检索结果-南通市图书馆

痹肿消汤对类风湿关节炎患者日常生活能力的影响

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究与临床康复 2007年第12期11卷 2272-2274,2278页

作者：蒋勇前梁清华刘小春熊新贵范荣王娟中南大学湘雅医院中西医结合研究所湖南省长沙市410008

目的:观察痹肿消汤治疗前后类风湿关节炎患者主动活动度及日常生活能力的改变,论证痹肿消汤的临床疗效。方法:选择于2004-10/2006-05在中南大学湘雅医院中西医结合科治疗的活动期类风湿关节炎患者86例,痹肿消汤组44例和甲氨喋呤组42例... 详细信息

目的:观察痹肿消汤治疗前后类风湿关节炎患者主动活动度及日常生活能力的改变,论证痹肿消汤的临床疗效。方法:选择于2004-10/2006-05在中南大学湘雅医院中西医结合科治疗的活动期类风湿关节炎患者86例,痹肿消汤组44例和甲氨喋呤组42例。痹肿消汤组用痹肿消汤(白花蛇舌草15g,丹参15g,苡米30g,骨碎补15g,络石藤20g,肿节风30g等共16味药,购自湘雅医院中药房;常规煎汤,药液浓度为1.038g/mL)治疗,2次/d口服,每日1剂。甲氨喋呤组选用甲氨喋呤(20mg,1次/周,配以等量叶酸口服)和尼美舒利片(0.1g,2次/d)联合用药,均治疗3个月为1疗程。比较两组患者关节疼痛指数、关节压痛指数、关节肿胀指数、晨僵时间、握力以及日常生活能力等指标。关节肿胀指数、关节疼痛指数,关节压痛指数评定按美国风湿病协会制订标准。采用改良Barthe1指数分别评定患者治疗前和治疗后的日常生活能力。评估内容10项,包括洗澡、修饰各5分,进餐、穿衣、用厕、可控制大便、可控制小便、上下楼梯各10分,床椅转移、平地行走45m各15分。结果:纳入类风湿关节炎患者86例全部进入结果分析。痹肿消汤组的患者其晨僵时间、关节疼痛、关节肿胀、关节压痛、关节功能障碍指数及双手平均握力以及日常生活能力评分各项指标均较治疗前均显著改善(ppp<0.01～0.05)。结论:痹肿消汤和传统的非类固醇抗炎药和慢作用药物联合应用均能改善类风湿关节炎患者关节主动活动度及提高患者日常生活能力,但痹肿消汤效果更为明显。

关键词：关节炎类风湿日常生活活动中药疗法消炎药非甾类

粒细胞吸附分离性输血治疗伴有类风湿性关节炎患者的下肢溃疡:3例成功治疗病例报道

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 13-14页

作者： mori S. Nagashima m. Yoshida K. S. Yoshino 刘超 Dept. of Joint Disease/rheumatism Nippon Medical School 1- 1- 5 Sendagi Bunkyo-ku Tokyo 113- 8603 JapanDr.

Background. The treatment of inflammatory leg ulcers complicated by r heumatoi d arthritis (ra), which are unresponsive to conventional care, can be frustratin g. Furthermore, as granulocytes and monocytes (Gm) are major sources of inflamma tory cytokines, they have the potential to initiate and perpetuate in-flammato ry skin lesions. Accordingly, a recent study reported the remission of pyoderma gangrenosum following the reduction of activated peripheral blood Gm by adsorpti ve apheresis (GmA). methods. In this clinical study, we applied GmA to three cas es, each with one leg ulcer below the knee and ra. The ulcers had not responded to conventional therapy, including disinfection, dressing, and antimicrobials, a nd therefore were thought to represent inflammatory vasculitic lesions. GmAwas p erformed using a column with a capacity of 335mL, filledwith cellulose acetate b eads that selectively adsorb granulocytes and monocytes/macrophages (Adacolumn). Each patient received one GmA session/week for five consecutive weeks. The dura tion of one session was 60 min, with a flow rate of 30 mL/min. results. The ulce rs began to recede after two GmA sessions and, by the end of the fifth session, the ulcers in all three patients had healed. No recurrence has been observed up to the time of this report. The treatmentwas well tolerated and no severe sideef fects were observed. Conclusions. GmA, which depletes activated neutrophils and monocytes/macrophages, appears to be effective for inflammatory skin ulcers whic h do not respond to conventionalmedications.

