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RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIm axis in ovarian cancer cells

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Signal Transduction and Targeted Therapy 2018年第1期3卷 96-106页

作者： Xiaojuan Lin Jianfeng Shen Dan Peng Xinhong He Congjian Xu Xiaojun Chen Janos LTanyi Kathleen montone yi fan Qihong Huang Lin Zhang Xiaomin Zhong Center for Research on Reproduction and Women’s Health University of PennsylvaniaPhiladelphiaPA 19104USA Department of Gynecology and Obstetrics Key Laboratory of Obstetrics&Gynecologic and Pediatric Diseases and Birth Defects of Ministry of EducationWest China Second HospitalSichuan UniversityChengdu 610041P.R.China Key Laboratory for Stem Cells and Tissue Engineering Ministry of EducationCenter for Stem Cell Biology and Tissue EngineeringDepartment of BiologyZhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080P.R.China Beijing Friendship Hospital Capital Medical UniversityBeijing 100050P.R.China Obstetrics and Gynecology Hospital of Fudan University Shanghai 200011P.R.China Department of Obstetrics and Gynecology University of PennsylvaniaPhiladelphiaPA 19104USA Department of Pathology and Laboratory medicine University of PennsylvaniaPhiladelphiaPA 19104USA Department of Radiation Oncology University of PennsylvaniaPhiladelphiaPA 19104USA Shanghai Respiratory Research Institute Shanghai 200032P.R.China Department of Pulmonary and Critical Care medicine Zhongshan HospitalFudan UniversityShanghai 200032P.R.China Institute of Clinical Science Zhongshan HospitalFudan UniversityShanghai 200032P.R.China

LIN28B is an evolutionarily conserved RNA-binding protein that regulates mRNA translation and miRNA let-7 maturation in embryonic stem cells and developing *** evidence demonstrates that LIN28B is activated in cancer and serves as a critical ***,the underlying molecular mechanisms of LIN28B function in tumorigenesis are still largely *** we report that LIN28B was expressed in over half of the patients with epithelial ovarian cancer who were examined(n=584).Functional experiments demonstrated that LIN28B inhibited ovarian cancer cell ***,we showed that the proapoptotic factor BIm played an essential role in the antiapoptotic function of ***-IP microarray analysis suggested that LIN28B binds to mRNAs that are associated with the DNA damage pathway,such as AKT2,in ovarian cancer *** binding to AKT2 mRNA and enhancing its protein expression,LIN28B regulated FOXO3A protein phosphorylation and decreased the transcriptional level of BIm,which antagonized the antiapoptosis activity of *** together,these results mechanistically linked LIN28B and the AKT2/FOXO3A/BIm axis to the apoptosis *** findings may have important implications in the diagnosis and therapeutics of ovarian cancer.

关键词： AKT2 diagnosis apoptosis

Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells

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Frontiers of medicine 2021年第2期15卷 252-263页

作者： Guizhen Wang Qun Zhao Hui Zhang fan Liang Chen Zhang Jun Wang Zhenyin Chen Ran Wu Hong yu Beibei Sun Hua Guo Ruie Feng Kaifeng Xu Guangbiao Zhou State Key Laboratory of molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of membrane Biology Institute of ZoologyChinese Academy of Sciences&University of Chinese Academy of SciencesBeijing 100101China Hubei University of medicine Shiyan 442000China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Pulmonary and Critical Care medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Guizhou University School of medicine Guiyang 550025China School of Chinese materia medica Beijing University of Chinese MedicineBeijing 100029China

An unexpected observation among the COVID-19 pandemic is that smokers constituted only 1.4%–18.5%of hospitalized adults,calling for an urgent investigation to determine the role of smoking in SARS-CoV-2 ***,we show that cigarette smoke extract(CSE)and carcinogen benzo(a)pyrene(BaP)increase ACE2 mRNA but trigger ACE2 protein *** induces an aryl hydrocarbon receptor(AhR)-dependent upregulation of the ubiquitin E3 ligase Skp2 for ACE2 ***2 in lung tissues of non-smokers is higher than in smokers,consistent with the findings that tobacco carcinogens downregulate ACE2 in *** carcinogens inhibit SARS-CoV-2 spike protein pseudovirions infection of the *** that tobacco smoke accounts for 8 million deaths including 2.1 million cancer deaths annually and Skp2 is an oncoprotein,tobacco use should not be recommended and cessation plan should be prepared for smokers in COVID-19 pandemic.

