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Template-module assembly to prepare low-molecular-weight gene transport system with enhanced transmembrane capability

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Science China Chemistry 2014年第4期57卷 558-567页

作者： YANG Bin lv yin WANG QingRong LIU Yun AN Hong FENG Jun ZHANG XianZheng ZHUO RenXi Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University Construction Engineering Research Institute of the General Logistics Department

Based on specific host-guest interactions between amine-modified [3-cyclodextrin （CD-TAEA） and functional adamantane （AD） derivatives, a module-template strategy has been proposed for the construction of low-molecular-weight cationic assem- blies for gene transport. This strategy offers great flexibility in terms of the introduction of mono- or multi-functionality by the inclusion of one or more adamantane-based modules with the desired functionalities. As proof of concept, phenylboronic acid （PB） containing adamantane （PB-AD） was used as a model module in the hope of offering enhanced cytosolic delivery in con- sideration of the special affinity of PB groups with cell membranes. The physicochemical properties of the complexes formed with plasmid DNA, such as particle size, zeta potential and morphology were investigated. Confocal laser scanning microsco- py and flow cytometry experiments demonstrated the important contribution of the functional PB-AD module to the consider- ably enhanced intracellular internalization and uptake by cellular nuclei. Compared to the parent CD-TAEA, PB-AD/CD- TAEA assemblies mediated higher transfection rates, which were even comparable to that of PEI25K. In addition, PB-AD/CD- TAEA displayed much lower cytotoxicity than PEI25K in both 293T and HeLa cell lines. The encouraging results suggest that CD-TAEA can be developed as a powerful template capable of readily accommodating various AD-based modules giving versatile functionalities for improved transfection.

关键词： template-module assembly host-guest interaction gene delivery

Regulation of Cued Fear Expression via Corticotropin-ReleasingFactor Neurons in the Ventral Anteromedial Thalamic Nucleus

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Neuroscience Bulletin 2021年第2期37卷 217-228页

作者： yin lv Peng Chen Qing-Hong Shan Xin-Ya Qin Xiu-Hong Qi Jiang-Ning Zhou Hefei National Laboratory for Physical Sciences at the Microscale School of Life SciencesChinese Academy of Sciences Key Laboratory of Brain Function and DiseasesUniversity of Science and Technology of ChinaHefei 230027China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

The ventral part of the anteromedial thalamic nucleus(AMv)is in a position to convey information to the cortico-hippocampal-amygdalar circuit involved in the processing of fear ***-releasing-factor(CRF)neurons are closely associated with the regulation of stress and ***,few studies have focused on the role of thalamic CRF neurons in fear *** the present study,using a conditioned fear paradigm in CRF transgenic mice,we found that the c-Fos protein in the AMv CRF neurons was significantly increased after cued fear *** activation of AMv CRF neurons enhanced cued fear expression,whereas inhibition had the opposite effect on the cued fear ***,chemogenetic manipulation of AMv CRF neurons did not affect fear acquisition or contextual fear *** addition,anterograde tracing of projections revealed that AMv CRF neurons project to wide areas of the cerebral cortex and the limbic *** results uncover a critical role of AMv CRF neurons in the regulation of conditioned fear memory.

关键词： Corticotropin-releasing-factor neurons Ventral anteromedial thalamic nucleus Cued fear expression Chemogenetics

Design, synthesis and herbicidal activities of novel self-dispreading phenoxy carboxylic acid derivatives for the control of water hyacinth floating on the water surface

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Chinese Chemical Letters 2015年第8期26卷 1008-1010页

作者： lv-yin Zheng Ren-Miao Wu Wei Guo Wen-Hua You Yan-Lan Ling Xiao-Lin Fan Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province Gannan Normal University

A series of novel self-dispreading phenoxy carboxylic acid derivatives were designed and synthesized by I2 catalyzed one-step reaction. Their structures were confirmed by IR, NMR, and HRMS. The derivatives can self-spread and float on the water surface. Preliminary bioassays showed that some compounds, 3i–3p, had excellent herbicidal activities against water hyacinth. This strategy provided a novel approach for the water hyacinth control.

