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Atmospheric and Oceanic Science Letters 2013年第3期6卷 138-143页

作者： LI Shuanglin luo fei-fei Climate Change Research Center and Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of Sciences Graduate University of Chinese Academy of Sciences

The authors analyzed the lead-lag connection of the Atlantic Multidecadal Oscillation (AMO) with East Asian surface air temperatures (EATs) using instrumental records, and compared the results with the Pacific Decadal Oscillation (PDO). The maximum correlation was found when EATs led the AMO by five to seven years (with a correlation coefficient of 0.72, whereas the correlation coefficient was 0.91 when the AMO led EATs by 24-28 years). This is different from the PDO, which mostly correlated with EATs when the PDO led EATs by 13-15 years (with a correlation coefficient of 0.67, whereas the correlation coefficient was 0.76 when EATs led the PDO by 24-26 years). The PDO led the AMO by 19-21 years (with a correlation coefficient of 0.71, whereas the correlation coefficient was 0.84 when the AMO led the PDO by 16-18 years). These results support a previous understanding that EATs positively correlate with the AMO, and imply that the observed East Asian warming trend may have been slowing down since the early 2010s.

关键词： EATs AMO PDO instrumental records

Weaker connection between the Atlantic Multidecadal Oscillation and Indian summer rainfall since the mid-1990s

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Atmospheric and Oceanic Science Letters 2018年第1期11卷 37-43页

作者： luo fei-fei LI Shuanglin Tore FUREVIK Nansen-Zhu International Research Centre and Climate Change Research Center Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China Department of Atmospheric Science China University of Geosciences Wuhan China Geophysical Institute and Bjerknes Centre for Climate Research University of Bergen Bergen Norway

Previous studies have shown that the Atlantic Multidecadal Oscillation （AMO） can play an important role in modulating the variabilityoflndian summer monsoon rainfall （ISMR） over a 50-60-yr timescale. A significant positive correlation between the AMO and ISMR is found both in observations and models. However, instrumental records show that the relationship becomes non-significant or even of opposite sign after the mid-1990s, suggesting a weakening of the AMO-ISMR connection. The mechanism for the breakdown of the AMO-ISMR connection is investigated in the present work, and the results suggest that a substantial warming in the Indian-tropical western Pacific Ocean plays a role. The warming weakens the meridional gradient of tropospheric temperature between Eurasia and the indian Ocean, and reduces the meridional sea level pressure gradient between the Indian Subcontinent and Indian Ocean, weakening the Indian summer monsoon. Thus, warming in the Indian-tropical western Pacific Ocean seems responsible for the weakened connection between the AMO and ISM.

关键词： Atlantic MultidecadalOscillation Indian summerrainfall connection multidecadal variation

Relationships between the Oxygen Isotopes in East Asian Stalagmites and Large-Scale Atmospheric and Oceanic Modes

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Atmospheric and Oceanic Science Letters 2014年第6期7卷 540-545页

作者： JING Yuan-Yuan LI Shuanglin WAN Jiang-Hua luo fei-fei Institute of Atmospheric Physics Chinese Academy of Sciences College of Atmospheric Sciences Chengdu University of Information Technology

The stalagmite δ18O record is known to be associated with the climate, but the specifics of the relationship remain unclear. It may not represent variation in air temperature or precipitation, but instead reflect integral changes of monsoon circulation, especially water vapor sources(the so-called "circulation effect"). Since large-scale atmospheric-oceanic modes such as the Atlantic Multidecadal Oscillation(AMO), Pacific Decadal Oscillation(PDO), and North Atlantic Oscillation(NAO) exert significant effects on Asian monsoon, in this paper the authors investigate the relationships of the East Asian stalagmite δ18O record with these modes. The last three centuries form the focus of our study, for which the authors use reconstructed as well as instrumental data. Considering the impacts of human activity, our analysis is conducted with respect to two periods—the pre- and post-industrial periods. The results show significant lead-lag connections: a positive correlation peaks when the PDO leads East Asian stalagmite δ18O by 3 years, which is persistent over the past 300 years; while the relationships of the AMO and NAO with the East Asian stalagmite δ18O record show significant differences in the post-industrial relative to the pre-industrial period. This implies that the East Asian stalagmite δ18O record may primarily reflect the PDO signal.