关键词： SARS-CoV-2 tobacco smoke benzo(a)pyrene ACE2 Skp2

金属诱导非晶硅横向晶化形成的多晶硅的生长研究

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固体电子学研究与进展 2001年第3期21卷 345-349页

作者：秦明 yuen C y Poon Vincent m C 黄庆安东南大学微电子中心南京210096 香港科技大学电子与电机工程系

详细研究了金属诱导非晶硅横向晶化时间、温度对晶化生长的影响。结果显示 ,晶化生长速度受温度影响较大 ,其最大生长速度在 6 2 5℃附近。在较高的温度下 ,非晶自发成核和晶化 ,从而限制了金属诱导晶体生长速度。镍诱导源的长度和厚度... 详细信息

详细研究了金属诱导非晶硅横向晶化时间、温度对晶化生长的影响。结果显示 ,晶化生长速度受温度影响较大 ,其最大生长速度在 6 2 5℃附近。在较高的温度下 ,非晶自发成核和晶化 ,从而限制了金属诱导晶体生长速度。镍诱导源的长度和厚度也对晶体生长有影响。

关键词：金属诱导横向晶化晶化速度镍诱导源晶化波多晶硅生长

Optimization of Casting Process for Heat and Abrasion Resistant Large Gray Iron Castings

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Tsinghua Science and Technology 2008年第2期13卷 152-156页

作者： S. m. yoo y. S. Cho C. C. Lee J. H. Kim C. H. Kim J. K. Choi Center for E-Design Korea Institute of Industrial Technology Kwanghee Casting mfg. Co. R&D Center Doosan Engine Co. Ltd.

Numerical simulations were used to optimize the casting design and conditions for large cast iron castings for marine engines, Simulations of the mold filling and solidification sequences were used to analyze the problems of previous casting conditions with marked improvements for large cylinder liner parts, The amount and positions of chills were optimized to improve the mechanical properties and to minimize the shrinkage and micro porosity in the castings. Ultra sonic testing, penetration testing, and mechanical property testing show no defects in the castings with the productivity significantly increased.

关键词： gray cast iron numerical simulation marine engine cylinder liner chill casting design optimization

大麦-双季稻轮作体系有机物料与化肥配施对大麦资源利用效率及产量的影响

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作物学报 2021年第12期47卷 2522-2531页

作者：张帆杨茜湖南省土壤肥料研究所湖南长沙410125

大麦(Hordaum vulgar L.)-双季稻轮作是长江中游典型的三熟种植制度。以开展34年的长期定位试验为平台,研究大麦-双季稻轮作模式里不同有机物料与化肥配施对冬季作物大麦光热水资源利用率、氮磷钾养分资源利用率及产量的影响,以期为资... 详细信息

大麦(Hordaum vulgar L.)-双季稻轮作是长江中游典型的三熟种植制度。以开展34年的长期定位试验为平台,研究大麦-双季稻轮作模式里不同有机物料与化肥配施对冬季作物大麦光热水资源利用率、氮磷钾养分资源利用率及产量的影响,以期为资源高效利用与大麦稳产增效的大麦-双季稻轮作模式施肥管理提供理论依据和数据支撑。结果表明:(1)有机肥氮替代60%化学氮处理(NPK+HOm)的光能生产效率、积温生产效率、水分生产效率比化肥氮磷钾+水稻秸秆处理(NPK+straw)分别提高了0.04 g mJ^(-1)、0.28 kg℃^(-1)d^(-1)hm^(-2)、0.08 kg m^(-3),增幅分别为10.5%、9.4%、9.6%(Pm)N、P、K养分偏生产力比NPK+straw处理分别提高了22.5%、23.4%、23.5%(Pm和NPK+HOm处理的NPK养分偏生产力和N素收获指数差异不显著;(3)大麦产量的稳定性与可持续性分析表明,NPK+straw处理有利于大麦稳产;(4)NPK+HOm处理能提高土壤肥力。综合来看,NPK+HOm处理在大麦光热水资源利用率和土壤培肥上优于其他施肥结构;NPK+LOm处理在大麦NPK养分资源利用率上优于其他施肥结构;NPK+LOm和NPK+HOm处理均能提高大麦产量。对大麦-双季稻轮作模式,秸秆还田结合有机肥与化肥配施调控大麦资源利用率与产量的协同提高是今后重要研究任务之一。

关键词：大麦大麦-双季稻轮作有机物料与化肥配施资源利用效率产量

Permo–Triassic and Liassic Tethyan Oceanic Tracts within the Pontide Belt Along the Southern margin of Eurasia, Northern Anatolia

