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Room for improvement: Patterns of referral misdiagnosis to a vascular anomalies center

Open Journal of Pediatrics 2013年第4期3卷 331-336页

作者： Daniel E. Levin Allison L. Speer James R. pierce Donna Nowicki Alex Arkader Philip Stanley Andre Panossian Dean m. Anselmo Vascular Anomalies Center Children’s Hospital Los Angeles University of Southern California Los Angeles USA

Objective: Vascular anomalies are a diagnostic and therapeutic challenge. Errors in diagnosis lead to treatment delay, inappropriate interventions and prolonged suffering. The aim of this study was to analyze patterns of misdiagnosis among patients referred to a vascular anomalies center (VAC). This will better define the problem and may be used to refine and improve referral guidelines for patients with vascular anomalies. Patients and methods: After IRB approval, we performed a single-center retrospective review of all patients referred to a vascular anomaly between January 1, 2008 and December 15, 2011. Evaluation of both referral and final diagnosis was made. Data regarding accuracy of diagnosis were determined and compared for both vascular tumors and malformations. Results: mean age was 7.9 ± 7.7 (13 days - 66 years). 42% had a correct diagnosis at the time of referral. Vascular tumors were correctly diagnosed more often than vascular malformations (58% vs 38%). The most common misdiagnosis for infantile hemangioma (IH) was venous malformation (Vm). The most common misdiagnosis for Vm was IH. Nonspecific and historical terms such as “mass”, “lymphangioma”, and “cavernous hemangioma” frequently appear as the referral diagnosis. Conclusion: Referral misdiagnosis is common. IH and Vm are frequently confused and if there is any uncertainty in the diagnosis, these patients should also be referred to a VAC, in addition to the more complicated anomalies. Outdated nomenclature remains prevalent and continued efforts should be made to adhere to International Society for the Study of Vascular Anomalies (ISSVA) classification. Improvements in diagnostic accuracy are likely to greatly improve patients’ care.

关键词： Vascular Anomaly misdiagnosis Venous malformation Infantile Hemangioma Arteriovenous malformation Vascular Anomalies Center

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生活中还需要学会放弃

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疯狂英语（初中天地） 2014年第4期 16-19页

作者： David pierce Susan

在很多人眼里，“quitter”往往是贬义词，用来形容一个人轻易放弃。我们自小就被灌输一种思想：如果你跌倒了，不要放弃，站起来，继续。但我们是否要不顾一切地坚持，即使我们坚持的方向是错的呢？

关键词：放弃学会生活贬义词灌输

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OEm汽车涂装车间技术的环境生命周期评价(二)

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中国涂料 2014年第11期29卷 25-30页

作者： C. Jason pierce Josh Seeley Eastman Chemical company

生命周期评价(LCA)是一种评价产品系统的环境影响和环境权衡的标准化方法。伊士曼化工公司完成了一项"从涂料到成品车涂装"的LCA研究,在该研究中,比较了5种有代表性的OEm汽车涂装车间工艺配置的温室气体(GHG)影响和挥发性有机化合物(VOC... 详细信息

生命周期评价(LCA)是一种评价产品系统的环境影响和环境权衡的标准化方法。伊士曼化工公司完成了一项"从涂料到成品车涂装"的LCA研究,在该研究中,比较了5种有代表性的OEm汽车涂装车间工艺配置的温室气体(GHG)影响和挥发性有机化合物(VOC)排放性能。涂装车间数据由IHS提供。这些工艺配置包括:1)三涂两烘(3C2B)水性(WB)底色漆和1K罩光清漆;2)3C2B WB底色漆和2K罩光清漆;3)3C2B低固含溶剂型底色漆和1K罩光清漆;4)三涂一烘(3C1B)高固含溶剂型底色漆和1K罩光清漆;5)3C1B WB底色漆和1K罩光清漆。本研究的目标是通过比较通用工艺技术类别来帮助理解差异和制定决策。本研究的结论是,3C1B高固含溶剂型工艺可以实现最低的GHG释放量,同时达到欧洲现行的VOC排放限值35 g/m2。但是,如果世界上某些地区的OEm选择不采用VOC减排技术,那么为了达到排放限值35g/m2,需要采用WB技术。这项LCA研究表明,高固含溶剂型技术是对环境影响最小,有利于可持续性发展的技术,建议政策制定者和利益相关者予以考虑。

