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The decision-making process for senior cancer patients: treatment allocation of older women with operable breast cancer in the UK

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Cancer Biology & Medicine 2015年第4期12卷 308-315页

作者： Jenna L.Morgan Paul Richards Osama Zaman Sue Ward Karen Collins Thompson Robinson Kwok-Leung Cheung Riccardo A.Audisio Malcolm W.Reed lynda wyld on behalf of the Bridging the Age Gap in Breast Cancer Trial Management Team Academic Unit of Surgical Oncology University of Sheffield Medical School Health Economics and Decision Science School for Health and Related Research University of Sheffield Center for Health and Social Care Research Sheffield Hallam University Collegiate Crescent Department of Cardiovascular Sciences University of Leicester School of Medicine University of Nottingham Royal Derby Hospital Center Department of Surgery University of Liverpool St Helens Teaching Hospital Brighton and Sussex Medical School University of Sussex

Objective: Up to 40% of women over 70 years with primary operable breast cancer in the UK are treated with primary endocrine therapy(PET) as an alternative to surgery. A variety of factors are important in determining treatment for older breast cancer patients. This study aimed to identify the patient and tumor factors associated with treatment allocation in this ***: Prospectively collected data on treatment received(surgery vs. PET) were analysed with multivariable logistic regression using the variables age, modified Charlson Comorbidity Index(CCI), activities of daily living(ADL) score, Mini-Mental State Examination(MMSE) score, HER2 status, tumour size, grade and nodal status. Results: Data were available for 1,122 cancers in 1,098 patients recruited between February 2013 and June 2015 from 51 UK hospitals. About 78% of the population were treated surgically, with the remainder being treated with PET. Increasing patient age at diagnosis, increasing CCI score, large tumor size(5 cm or more) and dependence in one or more ADL categories were all strongly associated with non-surgical treatment(P<0.05).Conclusion: Increasing comorbidity, large tumor size and reduced functional ability are associated with reduced likelihood of surgical treatment of breast cancer in older patients. However, age itself remains a significant factor for non-surgical treatment; reinforcing the need for evidence-based guidelines.

关键词： Frail elderly breast neoplasms decision-making

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Isolative Synthesis and Characterization of Cellulose and Cellulose Nanocrystals from Typha angustifolia

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Open Journal of Applied Sciences 2024年第9期14卷 2443-2459页

作者： lynda S. Mesoppirr Evans K. Suter Wesley N. Omwoyo Nathan M. Oyaro Simphiwe M. Nelana Department of Mathematics and Physical Science Maasai Mara University Narok Kenya Biotechnology and Chemistry Department Vaal University of Technology Vanderbijlpark South Africa

The application potential of cellulosic materials in natural composites and other fields needs to be explored to develop innovative, sustainable, lightweight, functional biomass materials that are also environmentally friendly. This study investigated Typha angustifolia (Typha sp.) as a potential new raw material for extracting cellulose nanocrystals (CNCs) for application in wastewater treatment composites. Alkaline treatments and bleaching were used to remove cellulose from the stem fibres. The CNCs were then isolated from the recovered cellulose using acid hydrolysis. The study showed a few distinct functional groups (O-H, -C-H, =C-H and C-O, and C-O-C) in the Fourier Transform Infrared (FTIR) spectra. A scanning electron microscope (SEM) revealed the smooth surface of CPC and CNCs, which resulted from removing lignin and hemicellulose from powdered Typha angustifolia. Based on the crystalline index, the powdered Typha angustifolia, CPC, and CNCs were 42.86%, 66.94% and 77.41%. The loss of the amorphous section of the Typha sp. fibre resulted in a decrease in particle size. It may be inferred from the features of a Typha sp. CNC that CNCs may be employed as reinforcement in composites for wastewater treatment.

