检索结果-南通市图书馆

Acute Effects of Stretching on Flexibility and Performance:A Narrative Review

在线全文

学校读者我要写书评

暂无评论

Journal of Science in Sport and Exercise 2019年第1期1卷 29-37页

作者： Camila d.lima Cassio V.Ruas david G.Behm Lee E.Brown School of Human Kinetics and Recreation Memorial University of NewfoundlandSt.John’sCanada Centre for Exercise and Sports Science Research(CESSR) School of Medical and Health SciencesEdith Cowan UniversityJoondalupAustralia department of Kinesiology California State UniversityFullerton7178 Loysburg StreetNavarreFL 32566USA

Passive and active stretching techniques have been shown to increase both chronic and acute range of motion(ROm).Acute ROm improvements can be countered by decreases in muscle performance,primarily after prolonged static stretching(SS)and proprioceptive neuromuscular facilitation(PNF)techniques when not incorporated into a full warm up *** contrast,ballistic stretching and dynamic stretching techniques typically induce either an increase or no change in muscular force and *** review explores studies that have investigated stretching responses on ROm,muscle functionality and ***,the literature demonstrates that prolonged acute SS and PNF stretching can elicit the greatest changes in flexibility,but without additional dynamic activities(*** warm up)can induce neuromuscular force and power output impairments,while increasing ROm and some sports specific *** response to stretching may be determined by the manipulation of confounding variables such as duration,population,volume,test specificity and *** increased dosage of some of these variables during stretching in isolation,augments ROm increases while attenuating muscle force output,except for stretching intensity which may lead to similar *** with high flexibility may have positive effects from stretching when tested on their sport specific performance,while general population may suffer greater negative *** control-ling these variables during stretching protocols may lead to misleading information regarding its effects on muscle performance.

关键词： Passive stretching Active stretching Range of motion Performance

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBimEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

mitochondrial GPX1 silencing triggers differential photosynthesis impairment in response to salinity in rice plants

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2016年第8期58卷 737-748页

作者： Yugo lima-melo Fabricio E.L.Carvalho márcio O.martins Gisele Passaia Rachel H.V.Sousa milton C.lima Neto márcia margis-Pinheiro Joaquim A.G.Silveira department of Biochemistry and molecular Biology Federal University of Ceará department of Genetics Federal University of Rio Grande do Sul

The physiological role of plant mitochondrial glutathione peroxidases is scarcely known. This study attempted to elucidate the role of a rice mitochondrial isoform（GPX1） in photosynthesis under normal growth and salinity conditions. GPX1 knockdown rice lines（GPX1s） were tested in absence and presence of 100 mm NaCl for 6 *** reduction of GPX1 s line under non-stressful conditions, compared with non-transformed（NT） plants occurred in parallel to increased H_2O_2 and decreased GSH contents. These changes occurred concurrently with photosynthesis impairment, particularly in Calvin cycle＇s reactions, since photochemical efficiency did not ***, GPX1 silencing and downstream molecular/metabolic changes modulated photosynthesis differentially. In contrast, salinity induced reduction in both phases of photosynthesis, which were more impaired in silenced *** changes were associated with root morphology alterations but not shoot growth. Both studied lines displayed increased GPX activity but H_2O_2 content did not change in response to salinity. Transformed plants exhibited lower photorespiration, water use efficiency and root growth, indicating that GPX1 could be important to salt tolerance. Growth reduction of GPX1 s line might be related to photosynthesis impairment, which in turn could have involved a cross talk mechanism between mitochondria and chloroplast originated from redox changes due to GPX1 deficiency.

关键词： CO2 assimilation glutathione peroxidase Oryza sativa photochemistry redox homeostasis

molecular basis and management of gastrointestinal stromal tumors

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第22期16卷 2726-2734页

作者： Ulas d Bayraktar Soley Bayraktar Caio m Rocha-lima division of Hematology and Oncology Sylvester Comprehensive Cancer Center University of Miami

molecularly targeted agents have dramatically impacted the management of several cancers. Targeting KIT has led to a new treatment paradigm in gastrointestinal stromal tumors (GISTs). KIT is a cell surface receptor with tyrosine kinases that, upon binding of its ligand, stem cell factor, activates various signaling pathways. Imatinib and sunitinib, both tyrosine kinase inhibitors directed to KIT, were approved for firstand secondline treatment of metastatic and unresectable GISTs. In this article, we will review the molecular pathogenesis of GISTs followed by a discussion of imatinib and sunitinib’s role in the treatment of GISTs. Finally, we will introduce novel therapeutic options for imatiniband sunitinib-resistant GISTs.

关键词： Gastrointestinal stromal tumor KIT Imatinib Sunitinib Nilotinib

metal-enriched nanoparticles and black carbon:A perspective from the Brazil railway system air pollution

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2021年第3期12卷 624-635页

作者： Bianca d.lima Elba C.Teixeira James C.Hower matheus S.Civeira Omar Ramírez Cheng-Xue Yang marcos L.S.Oliveira Luis F.O.Silva Postgraduate Program in Remote Sensing and meteorology Geosciences InstituteUniversidade Federal do Rio Grande do SulAv.Bento Gonçalves9500Porto AlegreRS 91501–970Brazil Research department Fundação Estadual de Proteção Ambiental Henrique Luís RoesslerAv.Borges de Medeiros261Porto AlegreRS 90020–021Brazil Center for Applied Energy Research University of Kentucky2540 Research Park DriveLexingtonKY 40511USA Postgraduate Program in mines Metallurgy and MaterialsUniversidade Federal do Rio Grande do SulAv.Bento Gonçalves9500Porto AlegreRS 91501–970Brazil Faculty of Engineering Environmental EngineeringUniversidad Militar Nueva GranadaKm 2 CajicáZipaquiráColombia Institute of Earth Science China University of Geosciences(Beijing)29 Xueyuan RdHaidian DistrictChina department of Civil and Environmental Universidad de la CostaCUCCalle 58#55-66BarranquillaAtlanticoColombia Universidad de lima Departamento de Ingeniería civil y Arquitectura.Avenida Javier Prado Este 4600–Santiago de Surco 1503Peru

Having a better understanding of air pollutants in railway systems is crucial to ensure a clean public *** study measured,for the first time in Brazil,nanoparticles(NPs)and black carbon(BC)on two groundlevel platforms and inside trains of the metropolitan Area of Porto Alegre(mAPA).An intense sampling campaign during thirteen consecutive months was carried out and the chemical composition of NPs was examined by advanced microscopy *** results showed that highest concentrations of the pollutants occur in colder seasons and influenced by variables such as frequency of the trains and passenger ***,internal and external sources of pollution at the stations were *** predominance of NPs enriched with metals that increase oxidative stress like Cd,Fe,Pb,Cr,Zn,Ni,V,Hg,Sn,and Ba both on the platforms and inside trains,including Fe-minerals as hematite and magnetite,represents a critical risk to the health of passengers and employees of the *** interdisciplinary and multi-analytical study aims to provide an improved understanding of reported adverse health effects induced by railway system aerosols.

关键词： Nanoparticles Potential hazardous elements Environmental chemistry Human health Railway environment Indoor air quality

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa department of Psychology and Neuroscience Duke UniversityDurhamNCUSA department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal dOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting