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Chinese Journal of Chemistry 2020年第2期38卷 144-150页

作者： Yingbin Zheng xiaoshan Feng Daifeng Lin Enhui Wu Yongjin luo Yufeng You Baoquan Huang Qingrong Qian Qinghua Chen Fujian Key Laboratory of Pollution Control&Resource Reuse Fujian Normal UniversityFuzhouFujian 350007China Fuqing Branch of Fujian Normal University FuqingFujian 350300China

Summary of main observation and conclusion A series of electrospun LaCoO3 perovskites derived from CoX2 (X =CH3COO-,NO3-) were prepared and investigated for total propane *** is shown that pure rhombohedral perovskite LaCoO3 from Co(CH3COO)2 can be obtained at a relatively low temperature,400 ℃,benefitting from the complexation effect of CH3COO-.On the other hand,CH3COO-can accelerate the complete decomposition of *** low-temperature process can protect LaCoO3 nanoparticles from growing up.

关键词： LaCoO3 oxidation. perovskite

薯蓣丸联合紫杉醇抑制三阴性乳腺癌细胞MDA-MB-231上皮间质转化作用和机制研究

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陕西中医 2023年第9期44卷 1163-1168页

作者：骆小珊谢甦朱曼荆黄雅珍朱久龙冯豆豆谢青蒙雁云凌湘力贵州医科大学贵州贵阳550004 贵州医科大学附属医院贵州贵阳550004 宁波市北仑区人民医院浙江宁波315800 南方医科大学附属中西医结合医院广东广州516006

目的:探究薯蓣丸联合紫杉醇抑制人三阴性乳腺癌MDA-MB-231细胞上皮间质转化(EMT)的作用和机制。方法:运用血清药理学方法制备SD大鼠空白血清和薯蓣丸含药血清,体外培养MDA-MB-231细胞。实验将其分组为空白组、紫杉醇组、薯蓣丸联合紫杉... 详细信息

目的:探究薯蓣丸联合紫杉醇抑制人三阴性乳腺癌MDA-MB-231细胞上皮间质转化(EMT)的作用和机制。方法:运用血清药理学方法制备SD大鼠空白血清和薯蓣丸含药血清,体外培养MDA-MB-231细胞。实验将其分组为空白组、紫杉醇组、薯蓣丸联合紫杉醇组三组。运用CCK8实验检测MDA-MB-231细胞的增殖情况;Transwell小室实验法检测细胞的侵袭、迁移能力变化;Western blot检测上皮间质转化相关分子标志物E-cadherin、Vimentin、N-cadherin、MMP2和PI3K/Akt/mTOR信号通路相关蛋白的表达;RT-qPCR检测E-cadherin、Vimentin、N-cadherin、MMP2 mRNA的表达。结果:与空白组相比,紫杉醇组和薯蓣丸联合紫杉醇组可显著抑制细胞的增殖、侵袭和迁移(P<0.01);与紫杉醇组相比,薯蓣丸联合紫杉醇组对细胞增殖、侵袭和迁移的抑制能力增强(P<0.01)。与空白组相比,紫杉醇组和薯蓣丸联合紫杉醇组细胞中E-cadherin蛋白表达上调,PI3K、Akt、mTOR、N-cadherin、Vimentin蛋白表达下调(P<0.05,P<0.01);与紫杉醇组相比,薯蓣丸联合紫杉醇组细胞中E-cadherin蛋白表达上调,Vimentin、MMP2、PI3K、Akt、p-Akt、mTOR、p-mTOR蛋白表达下调(P<0.05,P<0.01)。与空白组比较,紫杉醇组和薯蓣丸联合紫杉醇组均能上调E-cadherin,下调Vimentin、MMP2 mRNA的表达(P<0.01);与紫杉醇组比较,薯蓣丸联合紫杉醇组上调E-cadherin,下调N-cadherin、MMP2 mRNA表达能力增强(P<0.05,P<0.01)。结论:薯蓣丸联合紫杉醇可有效抑制三阴性乳腺癌细胞的侵袭、迁移和EMT进程,且效果优于紫杉醇单用,其机制可能与PI3K/Akt/mTOR信号通路受抑制相关。

