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Regulating Blood Clot Fibrin Films to Manipulate Biomaterial-Mediated Foreign Body Responses

Research 2024年第2期2023卷 565-581页

作者： Yang Zou Zhengjie Shan Zongpu Han Jieting Yang Yixiong Lin Zhuohong Gong lv xie Jieyun Xu Runlong xie Zhuofan Chen Zetao Chen Hospital of Stomatology Guanghua School of StomatologySun Yat-sen University and Guangdong Research Center for Dental and Cranial Rehabilitation and Material EngineeringGuangzhou 510055China

The clinical efficacy of implanted biomaterials is often compromised by host immune recognition and subsequent foreign body responses(FBRs).During the implantation,biomaterials inevitably come into direct contact with the blood,absorbing blood protein and forming blood *** studies have been carried out to regulate protein adsorption,thus manipulating ***,the role of clot surface fibrin films formed by clotting shrinkage in host reactions and FBR is often *** of the principle of fibrin film formation being relevant to fibrinogen or clotting factor absorption,it is feasible to manipulate the fibrin film formation via tuning the absorption of fibrinogen and clotting *** biological hydroxyapatite reserved bone architecture and microporous structure,the smaller particle size may expose more microporous structures and adsorb more fibrinogen or clotting ***,we set up 3 sizes(small,<0.2 mm;medium,1 to 2 mm;large,3 to 4 mm)of biological hydroxyapatite(porcine bone-derived hydroxyapatite)with different microporous structures to investigate the absorption of blood protein,the formation of clot surface fibrin films,and the subsequent *** found that small group adsorbed more clotting factors because of more microporous structures and formed the thinnest and sparsest fibrin *** thinnest and sparsest fibrin films increased inflammation and profibrosis of macrophages through a potential signaling pathway of cell adhesion-cytoskeleton-autophagy,leading to the stronger *** group adsorbed lesser clotting factors,forming the thickest and densest fibrin films,easing inflammation and profibrosis of macrophages,and finally mitigating ***,this study deepens the understanding of the role of fibrin films in host recognition and FBR and demonstrates the feasibility of a strategy to regulate FBR by modulating fibrin films via tuning the absorption of blood proteins.

关键词： Blood subsequent biomaterials

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社会加速视域下大学生学习异化风险的现实表征、生成逻辑及应对

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现代大学教育 2024年第5期40卷 101-109,112页

作者：吕榭陈武元厦门大学教育研究院厦门大学教师发展中心

社会加速深刻地改写了现代社会中的时间结构,身处其中的个体对时间结构的变化有着深切的感知。技术发展加速、社会变迁加速以及生活节奏加速影响了当下大学生学习的节奏、内容与目标等诸多方面。大学生身处班级集体、学校组织与社会之中... 详细信息

社会加速深刻地改写了现代社会中的时间结构,身处其中的个体对时间结构的变化有着深切的感知。技术发展加速、社会变迁加速以及生活节奏加速影响了当下大学生学习的节奏、内容与目标等诸多方面。大学生身处班级集体、学校组织与社会之中,其行为和实践的节奏、速度、期限和顺序不自觉地受到社会加速所引发的竞争漩涡、时间焦虑和不确定性的影响,进而出现了与学习空间、与学习内容、与学习行为、与学习时间、与自我关系相异化的倾向。为应对大学生学习中的异化风险,大学生自身可以通过确定适己时间、设定长远目标、延迟满足等路径尝试找寻逆俗生存的力量;学校层面可以从评价体系方面进行改革以弱化同侪竞争的压力,为大学生创设慢慢成长、深度思考的学习文化,并为大学生提供完善的心理支持体系。

关键词：社会加速现代社会技术加速异化风险大学生学习时间自主性

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基于权重k邻近的通信网络安全漏洞自动化检测

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自动化与仪器仪表 2024年第4期 21-24,31页

作者：吕连谢东刚广西工业职业技术学院南宁530001

无线通信网络的安全漏洞检测是保护无线通信网络安全的重要任务,传统检测方法存在效率低下和错误率高的问题。因此,研究将权重概念引入到K邻近分类算法中,将其用于构建一种新型的无线通信网络的安全漏洞自动化检测方法。首先利用k邻近... 详细信息

无线通信网络的安全漏洞检测是保护无线通信网络安全的重要任务,传统检测方法存在效率低下和错误率高的问题。因此,研究将权重概念引入到K邻近分类算法中,将其用于构建一种新型的无线通信网络的安全漏洞自动化检测方法。首先利用k邻近对网络安全漏洞进行检测,然后再引入权重概念,以提升漏洞检测的性能,最后利用数据集来验证构建方法的性能。结果表明在相同的漏洞检测背景下,权重k邻近对漏洞的检测准确性平均值为93.26%,在200条漏洞数据中,检测耗时4.2 s。这表明构建的检测方法对于无线通信网络的安全保护具有一定的实际意义,具有较高的准确性和鲁棒性,有助于提高无线通信网络的安全性和可靠性。

