检索结果-南通市图书馆

Fish oils in parenteral nutrition: Why could these be important for gastrointestinal oncology?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2015年第9期7卷 128-131页

作者： lynnette r ferguson ACSrC/Discipline of Nutrition and Dietetics School of Medical Sciences Faculty of Medical and Health Sciences the University of Auckland

By the time a gastroenterology patient is moved to parenteral nutrition, he or she is usually in poor health. All parenteral nutrition formulae contain essen-tial nutrients, avoiding components that could cause an adverse reaction. The lipid component is often provided by a soy extract, containing all the fatty acids considered to be essential in the diet. Several trials have considered parenteral nutrition formulas with added fish oils, high in the long chain omega-3 polyunsaturated fatty acids, eicosapentaenoic acid(EPA) and docosahexaenoic acid(DHA). Given the range of biological functions associated with such compounds, especially in reducing inflammatory symptoms, this move would appear rational. However, while data from such trials are often positive, there has been variability among results. Some of this variability could be caused by environmental contaminants in the fish, and/or oxidation of the lipids because of poor storage. The situation is complicated by a recent report that fish oils may counter the effects of platinum chemotherapy. However, this effect associated with a minor component, hexadeca-4,7,10,13-tetraenoic acid. It is suggested that pure DHA and EPA would be beneficial additions to parenteral nutrition, reducing the probability of carcinogenesis and enhancing rational disease management. However, the jury is still out on fish oils more generally.

关键词： Inflammatory bowel diseases Colorectal cancer Fish

recent advances in understanding of interactions between genes and diet in the etiology of colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2010年第3期2卷 125-129页

作者： lynnette r ferguson Discipline of Nutrition University of Auckland

At an international level, colorectal cancer (CrC) is a major cause of morbidity and mortality. Diet plays a major etiologic role, and a range of putative dietary carcinogens have been identified. The probability with which these lead to mutations, and thereby cause cancer, is strongly impacted by variants in genes coding for xenobiotic metabolizing or DNA repair enzymes. Nutrient def iciencies also play a role, which will be exacerbated by variants in metabolic genes. However, many of the causal genes in sporadic CrC have hitherto proved elusive. The power of large international collabor ations, coupled with genome-wide association studies, has implicated a major functional role of the tumour growth factor-β pathway in CrC susceptibility. Nutrient regulation of gene expression may be especially important here. Future large collaborative studies must consider gene-gene and gene-diet interactions, coupled with high throughput genomic technologies, in order to uncover the relative roles of genetic variants, mutagenic xenobiotics, nutrient imbalance and gene expression in the etiology of CrC.

关键词： Transforming growth factor β Colorectal cancer Single nucleotide polymorphisms Genome wide association studies Gene expression

Micro rNA biomarkers predicting risk,initiation and progression of colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第33期22卷 7389-7401页

作者： Kyungjin Lee lynnette r ferguson Medical Programme and Discipline of Nutrition and Dietetics and Auckland Cancer Society research Centre Faculty of Medical and Health ScienceThe University of Auckland Discipline of Nutrition and Dietetics and Auckland Cancer Society research Centre Faculty of Medical and Health ScienceThe University of Auckland

Colorectal cancer is a major global cause of morbidity and mortality. Current strategies employed to increase detection of early,curable stages of this disease are contributing to a reduction of the negative health impact from it. While there is a genetic component to the risk of disease,diet and environment are known to have major effects on the risk of an individual for developing the disease. However,there is the potential to reduce the impact of this disease further b y preventing disease develop ment. Biomarkers which can either predict the risk for or early stages of colorectal cancer could allow intervention at a time when prospects could be modified by environmental factors,including lifestyle and diet choices. Thus,such biomarkers could be used to identify high risk individuals who would benefit from lifestyle and dietary interventions to prevent this disease. This review will give an overview on one type of biomarker in the form of micro rNAs,which have the potential to predict an individual's risk for colorectal cancer,as well as providing a highly sensitive and non-invasive warning of disease presence and/or progression. Micro rNA biomarkers which have been studied and whose levels look promising for this purpose include Mi r-18 a,Mi r-21,Mi r-92 a,Mi r-135 b,Mi r-760,Mi r-601. Not only have several individual micro rNAs appeared promising as biomarkers,but panels of these may be even more useful. Furthermore,understanding dietary sources and ways of dietary modulation of these micro rNAs might be fruitful in reducing the incidence and slowing the progression of colorectal cancer.