关键词： phenoxy carboxylic floating catalyzed spread afford facile benzene acetic tetra

Outcomes of high-grade aneurysmal subarachnoid hemorrhage patients treated with coiling and ventricular intracranial pressure monitoring

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World Journal of Clinical Cases 2021年第19期9卷 5054-5063页

作者： Li-Li Wen Xiao-Ming Zhou Sheng-yin lv Jiang Shao Han-Dong Wang Xin Zhang Department of Neurosurgery Jinling HospitalNanjing University School of MedicineNanjing 210002Jiangsu ProvinceChina Department of Neurology The Second Hospital of NanjingNanjing 210003Jiangsu ProvinceChina

BACKGROUND High-grade aneurysmal subarachnoid hemorrhage is a devastating disease with a low favorable *** intracranial pressure is a substantial feature of high-grade aneurysmal subarachnoid hemorrhage that can result to secondary brain *** control of intracranial pressure including decompressive craniectomy and external ventricular drainage had been reported to be associated with improved *** in recent years,little is known whether external ventricular drainage and intracranial pressure monitoring after coiling could improve outcomes in high-grade aneurysmal subarachnoid *** To investigate the outcomes of high-grade aneurysmal subarachnoid hemorrhage patients with coiling and ventricular intracranial pressure *** A retrospective analysis of a consecutive series of high-grade patients treated between Jan 2016 and Jun 2017 was *** our center,followed by continuous intracranial pressure monitoring,the use of ventricular pressure probe for endovascular coiling and invasive intracranial pressure monitoring in the acute phase is considered to be the first choice for the treatment of high-grade *** retrospectively analyzed patient characteristics,radiological features,intracranial pressure monitoring parameters,complications,mortality and *** A total of 36 patients were included,and 32(88.89%)*** overall mortality rate was 11.11%.No patient suffered from aneurysm *** intracranial pressure in 33 patients(91.67%)was maintained within the normal range by ventricular drainage during the treatment.A favorable outcome was achieved in 18 patients(50%)with 6 mo *** cerebral ischemia and Glasgow coma scale were considered as significant predictors of outcome(2.066 and-0.296,respectively,P<0.05).CONCLUSION Ventricular intracranial pressure monitoring may effectively maintain the intracranial pressure within the normal *** the small number of cases in th

关键词： Subarachnoid hemorrhage High-grade Outcome Ventricular drainage Intracranial pressure

Rare spontaneous extensive annular intramural esophageal dissection with endoscopic treatment: A case report

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World Journal of Clinical Cases 2021年第36期9卷 11467-11474页

作者： Jian-Wen Hu Qian Zhao Chi-Yv Hu Jie Wu Xiang-yin lv Xiang-Hong Jin Department of Gastroenterology Dongyang People's HospitalDongyang 322100Zhejiang ProvinceChina

BACKGROUND Intramural esophageal dissection(IED)is a rare disease that should be considered in patients with chest pain,dysphagia,and *** it occurs most frequently in older adult women with impaired coagulation or as a sequela of endoscopy,the incidence of spontaneous IED without an obvious causative agent has risen *** SUMMARY This report describes a case of extensive annular IED in a 75-year-old male patient who presented with dysphagia for the past *** barium meal radiography revealed slow passage of diluted iohexol through the esophagus after swallowing,prominent luminal dilation,obstruction of the lower segment with only a small amount of contrast medium entering the gastric cavity,and no obvious *** revealed smooth esophageal mucosa;several esophageal mucosal bridges and webbed mucosa were observed approximately 22 cm from the *** mucosal surface was occasionally rough and uneven,and the length of the esophageal mucosal defect exceeded 10 *** anatomy was considered to be annular because the mucosal bridge connecting the proximal and distal tube was not attached to the surrounding *** final diagnosis was spontaneous extensive annular *** treated the patient successfully using endoscopic esophagotomy,which completely relieved the symptoms without *** Spontaneous annular IED can be treated successfully by endoscopic resection of the mucosal septum between the true and false lumen.

