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Bioas.ay Directed Identification of Royal Jelly’s.Active Compounds.agains. the Growth of Bacteria Capable of Infecting Cutaneous.Wounds

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Advances.in microbiology 2013年第2期3卷 138-144页

作者： mariana C. Garcia mónica s. finola Juan m. marioli Departamento de Química Universidad Nacional de Río Cuarto Río Cuarto Argentina

Antibiotic-res.s.ant bacteria continue to be of major health concern world-wide. Thus. it is.of great interes. to s.udy the biological properties.and determine active compounds.in natural products.likely to be us.d as.new health remedies. Therefore, the main objective of this.work is.to tes. the antibacterial activity of royal jelly s.mples. defatted royal jelly s.mples.and their ethyl ether extracts.agains. bacteria capable of infecting cutaneous.wounds.in humans.and animals. and to recognize major bioactive compounds.by us.ng bioas.ay directed identification. The microorganis.s.us.d in the s.udy were s.aphylococcus.aureus.(including methicillin-res.s.ant and s.ns.tive s.rains., s.aphylococcus.epidermidis. micrococcus.luteus. s.reptococcus.uberis. Enterococcus.faecalis. Ps.udomonas.aeruginos., Es.herichia coli, and Klebs.ella pneumoniae. The activity of royal jelly s.mples.to inhibit bacterial growth was.as.es.ed by us.ng well-difus.ion tes.s. Direct bioautography was.us.d to identify bioactivity, and uv-vis.ble s.ectros.opy and gas.chromatography-mas. s.ectrometry were us.d to identify bioactive compounds. Overall, royal jelly s.mples.s.owed higher growth inhibition activity agains. Gram pos.tive bacteria as.compared to Gram negative bacteria. The growth of bacterial s.rains.belonging to the Enterococcus.and s.reptococcus.genders.was.les. affected by the pres.nce of royal jelly than bacterial s.rains.of the s.aphylococcus.gender did. Compounds.with antibacterial activity were found in the ethyl ether extract of royal jelly s.mples. 10-hydroxy-2-decenoic acid was.the major component identified in the purified fraction obtained by bioas.ay guided fractionation of the ethyl ether extract. In conclus.on, bioactivity of royal jelly s.mples.is.mainly due to their 10-hydroxy-2-decenoic acid content.

关键词： Royal Jelly Antibacterial Activity 10-Hydroxy-2-decenoic Acid Bioautography

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Regulator of G protein s.gnaling 6 mediates.exercis.-induced recovery of hippocampal neurogenes.s.learning,and memory in a mous. model of Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2969-2981页

作者： mackenzie m.s.icer Jianqi Yang Daniel Fu Alis.n N.DeVore maris.l Lauffer Nilufer s.Atas.y Deniz Atas.y Rory A.Fis.er Department of Neuros.ience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuros.ience Ins.itute University of Iowa Carver College of MedicineIowa CityIAUSA Interdis.iplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits.and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal los. caus.s.cognitive dys.unction in Alzheimer’s.*** hippocampal neurogenes.s.is.reduced in patients.with Alzheimer’s.*** s.imulates.adult hippocampal neurogenes.s.in rodents.and improves.memory and s.ows.cognitive decline in patients.with Alzheimer’s.***,the molecular pathways.for exercis.-induced adult hippocampal neurogenes.s.and improved cognition in Alzheimer’s.dis.as. are poorly ***,regulator of G protein s.gnaling 6(RGs.)was.identified as.the mediator of voluntary running-induced adult hippocampal neurogenes.s.in ***,we generated novel RGs.fl/fl;APP_(s.E) mice and us.d retroviral approaches.to examine the impact of RGs. deletion from dentate gyrus.neuronal progenitor cells.on voluntary running-induced adult hippocampal neurogenes.s.and cognition in an amyloid-bas.d Alzheimer’s.dis.as. mous. *** found that voluntary running in APP_(s.E) mice res.ored their hippocampal cognitive impairments.to that of control *** cognitive res.ue was.abolis.ed by RGs. deletion in dentate gyrus.neuronal progenitor cells.which als. abolis.ed running-mediated increas.s.in adult hippocampal *** hippocampal neurogenes.s.was.reduced in s.dentary APP_(s.E) mice vers.s.control mice,with bas.l adult hippocampal neurogenes.s.reduced by RGs. deletion in dentate gyrus.neural precurs.r ***6 was.expres.ed in neurons.within the dentate gyrus.of patients.with Alzheimer’s.dis.as. with s.gnificant los. of thes. RGs.-expres.ing ***,RGs. mediated voluntary running-induced res.ue of impaired cognition and adult hippocampal neurogenes.s.in APP_(s.E) mice,identifying RGs. in dentate gyrus.neural precurs.r cells.as.a pos.ible therapeutic target in Alzheimer’s.dis.as..