关键词：三阴性乳腺癌薯蓣丸紫杉醇上皮间质转化 MDA-MB-231细胞侵袭转移 PI3K/Akt/mTOR信号通路

Acceptable Environmental Risk Level Research Methods

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Acceptable Environmental Risk Level Research Methods

焦点解决模式在国内护理领域的研究现状及热点可视化分析

社会科学与环境保护国际会议

作者： Fan xiaoshan luo Hong Department of Environment and Economy Chinese Research Academy of Environmental Science

A necessary precondition to recognizing environmental risk warning signs and to reliable risk management is the confirmation of an acceptable risk level. Based on the conceptual definition of an acceptable environmental risk level, research method systems are being established and combined with environmental risk assessment and acceptor appraisal. This will assist in establishing a scientific basis for environmental risk management.

关键词： risk acceptable environmental risk level risk acceptor

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健康研究 2024年第4期44卷 421-425页

作者：赵一慧封亚萍杨晓珊薛博文陈情情杨阳骆宏杭州师范大学护理学院浙江杭州311121 杭州师范大学附属医院浙江杭州310015

目的分析焦点解决模式在护理领域的研究趋势,为国内相关研究提供参考。方法以中国知网和维普数据库为文献来源,应用CiteSpace V(5.8.R3)绘制焦点解决模式在国内护理领域的作者、机构及关键词等图谱,分析近年来该领域的研究热点及趋势。... 详细信息

目的分析焦点解决模式在护理领域的研究趋势,为国内相关研究提供参考。方法以中国知网和维普数据库为文献来源,应用CiteSpace V(5.8.R3)绘制焦点解决模式在国内护理领域的作者、机构及关键词等图谱,分析近年来该领域的研究热点及趋势。结果最终纳入文献1120篇,焦点解决模式在国内护理领域研究发文量呈上升趋势,暂未形成规模较大的合作研究团队。该领域研究对象多为护士群体和糖尿病、呼吸系统疾病等慢性病患者,研究主要通过焦点解决模式对护士进行心理干预以及对患者进行健康教育和护理干预。结论我国焦点解决模式在护理领域的应用尚处于初级阶段,未来各作者、机构之间应多加强合作联系,积极创新焦点解决模式,提升其在护理领域的研究和应用水平。

关键词：焦点解决模式护理 CiteSpace软件研究热点可视化分析

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蔗渣智能液压打包机设计与试验

农业工程 2024年第4期14卷 97-100页

作者：黄伟华郑镇辉王槊韦丽娇葛畅罗冠宇林建云林晓山中国热带农业科学院农业机械研究所湛江市保护性耕作装备工程技术研究中心广东湛江524000 廉江市东方机械有限公司广东湛江524000 广东粤凯机械有限公司广东湛江524000 广东农海科技有限公司广东湛江524000

开发了一款蔗渣智能液压打包机(以下简称蔗渣打包机),采用结构紧凑、稳定性较好的一体化液压回路系统执行打包动作。设计了基于PLC的控制系统,以简化设备操作,实现所需的控制功能。系统能够远程控制蔗渣打包机的启动、打包、送料、计数... 详细信息

开发了一款蔗渣智能液压打包机(以下简称蔗渣打包机),采用结构紧凑、稳定性较好的一体化液压回路系统执行打包动作。设计了基于PLC的控制系统,以简化设备操作,实现所需的控制功能。系统能够远程控制蔗渣打包机的启动、打包、送料、计数和停止等动作,同时可以单独控制蔗渣打包机各个电气设备的启停。该系统还具备智能打包功能,可显著改善工作环境,提高工作效率,降低成本。1名操作员能够同时管理3~4台设备,同时远程控制功能还可以避免因工人操作设备而引发的安全事故。