关键词： Typha angustifolia Cellulose Acid Hydrolysis Chemically Purified Cellulose Cellulose Nanocrystals

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Associated Factors with Early Sexual Intercourse among In-School Adolescents in Brazzaville

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Open Journal of Pediatrics 2024年第5期14卷 898-907页

作者： Aymar Pierre Gildas Oko Dumez Ngoma Judicaël Kambourou Eryx Darius Mbou Essie Neli Yvette Ngakengni lynda Tchidjo Ngamo Georges Marius Moyen Faculty of Health Sciences Marien Ngouabi University of Brazzaville Brazzaville Congo Department of Pediatrics Teaching Hospital Center of Brazzaville Brazzaville Congo

Background: Early sexual intercourse (ESI) is a global public health problem. In Congo, associated factors with ESI have been under-studied. Objective: To analyse factors associated with early sexual intercourse among in-school adolescents in Brazzaville. Method: A cross-sectional analytic study with three-stage random sampling was carried out from March 2 to June 2, 2022 in Brazzaville secondary and high schools. Adolescents in the selected schools were interviewed about their sexual and social behaviour, and their family and school environment. Multivariate analysis using logistic regression was used to identify factors associated with ESI. The significance level of the p-value was set at 5% and the confidence interval at 95%. Results: Of a total of 1100 adolescents surveyed, 800 (72.7%) had ESI, 98% of them were female. The main reason for early initiation of sexual intercourse was curiosity (81.8%). Non-use of condoms and multiple sexual partnerships were noted respectively in 98.7% and 68.7% of adolescents who had experienced ESI. Female gender (p Conclusion: The prevalence of ESI is high, and the factors identified in this study may help to reduce it.

关键词： Associated Factors Early Sex Adolescents Brazzaville

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Osteocyte Remodeling of the Perilacunar and Pericanalicular Matrix

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International Journal of Oral Science 2009年第2期1卷 59-65页

作者： Hai Qing lynda F. Bonewald Department of Oral Biology University of Missouri-Kansas City Kansas City USA Department of Prosthodontics West China College of Stomatology Sichuan University Chengdu China

With additional functions of osteocytes being identified, the concept that osteocytes are just ＂static lacunar-dwelling cells＂ is no longer accepted. We reviewed most of the relevant literature on osteocyte＇s function in the direct remodeling of the perilucunar matrix, discussing the advantages and disadvantages. Special attention was paid to how the negative researchers argue about the ＂osteocytic osteolysis＂ principle, and how the positive side addressed the arguments. We also discussed the newly found data of osteocytic remodeling function from our group. With more biotechnology in hand, there is increased excitement in the prospect of now being able to answer the two important questions： do osteocytes have the capability to remove mineral from the perilacunar matrix and if so what are the molecular and cellular mechanisms？ do osteocytes have the capability to deposit new mineral on the perilacunar matrix and if so what are the cellular and molecular mechanisms？

关键词： osteocyte osteocytic resorption remodeling,osteocytic osteolysis

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A fully bio-sourced adsorbent of heavy metals in water fabricated by immobilization of quinine on cellulose paper

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Journal of Environmental Sciences 2019年第10期31卷 174-183页

作者： Ehu C.Aka Medy C.Nongbe Tchirioua Ekou lynda Ekou Vincent Coeffard Francois-Xavier Felpin Universite de Nantes CNRS UMR 6230CEISAM2 rue de la Houssinière44322 Nantes Cedex 3France Universite Nangui Abrogoua Laboratoire de Thermodynamique et de Physico-Chimie du Milieu02 BP 801 Abidjan 02Cote d'lvoire

The fabrication of a fully bio-sourced adsorbent of Cd(Ⅱ)by covalent immobilization of quinine on cellulose paper is *** double bond of commercially available quinine was converted to a terminal alkyne function which was reacted with cellulose paper,chemically modified with azide functions,through a 1,3-dipolar cycloaddition,leading to *** adsorption efficiency of Cell-Quin was investigated to determine the optimal pH,contact time and dose of adsorbent,ultimately leading to high levels of *** mechanism of adsorption of Cell-Quin was deeply rationalized through kinetic experiments and isotherm *** also showed that Cell-Quin could adsorb other heavy metals such as Cu(Ⅱ),Pb(Ⅱ),Ni(Ⅱ)and Zn(Ⅱ).

