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Journal of Cancer metastasis and Treatment 2018年第1期4卷 300-314页

作者： Shrefa A.Hadadi Haiwen Li reza Rafie Paul Kaseloo Sarah m.Witiak Rafat A.Siddiqui Food Chemistry and Nutrition Science Laboratory Virginia State UniversityPetersburgVA 23806USA Cooperative Extension Agricultural Research StationCollege of AgricultureVirginia State UniversityPetersburgVA 23806USA Department of Biology College of Natural and Health SciencesVirginia State UniversityPetersburgVA 23806USA

Aim:Breast cancer is typically detected either during a screening examination or after a woman notices a *** cancers have different phenotypes depending on the presence/absence of an estrogen receptor(ER)and/or an epidermal growth factor(Her-2)*** objective of the present investigation was to investigate growth inhibitory activity of methanol-,ethanol-,and water-extracts from papaya fruit and leaves on mDA-mB-231(ER-/Her-2-),mCF-7(ER+/Her-2-),SK-BR-3(ER-/Her-2+)and mDA-mB-361,AU565(ER+/Her-2+)breast cancer ***:The anti-oxidation potential of papaya extracts was determined by assessing their total polyphenol content,total flavonoid content and by assaying their anti-oxidation *** effects on breast cancer cells proliferation were determined using a WST-1 ***:The seeds and leaves contained higher anti-oxidation potential than that of the skin and pulp *** data indicate that methanol-and ethanol-extracts of papaya leaves,skin,pulp,and seeds have no effect on any of the breast cancer cell lines,whereas water-extract of leaves and seeds caused low to modest cytotoxic effects only on ER-negative breast cancer cell ***:Our data suggest that bioactive compound in papaya leaves can be potentially used to develop anti-cancer agents for ER-negative breast cancer.

关键词： Breast cancer papaya leaves antioxidants polyphenols

Comparison of Essential Oil Components and Antioxidant Activity between Salvia syriaca and Salvia aristata in Their Natural Habitats in West Azerbaijan Province, Iran

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Journal of Pharmacy and Pharmacology 2015年第8期3卷 400-404页

作者： Forouzin Farshid Jamei Rashid Heidari reza Department of Biology Faculty of Science Urmia University Urmia *** West Azerbaijan Iran

The aerial parts of two Salvia species were collected at the beginning of flowering stage in June 2013. The essential oil of the air-dried parts of plants was extracted by hydro distillation and the chemical composition of the essential oils of S. aristata and S. syriaca collected in West Azerbaijan （Iran） was studied by means of GC-mS analysis. Total of 18 compounds were identified： 11 compounds were for S. syriaca with total oil of 90.98% and 7 compounds were for S. aristata with total oil of 98.23%. S. aristata had the most concentration of essential oil between these species. In S. syriaca, the main compounds were l, 6-cineole （46.45%） and camphor （27.58%）. In S. aristata, the main compound was benzene, 1, 3-his m-pheoxypheoxy （95.42%）. Other compounds with low concentrations were transcaryophyllene （0.77%） and 1, 3-benzodioxole, 4-methoxy 6-2 （0.98%）. In this study, the in vitro antioxidant activities of the essential oil of two Salvia species were examined （prepared by using ethanol 99.5% solvent）. Between two species screened, S. aristata had the most antioxidant activity （31%）. It was followed by S. syriaca （24%）.

关键词： Salvia aristata Salvia syriaca antioxidant activity GC-mS

Expression of Acyl-lipid 12-desaturase Gene in Prokaryotic and Eukaryotic Cells and Its Effect on Cold Stress Tolerance of Potato

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Journal of Integrative Plant Biology 2010年第3期52卷 289-297页

作者： reza maali Amiri Natalia O. Yur'eva Khristina R. Shimshilashvili Irina V. Goldenkova-Pavlova Vasiliy P. Pchelkin Elmira I. Kuznitsova Vladimir D. Tsydendambaev Tamara I. Trunova Dmitry A. Los Gholamreza Salehi Jouzani Alexander m. Nosov Department of Agronomy and Plant Breeding University College of Agriculture and Natural Resources of the University of Tehran K.A.Timiryazev Institute of Plant Physiology Russian Academy of Sciences (RAS) Vavilov Institute of General Genetics Agricultural Biotechnology Researches Institute of Iran (ABRII) Department of Plant Physiology Moscow State University

