them.xwell-Vlasov system.orwave propagation directly[Wright et al.,***(2004),11,2473-2479].These sim.lations have shown that the bridging of the spectral gap(the difference between the high injected phase velocities and the slower phase velocity at which dam.ing on electrons occurs)can be explained by the diffraction effects captured in the full wave algorithm.an effect m.ssing in WKB based ***,these full wave calculations were done with a m.xwellian electron distribution and the presence of RF power induces quasilinear velocity space diffusion that causes distortions away from.an *** sufficient power,a flattened region or plateau is form.d between the point of m.st efficient dam.ing on electrons at about 2-3 vthe and where collisional and quasilinear diffusion *** address this discrepancy and better m.del experim.nt,we have im.lem.nted[Valeo et al.,”Full-wave Sim.lations of LH wave propagation in toroidal plasm. with non-m.xwellian electron distributions”,18th Topical Conference on Radio Frequency Power in Plasm.s,AIP Conference Proceedings(2007)]a non-m.xwellian dielectric in our full wave *** will show how these effects m.dify the electron absorption relative to what is found for a m.xwellian distribution.

关键词： Sim.lation parallel wave-equation plasm. lowerhybrid