关键词： stalagmite oxygen isotope large-scale circulation lead-lag correlation East Asian climate

Association of serum uric acid levels with the progression of Parkinson＇s disease in Chinese patients

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Chinese Medical Journal 2012年第4期125卷 583-587页

作者： Sun Cong-cong luo fei-fei Wei Lei Lei Mi Li Guo-fei Liu Zhuo-lin Le Wei-dong Xu Ping-yi Sun Yat Sen Univ Affiliated Hosp 1 Dept Neurol Guangzhou 510080 Guangdong Peoples R China Henan Univ Huaihe Hosp Dept Neurol Kaifeng 47500 Henan Peoples R China Baylor Coll Med Dept Neurol Houston TX 77030 USA Shanghai Jiao Tong Univ Sch Med Shanghai 200025 Peoples R China Chinese Acad Sci Inst Biol Sci Inst Hlth Sci Key Lab Stem Cell Biol Shanghai 200025 Peoples R China

Background Uric acid （UA） is suspected to play a neuro-protective role in Parkinson＇s disease （PD）.This study aimed to evaluate whether the serum UA level was associated with the disease progression of PD in a relatively large population of Chinese *** Serum UA levels were measured from 411 Chinese PD patients and 396 age-matched controls; following the uric acid colorimetric method,the serum creatinine （Scr） levels were also measured to reduce the bias caused by possible differences in renal excretion *** disease progression was scored by Hoehn and Yahr （H＆Y） scales and disease durations; PD group was divided into 3 subgroups according to H＆Y ***-samples ttest was performed to analyze the differences between PD group and control *** analysis of covariance was performed to analyze the differences between PD *** rank-correlation was performed to evaluate the associations between serum UA or Scr level and disease *** PD patients were found to have significantly lower levels of serum UA than controls （（243.38±78.91） vs.（282.97±90.80） pmol/L,P〈0.01）.As the disease progression,the serum UA levels were gradually *** was a significantly inverse correlation of UA levels with H＆Y scales （Rs=-0.429,P 〈0.01） and disease duration （Rs=-0.284,P 〈0.01） in PD patients of both females and *** significant difference of the Scr level between PD patients and controls was found （（70.01±14.70） vs.（69.84±16.46） μmol/L）,and the Scr level was not involved in disease *** Lower serum UA levels may possess a higher risk of PD,which may be a potential useful biomarker to indicate the progression of PD.

关键词： uric acid Parkinson's disease disease progression

A New Method for Predicting the Decadal Component of Global SST

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Atmospheric and Oceanic Science Letters 2012年第6期5卷 521-526页

作者： luo fei-fei LI Shuanglin GAO Yong-Qi Tore FUREVIK Nansen-Zhu International Research Centre and Climate Change Research Center Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Nansen Environmental and Remote Sensing Center/Bjerknes Center for Climate Research Bergen Norway Geophysical Institute and Bjerknes Center for Climate Research University of Bergen Bergen Norway

A simple approach that considers both internal decadal variability and the effect of anthropogenic forcing is developed to predict the decadal components of global sea surface temperatures (SSTs) for the three decades 2011-2040. The internal decadal component is derived by harmonic wave expansion analyses based on the quasiperiodic evolution of the Pacific Decadal Oscillation (PDO) and the Atlantic Multidecadal Oscillation (AMO), as obtained from observational SST datasets. Furthermore, the external decadal component induced by anthropogenic forcing is assessed with a second-order fit based on the ensemble of projected SSTs in the experiments with multiple coupled climate models associated with the third Coupled Model Intercomparison Project (CMIP3) under the Intergovernmental Panels on Climate Change (IPCC) Special Reports on Emissions Scenario (SRES) A1B. A validation for the years from 2002 to 2010 based on a comparison of the predicted and the observed SST and their spatial correlation, as well as the root mean square error (RMSE), suggests that the approach is reasonable overall. In addition, the predicted results over the 50°S-50°N global band, the Indian Ocean, the western Pacific Ocean, the tropical eastern Pacific Ocean, and the North and the South Atlantic Ocean are presented.