关键词：蔗渣智能控制液压回路系统打包机远程控制

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A Sun Tracking System Design for a Large Dish Solar Concentrator

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International Journal of Clean Coal and Energy 2013年第2期2卷 16-20页

作者： xiaoshan Jin Guoqiang Xu Rongjiu Zhou Xiang luo Yongkai Quan School of Energy & Power Engineering Beihang University Beijing China Shouhang Resource Saving Company Limited Beijing China

Energy crisis promotes the development of renewable energy, especially the solar energy. Sun tracking system proposed in this paper is such a device for efficiency improvement. This closed loop tracking system with two axis sun tracking method is controlled by a programmable logic controller (PLC) and is used for a large dish solar collector. A combination tracking mode combined active and passive tracking methods used in the design make the tracker efficient whatever the circumstances. Two stepper motors and two reduction boxes move the device towards the sun with chain transmission. Besides sun tracking, the system also has functions of overheat monitoring, wind speed monitoring and measurement of illumination.

关键词： Renewable Energy Solar Energy Sun tracking PLC Combination Tracking Mode

Self-organization of unimolecular micelles in beam stream for functional mesoporous metal oxide nanofibers

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Fundamental Research 2022年第5期2卷 776-782页

作者： Chongfei Gu xiaoshan Fan Guihua Zhu Yuchi Fan Haifeng Wang Tao Zhao Qi Xiao Yuan Fang Xiaopeng Li Wan Jiang Lianjun Wang Pengpeng Qiu Wei luo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsDonghua UniversityShanghai 201620China

The use of linear amphiphilic block copolymers as templates is an important method for the preparation of mesoporous ***,the obtained assemblies are usually sensitive to synthetic conditions,which impedes the preparation of such mesoporous materials in certain ***,we report a universal strategy applying an amphiphilic multiarm triblock copolymer in the preparation of mesoporous metal oxide nanofibers(NFs)using one metal oxide(TiO_(2),ZrO_(2),WO_(3),CeO_(2)),or two(TiO_(2)/WO 3,TiO_(2)/ZrO_(2),TiO_(2)/CeO_(2))and three(TiO_(2)/WO_(3)/CuO)metal oxides as *** template consists of modified β-cyclodextrin as the center of the macromolecule which is attached sequentially to a block of polystyrene,poly(acrylic acid),and poly(ethylene oxide).Under electrospinning conditions,stable unimolecular micelles are formed and effectively co-assemble with metal ions to form fibrous *** indicated by various characterization methods,the synthesized TiO_(2) and its derived composite NFs maintain a straight and continuous fibrous structure after calcination,and TiO_(2) NFs exhibit uniform mesopores of 10.8 nm in diameter and a large Brunauer-Emmett-Teller surface area of 143.3 m^(2)g^(−1).Benefiting from the characteristic structure,still present after modification,Pt-decorated mesoporous TiO_(2) NFs display excellent ability in the visible-light photocatalytic degradation of tetracycline,which is superior to the commercial P25 *** study reveals a promising strategy for the preparation of fibrous mesoporous metal oxides.

关键词： Unimolecular micelles Self-assembly Electrospinning Mesoporous metal oxides Nanofibers

FBXW7βloss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3123-3143页

作者： Wenxia Wei Baifu Qin Weijie Wen Boyu Zhang Haidan luo Yuzhi Wang Hui Xu xiaoshan Xie Sicheng Liu Xin Jiang Mengan Wang Qin Tang Jiayu Zhang Runxiang Yang Zongmin Fan Haiwen Lyu Junzhong Lin Kai Li Mong-Hong Lee Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou510655China Guangdong Institute of Gastroenterology Guangzhou510655China Second Department of Medical Oncology The Third Affiliated Hospital of Kunming Medical UniversityKunming650118China Guangzhou Institute of Pediatrics Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou510623China Department of Colorectal Surgery Cancer CenterSun Yat-sen UniversityGuangzhou510060China Department of Oncology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou510655China

