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Buxu Tongyu Granule Alleviates Myocardial Ischemia by Activating Vascular Smooth Muscle Cell Soluble Guanylate Cyclase to Inhibit Abnormal Vasomotion

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Engineering 2024年第7期38卷 133-143页

作者： Shuang yang Yixiu Zhao Xiaoling Cheng Tingting Zhan Jiaying Tian Xue Liu Chunyue Ma Zhiqi Wang luying Jin Qian Liu yanli Wang Jian Huang Jinhui Wang yan Zhang Baofeng yang Department of Pharmacology&Key Laboratory of Cardiovascular Medicine Research Ministry of Education of the People’s Republic of ChinaCollege of PharmacyHarbin Medical UniversityHarbin 150081China National Key Laboratory of Frigid Zone Cardiovascular Diseases(NKLFZCD) Harbin Medical UniversityHarbin 150081China Department of Medicinal Chemistry and Natural Medicine Chemistry College of PharmacyHarbin Medical UniversityHarbin 150081China Research Unit of Noninfectious Chronic Diseases in Frigid Zones Chinese Academy of Medical SciencesHarbin 150081China

Myocardial ischemia is a serious threat to human health,and vascular dysfunction is its main *** Tongyu(BXTY)Granule is an effective traditional Chinese medicine(TCM)for treating myocardial ***,the underlying mechanism of BXTY is still *** this study,we demonstrate that BXTY ameliorates myocardial ischemia by activating the soluble guanylate cyclase(sGC)-30,50-cyclic guanosine monophosphate(cGMP)-protein kinase G(PKG)signaling pathway in vascular smooth muscle cells(VSMCs)to dilate the *** was given by gavage for ten consecutive days before establishing an animal model of acute myocardial ischemia in mice via the intraperitoneal injection of *** results showed that BXTY alleviated the symptoms of myocardial ischemia induced by pituitrin in mice,including electrocardiogram abnormalities and changes in plasma *** addition,BXTY dilated pre-constricted blood vessels and inhibited the vasoconstriction of the superior mesenteric artery in a dose-dependent but endothelial-independent *** effects were eliminated by preincubating vascular rings with the sGC inhibitors NS 2028 or ODQ,or with the PKG inhibitor KT ***,BXTY increased the protein expression of sGC-b1 and the intracellular second messenger cGMP level in mouse aortic vascular smooth muscle cells(MOVAs).NS 2028 or ODQ reversed these effects of *** expression level of the cGMP downstream effector protein PKG-1 increased after treating MOVAs with *** 2028,ODQ,or KT 5823 also reversed this effect of *** conclusion,BXTY can improve the symptoms of acute myocardial ischemia in mice,and activating the sGC-cGMP-PKG pathway in VSMCs to induce vasodilation is its key pharmacodynamic mechanism.

关键词： Myocardial ischemia Vasomotion Soluble guanylate cyclase Buxu Tongyu Granule

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药学学科科研绩效评价探讨

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科教文汇 2017年第28期 68-69页

作者：闫璐颖谢玉诚中国药科大学江苏南京210009

本文根据药学学科的特色,结合科研评价的目的,对药学学科的科研绩效评价进行了探讨。笔者认为要对药学学科科研工作者的科研业绩做出尽可能客观准确的评估和评价,要构建相对完备的药学学科科研绩效评价体系,除了将评价范围缩小在"学科"... 详细信息

本文根据药学学科的特色,结合科研评价的目的,对药学学科的科研绩效评价进行了探讨。笔者认为要对药学学科科研工作者的科研业绩做出尽可能客观准确的评估和评价,要构建相对完备的药学学科科研绩效评价体系,除了将评价范围缩小在"学科"的范畴外,还需要考虑到行业的因素,不能够一概而论。

关键词：药学学科科研绩效

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考虑平衡气体效应的乘波体特征线设计方法及气体模型影响

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南京航空航天大学学报 2024年第1期56卷 163-175页

作者：林鹭颖李沁严攀翁谊辉尤延铖李留刚厦门大学航空航天学院厦门361102 中国运载火箭技术研究院空间物理重点实验室北京100076

乘波体在高空高超声速飞行时,流场温度急剧升高,气体热力学性质发生改变,其气动特性与采用完全气体模型得到的结果存在差异,因此在飞行器设计中开展真实气体效应影响研究具有重要的工程价值。本文针对锥导乘波体设计提出了一种考虑平衡... 详细信息