关键词： decadal climate prediction internal decadal variability anthropogenic forcing SST

Homoclinic Solutions for a Class of Perturbed Fractional Hamiltonian Systems with Subquadratic Conditions

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1177-1196页

作者： Ying luo fei GUO Yan LIU School of Mathematics Tianjin UniversityTianjin 300354P.R.China Tianjin Key Laboratory of Brain-Inspired Intelligence Technology Tianjin300354P.R.China

In this paper,we consider the following perturbed fractional Hamiltonian systems{tD_(∞)^(α)(_(-∞)D_(t)^(α)u(t))+L(t)u(t)=■_(u)W(t,u(t))+■(u)G(t,u(t)),t∈R,u∈H^(α)(R,R^(N)),whereα∈(1/2,1],L∈C(R,R^(N×N))is symmetric and not necessarily required to be positive definite,W∈C1(R×R^(N,R))is locally subquadratic and locally even near the origin,and perturbed term G∈C1(R×R^(N,R))maybe has no parity in *** the perturbed method improved by the authors,a sequence of nontrivial homo clinic solutions is obtained,which generalizes previous results.

关键词： Perturbed fractional Hamiltonian systems subquadratic condition perturbed method homoclinic solutions multiplicity

3D robust anisotropic diffusion filtering algorithm for sparse view neutron computed tomography 3D image reconstruction

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Nuclear Science and Techniques 2024年第3期35卷 13-29页

作者： Yang Liu Teng-fei Zhu Zhi luo Xiao-Ping Ouyang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Xi’an 710024China

The most critical part of a neutron computed tomography(NCT) system is the image processing algorithm,which directly affects the quality and speed of the reconstructed *** types of noise in the system can degrade the quality of the reconstructed ***,to improve the quality of the reconstructed images of NCT systems,efficient image processing algorithms must be *** anisotropic diffusion filtering(ADF) algorithm can not only effectively suppress the noise in the projection data,but also preserve the image edge structure information by reducing the diffusion at the image ***,we propose the application of the ADF algorithm for NCT image *** compare the performance of different algorithms in NCT systems,we reconstructed images using the ordered subset simultaneous algebraic reconstruction technique(OS-SART) algorithm with different regular terms as image processing *** the iterative reconstruction,we selected two image processing algorithms,the Total Variation and split Bregman solved total variation algorithms,for comparison with the performance of the ADF ***,the filtered back-projection algorithm was used for comparison with an iterative *** reconstructing the projection data of the numerical and clock models,we compared and analyzed the effects of each algorithm applied in the NCT *** on the reconstruction results,OS-SART-ADF outperformed the other algorithms in terms of denoising,preserving the edge structure,and suppressing *** example,when the 3D Shepp–Logan was reconstructed at 25 views,the root mean square error of OS-SART-ADF was the smallest among the four iterative algorithms,at only *** universal quality index,mean structural similarity,and correlation coefficient of the reconstructed image were the largest among all algorithms,with values of 0.9877,0.9878,and 0.9887,respectively.

关键词： NCT OS-SART Sparse-view Anisotropic diffusion filtering

Sparse-view neutron CT 3D image reconstruction algorithm based on split Bregman method

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Nuclear Science and Techniques 2024年第9期35卷 41-55页

作者： Teng-fei Zhu Yang Liu Zhi luo Xiao-Ping Ouyang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Xi’an 710024China

