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Circulating insulin-like growth factor-binding protein 3 as prognostic biomarker in liver cirrhosis

World Journal of Hepatology 2016年第17期8卷 739-748页

作者： Carina Gabriela Correa Bruno da Silveira Colombo Marcelo Fernando Ronsoni Pedro Eduardo Soares e Silva Leonardo Fayad Telma Erotides Silva Letícia Muraro Wildner Maria Luiza Bazzo Esther Buzaglo Dantas-Correa Janaína luz Narciso-Schiavon Leonardo de Lucca Schiavon Division of Gastroenterology Federal University of Santa Catarina Department of Clinical Analysis Federal University of Santa Catarina

AIM: To investigate the prognostic significance of insulin-like growth factor-binding protein 3(IGFBP-3) in patients with ***: Prospective study that included two cohorts: outpatients with stable cirrhosis(n = 138) and patients hospitalized for acute decompensation(n = 189). Development of complications, mortality or liver transplantation was assessed by periodical phone calls and during outpatient visits. The cohort of stable cirrhosis also underwent clinical and laboratory evaluation yearly(2013 and 2014) in predefined study visits. In patients with stable cirrhosis, IGFBP-3 levels were measured at baseline(2012) and at second re-evaluation(2014). In hospitalized subjects, IGFBP-3 levels were measured in serum samples collected in the first and in the third day after admission and stored at-80 ℃. IGFBP-3 levels were measured by ***: IGFBP-3 levels were lower in hospitalized patients as compared to outpatients(0.94 mcg/mL vs 1.69 mcg/m L, P < 0.001) and increased after liver transplantation(3.81 mcg/m L vs 1.33 mcg/mL, P = 0.008). During the follow-up of the stable cohort, 17 patients died and 11 received liver transplantation. Bivariate analysis showed that death or transplant was associated with lower IGFBP-3 levels(1.44 mcg/mL vs 1.74 mcg/m L, P = 0.027). The Kaplan-Meier transplant-free survival probability was 88.6% in patients with IGFBP-3 ≥ 1.67 mcg/mL and 72.1% for those with IGFBP3 < 1.67 mcg/mL(P = 0.015). In the hospitalized cohort, 30-d mortality was 24.3% and was independently associated with creatinine, INR, SpO_2/FiO_2 ratio and IGFBP-3 levels in the logistic regression. The 90-d transplant-free survival probability was 80.4% in patients with IGFBP-3 ≥ 0.86 mcg/mL and 56.1% for those with IGFBP3 < 0.86 mcg/mL(P < 0.001). CONCLUSION: Lower IGFBP-3 levels were associated with worse outcomes in patients with cirrhosis, and might represent a promising prognostic tool that can be incorporated in clinical practice.

关键词： Liver cirrhosis Acute decompensation Insulin-like growth factor binding protein 3 Acute-onchronic liver failure Prognosis

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Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis

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World Journal of Gastroenterology 2023年第14期29卷 2202-2221页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029094BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919899ParanáBrazil

BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(***)-induced chronic *** practice guidelines currently recommend *** eradication as the preferred initial treatment for early-stage *** determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is *** To perform a meta-analysis to assess the rate of complete remission(CR)of ***-positive early-stage GML following bacterial *** We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September *** and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in ***-positive *** risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal *** pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects *** and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P50%,*** and meta-regression analyses were conducted to explore potential sources of *** The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text ***,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational *** overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 ***-positive early-stage GML patients,in whom *** was successfully eradicated,were incl

关键词： Lymphoma B-cell Marginal zone Gastric mucosa-associated lymphoid tissue lymphoma Stomach lymphoma Helicobacter pylori Therapeutics Eradication therapy

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20世纪前半叶中国古典诗词与戏曲的文学翻译——以洪涛生为例

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国际汉学 2020年第1期 66-76页

作者： [德]毕鲁直林施望(译) 德国科隆大学浙江大学人文学院

该文章原题为"Literary Translations of the Classical Lyric and Drama of China in the First Half of the 20th Century:The ‘Case’ of Vincenz Hundhausen (1878—1955)",收录于《从一到多:从中文翻译成欧洲语言》(De l’ un au multiple:Traductions du chinois vers les languese uropéennes, 1999),第63—83页。洪涛生(Vincenz Hundhausen,1878—1955)曾翻译多种中国文学作品,包括《西厢记》《琵琶记》《牡丹亭》等。本文发掘出了大量与洪涛生的出身、职业、翻译活动有关的资料,并对洪涛生同时代人对其翻译事业的评价进行了梳理。

关键词：中国文学作品中国古典诗词《琵琶记》《西厢记》《牡丹亭》同时代人翻译事业中文翻译

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含缝拱坝强震失效破坏振动台试验研究

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实验力学 2021年第2期36卷 279-286页

作者：张宇范哲周利剑卢召红东北石油大学土木建筑工程学院黑龙江大庆163318 中国水利水电科学研究院北京100038

为探究强震时含缝拱坝结构的承载能力及失效路径,在振动台上开展了一系列拱坝模型强震失效破坏试验。基于弹性力-重力准则设计试验,分别进行了不分缝、只有横缝、诱导缝与横缝联合作用这三种情况的振动台模型试验,试验中考虑了材料率相... 详细信息

