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Asian Pacific Journal of Tropical medicine 2011年第10期4卷 786-790页

作者： m Rowshahul Habib m rezaul karim Department of Biochemistry and molecular Biology Faculty of ScienceRajshahi UniversityRajshahi-6205Bangladesh

Objective:To investigate experimentally the possible antitumor effect of methanol extract(mE) of Calotropis gigantea L.(***) root bark and its petroleum ether(PEF) and chloroform(CF) soluble fractions against Ehrlich ascites carcinoma(EAC) in Swiss albino ***:The effects of mE(10 and 20 mg/kg),PEF(40 and 80 mg/kg) and CF(20 and 40 mg/kg) on the growth of EAC and life span of EAC bearing mice were *** profile and biochemical parameters(SAI.P,SGPT and SCOT) were also ***:Results of in vivo study showed a significant decrease in viable tumor cell count and a significant increase of life span in the mE and CF treated group compared to untreated *** life span of mE and CF treated animals was significandy(Pmg mE/kg) and 57.07%(40 mg CF/kg).mE and CF brought back the hematological parameter more or less normal *** and CF also restored the altered levels of serum alkaline phosphatase(SALP) and serum glutamate oxaloacetate transaminase(SGOT).Conclusions:methanol extract(mE) of *** root bark and its chloroform soluble fraction(CF) possesses significant antitumor activity.

关键词： Calotropis gigantea Antitumor Ehrlich ascites carcinoma Root bark

Tagetes erecta *** its mosquitocidal potency against Culex quinquefasciatus

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Asian Pacific Journal of Tropical Biomedicine 2011年第3期1卷 186-188页

作者： Farjana Nikkon m Rowshanul Habib Zahangir Alam Saud m rezaul karim Department of Biochemistry and molecular Biology Rajshahi University

Objective:To investigate mosquitocidal effects of ethanolic extract of(lowers of Tagetes erecta(***) and its chloroform and petroleum ether soluble fractions against the larvae of Culex quinquefasciatus(***).methods:The fresh flowers of *** were extracted in cold with ethanol(5.0 L) and after concentration,the ethanol extract was fractionated with chloroform and petroleum ether to afford a brownish syrupy suspension of ethanol extract(50.0 g),petroleum ether soluble fraction(18.6 g) and chloroform soluble fraction(23.8 g).The larvicidal effect of ethanol extract and their solvent fractions were determined by the standard procedure of WHO against different instars of ***:Among the tested samples the chloroform soluble fractions showed the highest toxicity and consequently,the lowest LC_(50) values(14.14 μ g/mL,17.06 μ g/mL.36.88 μ g/mL and 75.48 μ g/mL) for all the instars larvae of *** larvae showed comparative tolerance in the course of increasing age and ***:It can be concluded that the flowers of *** are very effective natural larvicide and could be useful against ***.

关键词： Tagetes erecta Linn. Culex quinquefasciatus Say mosquitocidal Larvae Larvicidal effect Toxicity

Inhibition of Ehrlich ascites carcinoma by manilkara zapota *** bark in Swiss albino mice

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Asian Pacific Journal of Tropical Biomedicine 2011年第6期1卷 448-451页

作者： m Abu Osman m mamunur Rasbid m Abdul Aziz m Rowshahul Habib m rezaul karim Department of Biochemistry and molecular Biology Faculty of ScienceRajshahi University

Objective:To evaluate the antitumor activity of manilkara zapota(***) *** bark against Ehrlich ascites carcinoma(EAC) in Swiss albino ***:The in vivo antitumour activity of the ethyl acetate extract of stem bark of *** L.(EASm) was evaluated at 50,100 and 200 mg/kg bw against EAC using mean survival *** administration of the extract of ***,viable EAC cell count and body weight in the EAC tumour hosts were *** animal was also observed for improvement in the haematological parameters(e.g.,heamoglobin content,red and white blood cells count and differential cell count) after EASm treatment. Results:Intraperitoneal administration of EASm reduced viable EAC cells,increased the survival lime,and restored altered haematological *** efficacy was observed for EASm at 100 mg/kg dose(Pm bark of *** *** significant antitumour activity.

