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Journal of Surface Engineered materials and Advanced Technology 2015年第1期5卷 17-23页

作者： Yonic Penaloza-mendoza Luis Ponce-cabrera Instituto Politecnico Nacional Cicata AltamiraAltamiraMéxico

TiO2 thin films were prepared on glass substrates using the PLD (Pulsed Laser Deposition) technique. In order to carry out the ablation process, a Nd:YAG laser was used emitting in 1064 nm wavelength at 10 Hz repetition rate, set up for operating in both single-pulse and multi-pulse regimes. A comparison of the deposition rate, the optical and morphological properties of the layers obtained from both ablation regimes was made, which showed that the multi-pulsed ablation produced layers with a higher surface quality and better optical properties.

关键词： Pulsed Laser Deposition Single-Pulse Ablation multi-Pulse Ablation TiO_(2) Thin Film

Analyzing the genomic and transcriptomic architecture of milk traits in murciano-Granadina goats

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Journal of Animal Science and Biotechnology 2020年第3期11卷 649-666页

作者： Dailu Guan Vincenzo Landi maría Gracia Luigi-Sierra Juan Vicente Delgado Xavier Such Anna Castelló Betlem cabrera Emilio mármol-Sánchez Javier Fernández-Alvarez JoséLuis Ruiz de la Torre Casañas Amparo martínez Jordi Jordana marcel Amills Centre for Research in Agricultural Genomics(CRAG) CSIC-IRTA-UAB-UBUniversitat Autònoma de Barcelona08193 BellaterraSpain Departamento de Genética Universidad de Córdoba14071 CórdobaSpain Departament de Ciència Animal i dels Aliments Facultat de VeterinàriaUniversitat Autònoma de Barcelona08193 BellaterraSpain Asociación Nacional de Criadores de Caprino de Raza murciano-Granadina(CAPRIGRAN) 18340 GranadaSpain Servei de Granges i Camps Experimentals Universitat Autònoma de Barcelona08193 BellaterraSpain

Background:In this study,we aimed to investigate the molecular basis of lactation as well as to identify the genetic factors that influence milk yield and composition in *** achieve these two goals,we have analyzed how the mRNA profile of the mammary gland changes in seven murciano-Granadina goats at each of three different time points,i.e.78 d(T1,early lactation),216 d(T2,late lactation)and 285 d(T3,dry period)after ***,we have performed a genome-wide association study(GWAS)for seven dairy traits recorded in the 1st lactation of 822 murciano-Granadina ***:The expression profiles of the mammary gland in the early(T1)and late(T2)lactation were quite similar(42 differentially expressed genes),while strong transcriptomic differences(more than one thousand differentially expressed genes)were observed between the lactating(T1/T2)and non-lactating(T3)mammary glands.A large number of differentially expressed genes were involved in pathways related with the biosynthesis of amino acids,cholesterol,triglycerides and steroids as well as with glycerophospholipid metabolism,adipocytokine signaling,lipid binding,regulation of ion transmembrane transport,calcium ion binding,metalloendopeptidase activity and complement and coagulation *** regard to the second goal of the study,the performance of the GWAS allowed us to detect 24 quantitative trait loci(QTLs),including three genome-wide significant associations:QTL1(chromosome 2,130.72-131.01 mb)for lactose percentage,QTL6(chromosome 6,78.90-93.48 mb)for protein percentage and QTL17(chromosome 17,11.20 mb)for both protein and dry matter ***,QTL6 shows positional coincidence with the casein genes,which encode 80%of milk ***:The abrogation of lactation involves dramatic changes in the expression of genes participating in a broad array of physiological processes such as protein,lipid and carbohydrate metabolism,calcium homeostasis,cell death and tissue remo