关键词：类风湿性关节炎细胞吸附输血治疗下肢溃疡分离性血管炎炎症细胞因子坏疽性脓皮病商品名单核巨噬细胞

IGrT技术在肺癌SBrT治疗靶区位置误差测定中的应用

在线全文

学校读者我要写书评

暂无评论

中国临床医学 2016年第6期23卷 841-845页

作者：王昌民胡伟刚彭佳元蔡旭伟傅小龙许青复旦大学附属肿瘤医院放疗科复旦大学上海医学院肿瘤学系上海200032 上海交通大学附属胸科医院放疗科上海200030

目的:探讨图像引导放射治疗(image guided radiation therapy,IGrT)技术在测定并校正肺部恶性肿瘤体部立体定向放射治疗(stereotactic body radiation therapy,SBrT)过程中靶区位置误差的意义。方法:选择复旦大学附属肿瘤医院收治的14... 详细信息

目的:探讨图像引导放射治疗(image guided radiation therapy,IGrT)技术在测定并校正肺部恶性肿瘤体部立体定向放射治疗(stereotactic body radiation therapy,SBrT)过程中靶区位置误差的意义。方法:选择复旦大学附属肿瘤医院收治的14例肺部恶性肿瘤并接受SBrT的患者。每次治疗前后均进行千伏级锥形束CT(kV-CBCT)扫描,与计划CT图像进行在线配准,校正误差后进行治疗。治疗后再次进行CBCT扫描并配准。分别记录治疗前后靶区位置误差。根据临床靶区(CTV)-计划靶区(pTV)外放公式mpTV(外放)=2.5Σ+0.7σ计算pTV外扩大小。结果:治疗前靶区位置左右、头脚、腹背方向误差最大值分别为10.0mm、16.9mm、8.7mm,误差平均值分别为(2.4±2.8)mm、(3.4±4.6)mm、(2.9±3.4)mm。在线校正并治疗后,靶区位置左右、头脚、腹背方向的误差最大值分别为7.6mm、4.6mm、7.0mm,误差平均值分别为(2.1±2.0)mm、(1.5±1.6)mm、(1.7±2.0)mm。无图像引导pTV外扩大小为左右7.96mm、头脚11.72mm、腹背9.63mm,有图像引导并在线校正pTV外扩大小为左右6.65mm、头脚4.87mm、腹背5.65mm。结论:IGrT技术可即时校正SBrT治疗前由摆位引起的靶区位置误差,并测定治疗过程中的靶区位置移动,能提高治疗精度,并有助于pTV外扩的制定。

关键词：图像引导放射治疗体部立体定向放射治疗误差计划靶区

细胞间的相互作用对鼠胚胎癌细胞的药物诱导分化的影响

在线全文

学校读者我要写书评

暂无评论

昆明医科大学学报 1985年第Z1期 23-28页

作者：孙君洁 J.坎比安·皮卡多 J.克雷格 m.W.麦克柏尼昆明医学院渥太华大学渥太华大学渥太华大学

不论从对分化的一般了解还是对恶性生长的了解来说,鼠畸胎癌都是非常有价值的实验系统。胚胎癌细胞(EC cells)是畸胎癌的多能干细胞,其体外培养的细胞系可经某种物质处理而被诱导分化。胚胎癌细胞系 p19的细胞集合物(aggregates)可以被... 详细信息