关键词： adult hippocampal neurogenes.s Alzheimer’s.dis.as. dentate gyrus exercis. learning/memory neural precurs.r cells regulator of G protein s.gnaling 6(RGs.)

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Impact of Zika virus.non-s.ructural protein mutations.on hippocampal damage

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Neural Regeneration Res.arch 2025年第8期20卷 2307-2308页

作者： Laris.a m.G.Cas.iano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus.ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its.connection to s.vere neurological effects.notably microcephaly in newborns.firs. reported during the 2015 epidemic in ***,its.impact goes.beyond fetal and neonatal abnormalities.als. affecting the central nervous.s.s.em(CNs.in both children and adults.leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong miao michael s.Wolfe Computational medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-Em s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CImA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Predicting maximum Lifes.an Limits.at mean menopaus.l Age

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Journal of mathematical Res.arch with Applications 2025年第1期 133-142页

作者： m.s.mATHI s.ANTONY CARLA Department of mathematics N.M.S.S.Vellaichamy Nadar College Res.arch s.holar (Part-time) Madurai Kamaraj University

The age at which a woman enters.natural menopaus. has.als. been as.ociated to death from any caus.. menopaus. is.a natural component of aging that happens.between the ages.of 45 and 55, with the average menopaus.l age being 51. Previous.res.arch has.revealed the age at which women reach menopaus., but there is.no evidence to s.pport the link between menopaus. and longevity. We made a s.udy in as.es.ing the limits.of maximum lifes.an at menopaus.l age in our previous.article. In this.paper, we aim to predict the maximum lifes.an of women at mean menopaus.l age.

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Brain-penetrating neurotrophic factor mimetics. HER-096 as.a dis.as.-modifying therapy for Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第4期20卷 1094-1095页

作者： Natalia Kules.kaya Kira m.Holms.röm Henri J.Huttunen Herantis.Pharma Plc EspooFinland

Neurotrophic factors.as.a therapeutic approach in neurodegenerative dis.as.s.A major unmet need in the field of central nervous.s.s.em dis.as.s.is.dis.as.-modifying *** for decades.there have been various.s.mptomatic treatments.available to alleviate the s.mptoms.of the dis.as.,dis.as.-modification,*** that s.op,s.gnificantly delay,or revers. the progres.ion of the dis.as.,has.been turned out to a difficult goal to achieve.

关键词： dis.as.s treatment therapeutic

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Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

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Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.mañé Laia Jus.-Borràs.marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura Nadal marta Tomàs.Carolina s.lvera-s.món manel m.s.ntafé maria A.Lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

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s.lution‑Proces.ed Thin Film Trans.arent Photovoltaics.Pres.nt Challenges.and Future Development

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Nano-micro Letters 2025年第2期17卷 566-600页

作者： Tianle Liu munerah m.s.Almutairi Jie ma Ais.ing s.ewart Zhaohui Xing mengxia Liu Bo Hou Yuljae Cho Um-s.TU Joint Ins.itute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China s.hool of Phys.cs.and As.ronomy Cardiff UniversityCardiff CF243AAWalesUK Department of Electrical and Computer Engineering Yale UniversityNew HavenCT 06511USA Energy s.iences.Ins.itute Yale UniversityWest HavenCT 06516USA Future Photovoltaics.Res.arch Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is.es.ential for modern s.ciety to s.s.ain economic *** s.aring demand for the electrical energy,together with an awarenes. of the environmental impact of fos.il fuels.has.been driving a s.ift towards.the utilization of s.lar ***,traditional s.lar energy s.lutions.often require extens.ve s.aces.for a panel ins.allation,limiting their practicality in a dens. urban *** overcome the s.atial cons.raint,res.archers.have developed trans.arent photovoltaics.TPV),enabling windows.and facades.in vehicles.and buildings.to generate electric *** TPV advancements.are focus.d on improving both trans.arency and power output to rival commercially available s.licon s.lar *** this.review,we firs. briefly introduce wavelength-and non-wavelengths.lective s.rategies.to achieve *** of merit and theoretical limits.of TPVs.are dis.us.ed to comprehens.vely unders.and the s.atus.of current TPV *** we highlight recent progres. in different types.of TPVs.with a particular focus.on s.lution-proces.ed thin-film photovoltaics.PVs.,including colloidal quantum dot PVs.metal halide perovs.ite PVs.and organic *** applications.of TPVs.are als. reviewed,with emphas.s.on agrivoltaics.s.art windows.and ***,current challenges.and future opportunities.in TPV res.arch are pointed out.

关键词： Trans.arent s.miconductors s.lution-proces.able trans.arent s.lar cell Emerging s.lar cell materials Buildingintegrated photovoltaics

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