关键词：生命周期评价 LCA 涂装车间汽车温室气体 GHG

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OEm汽车涂装车间技术的环境生命周期评价(一)

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中国涂料 2014年第10期29卷 22-26页

作者： C.Jason pierce Josh Seeley Eastman Chemical company

关键词：生命周期评价 LCA 涂装车间汽车温室气体 GHG

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α-干扰素对慢性髓细胞白血病骨髓纤维化的治疗效应

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德国医学 2000年第1期17卷 22-24页

作者： m.Wilhelm C.Bueso-Ramos SO'Brien S.pierce m.Keating m.Talpaz Hm.Kantarjian 何冬梅 medizinische Poliklinik University of Würzburg Germany 广州暨南大学医学院

慢性髓细胞白血病(CmL)是多能干细胞的克隆性疾病。它具有特征性的染色体 t(9;22)(q34;q11)易位,形成 Ph 染色体。许多研究表明,CmL 的自然病程涉及骨髓网硬蛋白进行性的堆积,尽管进展的速度各不相同。推测骨髓重度纤维化和 CmL 的加速... 详细信息

慢性髓细胞白血病(CmL)是多能干细胞的克隆性疾病。它具有特征性的染色体 t(9;22)(q34;q11)易位,形成 Ph 染色体。许多研究表明,CmL 的自然病程涉及骨髓网硬蛋白进行性的堆积,尽管进展的速度各不相同。推测骨髓重度纤维化和 CmL 的加速期或急变期的发展密切相关,两者都与预后差有关。另外,骨髓纤维化引起骨髓衰竭并发症。

关键词：慢性白血病骨髓纤维化 CmL α-干扰素

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International expert consensus on laparoscopic pancreaticoduodenectomy

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 464-483页

作者： Renyi Qin michael L.Kendrick Christopher L.Wolfgang Barish H.Edil Chinnusamy Palanivelu Rowan WParks Yinmo Yang Jin He Taiping Zhang Yiping mou Xianjun Yu Bing Peng Palanisamy Senthilnathan Ho-Seong Han Jae Hoon Lee michiaki Unno Steven WmOlde Damink Virinder Kumar Bansal pierce Chow Tan To Cheung Nim Choi Yu-Wen Tien Chengfeng Wang manson Fok Xiujun Cai Shengquan Zou Shuyou Peng Yupei Zhao Department of Biliary-Pancreatic Surgery Affiliated Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina mayo Clinic RochesterMNUSA Division of Surgical Oncology Department of SurgeryThe John Hopkins University School of MedicineBaltimoreMDUSA Department of Surgery University of OklahomaOklahoma CityOKUSA Department of Surgical Gastroenterology and Hepatopancreatobiliary Surgery GEM Hospital and Research CentreCoimbatoreTamil NaduIndia Clinical Surgery Royal Infirmary of Edinburgh and University of EdinburghEdinburghUK Department of General Surgery Peking University First HospitalBeijingChina Department of Surgery Johns Hopkins Medical InstitutionsBaltimoreMDUSA Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Gastroenterology and Pancreatic Surgery Zhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhouChina Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterFudan UniversityShanghaiChina Department of Pancreatic Surgery West China HospitalSichuan UniversityChengduChina Department of Surgery Seoul National University College of MedicineSeoul National University Bundang HospitalSeoulKorea Division of Hepatopancreatobiliary Surgery Department of SurgeryAsan Medical CenterSeoulKorea Department of Surgery Tohoku University Graduate School of MedicineSendaiJapan Department of Surgery NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical CentreMaastrichtThe Netherlands Department of Surgical Disciplines All India Institute of Medical SciencesNew DelhiIndia Department of Hepatopancreatobiliary and Transplant Surgery Singapore General HospitalSingaporeSingapore Department of Surgery The University of Hong KongQueen Mary HospitalHong KongChina Department of General Surgery Hospital Conde S.JanuárioMacaoChina Department of Surgery National Ta