不论从对分化的一般了解还是对恶性生长的了解来说,鼠畸胎癌都是非常有价值的实验系统。胚胎癌细胞(EC cells)是畸胎癌的多能干细胞,其体外培养的细胞系可经某种物质处理而被诱导分化。胚胎癌细胞系 p19的细胞集合物(aggregates)可以被维生素 A 酸(r A)或二甲亚砜(DmSO)诱导分化。我们还分离出不被 ra 或 DmSO诱导分化的突变型克隆系,以便进一步研究这两种物质诱导的发育过程的性质。本文将探讨这些突变型是否可作为提供细胞外发育信号存在的证据。实验设计依照 rosenst—

关键词：诱导分化胚胎癌细胞 DmSO 亚砜细胞分化鼠胚胎集合物药物

Families of Dothideomycetes

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Fungal Diversity 2013年第6期63卷 1-313页

作者： Kevin D.Hyde E.B.Gareth Jones Jian-Kui Liu Hiran Ariyawansa Eric Boehm Saranyaphat Boonmee Uwe Braun putarak Chomnunti pedro W.Crous Dong-Qin Dai paul Diederich Asha Dissanayake mingkhuan Doilom Francesco Doveri Singang Hongsanan ruvishika Jayawardena James D.Lawrey Yan-mei Li Yong-Xiang Liu robert Lücking Jutamart monkai Lucia muggia matthew p.Nelsen Ka-Lai pang rungtiwa phookamsak Indunil C.Senanayake Carol A.Shearer Satinee Suetrong Kazuaki Tanaka Kasun m.thambugala Nalin N.Wijayawardene Saowanee Wikee Hai-Xia Wu Ying Zhang Begoña Aguirre-Hudson S.Aisyah Alias AndréAptroot Ali H.Bahkali Jose L.Bezerra D.Jayarama Bhat Erio Camporesi Ekachai Chukeatirote Cécile Gueidan David L.Hawksworth Kazuyuki Hirayama Sybren De Hoog Ji-Chuan Kang Kerry Knudsen Wen-Jing Li Xing-Hong Li Zou-Yi Liu Ausana mapook Eric H.C.mcKenzie Andrew N.miller peter E.mortimer Alan J.L.phillips Huzefa A.raja Christian Scheuer Felix Schumm Joanne E.Taylor Qing Tian Saowaluck Tibpromma Dhanushka N.Wanasinghe Yong Wang Jian-Chu Xu Supalak Yacharoen Ji-Ye Yan min Zhang Key Laboratory for plant Biodiversity and Biogeography of East Asia(KLpB) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201Yunnan China World Agroforestry Centre East Asia NodeHeilongtanKunming 650201China Institute of Excellence in Fungal research Chiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Institute Ocean Earth Sciences Kuala Lumpur 50603SelangorMalaysia Department of Botany and microbiology King Saudi UniversityRiyadhSaudi Arabia 42 Longacre Drive LivingstonNJ 07039USA Institut für Biologie Bereich Geobotanik und Botanischer GartenHerbariumMartin-Luther-UniversitätNeuwerk 2106099 Halle(Saale)Germany CBS-KNAW Fungal Biodiversity Centre Uppsalalaan 83584CT UtrechtThe Netherlands musée National d’histoire Naturelle 25 rue Munster2160 LuxembourgLuxembourg Institute of plant and Environment protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Via dei Funaioli 22 57126 LivornoItaly Department of Environmental Science and policy George Mason University4400 University DriveFairfaxVA 22030-4444USA International Fungal research and Development Centre Key Laboratory of Resource Insect Cultivation&Utilization State Forestry AdministrationKunming 650224People’s Republic of China The research Institute of resource Insects Chinese Academy of ForestryKunming 650224People’s Republic of China Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyangGuizhou 550006People’s Republic of China Science and Education Integrative Research(Botany)The Field Museum1400 South Lake Shore DriveChicagoIL 60605-2496USA Institute of plant Sciences University of GrazHolteigasse 68010 GrazAustria Department of Life Science University of TriesteVia L.Giorgieri 10TriesteItaly Committee on Evolutionary Biology University of Chicago1025 E.57th StreetChicagoIL 60637USA Institute ofmarine Biology and Center of Excellence for the Oceans Taiwan

