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The skeleton gets a （reproductive） life

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Asian Journal of Andrology 2011年第5期13卷 651-652页

作者： Charles m Allan David l Handelsman ANZAC Research Institute Concord Hospital Universityof Sydney Sydney NSW 2139 Australia

To most well-informed scientists who do not work on bone, the idea that bones determine anything other than your posture and location for the miseries of arthritis would come as quite a surprise. It would be like imagining that the walls of our home played something more than a passive role in the complexities of the lives conducted within. Yet something precisely as radical as that is what Karsenty and his colleagues boldly imagined,1 and then provocatively established in a series of studies over the past decade.20steocalcin （OCN） is a vitamin K- dependent peptide hormone secreted by the bone-formine osteoblasts.

关键词： reproductive David J Handelsman

Biochemical indicators for neuronal regeneration during intrathecal triamcinolone application in multiple sclerosis

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Neural Regeneration Research 2015年第3期10卷 377-379页

作者： Thomas müller Sven lütge Department of Neurology St.Joseph Hospital Berlin-Weiβensee

multiple sclerosis （mS） is a chronic inflammatory disease of the central nervous system （CNS）. Essential charac- teristics are demyelination, inflammation and neurode- generation. This process affects the white and grey matter in the CNS. mS patients experience various progression subtypes in association with the cerebral or spinal, acute inflammatory or glial sclerotic lesions （mtiller, 2009）. most patients end up in a progressive, smouldering, chronic inflammatory process （mUller, 2009）. Current predominantly used 1.5 respectively 3 Tesla mRI with Gadolinium~ application visualize the various old and acute lesions. They serve as a biological marker in com- bination with standardised assessment of brain atrophy, black holes, etc. However, mRI with a stronger magnetic 7 Tesla field with better sensitivity gave hints on an on- going, acute inflammatory, smouldering process even with Gadolinium~ enhancing acute lesions in the brain and the spinal cord in progressive, so-called relapse free mS patients （mtiller, 2009; Sinnecker et al., 2012）. Ad- ditionally, progress of mS is determined with subjective standardised clinical ratings （Sinnecker et al., 2012）. Both methods are used for the evaluation of the efficacy of relapse rate reducing drugs. These compounds, i.e., in- terferons, teriflunamide, glatiramer acetate, fingolimod, fumarate or monoclonal antibodies, preponderantly weaken the malfunction of the peripheral immune system in relapse remitting mS patients. These mS drugs share one common disadvantage. They do not stop progression or improve mS within a framework of a regenerative process. They do not enable reversal of symptoms, for in- stance functional deficits or spasticity （mtiller, 2009）.

关键词： RGma Biochemical indicators for neuronal regeneration during intrathecal triamcinolone application in multiple sclerosis EDSS

外源性碱性成纤维细胞生长因子促进大鼠创面愈合的机制

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中国组织工程研究 2025年第11期29卷 2243-2251页

作者：李振超杜喜玲韩志新牛大伟樊昌伟安阳市人民医院整形烧伤科河南省安阳市455000 鹤壁职业技术学院河南省鹤壁市458000

背景:深入揭示外源性碱性成纤维细胞生长因子促进创面愈合的分子机制。目的:探讨外源性碱性成纤维细胞生长因子对大鼠创面修复中巨噬细胞表型转换和肉芽再生的影响。方法:(1)体外细胞实验:分为正常对照组、低剂量碱性成纤维细胞生长因... 详细信息

