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Efficient and cost-effective method to synthesize highly purified Ti_(4)AlN_(3) and Ti_(2)AlN

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Journal of Advanced Dielectrics 2019年第1期9卷 55-58页

作者： Muhammad Faraz Ud Din Chenhui Yang Yi Tang* Yapeng Tian Yangyang luo Yutao Wu Wenxiu Que Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education and International Center for Dielectric Research and Shaanxi Engineering Research Center of Advanced Energy Materials and Devices School of Electronic and Information Engineering Xi’an Jiaotong UniversityXi’anShaanxi 710049P.R.China Hangzhou Joy Energy Technology Ltd Co. 83 Hongken Road Xiaoshan Economic Development Zone Hangzhou 311200ZhejiangP.R.China

Nitrides MAX have attracted ever-growing interest owing to its unique metallic and ceramic characteristics and ***,we report on the synthesis of highly purified Ti_(2)AlN and Ti_(4)AlN_(3) powders from Ti,Al and TiN powders by a facile atmosphere sintering *** obtained nitrides show highly pure phase and excellent layered *** for the composition difference of raw materials,both the nitrides can be sintered and obtained by same sintering temperature and holding time,which thus makes less processing time and less usage of synthesis parameters as compared to previously synthesis *** our knowledge,present work is one of the few reports on synthesis of Ti_(4)AlN_(3) and Ti_(2)AlN using atmosphere sintering ***,the lattice changes of the layered structure of Ti_(2)AlX(X/C=N)were studied by changing the composition of X position from the synthesis of Ti_(2)AlCN and Ti_(2)AlC,and the optimal formulation and synthesis mechanism of Ti_(4)AlN_(3) were also studied.

关键词： Ti_(4)AlN_(3) Ti_(2)AlN atmosphere sintering method nitrides MAX

1960-2012年澜沧江-湄公河流域气候变化趋势及不同区间的径流响应

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水资源与水工程学报 2020年第4期31卷 1-8页

作者：谈晓珊王婕唐雄朋杨娜罗贤李杨王国庆水利部南京水利水文自动化研究所江苏南京210012 水利部水文水资源监控工程技术研究中心江苏南京210017 水利部应对气候变化研究中心江苏南京210022 南京水利科学研究院水文水资源与水利工程科学国家重点实验室江苏南京210022 云南大学国际河流与生态安全研究院云南昆明650500 内蒙古自治区水资源与水权收储中心内蒙古呼和浩特010020

气候变化是河川径流变化的主要驱动因素,分析流域气候变化及径流响应对有效适应气候变化具有重要意义。基于普林斯顿全球气象驱动数据集资料和澜沧江-湄公河(简称澜湄流域)干流8个水文站的实测径流资料,分析了澜湄流域不同区间气温、降... 详细信息

气候变化是河川径流变化的主要驱动因素,分析流域气候变化及径流响应对有效适应气候变化具有重要意义。基于普林斯顿全球气象驱动数据集资料和澜沧江-湄公河(简称澜湄流域)干流8个水文站的实测径流资料,分析了澜湄流域不同区间气温、降水的演变趋势以及不同阶段降水-径流的响应关系。结果表明:1960-2012年期间,澜湄流域不同区间年气温呈现显著性升高趋势,其中,上游区间升温幅度较大,超过0.2℃/10a;同期,澜湄流域的8个区间只有"旧州-允景洪"区间年降水量呈现减少趋势,其余各区年降水量均为不同程度的增加趋势;此外,所有区间春季降水量均为增加趋势,冬季降水量大多为减少趋势;8个区间的年径流系数序列突变大多发生在20世纪60年代;澜湄流域不同区间降水-径流关系存在一定的差异,不同阶段降水-径流关系发生了不同程度的改变;相同降水条件下,"琅勃拉邦-穆达汉"区间在2000年以后的产流量大多高于前期,而"旧州-允景洪"区间和"清盛-琅勃拉邦"区间后期径流量大多低于第1阶段径流量。

关键词：气候变化趋势径流响应气温降水澜沧江-湄公河流域

Value of CT to assess calcification patterns in thyroid nodules

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中华内分泌外科杂志 2017年第4期11卷 301-306页

作者： Wei Peiying Shu Yanyan Han Zhijiang luo Dingcun Department of Radiology Hangzhou First People's Hospital Nanjing Medical University Hangzhou 310000 China Department of Radiology the First People's Hospital of Xiaoshan Hangzhou 310000China Department of Surgical Oncology Hangzhou First People's Hospital Nanjing Medical University Hangzhou 310000 China