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Acta Geologica Sinica(English Edition) 2017年第S1期91卷 33-34页

作者： E.SARIFAKIOGLU y.DILEK m.SEVIN S.PEHLIVAN O.K EmIR A.mOLLER T.BAyANOVA I.UySAL m.KELES General Directorate of mineral Research & Explor Department of Geology & Env.Earth Science Miami University The University of Kansas Department of Geology Geol.Inst.of the Kola Science Centre of the RAS Dept.of Geol.Engineering Karadeniz Technical University makro yet.madencilik

The Pontide belt in northern Turkey includes three major tectonic terranes,the Strandja massif（Sj m）,and the Istanbul（ISZ）and Sakarya Zones（SZ）(Fig.1).We present new age and geochemical data from ophiolites and ophiolitic mélanges within the Sakarya Zone and show that these mafic–ultramafic rocks are the remnants of Tethyan oceanic lithosphere formed in different tectonic *** main ophiolite occurrences investigated in this study along the Karakaya Suture（KS）are associated with the latest Triassic Cimmeride orogeny,and in the Küre–yusufeli ophiolite belt are part of the Alpide *** Karakaya Suture Zone ophiolites in northern west Turkey are comprised mainly of the Denizgoren（?anakkale）ophiolite,Bo?azk?y（Bursa）,Geyve（Sakarya）,Almac?k（Düzce）and?ele（Bolu）*** Denizg?ren ophiolite largely contains upper mantle peridotites,which are equivalents of the Permo–Triassic Lesvos peridotites and mélange units farther SW in the northern Aegean *** Bo?azk?y ophiolite includes serpentinite and metagabbro,and the Almac?k and Geyve ophiolites display an almost complete Penrose–type sequence consisting of serpentinizeduppermantleperidotites,cumulate ultramafic–mafic rocks,isotropic gabbros,dolerite and plagiogranite dikes,and extrusive rocks.U–Pb zircon dating of plagiogranite dikes from?ele has revealed an igneous age of 260 ma,and 255,235,227 ma from Almac?k（Bozkurt et al.,2012a,b）.Consistent with the previouslypublished Permo–Triassic age,we obtained a 268.4±6.3 ma U–Pb zircon age from a plagiogranite dike within the Almacik ophiolite to the *** KS ophiolite belt containing the?ele,Almac?k,Geyve ophiolites within the SZ extends westward into the Armutlu Peninsula and then into the Biga Peninsula（***?ren ophiolite）and most likely connects with the remnants of the Triassic meliata–meliac ocean basin（Stampfli and Borel,2002）in the Balkan *** KS ophiolites also continue eastward within the Pontide Belt into the Elekda?ophiolite（e

关键词： Triassic and Liassic Tethyan Oceanic Tracts within the Pontide Belt Along the Southern margin of Eurasia rock KS Pb Permo Northern Anatolia

Impact of the Three Gorges Dam on Regulation and Storage Capacity of Poyang Lake

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Journal of Landscape Research 2020年第6期12卷 50-55页

作者： CHEN mofei fan Shaoying DENG Jinyun WANG Xiaopeng Changjiang Institute of Survey PlanningDesign and ResearchWuhanHubei 430010China yellow River Hydropower Development Corporation JiyuanHenan 459017China State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhanHubei 430072China yellow River Engineering Consulting Co. Ltd.ZhengzhouHenan 450003China

The regulation and storage capacity of Poyang Lake is infl uenced by the fl ow from the main stream of the yangtze River and the fi ve rivers in the Poyang Lake *** the operation of the Three Gorges Dam(TGD),hydrological changes in the main stream of the yangtze River impact water exchange between the yangtze River and Poyang *** on the analysis of measured data and factors infl uencing outfl ow at Hukou station,a new empirical formula describing outfl ow at Hukou station and critical water level for lake storage capacity is *** change in monthly storage capacity of Poyang Lake before and after the construction of the TGD is analyzed *** results show that the fl ows from the main stream of the yangtze River and the fi ve rivers in the Poyang Lake basin affect outfl ow and water storage capacity by changing the water level difference between Xingzi and Hukou stations and by changing the water level at Hukou *** the yangtze River and the fi ve rivers in the Poyang Lake basin differ in process and *** the water level at Hukou station remains consistent,when the fl ow from the fi ver rivers increases by 1,000 m3/s,the outfl ow at Hukou station increases by 304 m3/*** the fl ow from the main stream of the yangtze River increases by 1,000 m3/s,the outfl ow at Hukou station decreases by 724 m3/*** addition,the operation of the TGD affects the water storage capacity of Poyang *** water volume of Poyang Lake decreases by 49.4%in September,but increases by 47.7%in may.