We report the expression profile of acyl-lipid △12-desaturase （desA） gene from Synechocystis sp. PCC6803 and its effect on cell membrane lipid composition and cold tolerance in prokaryotic （Escherichia coil） and eukaryotic （Solanum tuberosum） cells. For this purpose, a hybrid of desA and reporter gene encoding thermostable lichenase （licBm3） was constructed and used to transform these cells. The expression of this hybrid gene was measured using qualitative （Petri dish test, electrophoregram and zymogram） and quantitative methods （spectrometry and gas liquid chromatography assays）. The maximum level of linoleic acid in the bacterial cells containing hybrid gene was 1.9% of total fatty acids. Cold stress tolerance assays using plant damage index and growth parameters showed that cold tolerance was enhanced in primary transgenic lines because of increased unsaturated fatty acid concentration in their lipids. The greatest content of 18：2 and 18：3 fatty acids in primary transgenic plants was observed for lines 2 （73%） and 3 （41%）. Finally, our results showed that desaturase could enhance tolerance to cold stress in potato, and desaturase and lichenase retain their functionality in the structure of the hybrid protein where the enzymatic activity of target gene product was higher than in the case of reporter lichenase gene absence in the construction.

关键词： Expression of Acyl-lipid 12-desaturase Gene in Prokaryotic and Eukaryotic Cells and Its Effect on Cold Stress Tolerance of Potato gene

Treatment of Benzene,Toluene and Xylene Contaminated Air in a Bioactive Foam Emulsion Reactor

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Chinese Journal of Chemical Engineering 2010年第1期18卷 113-121页

作者： Farshid Ghorbani Shahna Faride Golbabaei Javad Hamedi Hossein mahjub Hossein reza Darabi Seyed Jamaladdin Shahtaheri Department of Occupational Health School of Public Health & Institute of Public Health Research Tehran Iran Department of Occupational Health School of Public Health Centre of Health Research Hamadan University of Medical Science Hamadan Iran Division of microbiology Department of Biology Faculty of Science University of Tehran Iran Department of Biostatics & Epidemiology School of Public Health Centre of Health Research Hamadan University of Medical Science Hamadan Iran Chemistry & Chemical Engineering Institute oflran Tehran Iran

A novel bioactive foam emulsion bioreactor for benzene,toluene and xylene(BTX)contaminated air streams treatment has been *** gas-liquid interfacial area by biocompatible foam and driving force for mass transfer by a water immiscible organic phase were increased in this *** effect of several parameters such as gas residence time,oxygen content,and organic phase concentration on bioreactor performance was studied. Experimental results showed an average elimination capacity(EC)of 220 g·m3·h -1with removal efficiency(RE) of 89.59%for BTX inlet concentration of 1 g·m3at 15 s gas residence time in the *** statistical developed model predicted that the maximum elimination capacity of the reactor for BTX could be reached to 423.45 g·m3·h -*** operation of the bioreactor with high EC and RE was demonstrated by optimizing the operational parameters of the *** the results suggest that the bioreactor developed can be very effective systems to treat BTX vapors.

关键词： air pollution control bioactive foamed reactor biodegradation BTX

模糊环境下汽车故障模式风险水平综合评价方法

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机械科学与技术 2021年第12期40卷 1952-1960页

作者：周文财魏朗邱兆文 reza Langari 长安大学汽车学院西安710064 Texas A&m University Engineering Technology and Industrial DistributionCollege Station 77843-3123

针对车辆故障模式风险评价,提出了一种新的模糊综合评价方法,即先利用基于维修数据的失效模式与效果分析(FmEA)筛选出关键故障模式进行进一步研究,再分别采用模糊层次分析法(AHP)与模糊扩展全乘比例多目标优化(mULTImOORA)计算风险评价... 详细信息

针对车辆故障模式风险评价,提出了一种新的模糊综合评价方法,即先利用基于维修数据的失效模式与效果分析(FmEA)筛选出关键故障模式进行进一步研究,再分别采用模糊层次分析法(AHP)与模糊扩展全乘比例多目标优化(mULTImOORA)计算风险评价因素与故障模式的权重,通过计算车辆故障模式的最终权重得到故障模式进行风险排序。同时利用逻辑语言表征评审专家的评估信息并将其转化为三角模糊数,实现了客观维修数据与专家经验判断的有机结合。利用本文提出的新评价方法对现代一款轻型客车进行故障模式风险评估与排序,进行灵敏度分析验证此方法的有效性。

