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robotic-assisted retroperitoneal lymph node dissection for stage II testicular cancer

Asian Journal of Urology 2024年第1期11卷 121-127页

作者： George McClintock Ahmed S.Goolam Don Perera ryan Downey Scott Leslie Peter Grimison Henry Woo Peter ferguson Nariman Ahmadi Department of Urology Chris O'Brien LifehouseSydneyNSWAustralia Department of Anaesthesia Chris O'Brien LifehouseSydneyNSWAustralia The University of Sydney SydneyNSW2006Australia Department of Medical Oncology Chris O'Brien LifehouseSydneyNSWAustralia

Objective:To evaluate the perioperative as well as early oncological outcomes of patients undergoing robotic retroperitoneal lymph node dissection for treatment of testicular ***:We conducted a prospective consecutive case series of patients undergoing robotic assisted retroperitoneal lymph node dissection for metastatic testicular cancer between May 2018 and July 2021 at our *** were collected on patient and tumour characteristics,intraoperative and postoperative parameters,and functional and oncological *** statistics are ***:Nineteen patients were identified;18(94.7%)completed the procedure robotically and one was converted to open surgery;78.9%of patients had stage≥IIB and 12(63.2%)patients had undergone prior *** median operative time was 300(interquartile range[IQr]240-315)*** blood loss was 100(IQr 50-175)*** length of stay was 2(range 1-11)*** robotically completed patients commenced diet and passed flatus on Day 1 and were discharged by Day *** median lymph node yield was 40.5(IQr 38-51)*** patients undergoing nerve-sparing procedures recovered antegrade ejaculatory *** patient had a Clavien-Dindo III complication(chylous ascites requiring drainage).At a median follow-up of 22.3(IQr 16.3-24.9)months,one patient developed retroperitoneal recurrence,which was successfully treated with second-line chemotherapy;no other patients have had ***:robotic retroperitoneal lymph node dissection is a safe and feasible alternative to open surgery in appropriately selected patients,offering low *** oncological outcomes are *** cohorts and longer follow-ups are required to validate our institution's findings.

关键词： retroperitoneal lymph node dissection robotic surgery Testicular cancer retroperitoneal node dissection

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MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural regeneration research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma Jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux ferguson Shenfeng Qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural regeneration research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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低危宫颈癌妇女单纯子宫切除术与根治性子宫切除术的比较

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中国临床药理学杂志 2024年第8期40卷 1159-1159页

作者： PLANTE M KWON J S ferguson S 王超群

回顾性资料显示,早期低危宫颈癌患者参数浸润发生率较低,这就提出了这些患者是否需要根治性子宫切除术的问题。然而,比较根治性和单纯性子宫切除术结果的大型随机试验数据缺乏。本研究进行了一项多中心、随机、非劣效性试验,比较了低危... 详细信息

回顾性资料显示,早期低危宫颈癌患者参数浸润发生率较低,这就提出了这些患者是否需要根治性子宫切除术的问题。然而,比较根治性和单纯性子宫切除术结果的大型随机试验数据缺乏。本研究进行了一项多中心、随机、非劣效性试验,比较了低危宫颈癌(病变≤2cm,间质浸润有限)患者的根治性子宫切除术和单纯性子宫切除术,包括淋巴结评估。主要结局是3年盆腔肿瘤复发(盆腔复发)。预先规定的3年盆腔复发组间差异的非劣效性界限为4个百分点。

关键词：根治性子宫切除术盆腔肿瘤回顾性资料间质浸润宫颈癌患者盆腔复发预先规定低危

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A simulation-based evaluation of the absolute and comparative approaches in a code compliance process from the energy use perspective: Cold-climate case study

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Building Simulation 2022年第8期15卷 1401-1418页

作者： Sara Gilani Alex ferguson Meli Stylianou CanmetENErGY-Ottawa Natural Resources Canada1 Haanel DrOttawaON K1A 1M1Canada

Like many countries,Canada's building code includes a performance compliance path that compares the energy use of a proposed design to that of a reference ***,provinces across Canada are contemplating an alternative absolute energy use intensity ***,the effect of adopting the absolute approach on house design is not well *** study first developed a proof-of-concept methodology for a technical simulation-based comparison of the two ***,it performed a comparative analysis between the design outcomes of the two approaches using the developed *** this end,statistically representative archetypes were configured to comply with the prescriptive requirements of the building *** characteristics of each archetype were then varied through parametric study,and the resulting energy performance under the absolute and comparative approaches were *** results of this study indicated that the two approaches had different effects on the design and energy use of houses in heating-dominated climate *** performing better under the absolute approach consumed less energy and exhibited more compact architectural *** houses were also less sensitive to improvements in airtightness and envelope than houses performing better under the comparative *** results suggest that adopting the absolute approach based on the energy use intensity metric in building codes would encourage design and construction of houses with higher energy efficiency.

关键词： performance path energy efficiency absolute target percent better than code reference building archetype

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An Empirical Study on the Impact of Automation on the requirements Analysis Process

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Journal of Computer Science & Technology 2007年第3期22卷 338-347页

作者： Giuseppe Lami robert W.ferguson Istituto di Scienza e Tecnologie dell'Informazione"Alessandro Faedo" 1-56124 Pisa Italy Software Engineering Institute Carnegie Mellon University 15213 PittsburghPAU.S.A.

requirements analysis is an important phase in a software project. The analysis is often performed in an informal way by specialists who review documents looking for ambiguities, technical inconsistencies and incomplete parts. Automation is still far from being applied in requirements analyses, above all since natural languages are informal and thus difficult to treat automatically. There are only a few tools that can analyse texts. One of them, called QuArS, was developed by the Istituto di Scienza e Tecnologie dell＇Informazione and can analyse texts in terms of ambiguity. This paper describes how QuArS was used in a formal empirical experiment to assess the impact in terms of effectiveness and efficacy of the automation in the requirements review process of a software company.