Dothideomycetes comprise a highly diverse range of fungi characterized mainly by asci with two wall layers(bitunicate asci)and often with fissitunicate *** species are saprobes,with many asexual states comprising important plant *** are also endophytes,epiphytes,fungicolous,lichenized,or lichenicolous *** occur in terrestrial,freshwater and marine habitats in almost every part of the *** accept 105 families in Dothideomycetes with the new families Anteagloniaceae,Bambusicolaceae,Biatriosporaceae,Lichenoconiaceae,muyocopronaceae,paranectriellaceae,roussoellaceae,Salsugineaceae,Seynesiopeltidaceae and Thyridariaceae introduced in this *** family is provided with a description and notes,including asexual and asexual states,and if more than one genus is included,the type genus is also *** family is provided with at least one figure-plate,usually illustrating the type genus,a list of accepted genera,including asexual genera,and a key to these genera.A phylogenetic tree based on four gene combined analysis add support for 64 of the families and 22 orders,including the novel orders,Dyfrolomycetales,Lichenoconiales,Lichenotheliales,monoblastiales,Natipusillales,phaeotrichales and *** paper is expected to provide a working document on Dothideomycetes which can be modified as new data comes to *** is hoped that by illustrating types we provide stimulation and interest so that more work is carried out in this remarkable group of fungi.

关键词： Acrospermales Asterinales Botryosphaeriales Capnodiales Dothideales Dyfrolomycetales Hysteriales Jahnulales Lichenoconiales Lichenotheliales microthyriales monoblastiales myriangiales mytilinidiales Natipusillales patellariales phaeotrichales phylogeny pleosporales Strigulales Taxonomy Trypetheliales Tubeufiales Type species Venturiales

引入AHp熵值赋权的武装直升机作战效能评估

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

兵工自动化 2018年第2期37卷 88-91页

作者：苗李达侯学隆海军航空大学研究生管理大队山东烟台264001 海军航空大学五系山东烟台264001

为解决传统熵值法评价指标赋权时,会出现指标权重过大的问题,引入层次分析法(analytic hierarchy process,AHp)的赋权方式对熵值法进行改进。对指标差异性系数进行两两对比来求解指标权重,通过实际数据检验,指出传统熵值法的弊端,构造... 详细信息

为解决传统熵值法评价指标赋权时,会出现指标权重过大的问题,引入层次分析法(analytic hierarchy process,AHp)的赋权方式对熵值法进行改进。对指标差异性系数进行两两对比来求解指标权重,通过实际数据检验,指出传统熵值法的弊端,构造基于信息熵的判断矩阵并求解出指标权重,分别使用传统熵值法和引入AHp的熵值赋权法对武装直升机作战能力的7项指标赋权进行作战效能评估。结果表明:该方法能弥补传统熵值法赋权时单一指标权重可能过大的不足,赋权结果更加合理,武装直升机作战能力随某个指标变化的评估结果也更为准确。

关键词：武装直升机熵值法层次分析(AHp)法效能评估

Vitamin D<sub>3</sub>receptor Activation rescued Corticostriatal Neural Activity and Improved motor Function in –D<sub>2</sub>r Tardive Dyskinesia mice model

在线全文

学校读者我要写书评

暂无评论

Journal of Biomedical Science and Engineering 2015年第8期8卷 520-530页

作者： Oluwamolakun O. Bankole Babafemi J. Laoye mujittapha U. Sirjao Azeez O. Ishola Damilola E. Oyeleke Wasiu G. Balogun Amin Abdulbasit Ansa E. Cobham Ibukun D. Akinrinade Olalekan m. Ogundele Department of Biological Sciences College of Sciences Afe Babalola University Ado-Ekiti Nigeria Department of Anatomy College of Medicine and Health Sciences Afe Babalola University Ado-Ekiti Nigeria Department of Anatomy College of Health Sciences University of Ilorin Ilorin Nigeria Department of physiology College of Health Sciences University of Ilorin Ilorin Nigeria Department of Anatomy College of Medicine University of Calabar Calabar Nigeria Instituto Gulbenkian de Ciencia Oerias Portugal Department of Anatomy Bingham University College of Medicine Karu Nigeria