关键词： Casein genes Dairy traits GWAS Lactation QTLs RNA-Seq

在中国的城市中创意产业的角色 ——国家与城市的更新者

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在中国的城市中创意产业的角色 ——国家与城市的更新者

作者： Laurinda luz Sanchez 浙江大学

学位级别：硕士

中国是世界上人口最多的国家,是具有五千年悠久历史文化的国家。现代世界闻名的许多元素都起源于中国,比如,造纸,火药,信用银行,指南针和纸币等。但是,如此光辉伟大的国家的形象是如何受损的呢?为什么如今世界把中国当作“世界工厂”呢... 详细信息

中国是世界上人口最多的国家,是具有五千年悠久历史文化的国家。现代世界闻名的许多元素都起源于中国,比如,造纸,火药,信用银行,指南针和纸币等。但是,如此光辉伟大的国家的形象是如何受损的呢?为什么如今世界把中国当作“世界工厂”呢?随着中国加入世界贸易组织,中国开始逐渐与国际接轨,加入一个全球化的世界。全球化的影响之一,就是文化的同质化。中国已经成为世界上经济增长最快的国家,中国正按照自己的思路去创建和属于自己的一席之地,让世界知道中国的声音。通过做这些,中国是为了让世界来认识中国的思维逻辑方式,而不仅仅是获得经济上的国际地位。而我的研究,就是中国是如何做到这些的,如何宣传自己的。出口文化软实力,是中国议程的主要目标。怀有创新的态度,这个国家计划在所有的主要城市建立创意集群,这将有助于创造一个城市创新的自我形象,以达到让创意集群起到城市再生器的作用。我的研究展示了上海莫干山路50号的m50创意工业园的案例,上海创意集群的先驱,被认为是一个真正内容的制造者,并专门展示翻修过的城市形象。与同类集群相比,这是它的特色。通过一系列的采访,我希望有个更好的理解：是否可能通过创意集群,在北京、上海、杭州这三个城市产生城市的更新和复兴。同时,也可以实现国家的目标,把这些城市转化成为创新型的城市,重塑城市的形象,进而重塑和丰富国家形象。

关键词：创意产业创新创意集群城市更新者

Feynman integrals and hypergeometric functions

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International Journal of modeling, Simulation, and Scientific Computing 2014年第S1期5卷 1-13页

作者： Héctor Luna García luz maría García Departamento de Ciencias Básicas UAm-Azcapotzalco Av.San Pablo 18002200MéxicoD.F.México

We review Davydychev method for calculating Feynman integrals for massive and no massive propagators,by employing mellin-Barnes transformation and the dimensional regularization scheme,same that lead to hypergeometric... 详细信息

关键词： Quantum field theory propagators dimensional regularization mellin-Barnes integrals

Effect of thatch on water-soluble phosphorus of pasture soil fertilized with broiler litter

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Journal of Forestry Research 2002年第1期13卷 71-73页

作者：陈欣张庆忠 m.L.cabrera 中科院应用生态研究所沈阳110016 Dep.of Crop and Soil Sciences

The presence of a thatch layer in established pastures could reduce the contact between broiler litter and soil, thus increasing the potential for surface runoff contamination with litter P. We conducted a laboratory study to evaluate the effect of a thatch layer on the dynamics of water-soluble P in undisturbed cores taken from a pasture. Cores with and without a thatch layer received a surface application of broiler litter (5 thm-2) and were incubated at 25 oC for 56 d. The result showed that on the soil surface the contents of water soluble-P (39 kghm-2) of the cores with the thatch layer was higher than that (20 kghm-2) of the cores without the thatch layer. Therefore on well-established pastures fertilized with broiler litter, the presence of a thatch layer might lead to high concentrations of water-soluble P on the soil surface.