Importance:While laparoscopic pancreaticoduodenectomy(LPD)is being adopted with increasing enthusiasm worldwide,it is still challenging for both technical and anatomical ***,there is no consensus on the technical standards for ***:The aim of this consensus statement is to guide the continued safe progression and adoption of *** Review:An international panel of experts was selected based on their clinical and scientific expertise in laparoscopic and open *** were produced upon reviewing the literature and assessed by the members of the expert *** literature search and its critical appraisal were limited to articles published in English during the period from 1994 to *** Web of Science,medline,and Cochrane Library and Clinical Trials databases were searched,The search strategy included,but was not limited to,the terms'laparoscopic','pancreaticoduodenectomy,'pancreatoduodenectomy','Whipple's operation',and'minimally invasive surgery'.Reference lists from the included articles were manually checked for any additional studies,which were included when *** method was used to establish expert consensus and the AGREE II-GRS Instrument was applied to assess the methodological quality and externally validate the final *** statements were further discussed during a one-day face-to-face meeting at the 1st Summit on minimally Invasive Pancreatico-Biliary Surgery in Wuhan,***:Twenty-eight international experts from 8 countries constructed the expert *** statements were produced by the members of the expert *** least 80%of responders agreed with the majority(80%)of *** than three randomized controlled trials published to date,most evidences were based on level 3 or 4 studies according to the AGREE II-GRS *** and Relevance:The Wuhan international expert consensus meeting on LPD has produced a set of clinical practice statement

关键词： Consensus pancreaticoduodenectomy laparoscopy Delphi technique

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兒童时期急性白血病

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中华儿科杂志 1958年第6期9卷

作者： pierce m. I.

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TLR2 and TLR4 in Parkinson’s disease pathogenesis:the environment takes a toll on the gut

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Translational Neurodegeneration 2021年第4期10卷 611-629页

作者： Anastazja m.Gorecki Chidozie C.Anyaegbu Ryan S.Anderton School of Biological Science University of Western AustraliaCrawleyWAAustralia Neurodegenerative Disorders Research Group Perron Institute for Neurological and Translational ScienceNedlandsWAAustralia Curtin Health Innovation Research Institute Ralph and Patricia Sarich Neuroscience Research InstituteCurtin UniversityNedlandsWAAustralia Faculty of medicine Nursing and Midwifery and Faculty of Health SciencesUniversity of Notre Dame AustraliaFremantleWAAustralia School of Nursing MidwiferyHealth Sciences and PhysiotherapyUniversity of Notre Dame AustraliaFremantleWAAustralia

Parkinson's disease(PD)is an incurable,devastating disorder that is characterized by pathological protein aggregation and neurodegeneration in the substantia *** recent years,growing evidence has implicated the gut environment and the gut-brain axis in the pathogenesis and progression of PD,especially in a subset of people who exhibit prodromal gastrointestinal ***,perturbations of gut homeostasis are hypothesized to contribute toα-synuclein aggregation in enteric neurons,which may spread to the brain over decades and eventually result in the characteristic central nervous system manifestations of PD,including neurodegeneration and motor ***,the mechanisms linking gut disturbances andα-synuclein aggregation are still unclear.A plethora of research indicates that toll-like receptors(TLRs),especially TLR2 and TLR4;are critical mediators of gut *** their established role in innate immunity throughout the body,studies are increasingly demonstrating that TLR2 and TLR4 signalling shapes the development and function of the gut and the enteric nervous ***,TLR2 and TLR4 are dysregulated in patients with PD,and may thus be central to early gut dysfunction in *** better understand the putative contribution of intestinal TLR2 and TLR4 dysfunction to earlyα-synuclein aggregation and PD,we critically discuss the role of TLR2 and TLR4 in normal gut function as well as evidence for altered TLR2 and TLR4 signalling in PD;by reviewing clinical,animal model and in vitro *** evidence on the immunological aetiology ofα-synuclein aggregation is also discussed,with a focus on the interactions ofα-synuclein with TLR2 and *** propose a conceptual model of PD pathogenesis in which microbial dysbiosis alters the permeability of the intestinal barrier as well as TLR2 and TLR4 signalling,ultimately leading to a positive feedback loop of chronic gut dysfunction promotingα-synuclein aggregation in enteric an