关键词： Stage–discharge relation Regulation and storage capacity of Poyang Lake Water exchange Three Gorges Dam

Wuzi yanzong Pill Plays A Neuroprotective Role in Parkinson’s Disease mice via Regulating Unfolded Protein Response mediated by Endoplasmic Reticulum Stress

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Chinese Journal of Integrative medicine 2023年第1期29卷 19-27页

作者： LI yan-rong fan Hui-jie SUN Rui-rui JIA Lu yANG Li-yang ZHANG Hai-fei JIN Xiao-ming XIAO Bao-guo mA Cun-gen CHAI Zhi The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation method to Treat multiple Sclerosis of State Administration of Traditional Chinese medicine Shanxi University of Chinese MedicineJinzhongShanxi Province030619China Institute of Brain Science Department Neurology of First Affiliated HospitalShanxi Datong UniversityDatongShanxi Province037009China Department of Anatomy and Cell Biology Department of Neurological SurgerySpinal Cord and Brain Injury Research GroupStark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisIN46202USA Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai200025China

Objective:To investigate the protective effects and its possible mechanism of Wuzi yanzong Pill(WyP) on Parkinson’s disease(PD) model ***:Thirty-six C57BL/6 male mice were randomly assigned to 3 groups including normal,PD,and PD+WyP groups,12 mice in each *** week of intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(mPTP) was used to establish the classical PD model in ***,mice in the PD+WyP group were administrated with 16 g/kg WyP,twice daily by *** 14 days of administration,gait test,open field test and pole test were measured to evaluate the movement *** hydroxylase(TH) neurons in substantia nigra of midbrain and binding immunoglobulin heavy chain protein(GRP78) in striatum and cortex were observed by *** levels of TH,GRP78,p-PERK,p-elF2α,ATF4,p-IRE1α,XBP1,ATF6,CHOP,ASK1,p-JNK,Caspase-12,-9 and-3 in brain were detected by Western ***:Compared with the PD group,WyP treatment ameliorated gait balance ability in PD mice(Pmilarly,WyP increased the total distance and average speed(Pme and pole time(Pmoreover,WyP significantly increased TH positive cells(Pmmunofluorescence showed WyP attenuated the levels of GRP78 in striatum and ***,WyP treatment significantly decreased the protein expressions of GRP78,p-PERK,p-elF2α,ATF4,p-IRE1α,XBP1,CHOP,Caspase-12 and Caspase-9(PyP ameliorated motor symptoms and pathological lesion of PD mice,which may be related to the regulation of unfolded protein response-mediated signaling pathway and inhibiting the endoplasmic reticulum stress-mediated neuronal apoptosis pathway.

关键词： Wuzi yanzong Pill Parkinson’s disease dopaminergic neurons endoplasmic reticulum stress apoptosis

Synthesis and characterization of nanocrystalline Ni produced by cryomilling in liquid nitrogen

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Rare metals 2007年第2期26卷 147-151页

作者： yANG Bin fan Jianzhong HAO Bin TIAN Xiaofeng CHENG Junsheng ZHANG Jishan State Key Laboratory for Advanced metals and materials University of Science and Technology Beijing Beijing 100083 China International Centre for materials Physics Chinese Academy of Sciences Shenyang 110016 China National Engineering and Technology Research Center for Nonferrous metals Composites General Research Institute for Nonferrous Metals Beijing 100088 China

NanocrystaUine Ni powders were successfully fabricated by mechanically milling at cryogenic temperature （cryomilling） with 1 wt.%y2O3 particles. The experimental results have shown that the Ni grain size is reduced to 25 nm after 2 h of cryomilling in the presence of the y2O3 particles. The cryomiUed Ni/y2O3 powders can maintain their nanocrystalline structure up to 900℃, or 62% of the melting point of Ni. A bulk nanocrystalline Ni/y2O3 material with a thermally stable grain size of approximately 100 nm was produced by cryomilling, cold isostatic pressing, followed by hot isostatic pressing. The microhardness of bulk nanocrystalline Ni/1wt.%y2O3 is 315 DPH, which is two times as high as that of conventional Ni.

关键词： nanocrystalline mechanical milling nickel characterization