背景:深入揭示外源性碱性成纤维细胞生长因子促进创面愈合的分子机制。目的:探讨外源性碱性成纤维细胞生长因子对大鼠创面修复中巨噬细胞表型转换和肉芽再生的影响。方法:(1)体外细胞实验:分为正常对照组、低剂量碱性成纤维细胞生长因子组、高剂量碱性成纤维细胞生长因子组以及碱性成纤维细胞生长因子+丙戊酸组,其中低、高剂量碱性成纤维细胞生长因子组细胞培养基中分别添加100,200μg/l碱性成纤维细胞生长因子,碱性成纤维细胞生长因子+丙戊酸组细胞培养基中添加200μg/l碱性成纤维细胞生长因子和20 mmol/l Notch1/Jagged1激动剂丙戊酸。通过Edu实验、划痕实验、小管生成实验检测碱性成纤维细胞生长因子对人脐静脉内皮细胞增殖、迁移和血管新生的影响。(2)体内动物实验:SD大鼠按照随机数字表法分为模型组、低剂量碱性成纤维细胞生长因子组、高剂量碱性成纤维细胞生长因子组以及碱性成纤维细胞生长因子+丙戊酸组,构建大鼠全层皮肤缺损开放性创面模型,其中低、高剂量碱性成纤维细胞生长因子组皮下注射100,200μg/l碱性成纤维细胞生长因子,碱性成纤维细胞生长因子+丙戊酸组大鼠皮下注射200μg/l碱性成纤维细胞生长因子的同时腹腔注射10 mg/kg丙戊酸。给药7,14 d检测大鼠创面的愈合率;TUNEl检测创面组织中的细胞凋亡情况;酶联免疫吸附实验检测大鼠血清中丙二醛、超氧化物歧化酶、肿瘤坏死因子α和白细胞介素10水平;免疫荧光检测创面组织中巨噬细胞的表型转换情况;免疫组化检测创面组织中增殖细胞核抗原、CD31和血管内皮生长因子的表达;Western blot法检测创面组织中Notch1、Jagged1的表达。结果与结论:(1)与正常对照组相比,碱性成纤维细胞生长因子能明显促进人脐静脉内皮细胞的增殖、迁移和血管新生,并且具有剂量依赖性;(2)与模型组相比,碱性成纤维细胞生长因子能明显促进创面的愈合,下调创面组织中的细胞凋亡率;降低大鼠血清中丙二醛和肿瘤坏死因子α水平,升高超氧化物歧化酶和白细胞介素10水平;促使创面组织中巨噬细胞向m2型转换,上调创面组织中增殖细胞核抗原、CD31和血管内皮生长因子的表达;抑制创面组织中Notch1、Jagged1的表达,并且均具有剂量依赖性。丙戊酸可部分逆转碱性成纤维细胞生长因子对创面愈合的促进作用。结果表明,碱性成纤维细胞生长因子能明显促进创面愈合与肉芽再生以及诱导巨噬细胞向m2型转换,这可能与调控Notch1/Jagged1信号有关。

关键词：碱性成纤维细胞生长因子全层皮肤缺损创面巨噬细胞表型转换肉芽再生 Notch1 Jagged1

Revision of the genus Inouenola lászló,Ronkay & Witt,2010(lepidoptera,Noctuoidea,Nolidae,Nolini) with description of 6 new species

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Journal of Forestry Research 2015年第2期26卷 457-467页

作者： Gyula m.lászló Gábor Ronkay lászló Ronkay Fadrusz u.25 Budapest 1114Hungary Heterocera Press ltd. Szt.István krt.4Budapest 1137Hungary Department of Zoology Hungarian Natural History Museum

This paper contains the revision of the genus Inouenola la′szlo′,Ronkay ＆ Witt,2010 and presents the checklist of the known taxa and their distribution and the description of six new species（Inouenola brunneolinea... 详细信息

关键词： Inouenola Nolini Nolidae Noctuoidea New species New status South East Asia

NUmERICAl SImUlATION OF SUCCINONITRITE DENDRITIC GROWTH IN A FORCED FlOW

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Acta metallurgica Sinica(English letters) 2008年第6期21卷 444-450页

作者： Z. Chen C.l. Chen l.m. Hao School of Science Department of Applied Physics Shaanxi Key Laboratory of Condensed Matter Structures and Properties Northwestern Polytechnical University Xi＇an 710072 China School of Science Xi＇an University of Science ＆ Technology Xi＇an 710054 China

Numerical simulation based on phase field method is performed to describe solidification process of pure material in a free or forced flow. The evolution of the interface is showed, and the effects of mesh grid and flow velocity on succinonitrite shape are studied. These results indicate that crystal grows into an equiaxial dendrite in a free flow and into an asymmetrical dendritic in a forced flow. With increasing flow velocity, the upstream dendritic arm tip grows faster and the downstream arm grows slower. However, the evolution of the perpendicular tip has no significant change. In addition, mesh grid has no influence on dendritic growth shape when mesh grid is above 300×300.

关键词： Phase field method Forced flow Dendritic Succinonitrite Tip velocity

Artificial Intelligence Based Smart Routing in Software Defined Networks

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Computer Systems Science & Engineering 2023年第2期44卷 1279-1293页

作者： C.Aswini m.l.Valarmathi Department of Information Technology Government College of TechnologyCoimbatore641013India Department of Computer Science and Engineering Dr.Mahalingam College of Engineering and TechnologyPollachi642003India

In a non-static information exchange network,routing is an overly com-plex task to perform,which has to satisfy all the needs of the *** Deﬁned Network(SDN)is the latest and widely used technology in the future communication networks,which would provide smart routing that is visible *** various features of routing are supported by the information centric network,which minimizes the congestion in the dataﬂow in a network and pro-vides the content awareness through its mined *** to the advantages of the information centric network,the concepts of the information-centric net-work has been used in the paper to enable an optimal routing in the software-deﬁned *** there are many advantages in the information-centric network,there are some disadvantages due to the non-static communication prop-erties,which affects the routing in *** this regard,artiﬁcial intelligence meth-odology has been used in the proposed approach to solve these difﬁculties.A detailed analysis has been conducted to map the content awareness with deep learning and deep reinforcement learning with *** novel aligned internet investigation technique has been proposed to process the deep reinforcement *** performance evaluation of the proposed systems has been con-ducted among various existing approaches and results in optimal load balancing,usage of the bandwidth,and maximization in the throughput of the network.