关键词：失效模式与效果分析车辆维修数据模糊层次分析法模糊扩展全乘比例多目标优化三角模糊数

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A Novel Stochastic Framework for the Optimal Placement and Sizing of Distribution Static Compensator

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Journal of Intelligent Learning Systems and Applications 2013年第2期5卷 90-98页

作者： reza Khorram-Nia Aliasghar Baziar Abdollah Kavousi-Fard Department of Electrical and Computer Engineering Safashahr Branch Islamic Azad University Safashahr Iran

This paper proposes a new stochastic framework based on the probabilistic load flow to consider the uncertainty effects in the Distribution Static Compensator (DSTATCOm) allocation and sizing problem. The proposed method is based on the point estimate method (PEm) to capture the uncertainty associated with the forecast error of the loads. In order to explore the search space globally, a new optimization algorithm based on bat algorithm (BA) is proposed too. The objective functions to be investigated are minimization of the total active power losses and reducing the voltage deviation of the buses. Also to reach a proper balance between the optimization of both the objective functions, the idea of interactive fuzzy satisfying method is employed in the multi-objective formulation. The feasibility and satisfying performance of the proposed method is examined on the 69-bus IEEE distribution system.

关键词： DSTATCOm Allocation Uncertainty multi-Objective Optimization 2 m Point Estimate method

Efficiency improvement by using metal–insulator‑semiconductor structure in InGaN/GaN micro‑light‑emitting diodes

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Frontiers of Optoelectronics 2024年第1期17卷 77-84页

作者： Jian Yin David Hwang Hossein Zamani Siboni Ehsanollah Fathi reza Chaji Dayan Ban Department of Electrical and Computer Engineering Waterloo Institute NanotechnologyUniversity of WaterlooWaterlooON N2L 3G1Canada Vuereal InC. 440 Philip StreetUnit 100WaterlooON N2L 5R9Canada

InGaN/GaN micro-light-emitting diodes(micro-LEDs)with a metal–insulator-semiconductor(mIS)structure on the sidewall are proposed to improve *** this mIS structure,a sidewall electrode is deposited on the insulating layer-coated sidewall of the device mesa between a cathode on the bottom and an anode on the ***(EL)measurements of fabricated devices with a mesa diameter of 10μm show that the application of negative biases on the sidewall electrode can increase the device external quantum efficiency(EQE).In contrast,the application of positive biases can decrease the *** band structure analysis reveals that the EQE is impacted because the application of sidewall electric fields manipulates the local surface electron density along the mesa sidewall and thus controls surface Shockley–Read–Hall(SRH)*** suggested strategies,reducing insulator layer thickness and exploring alternative materials,can be implemented to further improve the EQE of mIS micro-LEDs in future fabrication.

关键词： micro-LED GaN EQE improvement micro-fabrication

Amperometric Hydrogen Peroxide Biosensor Based on Horseradish Peroxidase Entrapped in Titania Sol-Gel Film on Screen-Printed Electrode

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American Journal of Analytical Chemistry 2013年第11期4卷 607-615页

作者： reza E. Sabzi Fereshteh Rasouli Farshad Kheiri Department of Chemical Engineering Urmia University of Technology Urmia Iran Department of Chemistry Faculty of Science Urmia University Urmia Iran Department of Chemistry Faculty of Science Urmia University Urmia Iran Institute of Biotechnology Urmia University Urmia Iran

We report the fabrication of disposable and flexible Screen-Printed Electrodes (SPEs). This new type of screen-printed electrochemical platform consists of Ag nanoparticles (AgNPs) and graphite composite. For this purpose, silver nanoparticles were first synthesized by a chemical reduction method. The morphology and structure of the AgNPs were analyzed using a Scanning Electron microscope (SEm) and UV-Visible spectroscopy. Graphite was chosen as the working electrode material for the fabrication of a thick-film. The fabrication of a screen-printed hydrogen peroxide biosensor consisting of three electrodes on a polyethylene terephthalate (PET) substrate was performed with a spraying approach (working, counter and reference: enzyme electrode, graphite, pseudo reference: Ag/AgCl). This biosensor was fabricated by immobilizing the peroxidase enzyme (HRP) in a Titania sol-gel membrane which was obtained through a vapor deposition method. The biosensor had electrocatalytic activity in the reduction of H2O2 with linear dependence on H2O2 concentration in the range of 10-5 to 10-3 m;the detection limit was 4.5 × 10-6 m.