为探究强震时含缝拱坝结构的承载能力及失效路径,在振动台上开展了一系列拱坝模型强震失效破坏试验。基于弹性力-重力准则设计试验,分别进行了不分缝、只有横缝、诱导缝与横缝联合作用这三种情况的振动台模型试验,试验中考虑了材料率相关性的影响,忽略了库水-拱坝相互作用。结果表明,强震作用时由于设缝处的抗拉能力较低,导致缝位置首先发生开裂,拱向应力的传导路径遭到破坏,此后结构破坏以悬臂梁形式为主;科学合理设置缝的形式和位置,可以有效耗散地震能量,提高拱坝极限承载能力。本文研究结果可为高拱坝的抗震分缝设计和超载能力评估提供试验依据。

关键词：拱坝振动台试验失效模式极限承载能力横缝诱导缝

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Towards curative therapy in gastric cancer:Faraway, so close!

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World Journal of Gastroenterology 2015年第41期21卷 11609-11620页

作者： Marília Cravo Catarina Fidalgo Rita Garrido Tania Rodrigues Gon?alo luz Carolina Palmela Marta Santos Fábio Lopes Rui Maio Gastroenterology Department Surgery and Oncology ClinicsHospital Beatriz Angelo

Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer(GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments.

关键词： Gastric cancer Multidisciplinary treatment Therapeutic strategies Curative surgery

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节水方法:市政管网中的渗漏控制

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水工业市场 2008年第2期 10-14页

作者： Augusto Pretner Alessandro Bettin luz Sainz Jia Yangwen 意大利SGI公司(SGIGalli) 中国水利水电科学研究院水资源研究所(IWHR)

在黄、淮、海河(3-H)流域,用水的需求与水的供应的不对称,使得节水成为这一地区社会经济和环境发展中需要优先考虑的事情。在这个背景下,市政供水管网的渗漏控制为促进水的保存和提高供水服务的成效提供了一个绝佳的机会。实际上,市政... 详细信息

在黄、淮、海河(3-H)流域,用水的需求与水的供应的不对称,使得节水成为这一地区社会经济和环境发展中需要优先考虑的事情。在这个背景下,市政供水管网的渗漏控制为促进水的保存和提高供水服务的成效提供了一个绝佳的机会。实际上,市政供水管网会损失超过一半的供水量,这种资源的浪费不仅造成环境的破坏,而且增加了供水的成本,因为需要更多的化学物质去处理水,以及在市政供水管网中消耗更多的能源去传输水。本文从经济和环境的角度出发,在市政供水管网中实施主动渗漏控制的优势所在。阐述了国际上实施渗漏控制的最佳实践的概况,并将重点放在了获取经济渗漏控制水平的方法上,展示了预防性的渗漏策略是如何通过流量和压力控制来进行市政供水管网优化,从而使之缩短回报周期,并通过水的保存和提高供水机构的财政与运作成效来增加附加值。

关键词：水节约渗漏经济的

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节水方法:市政管网中的渗漏控制

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水工业市场 2007年第12期 57-59页

作者： Augusto Pretner Alessandro Bettin luz Sainz Jia Yangwen 意大利SGI公司(SGI Galli) 中国水利水电科学研究院水资源研究所(IWHR)

关键词：水节约渗漏经济的

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Original article Schistosomiasis in China： acute infections during 2005-2008

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Chinese Medical Journal 2009年第9期122卷 1009-1014页

作者： LI Shi-zhu Acosta luz WANG Xian-hong XU Li-li WANG Qiang QIAN Ying-jun WU Xiao-hua GUO Jia-gang XIA Gang WANG Li-ying ZHOU Xiao-nong National Institute of Parasitic Diseases Chinese Center for DiseaseControl and Prevention Shanghai 200025 China Research Institute for Tropical Medicine Alabang MuntinlupaCity 1781 Philippines Ministry of Health Beijing 100044 China

Background Significant progress has taken place over the past 50 years in the control of schistosomiasis japonica in China. However, the available data suggested that schistosomiasis has re-emerged shortly after the World Bank Loan Project which was conducted from 1992 to 2001. The national control program with a revised strategy to control schistosomiasis by using integrated measures has been implemented since 2005. In this study, we aimed to evaluate the effect of the national program on schistosomiasis control from 2005 to 2008.Methods A retrospective study was carried out to analyze the epidemic patterns of acute infections with Schistosoma japonicum （S. japonicum）, based on the number of acute cases annually collected from the web-based national communicable diseases reporting system from 2005 to 2008.Results A total of 564, 207, 83 and 57 acute cases infected with S. japonicum were reported nationwide in 2005, 2006, 2007 and 2008, respectively, with an average annual reduction rate of 46.35% during last four years. Six outbreaks of acute infection with S. japonicurn were reported in 2005 but none in the period of 2006 to 2008. All acute cases that were reported mainly came from the lake regions and became infected during the higher risk periods from the 27th to 43rd weeks of the year. Most of these cases are students （44.87%）, farmers （31.51 %） and fishermen （7.79%） who got the infection by water contact mainly through swimming （41.49%） and production activities （40.25%）. With time, the proportion of imported cases among all acute cases increased due to more frequent movement of people that has occurred with a more mobile population.Conclusions The national control program on schistosomiasis aliened with the revised control strategy has been effectively brought into effect. However, there is still a significant risk of infection among students, farmers and fishermen living in the lake regions. Therefore, it is important to strengthen control measures amo