关键词： Biomarkers Epigenetics risk Colorectal cancer Predisposition MicrorNA

Why interleukin-10 supplementation does not work in Crohn's disease patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第25期19卷 3931-3941页

作者： Gareth J Marlow Dominique van Gent lynnette r ferguson Discipline of Nutrition Faculty of Medical and Health Sciences The University of Auckland Auckland 1142 New Zealand Gareth J Marlow Lynnette R Ferguson Nutrigenomics New Zealand The University of Auckland

Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) or ulcerative colitis are chronic intestina disorders, which are on the increase in "Westernised" countries. IBD can be caused by both genetic and environmental factors. Interleukin-10 (IL-10) is an immunoregulatory cytokine that has been identified as being involved in several diseases including IBD. Studies have shown that polymorphisms in the promoter region reduce serum levels of IL-10 and this reduction has been associated with some forms of IBD. Mouse models have shown promising results with IL-10 supplementation, as such IL-10 supplementation has been touted as being a possible alternative treatment for CD in humans. Clinical trials have shown that recombinant human IL-10 is safe and well tolerated up to a dose o 8 μg/kg. However, to date, the results of the clinica trials have been disappointing. Although CD activity was reduced as measured by the CD activity index IL-10 supplementation did not result in significantly reduced remission rates or clinical improvements when compared to placebo. This review discusses why IL-10supplementation is not effective in CD patients currently and what can be addressed to potentially make IL-10 supplementation a more viable treatment option in the future. Based on the current research we conclude that IL-10 supplementation is not a one size fits all treatment and if the correct population of patients is chosen then IL-10 supplementation could be of benefit.

关键词： Inflammatory bowel disease Crohn’s disease Interleukin-10 recombinant human interleukin-10

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

个体化营养与健康

英国医学杂志中文版 2021年第3期24卷 165-170页

作者： Jose M Ordovas lynnette r ferguson E Shyong Tai John C Mathers 袁亦芳(译) 武阳丰(校) JM-USDA-HNrCA at Tufts University BostonMAUSA Centro Nacional Investigaciones Cardiovasculares MadridSpain IMDEA Food Institute CEI UAM+CSICMadridSpain Faculty of Medical and Health Sciences The University of AucklandAucklandNew Zealand National University of Singapore Singapore Human Nutrition research Centre Institute of Cellular MedicineNewcastle UniversityNewcastle Upon TyneUnited Kingdom 北京大学临床研究所

Jose Ordovas及其同事认为,根据个体特征和行为进行个体化营养干预具有前景,但在实施之前还需要做更多的工作。膳食因素公认是导致心脏病、卒中、2型糖尿病、癌症等常见疾病的主要因素之一1-3。尽管已知疾病与膳食模式相关联.试图改变... 详细信息

Jose Ordovas及其同事认为,根据个体特征和行为进行个体化营养干预具有前景,但在实施之前还需要做更多的工作。膳食因素公认是导致心脏病、卒中、2型糖尿病、癌症等常见疾病的主要因素之一1-3。尽管已知疾病与膳食模式相关联.试图改变膳食习惯进而影响公众健康和福祉的干预措施仍收效甚微。对于能够影响健康结果的行为,将干预措施个体化可能更凑效4-5,在本文中我们考量了个体化营养的相关证据。

关键词：膳食因素干预措施个体化营养膳食习惯 2型糖尿病公众健康膳食模式营养与健康

Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第29期14卷 4652-4661页

作者： lynnette r ferguson Claudia Huebner Ivonne Petermann richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han Discipline of Nutrition the University of AucklandPrivate Bag 92019 Auckland 1142 New Zealand Department of Gastroenterology Christchurch HospitalChristchurch 8140 New Zealand Crop and Food research Mosgiel 9053 New Zealand Agresearch Limited Mosgiel 9053 New Zealand

AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a Taqmanr assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. rESULTS: Individuals carrying the -308 G/A allele had a significantly (Or = 1.91, χ2 = 17.36, P reased risk of pancolitis, and a 1.57-fold increased risk (Or = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (Or = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (Or = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (Or = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes.

关键词： Tumour necrosis factor alpha Singlenucleotide polymorphisms Inflammatory boweldiseases Crohn's disease Ulcerative colitis

The first mitogenome of Lauraceae(Cinnamomum chekiangense)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Diversity 2024年第1期46卷 144-148页

作者： Changwei Bi Ning Sun Fuchuan Han Kewang Xu Yong Yang David K.ferguson State Key Laboratory of Tree Genetics and Breeding Co-Innovation Center for Sustainable Forestry in Southern ChinaKey Laboratory of Tree Genetics and Biotechnology of Educational Department of ChinaKey Laboratory of Tree Genetics and Silvicultural Sciences of Jiangsu ProvinceNanjing Forestry UniversityNanjing 210037China College of Information Science and Technology Nanjing Forestry UniversityNanjing 210037China research Institute of Subtropical Forestry Chinese Academy of ForestryHangzhou 311400China Co-Innovation Center for Sustainable Forestry in Southern China College of Life SciencesNanjing Forestry UniversityNanjing 210037China Department of Paleontology University of ViennaViennaAustria

There are three distinct genetic systems in higher plants,the dominant nuclear genome and the semi-autonomous organelle genomes(plastids and mitochondria).In contrast to the conserved plastid genome(plastome),the plant mitochondrial genome(mitogenome)is characterized by an intriguing“evolutionary paradox”distinguished by a remarkably low mutation rate but with a significantly high rearrangement rate(Palmer and Herbon,1988;Lai et al.,2022).