关键词： Pastures Water-soluble phosphorus Broiler litter

The cold-induced factor CBF3 mediates root stem cell activity,regeneration,and developmental responses to cold

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Plant Communications 2023年第6期4卷 197-211页

作者： Pablo Perez-Garcia Ornella Pucciariello Alvaro Sanchez-Corrionero Javier cabrera Cristina del Barrio Juan Carlos del Pozo mariano Perales Krzysztof Wabnik miguel A.moreno-Risueno Centro de Biotecnologíay Genómica de Plantas(Universidad Politécnica de madrid(UPm)–Instituto Nacional de Investigacióny Tecnología Agraria y Alimentaria–CSIC(INIA-CSIC)) MadridSpain

Plant growth and development involve the specification and regeneration of stem cell niches(SCNs).Although plants are exposed to disparate environmental conditions,how environmental cues affect developmental programs and stem cells is not well *** stem cells are accommodated in meristems in SCNs around the quiescent center(QC),which maintains their *** a combination of genetics and confocal microscopy to trace morphological defects and correlate them with changes in gene expression and protein levels,we show that the cold-induced transcription factor(TF)C-REPEAT BINDING FACTOR 3(CBF3),which has previously been associated with cold acclimation,regulates root development,stem cell activity,and ***3 is integrated into the SHORT-ROOT(SHR)regulatory network,forming a feedback loop that maintains SHR ***3 is primarily expressed in the root endodermis,whereas the CBF3 protein is localized to other meristematic tissues,including root *** of cbf3-1 using a wild-type CBF3 gene and a CBF3 fusion with reduced mobility show that CBF3 movement capacity is required for SCN patterning and regulates root ***,cold induces CBF3,affecting QC ***,exposure to moderate cold around 10℃–12℃promotes root regeneration and QC respecification in a CBF3-dependent manner during the recuperation *** contrast,CBF3 does not appear to regulate stem cell survival,which has been associated with recuperation from more acute cold(-4℃).We propose a role for CBF3 in mediating the molecular interrelationships among the cold response,stem cell activity,and development.

关键词： stem cells regeneration organ patterning protein movement cell fate low temperature

Re-engineering artificial muscle with microhydraulics

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microsystems & Nanoengineering 2017年第1期3卷 278-285页

作者： Jakub Kedzierski Eric Holihan Rafmag cabrera Isaac Weaver massachusetts Institute of Technology Lincoln Laboratory LexingtonMA 02420USA

We introduce a new type of actuator,the microhydraulic stepping actuator(mSA),which borrows design and operational concepts from biological muscle and stepper *** offer a unique combination of power,efficiency,and scalability not easily achievable on the *** actuator works by integrating surface tension forces produced by electrowetting acting on scaled droplets along the length of a thin *** muscle,mSAs have liquid and solid functional components and can displace a large fraction of their *** 100μm pitch mSA presented here already has an output power density of over 200 W kg^(−1),rivaling the most powerful biological muscles,due to the scaling of surface tension forces,mSA’s power density grows quadratically as its dimensions are reduced.

关键词： artificial muscle electrowetting linear actuator microactuator microsystem microhydraulic stepping actuator

Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism:WLB-73502,an analgesic with improved efficacy and safety profile compared to strong opioids

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Acta Pharmaceutica Sinica B 2023年第1期13卷 82-99页

作者： Alba Vidal-Torres Begoña Fernández-Pastor mónica García Eva Ayet Anna Cabot Javier Burgueño Xavier monroy Bertrand Aubel Xavier Codony luz Romero Rosalía Pascual maria Teresa Serafini Gregorio Encina Carmen Almansa Daniel Zamanillo manuel merlos Josémiguel Vela WeLab Barcelona Parc Cientific de BarcelonaBarcelona 08028Spain

Opioids are the most effective painkillers,but their benefit-risk balance often hinder their therapeutic ***-73502 is a dual,bispecific compound that binds sigma-1(S1R)and mu-opioid(mOR)***-73502 is an antagonist at the *** behaved as a partial mOR agonist at the G-protein pathway and produced no/unsignificantβ-arrestin-2 recruitment,thus demonstrating low intrinsic efficacy on mOR at both signalling *** its partial mOR agonism,WLB-73502exerted full antinociceptive efficacy,with potency superior to morphine and similar to oxycodone against nociceptive,inflammatory and osteoarthritis pain,and superior to both morphine and oxycodone against neuropathic ***-73502 crosses the blood-brain barrier and binds brain S1R and mOR to an extent consistent with its antinociceptive *** to morphine and oxycodone,tolerance to its antinociceptive effect did not develop after repeated 4-week ***,contrary to opioid comparators,WLB-73502 did not inhibit gastrointestinal transit or respiratory function in rats at doses inducing full efficacy,and it was devoid of proemetic effect(retching and vomiting)in ferrets at potentially effective ***-73502 benefits from its bivalent S1R antagonist and partial mOR agonist nature to provide an improved antinociceptive and safety profile respect to strong opioid therapy.

