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Safety, immunogenicity and protective effectiveness of heterologous boost with a recombinant COVID-19 vaccine (Sf9 cells) in adult recipients of inactivated vaccines

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1165-1173页

作者： Wenxin luo Jiadi Gan zhu luo Shuangqing Li Zhoufeng Wang Jiaxuan Wu Huohuo Zhang Jinghong Xian Ruixin Cheng Xiumei Tang Yi Liu Ling Yang Qianqian Mou Xue Zhang Yi Chen Weiwen Wang Yantong Wang Lin Bai Xuan Wei Rui Zhang Lan Yang Yaxin Chen Li Yang Yalun Li Dan Liu Weimin Li Lei Chen Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduChina Institute of Respiratory Health Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengduChina Precision Medicine Center Precision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduChina State Key Laboratory of Respiratory Health and Multimorbidity West China HospitalChengduChina Institute of Respiratory Health and Multimorbidity West China HospitalSichuan UniversityChengduChina Clinical Trial Center West China HospitalSichuan UniversityChengduChina General Practice Medical Center West China HospitalSichuan UniversityChengduChina Fangcao Community Health Service Center of Chengdu High-tech Zone ChengduChina The Research Units of West China Chinese Academy of Medical SciencesWest China HospitalChengduChina West China School of Nursing Sichuan UniversityChengduChina Department of Infection Control West China HospitalSichuan UniversityChengduChina Department of Pathology West China HospitalSichuan UniversityChengduChina Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology West China HospitalSichuan UniversityChengduChina

Vaccines have proven effective in protecting populations against COVID-19,including the recombinant COVID-19 vaccine(Sf9 cells),the first approved recombinant protein vaccine in *** this positive-controlled trial with 85 adult participants(Sf9 cells group:n=44;CoronaVac group:n=41),we evaluated the safety,immunogenicity,and protective effectiveness of a heterologous boost with the Sf9 cells vaccine in adults who had been vaccinated with the inactivated vaccine,and found a post-booster adverse events rate of 20.45%in the Sf9 cells group and 31.71%in the CoronaVac group(p=0.279),within 28 days after booster *** group reported any severe adverse *** the Sf9 cells vaccine booster,the geometric mean titer(GMT)of binding antibodies to the receptor-binding domain of prototype SARS-CoV-2 on day 28 post-booster was significantly higher than that induced by the CoronaVac vaccine booster(100,683.37 vs.9,451.69,p<0.001).In the Sf9 cells group,GMTs of neutralizing antibodies against pseudo SARS-CoV-2 viruses(prototype and diverse variants of concern[VOCs])increased by 22.23–75.93 folds from baseline to day 28 post-booster,while the CoronaVac group showed increases of only 3.29–10.70 ***,neutralizing antibodies against live SARS-CoV-2 viruses(prototype and diverse VOCs)increased by 68.18–192.67 folds on day 14 post-booster compared with the baseline level,significantly greater than the CoronaVac group(19.67–37.67 folds).A more robust Th1 cellular response was observed with the Sf9 cells booster on day 14 post-booster(mean IFN-γ+spot-forming cells per 2×105 peripheral blood mononuclear cells:26.66 vs.13.59).Protective effectiveness against symptomatic COVID-19 was approximately twice as high in the Sf9 cells group compared to the CoronaVac group(68.18%vs.36.59%,p=0.004).Our study findings support the high protective effectiveness of heterologous boosting with the recombinant COVID-19 vaccine(Sf9 cells)against symptomatic COVID-19 of dive

关键词： protective vaccine boost

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EAA及致孔剂PEG400改性PVDF膜的结构及其渗透性能

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精细化工 2024年第7期41卷 1606-1614页

作者：薛禹谭妍妍张道海罗筑秦舒浩武晓贵州民族大学化学工程学院贵州贵阳550025 贵州省材料产业技术研究院国家复合改性聚合物材料工程技术研究中心贵州贵阳550014 贵州大学材料与冶金学院贵州贵阳550025

为了调控聚偏氟乙烯(PVDF)膜的孔状结构和性能,以乙烯丙烯酸(EAA)为添加剂、PEG400为致孔剂,通过浸入沉淀相转换法制备了PVDF/EAA复合膜。采用SEM、FTIR表征了其结构和成分;对复合膜的渗透性能和抗污染性能进行了测试,考察了不同EAA、PE... 详细信息