关键词： Cellulose paper Quinine Heavy metal removal Adsorbent

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Contribution of phytoecological data to spatialize soil erosion:Application of the RUSLE model in the Algerian atlas

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International Soil and Water Conservation Research 2021年第4期9卷 502-519页

作者： lynda Boussadia-Omari Sylvain Ouillon Aziz Hirche Mustapha Salamani Mohamed Said Guettouche Akli Ihaddaden Dalila Nedjraoui University of Science and Technology Houari Boumediene(USTHB) Faculty of BiologyLaboratory of Plant Ecology and Environment(EVE)BPN°32 El AliaBab EzzouarAlgerAlgeria LEGOS IRDCNRSCNESUPSUniversity of ToulouseToulouseFrance University of Science and Technology of Hanoi(USTH) Vietnam Academy of Science and Technology(VAST)HanoiViet Nam University of Science and Technology Houari Boumediene Faculty of Earth SciencesGeography and Spatial PlanningLaboratory of Geomorphology and Georisk(G&G)AlgerAlgeria

Among the models used to assess water erosion,the RUSLE model is commonly *** makers can act on cover(C-factor)and conservation practice(P-factor)to reduce erosion,with less costly action on soil surface ***,the widespread use of vegetation indices such as NDVI does not allow for a proper assessment of the C-factor in drylands where stones,crusted surfaces and litter strongly influence soil *** sub-factors of C,canopy cover(CC)and soil cover(SC),can be assessed from phytoecological measurements that include gravel-pebbles cover,physical mulch,annual and perennial *** paper introduces a method to calculate the C-factor from phytoecological data and,in combination with remote sensing and a geographic information system(GIS),to map it over large areas.A supervised classification,based on field phytoecological data,is applied to radiometric data from Landsat-8/OLI satellite ***,a C-factor value,whose SC and CC subfactors are directly derived from the phytoecological measurements,is assigned to each land cover *** method and RUSLE are implemented on a pilot region of 3828 km^(2) of the Saharan Atlas,composed of rangelands and steppe formations,and intended to become an *** protective effect against erosion by gravel-pebbles(50%)is more than twice that of vegetation(23%).The C-factor derived from NDVI(0.67)is higher and more evenly distributed than that combining these two contributions(0.37 on average).Finally,priorities are proposed to decision-makers by crossing the synthetic map of erosion sensitivity and a decision matrix of management priorities.

关键词： Water erosion Vulnerability Remote sensing Land-use mapping Aridity Soil protection Algerian atlas

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How authentic leadership influences employee proactalty： the sequential mediating effects of psychological empowerment and core self-evaluations and the moderating role of employee political skill

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Frontiers of Business Research in China 2018年第1期12卷 61-81页

作者： Jing Zhang lynda J. Song Yue Wang Guangjian Liu Department of Organization andHuman Resources School ofBusiness Renmin University ofChina Beijing 100872 China Department of Organization andHuman Resources School ofBusiness Renmin University ofChina Room 909 Mingde BusinessBuilding No. 59 ZhongguancunStreet Haidian District Beijing10087

This study aims to examine the relationship between authentic leadership and employee proactive behavior. Based on self-determination theory, we argue that such a relationship is sequentially mediated by psychological empowerment and core self-evaluations. In addition, political skill plays a moderating role in the third stage. These hypotheses are validated by a sample of 65 leaders and 275 subordinates from two private enterprises in China's Mainland. Results show that authentic leadership Clime I） influences employees＇ proactive behavior Clime 3） through the psychological empowerment （Time I） and core self-evaluations of employees （Time 2）, and the relationship between core self-evaluations and proactive behavior is positively moderated by employees＇ political skill. In addition, bootstrapping results also verify the moderating role played by employees＇ political skill in the indirect relationship between authentic leadership and proactive behavior through core self-evaluations. Theoretical and managerial implications are further discussed in the light of these findings.