乘波体在高空高超声速飞行时,流场温度急剧升高,气体热力学性质发生改变,其气动特性与采用完全气体模型得到的结果存在差异,因此在飞行器设计中开展真实气体效应影响研究具有重要的工程价值。本文针对锥导乘波体设计提出了一种考虑平衡气体效应的特征线方法(Method of characteristic, MOC),基于不同半锥角和不同流动捕获曲线生成了不同外形的乘波体,并使用快速估算方法估算平衡气体条件和完全气体条件下各乘波体的气动特性和几何特征参数,研究了不同气体模型对乘波体设计结果的影响。研究结果表明,高马赫数下基于平衡气体模型设计得到的乘波体升阻比、容积率和俯仰力矩系数等特性参数相比完全气体结果存在差异,并且平衡气体效应对不同外形乘波体的影响程度和影响规律不同。

关键词：高超声速平衡气体乘波体特征线方法气动特性

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Analysis on Affordable Housing Financial Mechanism in USA

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学术界 2015年第7期 274-281页

作者： Wang Xiaoxiao yan Jie Li luying College of Landscape Architecture Nanjing Forestry University Nanjing Jiangsu 210037 Customer Management Center China Development Bank Beijing 100031 Nanfang College Nanjing Forestry University Nanjing Jiangsu 210037

Affordable housing development consists of many stages and financing is one stage which plays a critical *** housing developers easy access to high- quality and low-cost capital is an effective way to encourage them to develop more affordable *** paper mainly focuses on affordable housing finance mechanism in *** first section is an overview of affordable housing in terms of definition,functions and current regulations for affordable *** the second section,there is an introduction of the whole affordable housing financing *** of the available financing resources are discussed in this *** fund resources are discussed in the third *** purpose of this paper is to provide housing developers an overview about affordable housing financing market and introduce several mainstream ones in *** well,this paper will provide an analysis for Chinese affordable housing developers about what they can learn from the USA and what potential opportunities are in China.

关键词：经济适用住房机制分析美国经济适用房融资机制金融开发商保障性

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铁酸镍负载杉木屑生物炭活化过一硫酸盐降解磷酸氯喹

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复合材料学报 2024年第8期41卷 4310-4323页

作者：王俊辉张菁玮孙静鄢经缘徐梓淞江露莹黄燕韩彪张寒冰郝格日乐何思静朱华凤广西大学资源环境与材料学院南宁530004 广西壮族自治区环境保护科学研究院南宁530022 广西大学化学化工学院广西石化资源加工及过程强化技术重点实验室南宁530004 广西大学广西新污染物监测预警与环境健康评估重点实验室南宁530004

近年来,磷酸氯喹(Chloroquine phosphate,CQP)作为治疗新冠的特效药得到广泛应用,并且由于其具有优异的抗炎症和抗疟疾能力,在疫情结束后仍发挥着重要作用。磷酸氯喹的大量使用对环境造成严重的潜在危害。将废弃的木屑资源化利用,通过... 详细信息

近年来,磷酸氯喹(Chloroquine phosphate,CQP)作为治疗新冠的特效药得到广泛应用,并且由于其具有优异的抗炎症和抗疟疾能力,在疫情结束后仍发挥着重要作用。磷酸氯喹的大量使用对环境造成严重的潜在危害。将废弃的木屑资源化利用,通过共沉淀-无氧煅烧法制备出具有磁回收能力的铁酸镍负载杉木屑生物炭复合材料(Nickel ferrate loaded biochar,NiFe_(2)O_(4)@BC),并研究其活化过一硫酸盐(Peroxymonosulfate,PMS)降解CQP的性能。利用多种表征对NiFe_(2)O_(4)@BC复合材料的组成结构、表面官能团和石墨化程度进行分析,相较于未改性的杉木屑生物炭(Fir sawdust biochar,BC),将具有磁性NiFe_(2)O_(4)的负载在生物炭上,使复合材料的石墨化程度提高,缺陷活性位点也得到增多,对CQP的去除效果得到巨大提高。主要考察了NiFe_(2)O_(4)@BC投加量、PMS浓度、溶液初始pH、共存无机阴离子与腐殖酸在降解CQP过程中的影响。研究表明:当Ni Fe_(2)O_(4)@BC投加量为0.5 g/L,PMS浓度为1.0 mmol/L,CQP浓度为10 mg/L的条件下,CQP去除率在120 min达到89%。在偏酸性或者偏碱的条件下更有利于CQP的降解,腐殖酸(Humic acid,HA)对NiFe_(2)O_(4)@BC活化PMS降解CQP具有促进作用。淬灭实验证实,自由基途径和非自由基途径生成的·OH与^(1)O_(2)主导了NiFe_(2)O_(4)@BC/PMS体系对CQP的降解。在同等条件下,对多种污染物均能达到80%以上的降解效果。此外,NiFe_(2)O_(4)@BC循环使用5次后,活化PMS去除CQP的效率仍能达到74%左右。本文为废弃杉木屑高效、绿色的资源化利用提供了新策略和借鉴意义。

