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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Deformed photon-added entangled squeezed vacuum and one-photon states: Entanglement, polarization, and nonclassical properties

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Chinese Physics B 2016年第4期25卷 47-56页

作者： A karimi m k Tavassoly Atomic and molecular Group Faculty of Physics Yazd University Physics Group Islamic Azad University of Abadeh The Laboratory of Quantum Information Processing Yazd University

In this paper, after a brief review on the entangled squeezed states, we produce a new class of the continuous-variable- type entangled states, namely, deformed photon-added entangled squeezed states. These states are obtained via the iterated action of the f-deformed creation operator A = f（n）a＋ on the entangled squeezed states. In the continuation, by studying the criteria such as the degree of entanglement, quantum polarization as well as sub-Poissonian photon statistics, the two- mode correlation function, one-mode and two-mode squeezing, we investigate the nonclassical behaviors of the introduced states in detail by choosing a particular f-deformation function. It is revealed that the above-mentioned physical properties can be affected and so may be tuned by justifying the excitation number, after choosing a nonlinearity function. Finally, to generate the introduced states, we propose a theoretical scheme using the nonlinear Jaynes-Cummings model.

关键词： squeezed states deformed photon-added entangled states entanglement quantum polarization

Failure pattern in ceramic metallic target under ballistic impact

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Defence Technology（防务技术） 2024年第10期40卷 173-190页

作者： m.A.Iqbal m.k.k.a. Department of Civil Engineering Indian Institute of Technology RoorkeeRoorkee 247667India Department of Civil Engineering Aligarh Muslim UniversityAligarh202002India

The ballistic resistance and failure pattern of a bi-layer alumina 99.5%-aluminium alloy 1100-H12 target against steel 4340 ogival nosed projectile has been explored in the present experimental cum numerical *** the experimental investigation,damage induced in the ceramic layer has been quantified in terms of number of cracks developed and failure zone *** resultant damage in the backing layer has been studied with variation in the bulge and perforation hole in the backing layer with the varying incidence *** discussion of the experimental results has been further followed by three dimensional finite element computations using ABAQUS/Explicit finite code to investigate the behaviour of different types of bi-layer targets under multi-hit projectile *** JH-2 constitutive model has been used to reproduce the behaviour of alumina 99.5%and JC constitutive model has been used for steel 4340 and aluminium alloy *** total energy dissipation has been noted to be of lesser magnitude in case of sub-sequential impact in comparison to simultaneous impact of two *** distance between the impact points of two projectiles also effected the ballistic resistance of bi-layer *** ballistic resistance of single tile ceramic front layer and four tile ceramic of equivalent area found to be dependent upon the boundary conditions provided to the target.

关键词： Ballistic resistance Bi-layer target Ceramic metal armour multi-hit impact Finite element modelling

The performance of a dissipative electrooptomechanical system using the Caldirola–kanai Hamiltonian approach

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Communications in Theoretical Physics 2023年第7期75卷 123-131页

作者： m m Atabaki m k Tavassoly A Behjat m Hassani Nadiki k Javidan Optics and Laser Group Faculty of PhysicsYazd UniversityYazdIran Department of Physics School of SciencesFerdowsi University of MashhadMashhad 91775-1436Iran

By combining all optical,electronic,and mechanical capabilities,electro-optomechanical systems,along with the use of mechanical displacement,the conversion of low-frequency electrical signals into much higher-frequency optical signals is *** process provides several capabilities that have very important applications in various fields,including classical,as well as quantum *** this regard,the inevitable effect of dissipation on the performance indicators of such systems is one of the important issues affecting its *** approach for investigating the effect of dissipation is based on a time-dependent Hamiltonian has been known as the Caldirola-kanai(Ck)Hamiltonian,wherein the exponentially increasing mass,i.e.m(t)=m0(eγt)enters the mechanical oscillator *** this approach shows that,the performance of the system under the influence of dissipation with Ck Hamiltonian formalism,in which the dissipation terms are embedded in the Hamiltonian,are more logical,analytical,and reliable than considering the effect of dissipation with the phenomenological method(including the dissipation effects in the equations of motion by hand),which has been recently used in Bagci et al.(Nature,507,81,2014).In our method,it is also possible to monitor the performance of the system via the adjustment of dissipation components,i.e.,resistance R and reactance L(and Ck damping parameterγ)in the electrical(mechanical membrane)part of the system.

关键词： dissipative system electro-optomechanical system Caldirola-kanai Hamiltonian

Generalization properties of restricted Boltzmann machine for short-range order

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Chinese Physics B 2023年第6期32卷 556-562页

作者： m A Timirgazin A k.a.zhnikov Udmurt Federal Research Center Ural Branch of RASIzhevsk 426067Russia

A biased sampling algorithm for the restricted Boltzmann machine(RBm) is proposed, which allows generating configurations with a conserved quantity. To validate the method, a study of the short-range order in binary alloys with positive and negative exchange interactions is carried out. The network is trained on the data collected by monte–Carlo simulations for a simple Ising-like binary alloy model and used to calculate the Warren–Cowley short-range order parameter and other thermodynamic properties. We demonstrate that the proposed method allows us not only to correctly reproduce the order parameters for the alloy concentration at which the network was trained, but can also predict them for any other concentrations.