Haloperidol-induced dyskinesia has been linked to a reduction in dopamine activity characterized by the inhibition of dopamine receptive sites on D2-receptor (D2r). As a result of D2r inhibition, calcium-linked neural activity is affected and seen as a decline in mo-tor-cognitive function after prolonged haloperidol use in the treatment of psychotic disorders. In this study, we have elucidated the relationship between haloperidol-induced tardive dyskinesia and the neural activity in motor cortex (m1), basal nucleus (Cpu), prefrontal cortex (pFC) and hippocampus (CA1). Also, we explored the role of Vitamin D3 receptor (VD3r) activation as a therapeutic target in improving motor-cognitive functions in dyskinetic mice. Dyskinesia was induced in adult BALB/c mice after 28 days of haloperidol treatment (10 mg/Kg;intraperitoneal). We established the presence of abnormal involuntary movements (AIms) in the haloperidol treated mice (-D2) through assessment of the threshold and amplitude of abnormal involuntary movements (AIms) for the Limbs (Li) and Orolingual (Ol) area (Li and Ol AIms). As a confirmatory test, the dyskinetic mice (-D2) showed high global AIms score when compared with the VD3ra intervention group (-D2/+VDr) for Li and Ol AIms. Furthermore, in the behavioral tests, the dyskinetic mice exhibited a decrease in latency of fall (LOF;rotarod-p 2/+VDr), 100 mg/Kg for 7 days, Cpu-CA1 burst activity was restored leading to a decrease in abnormal movement, and an increase in motor function. Ultimately, we deduced that VD3ra activation reduced the threshold of abnormal movement in haloperidol induced dyskinesia.

关键词： Haloperidol VD3r Dyskinesia D2r Neural Activity Corticostriatal

多形性胶质母细胞瘤区域性DTI派生的张量指标的诊断作用:p,q,L,Cl,Cp,Cs,ra,rD,AD,平均扩散系数和部分各向异性的同时评估

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2013年第3期 304-304页

作者： D.Cortez-Conradis r.Favila K.Isaac-Olive m.martinez-Lopez C.rios E.roldan-Valadez 林江南 Section of research and Innovation in mrI Magnetic Resonance UnitMedica Sur Clinic & Foundation

目的将较少用于诊断的近12个扩散张量成像(DTI)变量用于对脑肿瘤进行评估。目的是对过去10年报道的张量指标进行综合评估。方法对14例多形性胶质母细胞瘤(GBm)和28例对照组进行回顾性病例对照研究。根据传统颅脑mr序列和DTI的后处理影... 详细信息

目的将较少用于诊断的近12个扩散张量成像(DTI)变量用于对脑肿瘤进行评估。目的是对过去10年报道的张量指标进行综合评估。方法对14例多形性胶质母细胞瘤(GBm)和28例对照组进行回顾性病例对照研究。根据传统颅脑mr序列和DTI的后处理影像计算正常白质(NAWm),邻近和远处的水肿,环状强化区和囊变区的平均扩散率(mD),部分各向异性(FA),纯各向同性扩散(p),纯各向异性扩散(q),总扩散张量(L),线性张量(Cl),平面张量(Cp),球形张量(Cs),相对各向异性(ra),放射状扩散(rD)和轴向扩散系数(AD)。进行ANOVA和AUrOC分析。结果所有指标在ANOVA分析中均显示差异具有统计学意义(pra的功效最高;邻近水肿带和远处水肿带获得最佳诊断指标是rD和Cp,q是环状强化区最好的生物标志物,所有指标pmD作为公认的脑损伤生物标志物,已被其他指标超过。ra结合Cs、Cl和Cp,可能成为脑肿瘤评估的新指标。DTI张量指标在肿瘤各区域表现出不同的临床适用性。要点①DTI派生的张量指标可定性肿瘤的不同区域。②新的诊断试验功效评估须遵循初级STArD。③多形性胶质母细胞瘤的每个肿瘤区域用不同的张量指标进行检测。④FA和mD并不是肿瘤浸润最好的生物标志物。⑤某些张量指标的诊断作用可被交换应用。