ObjectiveTo assess the value of CT in identification and diagnosis of benign and malignant calcified thyroid nodules.MethodsRetrospective analysis was performed on the CT data of 313 surgically and pathologically confirmed cases with 378 calcified nodules. Based on the size, morphology, and number, calcification was divided into microcalcification (d≤2 mm and axis displayed in only one cross-section) , coarse calcification (d>2 mm or displayed in two or more cross-sections) , annular calcification (arc or annular) , and multiple microcalcifications (solitary multiple microcalcification without a soft tissue lump) ; a distribution of microcalcification, coarse calcification, and annular calcification as well as a clearer enhanced periphery or internal calcification than nonenhanced data in benign and malignant thyroid nodules were observed.ResultsThe 378 nodules consisted of 259 benign nodules (68.5%) (all were nodular goiters) and 119 malignant nodules (31.5%) (including 111 papillary thyroid carcinomas, 4 follicular carcinomas, 3 medullary thyroid carcinomas and 1 lymphoma) . Microcalcification was more common in malignant nodules (MNs) than in benign nodules (BNs) , with a rate of 43.6% vs 12.4%, respectively ( P≤0.05) , and its sensitivity, specificity, positive predicted value, and negative predicted value were 42.9%, 87.6%, 61.4% and 76.9%, respectively. Coarse calcification, annular calcification, and clearer enhanced periphery or internal calcification than nonenhanced data were more common in BNs than in MNs, with rates of 52.9% vs 20.2% ( P≤0.05) , 66.0% vs 42.0% ( P≤0.05) and 43.2% vs 19.3% ( P≤0.05) , respectively, whose sensitivity, specificity, positive predicted value and negative predicted value were 66.0% vs 22.4% vs 43.2%, 58.0% vs 86.6% vs 80.7%, 77.4% vs 78.4% vs 83%, and 43.9% vs 33.9% vs 39.8%, respectively. Two multiple microcalcifications without a soft tissue lump were MNs (papillary thyroid carcinoma) .

关键词：内分泌学患者临床治疗临床应用

衬底温度及退火对液滴外延法生长InAs量子点的影响

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功能材料 2018年第3期49卷 3203-3206,3212页

作者：许筱晓郭祥王一罗子江杨晨杨晓珊张之桓刘健丁召贵州大学大数据与信息工程学院贵阳550025 贵州财经大学信息学院贵阳550004

研究了In液滴法生长InAs量子点时不同衬底温度,以及是否引入退火的量子点生长情况并建立了物理模型。发现In原子沉积在衬底表面会首先沿[11-0]方向形成条状量子线,由于表面能会趋于最小,量子线会分裂成小段成为量子点的核心,当衬底温度... 详细信息

研究了In液滴法生长InAs量子点时不同衬底温度,以及是否引入退火的量子点生长情况并建立了物理模型。发现In原子沉积在衬底表面会首先沿[11-0]方向形成条状量子线,由于表面能会趋于最小,量子线会分裂成小段成为量子点的核心,当衬底温度从460℃上升至480℃时,量子点增多的同时量子线减少,且纳米结构的平均高度从4.09nm上升至4.58nm。在衬底温度为480℃的条件下引入退火后,扫描区域内只存在量子点结构,纳米结构平均高度上升至8.56nm。认为In液滴法生长量子点,是一个先形成量子线,量子线再分裂形成量子点的核心,继而捕捉由ES势垒束缚在台阶边缘的原子形成量子点的过程,退火的引入会促进量子线-量子点的转化,提高尺寸均匀性,并由此建立了物理模型。

关键词：量子点液滴外延法 InAs 衬底温度退火物理模型

高效液相色谱-串联质谱法同时测定保健品及中成药中非法添加的17种壮阳类化学药

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色谱 2016年第3期34卷 270-278页

作者：黄芳吴惠勤黄晓兰罗辉泰朱志鑫林晓珊马立果蒋娅兰中国广州分析测试中心广东省分析测试技术公共实验室广东广州510070 广东药学院中药学院广东广州510006 广东药学院公共卫生学院广东广州510024

建立了高效液相色谱-串联质谱(LC-MS/MS)同时测定补肾壮阳类保健品及中成药中非法添加的17种壮阳化学药的定性、定量分析方法。实验优化了前处理方法,并针对几对同分异构体成分优化了分离条件和质谱参数。样品经甲醇超声萃取,提取液经Ag... 详细信息

