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Evaluation of antitumour activity of Calotropis gigantea *** bark against Ehrlich ascites carcinoma in Swiss albino mice

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Asian Pacific Journal of Tropical medicine 2011年第10期4卷 786-790页

作者： m rowshahul habib m Rezaul karim Department of Biochemistry and molecular Biology Faculty of ScienceRajshahi UniversityRajshahi-6205Bangladesh

Objective:To investigate experimentally the possible antitumor effect of methanol extract(mE) of Calotropis gigantea L.(***) root bark and its petroleum ether(PEF) and chloroform(CF) soluble fractions against Ehrlich ascites carcinoma(EAC) in Swiss albino ***:The effects of mE(10 and 20 mg/kg),PEF(40 and 80 mg/kg) and CF(20 and 40 mg/kg) on the growth of EAC and life span of EAC bearing mice were *** profile and biochemical parameters(SAI.P,SGPT and SCOT) were also ***:Results of in vivo study showed a significant decrease in viable tumor cell count and a significant increase of life span in the mE and CF treated group compared to untreated *** life span of mE and CF treated animals was significandy(Pmg mE/kg) and 57.07%(40 mg CF/kg).mE and CF brought back the hematological parameter more or less normal *** and CF also restored the altered levels of serum alkaline phosphatase(SALP) and serum glutamate oxaloacetate transaminase(SGOT).Conclusions:methanol extract(mE) of *** root bark and its chloroform soluble fraction(CF) possesses significant antitumor activity.

关键词： Calotropis gigantea Antitumor Ehrlich ascites carcinoma Root bark

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Inhibition of Ehrlich ascites carcinoma by manilkara zapota *** bark in Swiss albino mice

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Asian Pacific Journal of Tropical Biomedicine 2011年第6期1卷 448-451页

作者： m Abu Osman m mamunur Rasbid m Abdul Aziz m rowshahul habib m Rezaul karim Department of Biochemistry and molecular Biology Faculty of ScienceRajshahi University

Objective:To evaluate the antitumor activity of manilkara zapota(***) *** bark against Ehrlich ascites carcinoma(EAC) in Swiss albino ***:The in vivo antitumour activity of the ethyl acetate extract of stem bark of *** L.(EASm) was evaluated at 50,100 and 200 mg/kg bw against EAC using mean survival *** administration of the extract of ***,viable EAC cell count and body weight in the EAC tumour hosts were *** animal was also observed for improvement in the haematological parameters(e.g.,heamoglobin content,red and white blood cells count and differential cell count) after EASm treatment. Results:Intraperitoneal administration of EASm reduced viable EAC cells,increased the survival lime,and restored altered haematological *** efficacy was observed for EASm at 100 mg/kg dose(Pm bark of *** *** significant antitumour activity.

关键词： manilkara zapota Antitumour activity Stem bark Ehrlich ascites carcinoma Haematological parameter

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