关键词：生物炭降解木屑铁酸镍磷酸氯喹过一硫酸盐

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造血干细胞移植后患儿预防接种的真实世界研究

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中国小儿血液与肿瘤杂志 2024年第3期29卷 204-208,223页

作者：陈璐曦安曦洲孟岩张璐颖窦颖重庆医科大学附属儿童医院血液肿瘤科国家儿童健康与疾病临床医学研究中心儿童发育疾病研究教育部重点实验室儿童感染免疫重庆市重点实验室重庆400014

目的了解造血干细胞移植(HSCT)后患儿预防接种的现状及家长对疫苗接种的认知度和担忧,为HSCT后患儿疫苗接种管理方案的改进提供参考。方法对接受HSCT后存活,且已停用免疫抑制剂的患儿进行问卷调查,对患儿一般情况、HSCT类型及治疗情... 详细信息

目的了解造血干细胞移植(HSCT)后患儿预防接种的现状及家长对疫苗接种的认知度和担忧,为HSCT后患儿疫苗接种管理方案的改进提供参考。方法对接受HSCT后存活,且已停用免疫抑制剂的患儿进行问卷调查,对患儿一般情况、HSCT类型及治疗情况、疫苗接种现状、家长对疫苗接种的认知程度进行统计分析。结果收集有效问卷152份,男109例(71.71%),女43例(28.29%);原发疾病占比最大的为原发性免疫缺陷病(50.66%,77/152),平均移植时间(30.03±2.74)(5~105)个月。41例(26.97%)患儿接种过疫苗,中位接种时间29个月,41例(26.97%)均接种过灭活疫苗,18例(11.84%)接种过减毒活疫苗;14例(9.21%)接种过新冠疫苗。移植后未接种疫苗患儿的原因主要是对疫苗接种认知不够。结论移植时间是影响HSCT后患儿预防接种的唯一因素,在以后的临床工作中,提高HSCT后患儿及家属对疫苗接种的认识,有助于提高疫苗接种率。

关键词：造血干细胞移植疫苗接种儿童

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Extended structural materials constructed from sulfate-centered Preyssler-type polyoxometalate with excellent electrocatalytic property

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Chinese Chemical Letters 2018年第9期29卷 1409-1412页

作者： Na Zhang luying Hong Aifang Geng Jinghui yan Shuang Yao Zhiming Zhang College of Chemistry and Environmental Engineering Changchun University of Science and Technology Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion School of Chemistry and Chemical Engineering Tianjin University of Technology

Sulfate-centered Preyssler-type polyoxometalate was used as the precursor to react with transition metal cations and organic ligand for constructing inorganic-organic hybrid materials {H[Ni2（H2O）4（Htrz）3]2（KSsW30O110）}·18H2O （trz = 1,2,4-triazole）（1）, which was characterized by single crystal X-ray diffraction analysis, energy-dispersive X-ray （EDX）, power X-ray diffraction （PXRD）, IR spectra and thermogravimetric （TG） analyses. In 1, the cylindrical vacancy of the inorganic crown-type anion （SsW30Ouo） captures a K^＋ ion resulting in the anion {KS5W3oO110）^9-, which was further connected by dimeric [Ni2（H2O）4（Htrz）3]2 metal-organic units into an one-dimensional （1D） chain-like structure. These 1D chains are further packed to form a three-dimensional （3D） supramolecular structure via Hbonding interactions. Here, the sulfate-centered Preyssler-typepolyoxometalate was firstly used to coordinate with transition metal cations and introduced into the inorganic-organic hybrid materials. Electrocatalytic study indicates that compound I exhibits good electrocatalytic activity toward reduction of H2O2 and NO2^-.

关键词： Preyssler-type Polyoxometalate Transition metal Supramolecular structure Electrocatalytic activity

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In-situ formed NiS/Ni coupled interface for efficient oxygen evolution and hydrogen evolution

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Journal of Materials Science & Technology 2020年第7期42卷 10-16页

作者： Chaoyi yan Jianwen Huang Chunyang Wu Yaoyao Li Yuchuan Tan luying Zhang Yinghui Sun Xiaona Huang Jie Xiong State Key Laboratory of Electronic Thin Film and Integrated Devices University of Electronic Science and Technology of ChinaChengdu610054China Chengdu Technological University Chengdu611730China Soochow Institute for Energy and Materials InnovationS&Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province Soochow UniversitySuzhou215006China