关键词： autonomous distinguished Palmer

Disparate outcomes in Hispanic patients with metabolic dysfunctionassociated steatotic liver disease/steatohepatitis and type 2 diabetes: Large cohort study

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第5期15卷 886-897页

作者： Joseph Matthew Gosnell George Golovko Esteban Arroyave Akshata Moghe Michael L Kueht Omar AbdulSaldarriaga Kevin H McKinney Heather L Stevenson Monique r ferguson Department of Pathology University of Texas Medical BranchGalvestonTX 77555United States Department of Pharmacology&Toxicology University of Texas Medical BranchGalvestonTX 77555United States Department of Medicine University of Texas Health Science Center at HoustonHoustonTX 77030United States Department of Surgery University of Texas Medical BranchGalvestonTX 77555United States Center for Tropical Diseases Department of Internal MedicineUniversity of Texas Medical BranchGalvestonTX 77555United States Department of Internal Medicine University of Texas Medical BranchGalvestonTX 77555United States

BACKGrOUND Metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASH)are a growing health burden across a significant portion of the global patient ***,these conditions seem to have disparate rates and outcomes between different ethnic *** combination of MASLD/MASH and type 2 diabetes increases the risk of hepatocellular carcinoma(HCC),and Hispanic patients experience the greatest burden,particularly those in South *** To compare outcomes between Hispanic and non-Hispanic patients in the United States,while further focusing on the Hispanic population within Southeast Texas to determine whether the documented disparity in outcomes is a function of geographical circumstance or if there is a more widespread reason that all clinicians must account for in prognostic *** This cohort analysis was conducted with data obtained from TriNetX,LLC(“TriNetX”),a global federated health research network that provides access to deidentified medical records from healthcare organizations *** cohort networks were used:University of Texas Medical Branch(UTMB)hospital and the United States national database collective to determine whether disparities were related to geographic regions,like Southeast *** This study findings revealed Hispanics/Latinos have a statistically significant higher occurrence of HCC,type 2 diabetes mellitus,and liver fibrosis/cirrhosis in both the United States and the UTMB Hispanic/Latino *** mortality in Hispanics/Latinos was lower within the United States group and not statistically elevated in the UTMB *** This would appear to support that Hispanic patients in Southeast Texas are not uniquely affected compared to the national Hispanic population.

关键词： Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis Hispanic Diabetes mellitus TriNetX Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Steatotic liver disease Hepatocellular carcinoma

role of β-microseminoprotein from prostate cancer initiationto recurrence: A mini-review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Urology 2014年第1期3卷 20-30页

作者： Nishi Karunasinghe Karen Bishop Pamela Murray Yuanye Xu Megan Goudie Lance Ng Shuotun Zhu Dug Yeo Han lynnette r ferguson Jonathan Masters Benji Benjamin Michael Holmes Auckland Cancer Society research Centre Faculty of Medical and Health Sciences The University of Auckland Discipline of Nutrition Faculty of Medical and Health Sciences The University of Auckland Urology Department Auckland Hospital radiology Department Auckland Hospital Urology Department Waikato Hospital

Medline/Pubmed articles relevant to this topic were considered using the search terms ?-microseminoprotein, MSMB, prostate secretory protein of 94 amino acids and PSP94. Full articles were retrieved when the abstract was considered relevant. In addition, other data related to this topic including our own are discussed. Summary of fi ndings-?-microseminoprotein(MSMB) is increasingly being considered as a marker for prostatecancer, as reduced levels have been associated with the disease. Here we review various aspects of this protein including its biological and physiological variants, binding proteins and immune modulation; its importance as a marker for biochemical recurrence of prostate cancer; prostate cancer related splice variants and its therapeutic utility. Two of the most important properties of MSMB are related to anticancer functions and immune modulation. Predominant expression of two(short and full-length) splice variants of MSMB has been observed from normal prostate and several other tissues. In benign prostate hyperplasia the short isoform is dominant, constituting 98% of this isoform, whereas in prostate cancer 96% constitute the fulllength isoform. The MSMB promoter single nucleotide polymorphism rs10993994 with the C allele functions as an activated cyclic adenosine monophosphate response element binding protein binding site. This C variant of rs10993994 could be responsible for the production of splice variants under variable conditions. MSMB has binding motifs to a few known proteins including immunoglobulin G and several Cysteine-rich secretory proteins family proteins. MSMB bound to these proteins is considered as immune modulating. Use of MSMB as a urinary marker for detecting aggressive prostate cancers that could resist radiation and surgical treatments, seems possible, but needs further investigation. The ratio of MSMB splice variants could also be a possible approach in understanding prostate cancers, with higher ratios indicating severe di

关键词： β-microseminoprotein Anticancer properties Immune modulation Splice variants Promoter single nucleotide polymorphism rs10993994 Biochemical recurrence