关键词： Screen-Printed Electrode Ag Nanoparticle Titania Sol-Gel Biosensor

Evaluation of bioefficacy ofα-cypermethrin in long lasting impregnated net(Interceptor~) using analytical method

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Asian Pacific Journal of Tropical medicine 2010年第8期3卷 642-646页

作者： Vatandoost Hassan mamivandpoor Hossein Shayeghi mansoreh Abai mohammad reza Yaghoobi-Ershadi mohammad reza Raeisi Ahmad Abtahi mohammad Rafie Fatemeh Nikpour Fatemeh Department of medical Entomology & Vector Control School of Public Health & National Institute for Health ResearchTehran University of Medical ScienceP.O.Box 6446Tehran 14155Iran Departments of malaria CDCMinistry of Health & Medical EducationIran

Objective:To evaluate relationship betweenα-cypermethrin residues in Interceptor~? nets by using HPTLC methods and mortality percentage in standard WHO’s method 'cone test' after repeated ***:Interceptor~? containingα-cypermethrin was provided by BASF *** washing procedure and bioassay tests were carried out according to the WHO-recommended *** vector,*** was exposed to impregnated bed net for three minutes and then mortality measured after 24 hour recovery *** analysis was carried out in chemical laboratory by using high performance thin layer chromatography ***:Result of cone bioassay method showed that washing reduced the efficacy of Interceptor~? bed net from 100%in unwashed nets to 15%at 20 *** 20 washes,nets contain(61.2±2.8) mg/m^2 resulting 15%mortality in cone *** activity was reduced when nets were ***:Results will provide an essential clue for monitoring and evaluation of bioefficacy of any long lasting impregnated bed net for quality *** of this study will be useful for *** investigators and people who wish to use pyrethroid-impregnated bed nets for malaria vector control.

关键词： Anopheles stephensi Interceptor malaria Bioassay test Analytical method

Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease

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Neural Regeneration Research 2022年第1期17卷 31-37页

作者： mercedes A.Hernández-Sapiéns Edwin E.reza-Zaldívar Ana L.márquez-Aguirre Ulises Gómez-Pinedo Jorge matias-Guiu Ricardo R.Cevallos Juan C.mateos-Díaz Víctor J.Sánchez-González Alejandro A.Canales-Aguirre Unidad de Evaluación Preclínica Unidad de Biotecnología Médica y FarmacéuticaCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Instituto de Neurociencias IdISSCHospital Clínico San CarlosMadridEspaña Biochemistry and molecular Genetics Department University of AlabamaBirminghamAlabama Unidad de Biotecnología Industrial Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Centro Universitario de los Altos Universidad de GuadalajaraGuadalajaraMéxico

The presenilin genes(PSEN1 and PSEN2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressive disease *** 1 is the catalytic core of theγ-secretase complex that conducts the intramembranous proteolytic excision of multiple transmembrane proteins like the amyloid precursor protein,Notch-1,N-and E-cadherin,LRP,Syndecan,Delta,Jagged,CD44,ErbB4,and *** 1 plays an essential role in neural progenitor maintenance,neurogenesis,neurite outgrowth,synaptic function,neuronal function,myelination,and ***,an imbalance caused by mutations in presenilin 1/γ-secretase might cause aberrant signaling,synaptic dysfunction,memory impairment,and increased Aβ42/Aβ40 ratio,contributing to neurodegeneration during the initial stages of Alzheimer’s disease *** review focuses on the neuronal differentiation dysregulation mediated by PSEN1 mutations in Alzheimer’s ***,we emphasize the importance of Alzheimer’s disease-induced pluripotent stem cells models in analyzing PSEN1 mutations implication over the early stages of the Alzheimer’s disease pathogenesis throughout neuronal differentiation impairment.

关键词： familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation Notch presenilin 1 PSEN1 mutations γ-secretase complex