关键词： manilkara zapota Antitumour activity Stem bark Ehrlich ascites carcinoma Haematological parameter

Analysis of a Composition Operator’s Eigenvalue Equation on Unitary Spaces by the Krein-Rutman Theorem

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Applied mathematics 2020年第2期11卷 76-83页

作者： A.N.m.rezaul karim Department of Computer Science&Engineering International Islamic University ChittagongBangladesh

The Krein-Rutman theorem is vital in partial differential equations that are non-linear and provides evidence of the presence of several significant eigenvalues useful in topological degree calculations, stability analysis, and bifurcation theory. Schr?der’s equation which has been used extensively in studies of turbulence is an equation with a single independent variable suitable for encoding self-similarity. The concept of Hilbert spaces has been an inner product space frequently used due to its convenience in countless dimensional vector analysis. This paper is aimed at proving a number of solutions through the Krein-Rutman theorem in unitary spaces especially in Hilbert spaces. It has been certainly observed that the whole Krein-Rutman theorem system has a fairly stable scope, and has strong regular features, and many non-linear elliptic operators need the most ethical principles to satisfy the comparison policy.

关键词： Krein-Rutman Theorem Unitary Space Bounded Solutions Diagonalization Schroder Equation

Determination of hemoglobin adduct of a musk xylene metabolite in trout as biomarker of exposure by gas chromatography mass spectrometry

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Journal of Environmental Sciences 2005年第6期17卷 989-992页

作者： mohammad Abdul karim mohammad rezaul Department of Chemistry and Biochemistry Baylor University P.O. Box 97348 Waco TX 76798-7348 USADepartment of Biochemistry and Molecular Biology University of Rajshahi Rajshahi 6205 Bangladesh

musk xylene（mX） is frequently used as fragrances in formulation of personal care products. Quantification of a bound 4-amino- mX（4-AmX） as cysteine adducts in trout hemoglobin（Hb） was made by gas chromatography-ion trap-mass spectrometry（GC/mS）. The Hb samples were collected from trout after 24 h exposure to mX at 10μg/g, and or menhaden oil（control）. The formation of cysteine-Hb adduct was observed from nitroso derivative of mX, released by alkaline hydrolysis. The released 4-AmX metabolite was extracted in n- hexane. The extract was then reduced by evaporation, and analyzed by GC/mS. When similar agreement of mass spectral features and retention time of 4-AmX were obtained in both standard and sample solutions, the presence of 4-AmX metabolite in the Hb was confirmed. The concentration of 4-AmX was found to be 3.1 × 10^-6 6.9 × 10^-6 mg/g in the Hb solution. Quantitation was made based on an internal standard, a calibration plot, and response factor. In the non-hydrolyzed and laboratory blank extracts, the 4-AmX metabolite was not detected. Additionally, coeluting and interfefing ions were observed in the biological samples.

关键词： biomarkers musk xylene metabolite Hb adducts fish exposure

Divide and recombine approach for warranty database: estimating the reliability of an automobile component

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Data Science and management 2024年第2期7卷 119-128页

作者： md rezaul karim Department of Statistics University of RajshahiRajshahi6205Bangladesh

The continuously updated database of failures and censored data of numerous products has become large, and on some covariates, information regarding the failure times is missing in the database. As the dataset is large and has missing information, the analysis tasks become complicated and a long time is required to execute the programming codes. In such situations, the divide and recombine (D&R) approach, which has a practical computational performance for big data analysis, can be applied. In this study, the D&R approach was applied to analyze the real field data of an automobile component with incomplete information on covariates using the Weibull regression model. model parameters were estimated using the expectation maximization algorithm. The results of the data analysis and simulation demonstrated that the D&R approach is applicable for analyzing such datasets. Further, the percentiles and reliability functions of the distribution under different covariate conditions were estimated to evaluate the component performance of these covariates. The findings of this study have managerial implications regarding design decisions, safety, and reliability of automobile components.

关键词： Weibull regression model Warranty database Reliability Em algorithm Divide and recombine approach managerial implications

Cell cycle regulation through primary cilium:A long-forgotten story

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BIOCELL 2021年第4期45卷 823-833页

作者： LIN LIU ZHOUWEN XU YUYAN JIANG mD rezaul karim XIAO HUANG Institute of Cell and Developmental Biology College of Life SciencesZhejiang UniversityHangzhou310058China

Protruded from cytomembrane,primary cilium is a widespread cell organelle that can be found in almost all cell types in *** of its comprehensive requirement in various cellular activities and various functions in different organs,primary cilium has been a valuable research area of human pathology research since the turn of the *** the potential application of the interaction between primary cilia and cell cycle regulation may be the most promising direction as many primary cilium-caused diseases are found to be caused by cell cycle dysregulation resulted from primary cilia ***,a deep understanding of the interaction between primary cilia and the cell cycle is in great *** in this review,we mainly described how the interaction between primary cilia and cell cycle proceeds and demonstrated three hypotheses raised from much different *** hypotheses include(1)Primary cilium as a cellular signaling hub to regulate the cell cycle,(2)Primary cilium as a reservoir of cell cycle regulation-related factors,and(3)Primary cilium as a cell cycle checkpoint or a ***,we also call for more attention on research of interaction between cell cycle and primary cilia and tried to point out some possible research directions for those who are interested.