关键词：权重 k近邻算法通信网络安全漏洞自动化

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Design of the Quantum Encoder and Decoder Using QCA

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光学学报 2012年第F12期32卷 292-298页

作者： lv Hongjun xie Guangjun School of Electrontc Science and Applied Physics Hefei University of Technology Hefei Anhui 230009 China

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The liquid phase separation of Bi-Ga hypermonotectic alloy under acoustic levitation condition

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Chinese Science Bulletin 2007年第11期52卷 1446-1450页

作者： HONG ZhenYu lv YongJun xie WenJun WEI BingBo Department of Applied Physics Northwestem Polytechnical University Xi'an 710072 China

Containerless treatment of Bi-58.5at%Ga hypermonotectic alloy is successfully performed with acous-tic levitation technique. Under acoustic levitation condition,the second phase (Ga) distributes almost homogeneously in solidification sample,opposite to macrosegregation in solidification sample under conventional condition. Stokes motion of the second liquid droplet (Ga) is significantly restrained un-der acoustic levitation condition. The analyses indicate that the melt vibration in the gravity direction forced by acoustic field can induce steady flow around the second liquid droplet,which influences droplet shape during its moving upward and consequently restrains Stokes motion velocity of the second liquid droplet.

关键词：声悬浮高导磁率合金液相分离斯托克司运动光谱运动

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Nanotopographic micro-nano forces finely tune the conformation of macrophage mechanosensitive membrane protein integrinβ_(2)to manipulate inflammatory responses

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Nano Research 2023年第7期16卷 9715-9729页

作者： Yuanlong Guo Yong Ao Chen Ye Ruidi Xia Jiaomei Mi Zhengjie Shan Mengru Shi lv xie Zetao Chen Hospital of Stomatology Sun Yat-sen University and Guangdong Provincial Key Laboratory of StomatologyGuangzhou 510055China Department of Microbiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

Finely tuning mechanosensitive membrane proteins holds great potential in precisely controlling inflammatory *** addition to macroscopic force,mechanosensitive membrane proteins are reported to be sensitive to micro-nano ***β_(2),for example,might undergo a piconewton scale stretching force in the activation ***-aspect-ratio nanotopographic structures were found to generate nN-scale biomechanical *** with the advantages of uniform and precisely tunable structural parameters,it is fascinating to develop low-aspect-ratio nanotopographic structures to generate micro-nano forces for finely modulating their conformations and the subsequent mechanoimmiune *** this study,low-aspect-ratio nanotopographic structures were developed to finely manipulate the conformation of integrinβ_(2).The direct interaction of forces and the model molecule integrinαXβ_(2)was first *** was demonstrated that pressing force could successfully induce conformational compression and deactivation of integrinαXβ_(2),and approximately 270 to 720 pN may be required to inhibit its conformational extension and *** low-aspect-ratio nanotopographic surfaces(nanohemispheres,nanorods,and nanoholes)with various structural parameters were specially designed to generate the micro-nano *** was found that the nanorods and nanohemispheres surfaces induce greater contact pressure at the contact interface between macrophages and nanotopographic structures,particularly after cell *** higher contact pressures successfully inhibited the conformational extension and activation of integrinβ_(2),suppressing focal adhesion activity and the downstream PI3K-Akt signaling pathway,reducing NF-κB signaling and macrophage inflammatory *** findings suggest that nanotopographic structures can be used to finely tune mechanosensitive membrane protein conformation changes,providing an effective strategy for precisely modulating inflammat

关键词： nanotopographic structures micro-nano forces mechanosensitive membrane proteins protein conformational changes inflammatory responses

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Exceptional reversed yield strength asymmetry in a rare-earth free Mg alloy containing quasicrystal precipitates

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Journal of Magnesium and Alloys 2024年第2期12卷 687-699页

作者： Qiang Yang Shuhui lv Zixiang Yan Zefeng xie Xin Qiu State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022PR China School of Materials Science and Engineering Changchun University of Science and Technology130022PR China

This work reports an exceptional reversed yield strength asymmetry at room temperature for a rare-earth free magnesium alloy containing a mass of fine dispersed quasicrystal(I-phase)*** exhibiting traditional basal texture,it owns an exceptional CYS/TYS as high as~*** back-scattered diffraction(EBSD)and transmission electron microscopy(TEM)examinations indicate pyramidal and prismatic dislocations plus tensile twinning being activated after immediate yielding in compression while basal and non-basal dislocations in tension.I-phase particles transferred the concentrated stress by self-twinning to provide the driving force for tensile twin initiating in neighboring grains,thereby significantly increasing the critical resolved shear stress of tensile twinning to possibly the level of pyramidal slip,finally leading to the dominance of pyramidal slip plus tensile twinning in texture *** results in a higher contribution on yield strength by~55 MPa in compression than in tension,which reasonably agrees with the experimental yield strength difference(~38 MPa).It can be concluded that I-phase particles influence deformation modes in tension and in compression,finally result in reversed yield strength asymmetry.