As a complement to X-ray computed tomography(CT),neutron tomography has been extensively used in nuclear engineer-ing,materials science,cultural heritage,and industrial *** of the attenuation matrix for neutron tomography with a traditional analytical algorithm requires hundreds of projection views in the range of 0°to 180°and typically takes several hours to *** a low time-resolved resolution degrades the quality of neutron *** the number of projection acquisitions is an important approach to improve the time resolution of images;however,this requires efficient reconstruction ***,sparse-view reconstruction algorithms in neutron tomography need to be *** this study,we investigated the three-dimensional reconstruction algorithm for sparse-view neu-tron CT *** enhance the reconstructed image quality of neutron CT,we propose an algorithm that uses OS-SART to reconstruct images and a split Bregman to solve for the total variation(SBTV).A comparative analysis of the performances of each reconstruction algorithm was performed using simulated and actual experimental *** to the analyzed results,OS-SART-SBTV is superior to the other algorithms in terms of denoising,suppressing artifacts,and preserving detailed structural information of images.

关键词： Neutron CT OS-SART Sparse-view 3D reconstruction Split Bregman Total variation

Impairment of Autophagic Flux After Hypobaric Hypoxia Potentiates Oxidative Stress and Cognitive Function Disturbances in Mice

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Neuroscience Bulletin 2024年第1期40卷 35-49页

作者： Shuhui Dai Yuan Feng Chuanhao Lu Hongchen Zhang Wenke Ma Wenyu Xie Xiuquan Wu Peng luo Lei Zhang fei fei Zhou fei Xia Li Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi'an 710000China National Translational Science Center for Molecular Medicine and Department of Cell Biology Fourth Military Medical UniversityXi'an 710000China Department of Neurosurgery The Central Hospital of BaojiBaoji 721000China Department of Ophthalmology Xijing HospitalFourth Military Medical UniversityXi'an 710000China

Acute hypobaric hypoxic brain damage is a potentially fatal high-altitude *** plays a critical role in ischemic brain injury,but its role in hypo-baric hypoxia(HH)remains *** we used an HH chamber to demonstrate that acute HH exposure impairs autophagic activity in both the early and late stages of the mouse brain,and is partially responsible for HH-induced oxidative stress,neuronal loss,and brain *** autophagic agonist rapamycin only promotes the initiation of *** proteome analysis,a screen showed that protein dynamin2(DNM2)potentially regulates autophagic *** of DNM2 significantly increased the formation of autolysosomes,thus maintaining autophagic flux in combination with ***,the enhancement of autophagic activity attenuated oxidative stress and neurological deficits after HH *** results contribute to evidence supporting the conclusion that DNM2-mediated autophagic flux represents a new therapeutic target in HH-induced brain damage.

关键词： Autophagy-Proteomics Oxidative stress Hypobaric hypoxia-Brain injury

Should we perform sigmoidoscopy for colorectal cancer screening in people under 45 years?

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1248-1255页

作者： Waiian Leong Jia-Qi Guo Chun Ning fei-fei luo Rui Jiao Dong-Ye Yang Division of Gastroenterology&Hepatology The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Department of Accident&Emergency The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Department of Anatomical Pathology The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Endoscopy Center The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChin

BACKGROUND The strategy for preventing colorectal cancer is screening by colonoscopy,which offers a direct way for detection and removal of adenomatous polyps(APs).American College of Gastroenterology guidelines recommend that people aged≥45 years should undergo colonoscopy;however,how to deal with people aged≤45 years is still *** To compare the prevalence of APs and high-grade neoplasia between the left and right colon in patients≤45 *** A retrospective observational study was conducted at a single tertiary III hospital in *** study included patients aged 18-45 years with undergoing initial colonoscopy dissection and pathological diagnosis AP or high-grade neoplasia between February 2014 and January *** number of APs in the entire colon while screening and post-polypectomy surveillance in following 1-3 years were *** A total of 3053 cases were *** prevalence of APs in the left and right colon was 55.0%and 41.6%,respectively(OR 1.7,95%CI 1.6-2.4;P3 polyps(14.1%;OR 0.3,95%CI 0.1-0.6;P<0.05).CONCLUSION This study suggests that flexible sigmoidoscopy would be an optimal approach for initial screening in people aged≤45 years and would be a more cost-effective and safe strategy.

关键词： Adenomatous polyps High-grade neoplasia Colonoscopy Flexible sigmoidoscopy