关键词： requirements/specifications analysis requirements/specifications tools process metrics

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Two-Way Interactions Between Equatorially-Trapped Waves and the Barotropic Flow

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Chinese Annals of Mathematics,Series B 2009年第5期30卷 539-568页

作者： James ferguson Boualem KHOUIDEr Maryam NAMAZI Department of Mathematics and Statistics University of Victoria Department of Mathematics and Statistics University of VictoriaPO BOX 3045 STN CSC Victoria

Lateral energy exchange between the tropics and the midlatitudes is a topic of great importance for understanding Earth＇s climate system. In this paper, the authors address this issue in an idealized set up through simple shallow water models for the interactions between equatorially trapped waves and the barotropic mode, which supports rossby waves that propagate poleward and can excite midlatitude teleconnection patterns. It is found here that the interactions between a Kelvin wave and a fixed meridionai shear （mimicking the jet stream） generates a non-trivial meridional velocity and meridional convergence in phase with the upward motion that can attain a maximum of about 50%, which oscillates on frequencies ranging from one day to 10 days. When, on the other hand, the barotropic flow is forced by slowly propagating Kelvin waves a complex flow pattern emerges; it consists of a phase-locked barotropic response that is equatoriaily trapped and that propagates eastward with the forcing Kelvin wave and a certain number of planetary rossby waves that propagate westward and toward the poles as seen in nature. It is suggested here that the poleward propagating waves are to some sort of multi-way resonant interaction with the phase locked response. Moreover, it is shown here that a numerical scheme with dispersion properties that depend on the direction perpendicular to the direction of propagation, namely the 2D central scheme of Nessyahu and Tadmor, can artificially alter significantly the topology of the wave fields and thus should be avoided in climate models.

关键词： Equatorially trapped waves Wave interactions Jet stream rossby waves Phase locked Dispersion relation Central scheme Climate modeling

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构建中国对外话语体系应对复杂严峻国际环境

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国际传播 2024年第1期 3-9页

作者： [英]大卫·弗格森周雨平(译) 江璐(译校) 外文出版社中国外文局北京外国语大学高级翻译学院

如何在当前复杂严峻的国际环境里推动中国对外话语体系建设?为回答这一问题,本文首先分析了美方如何破坏中美关系,探讨了“中国威胁论”如何影响西方发达国家的对华态度;在此基础上,本文认为,中国应在未来更加行之有效地与西方国家民众... 详细信息

如何在当前复杂严峻的国际环境里推动中国对外话语体系建设?为回答这一问题,本文首先分析了美方如何破坏中美关系,探讨了“中国威胁论”如何影响西方发达国家的对华态度;在此基础上,本文认为,中国应在未来更加行之有效地与西方国家民众进行对话。本文还为构建中国话语体系提出建设性意见,并阐释了这一对外话语体系的可行性。

关键词：中国对外话语中美关系人类命运共同体 “中国威胁论”

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Esophageal resection for high-grade dysplasia and intramucosal carcinoma: When and how?

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World Journal of Gastroenterology 2010年第30期16卷 3786-3792页

作者： Vani JA Konda Mark K ferguson Department of Medicine The University of Chicago Pritzker School of MedicineChicagoIL 60637United States Department of Surgery The University of Chicago Pritzker School of MedicineChicagoIL 60637United States

High-grade dysplasia (HGD) and intramucosal carcinoma (IMC) in the setting of Barrett’s esophagus have traditionally been treated with esophagectomy. However, with the advent of endoscopic mucosal resection and endoscopic ablative therapies, endoscopic therapy at centers with expertise is now an established treatment of Barrett’s-esophagus-related neoplasia, including HGD and IMC. Esophagectomy is today reserved for more selected cases with submucosal invasion, evidence for lymph node metastasis, or unsuccessful endoscopic therapy.

关键词： Barrett’s esophagus High-grade dysplasia Intramucosal carcinoma Endoscopic mucosal resection Esophagectomy

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Characterization of deep acceptor level in as-grown ZnO thin film by molecular beam epitaxy

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Chinese Physics B 2014年第9期23卷 364-368页

作者： M.Asghar K.Mahmood M.A.Hasan I.T.ferguson r.Tsu M.Willander Department of Physics The Islamia University of Bahawalpur Department of Electrical and Computer Engineering University of North Carolina Charlotte Department of Science and Technology Linkping University Norrkping

We report deep level transient spectroscopy results from ZnO layers grown on silicon by molecular beam epitaxy （MBE）, The hot probe measurements reveal mixed conductivity in the as-grown ZnO layers, and the current-voltage （l-V） measurements demonstrate a good quality p-type Schottky device. A new deep acceptor level is observed in the ZnO layer having activation energy of 0.49 ± 0.03 eV and capture cross-section of 8,57 ×10^-18 cm^2. Based on the results from raman spectroscopy, photoluminescence, and secondary ion mass spectroscopy （SIMS） of the ZnO layer, the observed acceptor trap level is tentatively attributed to a nitrogen-zinc vacancy complex in ZnO,

关键词： ZnO secondary ion mass spectroscopy photoluminescence raman spectroscopy

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