建立了高效液相色谱-串联质谱(LC-MS/MS)同时测定补肾壮阳类保健品及中成药中非法添加的17种壮阳化学药的定性、定量分析方法。实验优化了前处理方法,并针对几对同分异构体成分优化了分离条件和质谱参数。样品经甲醇超声萃取,提取液经Aglient Extend C18色谱柱(100 mm×2.1 mm,3.5μm)分离,流动相为乙腈和水(含有10 mmol/L乙酸铵),梯度洗脱,流速为0.25 mL/min,以电喷雾离子源正离子多反应监测(MRM)模式进行MS/MS检测。该方法能很好地分离并定量17种壮阳类化学药以及其中的3组同分异构体。该方法简便、快速、准确可靠,已经应用于补肾壮阳类保健品及中成药中非法添加壮阳类化学药的筛查及检测。统计近3年检测的样品,发现补肾壮阳类产品中非法添加成分检出率高,需引起相关监管部门的重视。

关键词：高效液相色谱-串联质谱壮阳类化学药保健品中成药非法添加

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絮凝法处理原水的研究进展

广东化工 2016年第7期43卷 148-149,169页

作者：钟振辉刘晓珊黄洁阳罗曼惠州市供水有限公司广东惠州516000 惠州大亚湾石化动力热力有限公司广东惠州516000

絮凝法是水处理工艺中常见的一道工序,此法能快速有效地降低原水浊度及其他污染物的浓度,因此研究絮凝法成为必然趋势。文章主要论述了絮凝反应机理、影响因素及发展历程。另外,文章还重点介绍了一种特殊的絮凝技术—加载絮凝法,为扩大... 详细信息

絮凝法是水处理工艺中常见的一道工序,此法能快速有效地降低原水浊度及其他污染物的浓度,因此研究絮凝法成为必然趋势。文章主要论述了絮凝反应机理、影响因素及发展历程。另外,文章还重点介绍了一种特殊的絮凝技术—加载絮凝法,为扩大絮凝技术的应用范围提供了有力的参考工具。

关键词：絮凝水处理综述

367例社区2型糖尿病患者中医体质与心血管危险因素分析

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中华中医药学刊 2017年第1期35卷 229-232页

作者：黄沁赵晓山孙世宁何丽清杨静陈洁瑜罗仁南方医科大学中医药学院广东广州510515 广州市天河区五山街社区卫生服务中心广东广州510660

目的:分析社区2型糖尿病患者中医体质类型与心血管危险因素的相关性。方法:将2014年10月—2015年9月期间在广州市天河区五山街社区进行免费健康体检的367例2型糖尿病患者纳入调查,建立健康档案,进行中医体质判定及心血管危险因素的判定... 详细信息

目的:分析社区2型糖尿病患者中医体质类型与心血管危险因素的相关性。方法:将2014年10月—2015年9月期间在广州市天河区五山街社区进行免费健康体检的367例2型糖尿病患者纳入调查,建立健康档案,进行中医体质判定及心血管危险因素的判定。结果:367例2型糖尿病患者中,平和体质54例,偏颇体质313例,最常见的3种偏颇体质为痰湿质(26.98%)、阴虚质(16.62%)及气虚质(16.08%);痰湿质、阳虚质、气虚质具有高龄倾向,与平和质比,差异有统计意义(P<0.05);痰湿质超重和肥胖率最高,与平和质、血瘀质、特禀质、阳虚质、阴虚质、气虚质比较,差异有统计意义(P<0.05);痰湿质心电图异常率最高,与湿热质、气郁质、平和质比较,差异有统计意义(P<0.05);湿热质吸烟喝酒率最高,与其它体质比较,差异有统计意义(P<0.01),血瘀质缺乏运动率最高,与平和质、阴虚质、湿热质、气虚质、特禀质比较,差异有统计意义(P<0.05);多元Logistic回归分析显示,痰湿质肥胖和超重的危险性分别是平和质的24.830倍(CI:6.327~97.436)和11.091倍(CI:4.649~26.460),湿热质肥胖和超重的危险性分别是平和质的9.843倍(CI:1.964~49.341)和5.605倍(CI:1.954~16.076),差异有统计学意义(P<0.01)。结论:社区2型糖尿病患者心血管危险因素与中医体质具有一定的相关性,社区管理中应重点加强对痰湿体质肥胖和超重患者的社区干预。

关键词： 2型糖尿病中医体质心血管危险因素社区管理

Simultaneous detection and characterization of toxigenic Clostridium difficile directly from clinical stool specimens

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Frontiers of Medicine 2018年第2期12卷 196-205页