为了调控聚偏氟乙烯(PVDF)膜的孔状结构和性能,以乙烯丙烯酸(EAA)为添加剂、PEG400为致孔剂,通过浸入沉淀相转换法制备了PVDF/EAA复合膜。采用SEM、FTIR表征了其结构和成分;对复合膜的渗透性能和抗污染性能进行了测试,考察了不同EAA、PEG400质量分数对复合膜结构和性能的影响。结果表明,与未加EAA的PVDF膜(E-0)相比,PVDF/EAA复合膜表现出更高的渗透性能、分离性能和抗污染性能。EAA可以改善复合膜表面的亲水性,PEG400可以提高铸膜液和凝固浴之间的亲和性,加快成膜速率,从而在膜表面形成更多的孔洞。当EAA质量分数为3%,PEG400的质量分数为4%时,PVDF/EAA复合膜(E-3)的纯水渗透通量和牛血清白蛋白截留率分别为271.57L/(m^(2)·h)和64.83%,比E-0分别提高了486.42%和116.10%;通量恢复率和总污染率分别为75.97%和46.51%,比E-0分别提升了19.37%和降低了26.92%。当EAA的质量分数为3%,PEG400的质量分数为3%时,PVDF/EAA复合膜(P-3)的孔隙率为53.33%,平均孔径为4.55 nm,比未加PEG400的PVDF/EAA复合膜(P-0)的孔隙率和平均孔径分别提高了33.33%和88.02%。

关键词：聚偏氟乙烯聚乙烯丙烯酸致孔剂渗透性能抗污染性能水处理技术

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基于OpenCV图像识别技术的金属环热胀冷缩实验研究

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物理通报 2024年第3期 107-110页

作者：罗柱龙婧广西师范大学附属外国语学校广西桂林541004 桂林师范高等专科学校广西桂林541199

基于OpenCV图像识别技术,将金属环热胀冷缩的形变量实时转换成图像像素数量的变化量,从而解决了难以实时观测热胀冷缩实验中物体微小形变量的问题,同时有利于帮助学生深入理解加热环状物体后,它的内孔径到底是变大了还是缩小了的疑难问题.

关键词：热胀冷缩实验人工智能 OpenCV图像识别

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高校实验室安全管理准入制度实施的应用研究

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中国标准化 2024年第12期 130-135页

作者：刘家鹤罗珠珠蔡立群甘肃农业大学资源与环境学院

实验室是高校建设和学科建设的重要基础和阵地,也是创新人才和实践教学的培养基地和互动平台。高校实验室安全直接关系到广大师生的生命财产安全,还关系到学校的安全和社会的稳定。实验室安全准入制度是实验室安全管理工作的重要组成部... 详细信息

实验室是高校建设和学科建设的重要基础和阵地,也是创新人才和实践教学的培养基地和互动平台。高校实验室安全直接关系到广大师生的生命财产安全,还关系到学校的安全和社会的稳定。实验室安全准入制度是实验室安全管理工作的重要组成部分,也是明确实验室安全职责的根本依据。本文通过对目前高校实验室安全管理现状进行剖析,针对层级管理目标模糊,开放实验室管理不规范,危化品全过程流向不清晰及安全准入认证机制缺乏监管等问题,构建多层次人员实验室安全、开放实验室、实验室危化品准入制度及实验室安全准入约束机制,旨在构建校、院、室三级联动安全管理责任体系,实现实验室安全管理与准入制度实施有机结合,切实提高实验室安全管理能力。

关键词：高校实验室标准化准入制度安全管理

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装配式铝合金人行天桥结构设计及性能分析

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粉煤灰综合利用 2024年第4期38卷 117-122页

作者：付志君罗柱冯鹏广东省建筑科学研究院集团股份有限公司广东广州510500 清华大学土木水利学院北京100084

铝合金人行天桥因质量轻、强度高、经久耐用等优势而得到广泛应用,传统的天桥结构设计方法存在分析模型过度简化导致结果偏差较大的问题。基于此,本文给出了一种装配式铝合金人行天桥的结构设计方法,用于提高结构设计分析结果的准确性... 详细信息

铝合金人行天桥因质量轻、强度高、经久耐用等优势而得到广泛应用,传统的天桥结构设计方法存在分析模型过度简化导致结果偏差较大的问题。基于此,本文给出了一种装配式铝合金人行天桥的结构设计方法,用于提高结构设计分析结果的准确性和可靠性。以珠海市某天桥为例,建立该天桥的精细化有限元分析模型,并对其强度、刚度和自振频率进行验算。结果表明:基本组合荷载作用下桁架梁的应力最大,且最大拉应力和最大压应力分别为设计强度的15.5%和14%,人群荷载与恒载作用下桁架梁的应力接近;天桥的最大挠度为最大竖向挠度允许值的28%,天桥的宽跨比是最小允许宽跨比的3.8倍;天桥侧向和竖向固有频率分别为最小允许值的1.92倍和1.87倍,均满足规范要求。

关键词：装配式铝合金天桥结构设计性能

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PI-type Iterative Learning Control for Nonlinear Electro-hydraulic Servo Vibrating System

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Chinese Journal of Mechanical Engineering 2009年第3期22卷 451-455页

作者： luo Xiaohui zhu Yuquan HU Junhua School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

For the electro-hydraulic servo vibrating system（ESVS） with the characteristics of non-linearity and repeating motion, a novel method, PI-type iterative learning control（ILC）, is proposed on the basis of traditional PID control. By using memory ability of computer, the method keeps last time＇s tracking error of the system and then applies the error information to the next time＇s control process. At the same time, a forgetting factor and a D-type learning law of feedforward fuzzy-inferring referenced displacement error under the optimal objective are employed to enhance the systemic robustness and tracking accuracy. The results of simulation and test reveal that the algorithm has a trait of high repeating precision, and could restrain the influence of nonlinear factors like leaking, external disturbance, aerated oil, etc. Compared with traditional PID control, it could better meet the requirement of nonlinear electro -hydraulic servo vibrating system.