关键词： machine learning short-range order Ising model restricted Boltzmann machine

An Overview of Bangladeshi Shipbuilding in the Light of Competitive Parameters

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Journal of Shipping and Ocean Engineering 2011年第1期1卷 8-19页

作者： N.m.G. Zakaria m.T. Ali k.a. Hossain Department of Naval Architecture and marine Engineering Bangladesh University of Engineering and Technology Dhaka 1000Bangladesh

Shipbuilding in Bangladesh has been considered as the most promising industry in the recent time and the country is dreaming to emerge as a middle income country within a short time by maintaining the upward trend of this sector. However, due to global nature and the long term sustainability of this shipbuilding industry, an investigation of competitiveness in terms of global standard is of prime importance. This paper focuses on studying some crucial competitive factors like labor skill, labor availability, labor man-hour, labor cost ＆ productivity for local shipbuilding in Bangladesh. The analysis also focuses on existing access to the resources like materials, knowledge and capital which are equally important factors for the expansion of shipbuilding. Comparison of these parameters with other nations have been made qualitatively and quantitatively to find the level of our shipbuilding. On the basis of existing condition and future vision, some recommendations have been made which might be useful for accelerating the development of this sector.

关键词： Shipbuilding competitive factor productivity R&D labor cost.

Synthesis of Aligned ZnO Nanorod Array on Silicon and Sapphire Substrates by Thermal Evaporation Technique

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Journal of materials Science & Technology 2011年第8期27卷 701-706页

作者： k.m.k. Srivatsa Deepak Chhikara m. Senthil kumar materials Physics and Engineering Division National Physical Laboratory Council of Scientific & Industrial Research (CSIR) Physics of Energy Harvesting Division National Physical Laboratory Council of Scientific & Industrial Research (CSIR)

High density ZnO nanorods were grown by thermal evaporation of Zn powder at 700℃ on Si （100） and sapphire （0001） substrates at atmospheric pressure without adding any catalyst. The nanorods were characterizated in terms of their structural and optical properties. The nanorods grown on Si have a diameter of 350-400 nm and a length of 1.2 μm while those on sapphire have a diameter of 600-800 nm and a length of 2.5 μm. During the structural characterization, it is noticed that the rods grow along the （0002） plane with perfect hexagonal facet. The room temperature photoluminescence spectrum showed a strong UV emission peak.a. 385 nm with a weak green band emission, which confirms that nanorods have good optical properties. It is observed that the oxygen partial pressure plays an important role to control the shape and size of the nanorods in thermal evaporation growth technique.

关键词： Thermal evaporation technique ZnO nanorods X-ray diffraction Photoluminescence

Aging Coefficient, Creep Coefficient and Extrapolating Aging Coefficient from Short Term Test for Sealed Concrete

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Journal of Wuhan University of Technology(materials Science) 2011年第1期26卷 154-159页

作者： Shrestha k m College of Civil Engineering Fuzhou University

Aging coefficient and creep coefficient are important parameters for creep analysis of any structure. With the aim to obtain those parameters, an experimental investigation is carried out on sealed concrete. Altogether ten specimens were tested, out of which four were for creep, two for shrinkage and remaining four for relaxation test. A year of relaxation test and two years of creep test results were analyzed to compute aging coefficient and creep coefficient. From regression analysis of observed and calculated aging coefficient using formula of Bazant and kim, modification for aging coefficient is performed and extrapolation equations are generated. Instead of ACI model, B3 model has been used to obtain compliance function as the parameters of B3 model seems more relevant to creep mechanism of concrete compared to that of ACI model.

关键词： stress strength ratio creep test experimental study B3 model regression analysis

Solution‑Processed Thin Film Transparent Photovoltaics:Present Challenges and Future Development

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Nano-micro Letters 2025年第2期17卷 566-600页

作者： Tianle Liu munerah m.S.Almutairi Jie ma Aisling Stewart Zhaohui Xing mengxia Liu Bo Hou Yuljae Cho Um-SJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Physics and Astronomy Cardiff UniversityCardiff CF243AAWalesUK Department of Electrical and Computer Engineering Yale UniversityNew HavenCT 06511USA Energy Sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovoltaics Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is essential for modern society to sustain economic *** soaring demand for the electrical energy,together with an awareness of the environmental impact of fossil fuels,has been driving a shift towards the utilization of solar ***,traditional solar energy solutions often require extensive spaces for a panel installation,limiting their practicality in a dense urban *** overcome the spatial constraint,researchers have developed transparent photovoltaics(TPV),enabling windows and facades in vehicles and buildings to generate electric *** TPV advancements are focused on improving both transparency and power output to rival commercially available silicon solar *** this review,we first briefly introduce wavelength-and non-wavelengthselective strategies to achieve *** of merit and theoretical limits of TPVs are discussed to comprehensively understand the status of current TPV *** we highlight recent progress in different types of TPVs,with a particular focus on solution-processed thin-film photovoltaics(PVs),including colloidal quantum dot PVs,metal halide perovskite PVs and organic *** applications of TPVs are also reviewed,with emphasis on agrivoltaics,smart windows and ***,current challenges and future opportunities in TPV research are pointed out.

关键词： Transparent semiconductors Solution-processable transparent solar cell Emerging solar cell materials Buildingintegrated photovoltaics