关键词： Signaling pathway Cell cycle checkpoint Ciliopathy Cancer

How do board features and auditor characteristics shape key audit matters disclosures?Evidence from emerging economies

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China Journal of Accounting Research 2023年第4期16卷 51-69页

作者： md mustafizur Rahaman md.rezaul karim UQ Business School The University of QueenslandBrisbaneQLD 4072Australia Department of Accounting and Information Systems University of DhakaDhaka 1000Bangladesh

This study examines how corporate board features and auditor characteristics in Bangladesh influence the disclosure of key audit matters(KAm)in annual reports from 2018 to *** ordinary least squares(OLS)regressions,the study finds that factors such as chair gender,the presence of women on the board,audit committee(AC)size,auditor tenure,and client-auditor relationship significantly affect KAm ***,AC expertise,family CEO succession,and board political connections do not have significant ***,having a family member CEO with a long-tenured auditor has a negative association with KAm disclosure,while a politically connected family CEO has a positive association with such ***,Big-4 auditors of important clients are negatively associated with KAm disclosure.

关键词： Key audit matters Board characteristics Auditor characteristics Corporate governance Bangladesh

Allometric relationship for estimating above-ground biomass of Aegialitis rotundifolia Roxb. of Sundarbans mangrove forest, in Bangladesh

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Journal of Forestry Research 2012年第1期23卷 23-28页

作者： mohammad Raqibul Hasan Siddique mahmood Hossain md. rezaul karim Chowdhury Forestry and Wood Technology Discipline Khulna University Khulna-9208 Bangladesh

Tree biomass plays a key role in sustainable management by providing different aspects of ecosystem. Estimation of above ground biomass by non-destructive means requires the dex;elopment of allometric equations. most researchers used DBH （diameter at breast height） and TH （total height） to develop allometric equation for a tree. Very few spe- cies-specific allometric equations are currently available for shrubs to estimate of biomass from measured plant attributes. Therefore, we used some of readily measurable variables to develop allometric equations such as girth at collar-height （GcH） and height of girth measuring point （GmH） with total height （TH） for A. rotundifolia, a mangrove species of Sundarbans of Bangladesh, as it is too dwarf to take DBH and too ir- regular in base to take Girth at a fixed height. Linear, non-linear and logarithmic regression techniques were tried to determine the best re- gression model to estimate the above-ground biomass of stem, branch and leaf. A total of 186 regression equations were generated from the combination of independent variables. Best fit regression equations were determined by examining co-efficient of determination （R：）, co-efficient of variation （Cv）, mean-square of the error （ms^r）, residual mean error （Rmax）, and F-value. multiple linear regression models showed more efficient over other types of regression equation. The performance of regression equations was increased by inclusion of Gmn as an independ- ent variable along with total height and GCH.

关键词： Aegialitis rotundifolia allometry biomass mangroves sundarbans

Responses of Aerobic Rice (Oryza sativa L.) to Iron Deficiency

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Journal of Integrative Agriculture 2012年第6期11卷 938-945页

作者： SHI Rong-li HAO Hong-mei FAN Xiao-yun md rezaul karim ZHANG Fu-SUO ZOU Chun-qin Key Laboratory of Plant-Soil Interaction Ministry of Education/Center for ResourcesEnvironment and Food SecurityDepartment of Plant NutritionChina Agricultural University

Aerobic rice has the advantage of saving water. most published work has focused on improving its yield, while few reported on its micronutrient status. In fact, Fe deficiency is a common nutritional problem in the production of aerobic rice. Short- term hydroponic culture experiments were conducted to study the response of aerobic rice to Fe deficiency and the effect of root exudates from Fe-deficient wheat on its Fe uptake ability. The results indicate that the amount of phytosiderophores （PS） released from aerobic rice did not increase under Fe deficient conditions. The Fe（III） reducing capacity of Fe-deficient aerobic rice did not increase and the solution pH did not decrease significantly. What＇s more, no obvious swelling was observed in the root tips. Aerobic rice did not show special responses to improve their Fe nutrition under Fe deficiency as both strategy I and II plants though they were very sensitive to Fe deficiency. This may be a reason which causes Fe deficiency problem in aerobic rice. However, root exudates from Fe-deficient wheat （PSw） could improve its Fe nutrition in the presence of insoluble Fe（OH）3. This suggests that aerobic rice could utilize Fe activated by PSw.

关键词： aerobic rice Fe(III)-reduction iron nutrition phytosiderophore release root tip swelling