关键词： Magnesium alloy Reversed yield strength asymmetry Transmission electron microscopy(TEM) Twinning Dislocations

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Pollution characteristics and quantitative source apportionment of heavy metals within a zinc smelting site by GIS-based PMF and APCS-MLR models

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Journal of Environmental Sciences 2024年第10期144卷 100-112页

作者： Huagang lv Zhihuang Lu Guangxuan Fu Sifang lv Jun Jiang Yi xie Xinghua Luo Jiaqing Zeng Shengguo Xue School of Metallurgy and Environment Central South UniversityChangsha 410083China Zhuzhou Qingshuitang Technology Co. Ltd.Zhuzhou 412000China New World Environment Protection Group of Hunan Changsha 410083China

The abandoned smelters present a substantial pollution threat to the nearby soil and *** this study,63 surface soil samples were collected from a zinc smelter to quantitatively describe the pollution characteristics,ecological risks,and source apportionment of heavy metal(loid)s(HMs).The results revealed that the average contents of Zn,Cd,Pb,As,and Hg were 0.4,12.2,3.3,5.3,and 12.7 times higher than the risk screening values of the construction sites,***,the smelter was accumulated heavily with Cd and Hg,and the contribution of Cd(0.38)and Hg(0.53)to ecological risk was 91.58%.ZZ3 and ZZ7 were the most polluted workshops,accounting for 25.7%and 35.0%of the pollution load and ecological risk,*** influence of soil parent materials on pollution was minor compared to various workshops within the *** with PMF,APCS-MLR and GIS analysis,four sources of HMs were identified:P1(25.5%)and A3(18.4%)were atmospheric deposition from the electric defogging workshop and surface runoff from the smelter;P2(32.7%)and A2(20.9%)were surface runoff of As-Pb foul acid;P3(14.5%)and A4(49.8%)were atmospheric deposition from the leach slag drying workshop;P4(27.3%)and A1(10.8%)were the smelting process of zinc *** paper described the distribution characteristics and specific sources of HMs in different process workshops,providing a new perspective for the precise remediation of the smelter by determining the priority control factors.

关键词： Smelter site Heavy metal(loid)s Source apportionment Positive matrix factorization Absolute principal component score-multiple linear regression

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Molecular dynamics study of water molecules nucleation for fine particle removal:Effects of wettability and aggregation modes and comparison with experiment Author links open overlay panel

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Particuology 2024年第8期91卷 106-117页

作者： Junchao Xu Zhipeng Zhang Li lv Yunfei Zhang Yiming xie Huaqiang Chu School of Energy and Environment Anhui University of TechnologyMaanshan243002China College of Mechanical and Electrical Engineering China Jiliang UniversityHangzhou310018China

Water vapor nucleation on particle's surface plays an important role in dust removal,cloud formation,and particle ***,the selectivity of nucleation sites and the nucleation characteristic of water molecule on the particle's surface are still unclear,especially for the aggregated *** this paper,the effects of particle wettability and aggregation modes on the selectivity of nucleation sites and the nucleation characteristics were investigated using molecular dynamics *** results were compared with our earlier experimental *** illustrates how the contact angle of clusters,the growth velocity,and the growth duration are all influenced by the interaction coefficient between water and ***,the nucleation sites of water molecules on the particle aggregation surface exhibit a definite *** primary indicator of this selectivity is the preferential nucleation of water molecules at the interfaces of linear chain aggregation particles,at the inner side of non-linear chain aggregation particles,and at the centers of ring *** results are in good agreement with our previous experimental *** significantly,additional research has revealed that subcritical-size clusters typically aggregate on two-particle surfaces spacing when the spacing smaller than the critical cluster size.

关键词： Heterogeneous nucleation Water molecule Wettability Aggregation modes Molecule dynamics

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Biosorption Characteristics of Ectomycorrhizal Fungal Mycelium for Anthracene

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Biomedical and Environmental Sciences 2010年第5期23卷 378-383页

作者： YI HUANG,SHU-YING ZHANG,MING-JI lv,AND SHU-GUANG xie College of Environmental Sciences and Engineering,Peking University,Beijing 100871,China College of Environmental Sciences and Engineering Peking University Beijing 100871 China

Objective To investigate the potential of Gomphidius viscidus,a kind of ectomycorrhizal fungi,for phytoremediation of anthracene in *** Absorptioe changes of micro-habitat were studied in *** Ectomycorrhizal plants have a strong potential for remediation of polycyclic aromatic hydrocarn characteristics of both active and inactivated *** A high calculated adsorption capacity of 1 886.79 mg/g and 1 515.15 mg/g at 25 ℃,pH 6.0 for active and inactivated mycelia respectively,was obtained based on Langmuir *** ANT biosorption was more ideally characterized by the Langmuir model than by the Freundlich *** biosorption of anthracene to biomass was extremely fast and could be modeled with pseudo-second order adsorption ***,ectomycorrhizal mycelia demonstrated a strong ability to adjust the physiological process to get adapted to the change of micro-habitat.

关键词： Biosorption Phytoremediation Anthrocene Ectomycorrhizal fungi

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