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Modifying action of heavy metal salts on an-ti-inflammatory aspirin action

Health 2010年第6期2卷 630-633页

作者： Denis R. Husainov Viktoriya V. Shylina lvan l korenyuk Viktor F. Shulgin 不详

Nowadays pollution of the environment is one of the major problems of mankind. Moreover, studying of the effect of different kinds of med- icine on selected, specially bred, non-exposed to external pollutants animals is becoming distant from reality. Thus in this work we have investigated the modifying action of heavy metals on anti-inflammatory effect of aspirin. The investigation were carried out on rats which were injected during 7 days intraperitoneally by PbCl3, HgCl2, CdCl2 in concentration of 100, 20, 1 mg/kg accordingly, modulating accumulation of the metals in the organism tissues. On the 8 days inflammation was invoked by formalin. As anti-inflammatory medicine was use aspirin. Judging by obtained results the conclusion can be drawn that cadmium in concentration 1 mg/kg significantly increases anti-inflammatory aspirin activity. The observed outcome can be explained in the following way. It is generally known that zinc in a certain concentration demonstrates anti-inflammatory properties. Be- ing an element of the same group cadmium has similar properties and also can have anti-inflammatory action. lead and mercury suppre- ssed anti-inflammatory aspirin activity. Obvious inhibitory action of mercury and lead salts on aspirin action related to the fact that these elements by themselves were inflammation factors. From the obtained results the following conclusion can be drawn: a definite dose of anti-inflammatory medicine (aspirin) which is sufficient in normal conditions became less effective against the background of accumulation of ions of some heavy metals in an organism.

关键词： Heavy Metals lead Mercury Cadmium Acetylsalicylic Acid Prostaglandin Inflammation Anti-Inflammatory Activity

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Modifying action of heavy metal salts on anti-inflammatory aspirin action

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Health（健康） 2010年第6期

作者： Denis R. Husainov Viktoriya V. Shylina lvan l korenyuk Viktor F. Shulgin

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It's all about timing, early treatment with hyperbaric oxygen therapy and corticosteroids is essential in acute acoustic trauma

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Journal of Otology 2021年第4期16卷 237-241页

作者： A.B.Bayoumy R.P.Weenink E.lvan der Veen F.S.Besseling-Hansen A.D.M.Hoedemaeker F.J.Mde Jong M.Hvan der laan R.Swenker R.Avan Hulst J.Ade Ru Department of Otolaryngology Central Military HospitalMinistry of DefenseUtrechtthe Netherlands Department of Anesthesiology and Department of Hyperbaric Medicine Amsterdam University Medical CentersLocation AMCAmsterdamthe Netherlands Department of Otolaryngology-Head and Neck Surgery University Medical Centre UtrechtUtrechtthe Netherlands Diving Medical Centre Royal Netherlands NavyMinistry of DefenseDen Helderthe Netherlands

Background: Acute acoustic trauma (AAT) is an acute hearing impairment caused by intense noiseimpact. The current management strategy for AAT with substantial hearing loss in the Dutch militaryis the combination therapy with corticosteroids and hyperbaric oxygen therapy (HBOT). In a previousstudy, early initiation of the combination therapy was associated with better outcomes. Therefore, weperformed a new analysis to assess the difference in hearing outcome between patients in whomcombination therapy was started within two days, versus after more than two ***: A retrospective analysis was performed on military patients diagnosed with AAT with substantial hearing loss who presented between February 2018 and March 2020. Absolute and relativehearing improvement between first and last audiograms were calculated for all affected frequencies(defined as loss of 20 dB on initial audiogram). We also determined the amount of patients whorecovered to the level of Dutch military requirement, and performed speech discrimination ***: In this analysis, 30 male patients (49 ears) with AAT were included. The median age was 24.5years (IQR 23e29). The median time to initiation of therapy with corticosteroids and HBOT were one andtwo days, respectively. HBOT was started within two days in 31 ears, and after more than two days in 18ears. The mean absolute and relative hearing gains were 18.8 dB (SD 14.6) and 46.8% (SD 31.3) on allaffected frequencies. The 100% discrimination/speech perception level improved from 64.0 dB to 51.7 dB(gain 12.3 dB ± 14.1). There was significantly more improvement in absolute and relative hearingimprovement when HBOT was started in 2 days, compared to >2 ***: Our analysis shows results in favor of early initiation ( 2 days) of the combination treatmentof HBOT and corticosteroids in patients with AAT.

关键词： Hyperbaric oxygen therapy Acute acoustic trauma Hearing loss Corticosteroids Blast injury Noise-induced hearing loss

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