High-performance electrocatalysts for water splitting are desired due to the urgent requirement of clean and sustainable hydrogen *** reduce the energy barrier,herein,we adopt a facile in-situ surface modification strategy to develop a low-cost and efficient electrocatalyst for water *** synthesized mulberry-like NiS/Ni nanoparticles exhibit excellent catalytic performance for water *** overpotentials of 301 and 161 mV are needed to drive the current density of 10 mA cm^-2 accompanying with remarkably low Tafel slopes of 46 and 74 mV dec^-1 for oxygen evolution reaction(OER)and hydrogen evolution reaction(HER),***,a robust electrochemical stability is *** high-resolution X-ray photoelectron spectroscopy analyses reveal that the intrinsic HER activity improvement is attributed to the electron-enriched S on the strongly coupled NiS and Ni interface,which simultaneously facilitates the important electron transfer,consistent with the electrochemical impedance *** post characterizations demonstrate that surface reconstructed oxyhydroxide contributes to the OER activity and NiS/Ni is an OER *** structure construction with in-situ formation of active interface provides an effective way to design efficient electrocatalysts for energy conversion.

关键词： Water splitting Interface construction Electrocatalyst Bifunctional In-situ synthesis

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A smart MXene-copolymeric molecularly imprinted hydrogel with dual-response and photothermal conversion performance for specific recognition of cis-diol compounds

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Nano Research 2022年第3期15卷 2764-2772页

作者： Jingyang Zhao Yucheng Li Huatai Zhu Guifang Li Lingling Kang Jing Liu Jing He Jiandu Lei luying Wang Qiong yan Beijing Key Laboratory of Lignocellulosic Chemistry College of Material Science and TechnologyBeijing Forestry UniversityBeijing 100083China School of Science Beijing Jiaotong UniversityBeijing 100044China MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy Beijing Forestry UniversityBeijing 100083China

In this work,a novel MXene-copolymeric molecularly imprinted hydrogel(FMMIH)with temperature/pH dual response and photothermal conversion performance for selective recognition of cis-diol compounds is successfully *** MXene becomes an important part of the hydrogel’s skeleton by participating in the free radical polymerization ***,FMMIH exhibits improved mechanical properties and great photothermal conversion ***,based on the temperature/pH dual response,FMMIH can realize the controllable capture and release of ginsenoside Rb1 with cis diol structures through dual recognitions of functional groups and geometric *** the conditions of pH 8.5 and 25℃,the adsorption capacity of FMMIH is 26.3 mg·g^(-1) and the imprinting factor is 16.4,showing a good imprinting *** is worth noting that the volume shrinkage caused by photothermal conversion of the hydrogel is conducive to the elution of template molecules and greatly saves the time of desorption(the desorption efficiency is as high as 89.4%under light conditions for 30 min,which is 3.7 times in dark conditions).These excellent properties make it possible to have broad prospects in many fields such as separation of cis-diol compounds,drug delivery systems,and biosensors.

关键词： functional MXene photothermal conversion molecular imprinting temperature/pH response specific recognition

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3D Porous MXene Aerogel through Gas Foaming for Multifunctional PressureSensor

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Research 2022年第4期2022卷 321-331页

作者： Yongfa Cheng Li Li Zunyu Liu Shuwen yan Feng Cheng yang Yue Shuangfeng Jia Jianbo Wang Yihua Gao luying Li Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and Technology(HUST)Luoyu Road 1037Wuhan 430074China Information Materials and Intlligent Sensing Laboratory of Anhui Province Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationInstitutes of Physical Science and Information TechnologyAnhui UniversityHefei 230601China School of Physics and Technology Center for Electron MicroscopyMOE Key Laboratory of Artificial Micro-and Nano-Structures and the Institute for Advanced StudiesWuhan UniversityWuhan 430072China

The development of smart wearable electronic devices puts forward higher requirements for future flexible electronics. The design of highly sensitive and high-performance flexible pressure sensors plays an important role in promoting the development of flexible electronic devices. Recently, MXenes with excellent properties have shown great potential in the field of flexible electronics. However, the easy-stacking inclination of nanomaterials limits the development of their excellent properties and the performance improvement of related pressure sensors. Traditional methods for constructing 3D porous structures have the disadvantages of complexity, long period, and difficulty of scalability. Here, the gas foaming strategy is adopted to rapidly construct 3D porous MXene aerogels. Combining the excellent surface properties of MXenes with the porous structure of aerogel, the prepared MXene aerogels are successfully used in high-performance multifunctional flexible pressure sensors with high sensitivity (306 kPa^(-1)), wide detection range (2.3 Pa to 87.3 kPa), fast response time (35 ms), and ultrastability (>20,000 cycles), as well as self-healing, waterproof, cold-resistant, and heat-resistant capabilities. MXene aerogel pressure sensors show great potential in harsh environment detection, behavior monitoring, equipment recovery, pressure array identification, remote monitoring, and human-computer interaction applications.

关键词： MXene porous Porous

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