关键词： Content aware routing software deﬁned networks deep learning load balancing

Influence of aeration intensity on the performance of A/0-type sequencing batch mBR system treating azo dye wastewater

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Frontiers of Environmental Science & Engineering 2011年第4期5卷 615-622页

作者： Xinhua WANG Jingmei lI Xiufen lI Guocheng du laboratory of Environmental Biotechnology School of Environmental and Civil EngineeringJiangnan UniversityWuxi 214122China Key laboratory of Industrial Biotechnology Ministry of EducationJiangnan UniversityWuxi 214122China

Among the numerous parameters affecting the membrane bioreactor(mBR)performance,the aeration intensity is one of the most important *** the present investigation,an anoxic/aerobic-type(A/O-type)sequencing batch mBR system,added anoxic process as a pretreatment to improve the biodegradability of azo dye wastewater,was investigated under different aeration intensities and the impact of the aeration intensity on effluent quantity,sludge properties,extracellular polymeric substances(EPS)amount generated as well as the change of permeation flux were *** lower nor higher aeration intensities could improve A/O-type sequencing batch mBR *** results showed 0.15 m^(3)·h^(-1)aeration intensity was promising for treatment of azo dye wastewater under the conditions *** this aeration intensity,chemical oxygen demand(COD),ammonium nitrogen and color removal as well as membrane flux amounted to 97.8%,96.5%,98.7%and 6.21 l·m^(-2)·h^(-1),*** effluent quality,with 25.0 mg·l^(-1)COD,0.84 mg·l^(-1)ammonium nitrogen and 8 chroma,could directly meet the reuse standard in *** the meantime,the sludge relative hydrophobicity,the bound EPS,soluble EPS and EPS amounts contained in the membrane fouling layer were 70.3%,52.0 mg·g^(-1)VSS,38.8 mg·g^(-1)VSS and 90.8 mg·g^(-1)VSS,respectively,which showed close relationships to both pollutant removals and membrane flux.

关键词： batch membrane bioreactor azo dye aeration intensity extracellular polymeric substances sludge properties

Geometrical Scale-Sensitive Fatigue Properties of Ti-6.5Al-3.5mo-1.5Zr-0.3Si Alloys With α/β lamellar microstructures

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Journal of materials Science & Technology 2014年第12期30卷 1284-1288页

作者： B.Zhang Z.m.Song l.m.lei l.Kang G.P.Zhang Key laboratory for Anisotropy and Texture of materials Ministry of Education Northeastern University Shenyang National laboratory for materials Science Institute of Metal Research Chinese Academy of Sciences AVIC Commercial Aircraft Engine Co. Ltd.

Fatigue properties of the Ti-6.5Al-3.5mo-1.5Zr-0.3Si alloy sheets containing different numbers of α/β Widmansttten colonies in the thickness direction of the sheets were investigated by tensionetension fatigue testing. It is found that fatigue properties of the Ti alloy either in low- or high-stress amplitude regimes become more sensitive to the sheet thickness of the Ti alloy as the sheet thickness is comparable to the length scale of the Widmansttten colonies. The basic mechanism of such length scale-sensitive fatigue properties in the Ti alloy was elucidated.

关键词： Fatigue Ti alloy microstructure Size effect

Is the possible fine-structure constant drift also a test of a time-dependent Planck constant?

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Science China(Physics,mechanics & Astronomy) 2011年第12期54卷 2191-2195页

作者： ZTAS A. m. SmITH m. l. Engineering Physics Hacettepe University Jannek Fuel Inc. Phoenix

The recent publication of spatial and distance variation of the fine-structure constant, α, derived from astronomical data of quasar emissions (QE) is exciting. The decreasing value of α over time, derived from data obtained from the Very large Telescope (VlT) in Chile, encourages the search for other possible running constants. We surmise that emissions from distant supernovae, type Ia (SNe Ia), which are more blue than predictions are best explained by a decreasing Planck constant with increasing lookback time. We present some results from our theoretical work and comparison to the astronomical observations and suggest that both α and h might be running constants. more data are required to answer several questions about the origin of the "drifting" α and the possible time dependence of h. Astronomical tools such as SNe and QE may be the best means to secure the exacting data needed to confirm or deny these hypotheses.

关键词： alpha quasars distance measurement supernovae CmB