关键词：脑肿瘤扩散张量成像 mrI 敏感度和特异度统计学论题

Taxonomic circumscription and phylogenetics of novel didymellaceous taxa with brown muriform spores

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Studies in Fungi 2018年第1期3卷 152-175页

作者： Wanasinghe DN Jeewon r peršoh D Jones EBG Camporesi E Bulgakov TS Gafforov YS Hyde KD Key Laboratory for plant Biodiversity and Biogeography of East Asia(KLpB) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201Yunnan China Center of Excellence in Fungal research Mae Fah Luang UniversityChiang Rai57100Thailand World Agro Forestry Centre East and Central Asia132 Lanhei RoadKunming 650201Yunnan China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius AG Geobotany Faculty of Biology and BiotechnologyRuhr-Universitat BochumUniversitatsstraße 15044801 BochumGermany Nantgaredig 33B St.Edwards RoadSouthseaHants.PO53DHUK Societàper gli Studi Naturalistici della romagna C.P.144Bagnacavallo(RA)Italy A.m.B.Gruppo micologico Forlivese“Antonio Cicognani” Via Roma 18ForlìItaly A.m.B.Circolo micologico“Giovanni Carini” C.P.314BresciaItaly russian research Institute of Floriculture and Subtropical Crops Sochi354002Yana Fabritsiusa street2/28Krasnodar regionRussia Laboratory of mycology Institute of BotanyAcademy of Sciences of the Republic of Uzbekistan32 Durmon yuli StreetTashkent 100125Uzbekistan

Sexual morph of didymellaceous taxa are characterized by their ascomata with relatively thin peridium,cylindric-clavate to clavate,short-pedicellate or apedicellate asci,hyaline to brown,1-septate to muriform *** asexual morphs are coelomycetous and comprising pycnidial or acervulus conidiomata,phialidic,hyaline conidiogenous cells and hyaline or pale brown,septate or aseptate *** majority of these cosmopolitan species are plant associated fungi which can be pathogens on a wide range of hosts and some species are of particular relevance for quarantine *** studies have significantly improved the taxonomy and systematics of didymellaceous taxa based on molecular *** contrast to the accurate and detailed studies on the asexual morphs which are common obligate pathogens,information on their usually saprobic sexual morphs is still *** these phenotypically diverse species,spore characteristics are quite unique as most have hyaline spores with 0-1 septum,while only Neomicrosphaeropsis and Didymellocamarosporium are reported as producing pigmented,muriform *** dematiaceous muriform spores are characteristic of a considerable number of species that may be quite divergent in other *** taxonomic investigations on the diversity of didymellaceous taxa,we have isolated species from Alhagi pseudalhagi,Coronilla emerus,Cytisus sp.,Elaeagnus angustifolia and Spartium junceum in Italy,russia and Uzbekistan.A comprehensive phylogeny,based on four loci(ITS,LSU,rpb2 and tub2)is used to infer species *** morphological descriptions and in-depth phylogenetic investigations of five new species *** coronillae-emeri,microsphaeropsis spartii-juncei,Neomicrosphaeropsis alhagi-pseudalhagi,*** and *** are presented.

关键词： five new species coelomycetes Italy multi-gene phylogeny pleosporales russia saprobic taxonomic-ambiguity Uzbekistan