关键词： Parkinson’s disease TLR2 TLR4 α-Synuclein Gut-brain axis Gut barrier Gut homeostasis

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Changes in free amino acids and polyamine levels in Satsuma leaves in response to Asian citrus psyllid infestation and water stress

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Insect Science 2014年第6期21卷 707-716页

作者： Nasir S. A. malik Jose L. Perez madhurababu Kunta Joseph m. Patt Robert L. mangan USDA-ARS ERRC 600 E Mermaid lane Wyndmoor PA 19038-8598 USDA-ARS SPARC 2881 F&B Road College Station TX 77845 Texas A&m University-Kingsville Citrus Center 312 North International Blvd Weslaeo TX 78596 U. S. Horticultural Research Laboratory 2001 South Rock Road Fort Pierce FL 34945 Subtropical Horticultural Research Station 13601 Old Coulter Road Miami FL 33158 USDA-ARS 2413 E. Hwy 83 Weslaco TX 78596 USA

The effects of biotic and abiotic stresses on changes in amino acids and polyamine levels in Satsuma orange （Citrus unshiu; cultivar Owari） leaves were inves- tigated. Asian citrus psyllids Diaphorina citri （Kuwayama）（ACP） infestation was used to induce biotic stress while a water deficit was imposed to induce abiotic stress. Potted trees were infested by placing 50 psyllids on 3 citrus leaves enclosed in nylon mesh bags for 5 d. A parallel set of plants were kept water stressed by maintaining the soil at 20% water holding capacity for 5 d. Levels of total free amino acids were higher in water stressed and ACP infested leaves. Polyamine putrescine increased in infested leaves but not in water stressed leaves. Proline was the most abundant amino acid and its levels significantly increased by both biotic and abiotic stresses. Proline levels in infested leaves were significantly higher than the water stressed leaves. Histidine, methionine, asparagine, arginine, serine, and leucine levels also increased significantly in infested leaves, but in water stressed leaves only leucine, methionine, and threonine increased. Levels of amino acids, such as tyrosine, isoleucine, phenylalanine, glutamic acid, and alanine, declined in infested leaves. Under water stress asparagine, phenylalanine, serine, and histidine also declined compared to controls. This indicates that while proteolysis occurred under both stresses, metabolic conversion of amino acids was different under the two stresses. In ACP infested leaves some amino acids may be used as feeding material and/or converted into secondary metabolites for defense.

关键词： amino acids citrus Diaphorina citri polyamines

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Genomics and Functional Genomics of Citrus Huanglongbing Bacterium,‘Candidatus Liberibacter asiaticus'

Genomics and Functional Genomics of Citrus Huanglongbing Bac...

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中国植物病理学会第九届全国会员代表大会暨2010年学术年会

作者： C.m.Vahling USDA-ARS USHRLFort PierceFLUSA

Citrus Huanglongbing(HLB)is the most devastating disease of citrus in the world and currently threatens the survival of the citrus industry in Brazil and the United States,the top orange and juice producers in the *** is spread by citrus psyllids and is associated with a low-titer,phloem-limited infection by any of three uncultured species ofα-Proteobacteria:‘Candidatus Liberibacter asiaticus’(Las),

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