关键词： schistosomiasis acute infection control program China

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New Interpretations about Clonal Architecture for the Sour Pitaya (<i>Stenocereus gummosus</i>, Cactaceae), Arising from Microsatellite Markers of <i>de novo</i>Isolation and Characterization

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Open Journal of Genetics 2015年第1期5卷 1-11页

作者： Oscar Adrián Lozano Garza José L. León de la luz Susana Favela Lara Francisco J. García de León Laboratorio de Genética para la Conservación Centro de Investigaciones Biológicas del Noroeste La Paz Mexico Departamento de Ecología Facultad de Ciencias Biológicas Universidad Autónoma de Nuevo LeónSan Nicolás de los Garza Mexico

The use of molecular markers has improved the ecological and evolutionary research in the case of clonal reproduction species, allowing the identification of boundaries among clonal modules (ramets), genetic individuals (genets), and populations. Microsatellite markers were developed for Stenocereus gummosus, a columnar cactus with both sexual and clonal reproduction which is distributed in the Sonoran Desert, Mexico. 454-Pyrosequencing reads were analyzed to detect microsatellite markers. Forty primer pairs were screened to look for polymorphism. Nine loci were genotyped for two S. gummosus localities. Sampling strategy was intended to avoid collecting a genetic individual more than once, considering that clonal architecture for this cactus was previously deduced as clumped. Polymorphic loci exhibited low allele count, ranging from 2 - 7 (mean of 3.78 ± 0.62 SE);mean heterozygosity values were 0.221 and 0.234 HO and 0.408 and 0.306 HE, with FIS of 0.383 and 0.299, for peninsular and continental localities respectively. Unexpectedly, some multilocus genotypes were found repeated within locality, which were assumed as clones since data was evaluated as sufficient (clonal richness R of 0.966 and 0.897). These results were different from those previously reported: the distribution of clones might as well be intermingled, having a minimum ramet dispersion distance of 30 m. This characteristic was also consistent with the recent colonization proposed for this and other arid lands plants. A wider genetic neighborhood, due to clone dispersion might affect diversity indexes while increasing the chance of geitonogamy and mating among relatives. The markers isolation and its population characterization allowed addressing new questions about S. gummosus ecology, clonal reproduction and reproductive biology.

关键词： Cactaceae Clonal Architecture Microsatellites Pyrosequencing Stenocereus

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Comparison between endoscopic sclerotherapy and band ligation for hemostasis of acute variceal bleeding

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World Journal of Gastrointestinal Endoscopy 2011年第5期3卷 95-100页

作者： Gustavo Oliveira luz Fauze Maluf-Filho Sérgio Eiji Matuguma Fábio Yuji Hondo Edson Ide Jeane Martins Melo Spencer Cheng Paulo Sakai Gastrointestinal Endoscopy Unit Hospital das ClínicasSo Paulo University Medical School

AIM:To compare band ligation(BL) with endoscopic sclerotherapy(SCL) in patients admitted to an emergency unit for esophageal variceal rupture. METHODS:A prospective,randomized,single-center study without crossover was *** endoscopic diagnosis of esophageal variceal rupture,patients were randomized into groups for SCL or BL *** was performed by ethanolamine oleate intravascular injection both above and below the rupture point,with a maximum volume of 20 *** BL patients,banding at the rupture point was attempted,followed by ligation of all variceal tissue of the distal *** outcomes for both groups were initial failure of bleeding control(5 d) ,early re-bleeding(5 d to 6 wk),and complications,including *** May 2005 to May 2007,100 patients with variceal bleeding were enrolled in thestudy:50 SCL and 50 BL *** differences between groups were observed across gender,age,ChildPugh status,presence of shock at admission,mean hemoglobin levels,and variceal size. RESULTS:No differences were found between groups for bleeding control,early re-bleeding rates,complications,or *** 6 wk,36(80%) SCL and 33(77 %) EBL patients were alive and free of bleeding.A statistically significant association between Child-Pugh status and mortality was found,with 16%mortality in Child A and B patients and 84%mortality in Child C patients(P<0.001) . CONCLUSION:Despite the limited number of patients included,our results suggest that SCL and BL are equally efficient for the control of acute variceal bleeding.

关键词： Portal hypertension Hemorrhage Esophageal varices Gastrointestinal endoscopy Ligation Sclerotherapy

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