关键词： Authentic leadership Psychological empowerment Core self-evaluations,Proactive behavior Political skill

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Diagnosis of acute intermittent porphyria in a renal transplant patient:A case report

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World Journal of Transplantation 2022年第1期12卷 8-14页

作者： Cristina Sirch Niloufar Khanna lynda Frassetto Francesco Bianco Mary Louise Artero Nefrologia e Dialisi Azienda Sanitaria Universitaria Giuliano IsontinaTrieste 34100Italy Medicine California Northstate UniversityElk GroveCA 95757United States Internal Medicine Division of NephrologyUniversity of California San FranciscoSan FranciscoCA 94193United States

BACKGROUND Acute intermittent porphyria(AIP)is an inherited disorder of porphyrin metabolism with a worldwide distribution and a prevalence ranging from 1 to 9 per million *** is caused by an autosomal dominant-inherited mutation of low penetrance resulting in a deficiency of porphobilinogen deaminase(PBGD)*** attacks are provoked by stressors such as certain medications,alcohol,and *** herein present the first case report of AIP detected in a post-renal transplant *** SUMMARY The patient was a 65-year-old man who underwent transplantation 2 years previously for suspected nephroangiosclerosis and chronic interstitial *** subsequently developed diabetes mellitus which required insulin *** had been treated in the recent past with local mesalamine for *** presented with classic but common symptoms of AIP including intense abdominal pain,hypertension,and *** had multiple visits to the emergency room over a 6-mo period for these same symptoms before the diagnosis of AIP was *** urinary postprandial blood glucose level was 60 mg/24 h(normal,<2 mg/24 h).He was placed on a high carbohydrate diet,and his symptoms slowly *** This case report describes a common presentation of an uncommon disease,in which post-transplant complications and medications may have contributed to precipitating the previously undiagnosed *** hypothesize that the lowcarbohydrate diet and insulin with which our patient was treated may have led to the attacks of ***,our patient’s mesalamine treatment for proctitis may have led to an acute AIP crisis.A high index of suspicion is needed to consider the diagnosis of a heme synthesis disorder,which presents with the common symptoms of abdominal pain,high blood pressure,and anxiety.

关键词： Acute intermittent porphyria Post-transplantation diabetes Mesalamine Tacrolimus Renal transplantation Case report

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Gender differences in the impact on subjective well-being in China

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Economic and Political Studies 2018年第4期6卷 349-367页

作者： Tao Tao Byron Y.Lee lynda Jiwen Song Xiangdong Liu School of Sociology and Population Studies Center for Population and Development StudiesRenmin University of ChinaBeijingChina China Europe International Business School(CEIBS) ShanghaiChina School of Business Renmin University of ChinaBeijingChina

This article examines the relationship among subjective well-being(SWB),income and education in China through self-perceived social *** and women appear to use different socioeconomic markers to determine their self-perceived social status,which ultimately affects their subjective reports of *** using the data from the 2010 China General Social Survey(CGSS),this study finds a positive association between income and SWB for *** result also shows a positive association between education and SWB for ***,for women self-perceived social status is a strong mediator of income and happiness;while for men,selfperceived social status mediates the relationship between education and *** study highlights the importance of the cultural influence in understanding the differences in self-perceived social status outcomes by gender and how these differences ultimately influence the subjective measures of well-being in China.

关键词： China gender selfperceived status subjective well-being(SWB)

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The Cambridge Approach to Speaking Assessment

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基础教育外语教学研究 2003年第12期 31-34页

作者： lynda Taylon

Introduction Direct tests of speaking (and writing) have always beenstandard practice in Cambridge examinations for assessingboth first (L1) and second (L2) language proficiency andCambridge ESOL has a long experience of ‘direct’ *** some writers have claimed that perfor-mance tests date back only to the middle of the 20th century(McNamara 1996, Lowe 1988), it is worth noting that thevery first UCLES English language proficiency examina-

关键词：剑桥大学英语口语测试试题设计测试目的信度效度口语交际能力

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