关键词： Esophagectomy Rupture Esophageal mucosa Case report

Abrupt onset of type 1 diabetes mellitus during recombinant interferon-alpha 2b therapy in a patient with chronic hepatitis B

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World Journal of Gastroenterology 2008年第29期14卷 4713-4715页

作者： Yuan-Yuan lv Bing-yin Shi Hui Guo Department of Endocrinology First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

We describe a case of a 33-year-old female patient with chronic hepatitis B who developed type 1 diabetes mellitus (DM) after a 13-mo period of treatment with recombinant human interferon-alpha (IFN-α) 2b. The patient presented with polydipsia, polyuria, hypergly-cemia, diabetic ketoacidosis, combined with C-peptide secretion defi ciency and positive islet cell autoantibody (ICAb). IFN-α 2b treatment was terminated and in-stead insulin treatment was initiated. Five months after cessation of the recombinant human IFN-α 2b therapy, the patient remained insulin-dependent. Her serum HBV DNA became negative and serum transaminase returned to the normal level after a 10-mo period of IFN therapy. Type 1 DM induced by IFN-α is relatively rare in patients with chronic hepatitis B. We should pay more attention to patients on IFN-α therapy to avoid destruction of pancreatic beta cells. This is the first case report from China.

关键词： Interferon-alpha Islet cell autoantibody Type 1 diabetes mellitus Autoimmune disease Chronichepatitis B

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热成像系统中的视在温差研究

兵工学报 2010年第8期31卷 1059-1062页

作者：吕相银杨莉电子工程学院安徽省红外与低温等离子体重点实验室脉冲功率激光技术国家重点实验室安徽合肥230037

温度的差异是决定目标红外图像特征的一个重要因素,热成像系统的主要性能参数也都与温差有着直接的关系,红外伪装效能评估也与温差密切相关。研究热成像中的温差问题对研究目标的红外图像特征、热像仪的实际性能和红外对抗等都有着重要... 详细信息

温度的差异是决定目标红外图像特征的一个重要因素,热成像系统的主要性能参数也都与温差有着直接的关系,红外伪装效能评估也与温差密切相关。研究热成像中的温差问题对研究目标的红外图像特征、热像仪的实际性能和红外对抗等都有着重要的意义。讨论了大气衰减对辐射温差的影响;通过引入等效环境辐射温度的概念,分析了热成像的原理;得到了热成像中视在温度表达式;推导出了热成像中视在温差的理论计算公式。结果表明热像仪上的视在温差,不仅与目标本身温度和发射率有关,还和目标与背景(或目标不同部位)的温差和发射率差、大气透过率、等效环境辐射温度以及探测器有关。

关键词：电子技术热成像大气衰减视在温差等效环境辐射温度

盈余管理和内部控制缺陷认定标准披露——基于强制性内部控制评价报告披露的实证研究

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审计研究 2016年第4期 83-89页

作者：尹律南京理工大学经济管理学院 210094

盈余管理是影响内部控制缺陷认定标准披露的因素之一。学界已证明内部控制对于盈余管理发生作用,却没有深入研究盈余管理对于内部控制缺陷信息乃至缺陷认定标准披露的反作用。本文以沪深证券市场2013至2014年纳入内部控制规范体系实施... 详细信息

盈余管理是影响内部控制缺陷认定标准披露的因素之一。学界已证明内部控制对于盈余管理发生作用,却没有深入研究盈余管理对于内部控制缺陷信息乃至缺陷认定标准披露的反作用。本文以沪深证券市场2013至2014年纳入内部控制规范体系实施范围的上市公司为样本,实证检验盈余管理对于内部控制缺陷认定标准披露的影响。研究结果表明:盈余管理程度越高,内部控制缺陷的认定标准越不透明。该结论为管理层的机会主义行为提供经验证据,为内部控制信息质量的完善和优化提供理论引导和实践参考。

关键词：内控缺陷认定标准信息披露盈余管理

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从促进就业的角度看社会保障制度的完善

中国劳动关系学院学报 2011年第1期25卷 94-97页

作者：吕茵中国劳动关系学院公共管理系北京100048

就业与社会保障是确保人们获得体面生活的两个重要途径。正确认识就业与社会保障的关系,认真审视就业与社会保障之间的现实矛盾,努力实现就业与社会保障的良性互动发展,对于我国促进体面劳动,增进人民福祉,加快转变经济发展方式至关重要。

关键词：就业社会保障公共社会福利