Continuous de novo fatty acid synthesis is required for the biosynthetic demands of ***7 is a highly mutated gene in CRC,but its biological functions in cancer are not fully ***,we report that FBXW7β,a FBXW7 isoform located in the cytoplasm and frequently mutated in CRC,is an E3 ligase of fatty acid synthase(FASN).Cancer-specific FBXW7βmutations that could not degrade FASN can lead to sustained lipogenesis in ***9 signalosome subunit 6(CSN6),an oncogenic marker of CRC,increases lipogenesis via interacting with and stabilizing *** studies show that CSN6 associates with both FBXW7βand FASN,and antagonizes FBXW7β’s activity by enhancing FBXW7βautoubiquitination and degradation,which in turn prevents FBXW7β-mediated FASN ubiquitination and degradation,thereby regulating lipogenesis *** CSN6 and FASN are positively correlated in CRC,and CSN6-FASN axis,regulated by EGF,is responsible for poor prognosis of *** EGF-CSN6-FASN axis promotes tumor growth and implies a treatment strategy of combination of orlistat and ***-derived xenograft experiments prove the effectiveness of employing orlistat and cetuximab combination in suppressing tumor growth for CSN6/FASN-high ***,CSN6-FASN axis reprograms lipogenesis to promote tumor growth and is a target for cancer intervening strategy in CRC.

关键词： FBXW7 sustained FASN

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可接受环境风险水平研究方法

生态经济 2011年第7期27卷 174-176页

作者：范小杉罗宏中国环境科学研究院清洁生产与循环经济研究中心北京100012

可接受环境风险水平的确定是开展环境风险预警、实现高效环境风险管理的必要前提。在界定可接受风险水平概念、分析及其内涵的基础上,结合环境风险评价和风险受体调查问卷,初步构建了可接受风险水平研究方法体系,为进一步完善环境风险... 详细信息

可接受环境风险水平的确定是开展环境风险预警、实现高效环境风险管理的必要前提。在界定可接受风险水平概念、分析及其内涵的基础上,结合环境风险评价和风险受体调查问卷,初步构建了可接受风险水平研究方法体系,为进一步完善环境风险管理提供科学依据。

关键词：风险可接受风险水平风险受体

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多元时间序列分析的滑坡演化阶段划分

地球科学（中国地质大学学报） 2016年第4期41卷 711-717页

作者：罗文强李飞翱刘小珊黄丽中国地质大学数学与物理学院湖北武汉430074

滑坡的时间-位移曲线一般具有3个阶段特征,即初始变形阶段、等速变形阶段和加速变形阶段,不同演化阶段加速度具有不同的变化特点.目前往往是依据对加速度曲线特征的分析来人为划分演化阶段,缺少相应的理论支持和定量计算.针对上述问题,... 详细信息

滑坡的时间-位移曲线一般具有3个阶段特征,即初始变形阶段、等速变形阶段和加速变形阶段,不同演化阶段加速度具有不同的变化特点.目前往往是依据对加速度曲线特征的分析来人为划分演化阶段,缺少相应的理论支持和定量计算.针对上述问题,选取月降雨量、月库水位高程变化量对滑坡的累计位移建立多因素的时间序列预测模型.然后利用Chow分割点检验理论,以所建模型中F和LR统计量最大值点作为分割点对滑坡演化阶段进行划分.以新滩滑坡和三峡库区白水河滑坡为例,利用累计位移、降雨及库水位变化数据进行计算验证.结果表明,对多元时间序列模型进行Chow分割点检验可对滑坡的演化阶段进行准确划分,为滑坡的临滑预警预报提供重要判据.

关键词：滑坡演化多元时间序列 Chow分割点检验阶段划分工程地质