关键词： electro-hydraulic vibrating system PI iterative learning forgetting factor fuzzy inference

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From Proton Conductive Nanowires to Nanofuel Cells： A Powerful Candidate for Generating Electricity for Self-Powered Nanosystems

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Nano Research 2011年第11期4卷 1099-1109页

作者： Caofeng Pan Jun luo Jing zhu Beijing National Center for Electron Microscopy Laboratory of Advanced Materials State Key Laboratory of New Ceramics and FineProcessing Department of Material Science and Engineering Tsinghua University Beijing 100084 China

The likely goal of nanotectulology is the integration of individual nanodevices into a nanosystem, which includes the nanodevice（s）, power harvesting unit, data processing logic system, and possibly wireless communication unit. A nanosystem requires a nanoscale power source to make the entire package extremely small and high performance. The nanofuel and nanobiofuel cells developed here represent a new self-powering approach in nanotechnology, and their power output is high enough to drive nanodevices for performing self-powered sensing. This study shows the feasibility of building self-powered nanosystems for biological sciences, environmental monitoring, defense technology and even personal electronics.

关键词： Nation nanowire nanofuel cell nanobiofuel cell self-powered nanosystem

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Unconventional Hamilton-type variational principles for electromagnetic elastodynamics

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Science China(Physics,Mechanics & Astronomy) 2006年第1期49卷 119-128页

作者： luo En zhu Huijian YUAN Lei Department of Applied Mechanics and Engineering Sun Yat-sen University Guangzhou 510275 China Department of Applied Mechanics and Engineering Sun Yat-sen University Guangzhou 510275 China Department of Applied Mechanics and Engineering Sun Yat-sen University Guangzhou 510275 China

According to the basic idea of classical yin-yang complementarity and modern dual-complementarity, in a simple and unified new way proposed by luo, the unconventional Hamilton-type variational principles for electromagnetic elastodynamics can be established systematically. This new variational principles can fully characterize the initial-boundary-value problem of this dynamics. In this paper, the expression of the generalized principle of virtual work for electromagnetic dynamics is given. Based on this equation, it is possible not only to obtain the principle of virtual work in electromagnetic dynamics, but also to derive systematically the complementary functionals for eleven-field, nine-field and six-field unconventional Hamilton-type variational principles for electromagnetic elastodynamics, and the potential energy functionals for four-field and three-field ones by the generalized Legendre transformation given in this paper. Furthermore, with this approach, the intrinsic relationship among various principles can be explained clearly.

关键词： electromagnetic elastodynamics, unconventional Hamilton-type variational principle, principle of virtual work, dual-complementarity, initial-boundary-value problem.

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In situ synthesis of magnetic mesoporous silica via sol-gel process coupled with precipitation and oxidation

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Particuology 2011年第1期9卷 56-62页

作者： Junqi Zhao Yujun Wang Guangsheng luo Shenlin zhu The State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University Beijing 100084 China

A novel method was proposed for the in situ synthesis of magnetite-containing mesoporous silica SBA- 16 via a sol-gel process coupled with precipitation and oxidation. The effect of the added amounts of reactants on the mesostructural and magnetic properties of the magnetic mesoporous silica was inves- tigated, It was determined that the synthesized magnetic mesoporous silica with a total pore volume of 0.64-0.96 cm3/g and an average pore diameter of 4.0-14,9 nm had a relatively high saturation mag- netization value （1.11-5.77 emu/g） and a large surface area （258-747 m2/g）, Lysozyme was chosen as a model protein to test the performance of the magnetic mesoporous silica as a protein adsorbent, The high adsorption capacity （up to 212 mg/g） suggested a promising future as bimolecular hosts for the magnetic mesoporous silica.

关键词： Magnetic mesoporous silica Mesostructural property Magnetic property Protein absorbent

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Fluctuations of Single-Mode Laser Driven by Two Different Kinds of Colored Noise

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Communications in Theoretical Physics 2006年第4期45卷 630-636页

作者： WU Dan luo Xiao-Qin zhu Shi-Qun School of Physical Science and Technology Suzhou University Suzhou 215006 China

A single-mode laser with coupling between additive and multiplicative noise terms is investigated when the multiplicative noise and the coupling between two noise terms are colored fluctuations with finite correlation times T1 and T2. Combining the unified colored noise approximation （UCNA） and the functional analysis, the stationary probability distribution （SPD） and the variance of the laser intensity is derived. It is found that the colored nature of multiplicative noise and the coupling strength between two noise terms can affect both the structure and the height of the SPD, while the colored nature of the coupling between two noise terms can only affect the height of the SPD. The multiplicative noise can enhance the intensity fluctuations while the additive noise can reduce the fluctuations in a laser system. Numerical simulations are presented and consistent to the analytical results.

关键词： single-mode laser colored noise fluctuation coupling variance

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