关键词： WLB-73502 Sigma-1 receptor mu-opioid receptor Biased agonist Analgesic activity Chronic pain Neuropathic pain Safety

The Role of mutual Support Groups for the Control of Diabetes in a mexican City: Achievements and Limitations from the Patients’ Perspective

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Health 2014年第15期6卷 1984-1993页

作者： luz maría Tejada-Tayabas maría Judith Rios Lugo Faculty of Nursing Autonomus University of San Luis Potosi San Luis Potosí México

Background: mutual Support Groups (mSG) provides to the patient, the ability to effective self-management behaviors, such as taking prescribed medications, following diet and exercise regimens, self-monitoring, and coping emotionally with the rigors of living with diabetes. Physicians, nurses and health promoters from public primary Health Care Centers (HCC) are responsible for providing follow-up care through mSGs. However, although the mSG program has been carried out, in the last decade mexico presents the most alarming statistics in the prevalence and complications of Diabetes mellitus type II (Dm-II), suggesting a low impact of mSG in the strategy to support the effective control of the disease. Objetive: The aim of this work was to assess whether knowledge or benefits of effective management to control of Dm-II, also to identify strengths and limitations of mSGs, in six different Health Care Centers (HCC), in San Luis Potosi, mexico. This research provides an overview of patients’ perception, and significant issues that demand to adjust mGSs strategies, with the goal of exceed the expectations of current health statistics. methods: A qualitative evaluation was carried out, with an ethnographic approach design. The study included 28 diabetic persons, (21 women and 7 men from ruraland urban carecenters). Semi-structured interviews, non-participant observation, and structured content analysis were used. Results: Support groups give patients a way to address emotional issues, and learn about their disease and self-care, although some patients consider participation an inconvenient obligation. Support group users mention barriers such as lack of continuity in support group activities, inconvenient meeting times, and the difficulty of commuting to attend group sessions. They also mention that overworked health care workers find it difficult to provide leadership to keep the group going. These issues have multiple implications for the success of strategies to control

关键词： mutual Support Group Diabetes mellitus Qualitative Research Health Care Services mexico

Ant Species Richness Variation mediated by Seasonality in Two Ant-Acacias from Oaxaca, mexico

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Open Journal of Ecology 2021年第1期11卷 24-31页

作者： Sandra luz Gómez-Acevedo Javier martínez-Toledo Unidad de morfología y Función Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Mexico City México

Climatic conditions affect the richness of ants resulting in number variation throughout the year. The ants present in the Neotropical system Acacia-Pseudomyrmex have been previously studied considering only one sampl... 详细信息

Climatic conditions affect the richness of ants resulting in number variation throughout the year. The ants present in the Neotropical system m>Acacia-Pseudomyrmexm> have been previously studied considering only one sampling season. In contrast, in this study we analyze the richness in two ant-acacia systems during the rainy and dry seasons. The study was carried out on a plot located in the state of Oaxaca, mexico where 14 ant species, 3 mutualistic and 11 non-mutualistic were found, of which 2 represent new records for the state. Ant species number differed between ant-acacia species and between seasons. The highest richness was recorded in m>Acacia hindsiim> in both rainy and dry seasons, corresponding with a low-reward host. During the dry season, m>A. hindsii m>represents a highly valuable resource. This study shows that the neotropical system is much more dynamic than it has been previously considered and offers a valuable opportunity for subsequent ecological studies for a better understanding of this complex system.

关键词： Dolichoderinae Formicinae myrmicinae Pseudomyrmex