作者： Hanjiang Lai Chen Huang Jian Cai Julian Ye Jun She Yi Zheng Liqian Wang Yelin Wei Weijia Fang Xianjun Wang Yi-Wei Tang Yun luo Dazhi Jin The First People's Hospital of xiaoshan District Hangzhou 311021 China Department of Microbiology Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051 China Department of Disease Control and Prevention Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051 China Biotherapy Center for Medical Oncology the First Affiliated Hospital Zhejiang University Hangzhou 310003 China Department of Laboratory Medicine HangzhouFirst People's Hospital Hangzhou 310006 China Department of Laboratory Medicine Memorial Sloan Kettering Cancer Center Department of Pathology and Laboratory Medicine Weill Medical College of Cornell University New York NY 10065 USA

We employed a multiplex polymerase chain reaction （PCR） coupled with capillary electrophoresis （mPCR-CE） targeting six Clostridium difficile genes, including tPi, tcdA, tcdB, cdtA, cdtB, and a deletion in tcdC for simultaneous detection and characterization of toxigenic C. difficile directly from fecal specimens. The mPCR-CE had a limit of detection of 10 colony-forming units per reaction with no cross-reactions with other related bacterial genes. Clinical validation was performed on 354 consecutively collected stool specimens from patients with suspected C. difficile infection and 45 isolates. The results were compared with a reference standard combined with BD MAX Cdiff, real-time cell analysis assay （RTCA）, and mPCR-CE. The toxigenic C. difficile species were detected in 36 isolates and 45 stool specimens by the mPCR-CE, which provided a positive rate of 20.3% （81/399）. The mPCR-CE had a specificity of 97,2% and a sensitivity of 96.0%, which was higher than RTCA （χ^2 = 5.67, P = 0.017） but lower than BD MAX Cdiff （P = 0.245）. Among the 45 strains, 44 （97.8%） were determined as non- ribotype 027 by the mPCR-CE, which was fully agreed with PCR ribotyping. Even though ribotypes 017 （n = 8, 17.8%）, 001 （n = 6, 13.3%）, and 012 （n = 7, 15.6%） were predominant in this region, ribotype 027 was an important genotype monitored routinely. The mPCR-CE provided an alternative diagnosis tool for the simultaneous detection of toxigenic C. difficile in stool and potentially differentiated between RT027 and non-RT027.

关键词： Clostridium difficile multiplex PCR capillary electrophoresis detection characterization

Genetic Architecture of Childhood Kidney and Urological Diseases in China

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Phenomics 2021年第3期1卷 91-104页

作者： Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui luo Jinghai Li Jia Rao Hong Xu Department of Nephrology Children’s Hospital of Fudan UniversityNational Pediatric Medical Center of CHINA399 Wanyuan RoadShanghaiChina Shanghai Kidney Development and Pediatric Kidney Disease Research Center ShanghaiChina Shanghai Key Lab of Birth Defect Children’s Hospital of Fudan UniversityShanghai 201102China Department of Rheumatology Children’s Hospital of Fudan UniversityShanghaiChina Department of Urology Children’s Hospital of Fudan UniversityShanghaiChina Clinical Genetic Center Children’s Hospital of Fudan UniversityShanghaiChina Key Laboratory of Metabolism and Molecular Medicine Ministry of EducationDepartment of Biochemistry and Molecular BiologyInstitutes of Biomedical SciencesSchool of Basic Medical SciencesFudan UniversityShanghaiChina The Children Hospital of Zhejiang University School of Medicine HangzhouChina The First Affiliated Hospital of Sun Yat-Sen University GuangzhouChina Shandong Provincial Hospital JinanChina Bejing Children’s Hospital Affiliated to Capital University of Medical Science BeijingChina Children’s Hospital of Nanjing Medical University NanjingChina Wuhan Children’s Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Shanghai Children’s Medical Centre Shanghai Jiaotong University School of MedicineShanghaiChina Children’s Hospital of Chongqing Medical University ChongqingChina Shenzhen Children’s Hospital ShenzhengChina Shengjing Hospital of China Medical University ShenyangLiaoningChina Anhui Provincial Children’s Hospital HefeiChina Xuzhou Children’s Hospital XuzhouChina Henan Children’s Hospital ZhengzhouChina Guangzhou First People’s Hospital GuangzhouChina The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University WenzhouChina Qingdao Women and Children’s Hospital QingdaoChina Xiangya Hospital Central South University ChangshaHunanChina The First Affiliated Hospital of Xiamen University XiamenChina First Affiliated Hospital of Anhui Medical University HefeiC

Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary *** delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to *** analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal *** genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in *** profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were *** distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 *** diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic *** present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was *** data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

关键词： Chronic kidney disease(CKD) Exome sequencing(ES) Steroid-resistant nephrotic syndrome(SRNS) Congenital anomalies of the kidney and urinary tract(CAKUT) Nephronophthisis(NPHP) Polycystic kidney disease(PKD)