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Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling

Journal of Molecular Cell Biology 2020年第9期12卷 723-737页

作者： Li Liu Yudong Wu Cheng Zhang Chong Zhou Yining Li Yi Zeng Chunbo Zhang Rong Li Daya luo Lieliang Wang Long Zhang Shuo Tu Huan Deng shiwen luo Ye-Guang Chen Xiangyang Xiong Xiaohua Yan Department of Biochemistry and Molecular Biology School of Basic Medical SciencesNanchang UniversityNanchang 330006China Department of Breast Surgery Jiangxi Provincial Cancer HospitalNanchang 330029China School of Pharmacy Nanchang UniversityNanchang 330006China School of Basic Medical Sciences Nanchang UniversityNanchang 330006China Life Sciences Institute and Innovation Center for Cell Signaling Network Zhejiang UniversityHangzhou 310058China Department of Pathology The Fourth Affiliated Hospital of Nanchang UniversityNanchang 330003China Center for Experimental Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China The State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Institute of Biomedical Sciences Nanchang University Medical CollegeNanchang 330031China Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology Nanchang University Medical CollegeNanchang 330006China

Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression,yet the underlying mechanisms and functional mediators remain *** isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature adipocytes and cancer-associated adipocytes(CAAs)in *** CAAs exhibited significantly different gene expression profiles as assessed by transcriptome *** of the highly expressed genes in CAAs is granulocyte colony-stimulating factor(G-CSF).Treatment with recombinant human G-CSF protein or stable expression of human G-CSF in triple-negative breast cancer(TNBC)cell lines enhanced epithelial–mesenchymal transition,migration,and invasion of cancer cells,by activating ***,targeting G-CSF/Stat3 signaling with G-CSF-neutralizing antibody,a chemical inhibitor,or siRNAs for Stat3 could all abrogate CAA-or G-CSF-induced migration and invasion of breast cancer *** pro-invasive genes MMP2 and MMP9 were identified as target genes of G-CSF in TNBC ***,in human breast cancer tissues,elevated G-CSF expression in adipocytes is well correlated with activated Stat3 signal in cancer ***,our results suggest a novel strategy to intervene with invasive breast cancers by targeting CAA-derived G-CSF.

关键词： cancer-associated adipocyte G-CSF triple-negative breast cancer(TNBC) epithelial-mesenchymal transition(EMT) migration and invasion

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Adversarial attacks and defenses for digital communication signals identification

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Digital Communications and Networks 2024年第3期10卷 756-764页

作者： Qiao Tian Sicheng Zhang shiwen Mao Yun Lin College of Computer Science and Technology Harbin Engineering UniversityHarbin150001China College of Information and Communication Engineering Harbin Engineering UniversityHarbin150000China Department of Electrical and Computer Engineering Auburn UniversityAuburnAL36849USA

As modern communication technology advances apace,the digital communication signals identification plays an important role in cognitive radio networks,the communication monitoring and management *** has become a promising solution to this problem due to its powerful modeling capability,which has become a consensus in academia and ***,because of the data-dependence and inexplicability of AI models and the openness of electromagnetic space,the physical layer digital communication signals identification model is threatened by adversarial *** examples pose a common threat to AI models,where well-designed and slight perturbations added to input data can cause wrong ***,the security of AI models for the digital communication signals identification is the premise of its efficient and credible *** this paper,we first launch adversarial attacks on the end-to-end AI model for automatic modulation classifi-cation,and then we explain and present three defense mechanisms based on the adversarial *** we present more detailed adversarial indicators to evaluate attack and defense ***,a demonstration verification system is developed to show that the adversarial attack is a real threat to the digital communication signals identification model,which should be paid more attention in future research.

关键词： Digital communication signals identification AI model Adversarial attacks Adversarial defenses Adversarial indicators

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Stability Analysis of a Class of Nonlinear Fractional Differential Systems With Riemann-Liouville Derivative

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1883-1885页

作者： Ruoxun Zhang Shiping Yang shiwen Feng College of Teacher Education Xingtai UniversityXingtai 054001China College of Physics and Information Engineering Hebei Normal UniversityShijiazhuang 050016China

Dear Editor,This letter investigates the stability of n-dimensional nonlinear fractional differential systems with Riemann-Liouville *** using the Mittag-Leffler function,Laplace transform and the Gronwall-Bellman lemma,one sufficient condition is attained for the asymptotical stability of a class of nonlinear fractional differential systems whose order lies in(0,2).According to this theory,if the nonlinear term satisfies some conditions,then the stability condition for nonlinear fractional differential systems is the same as the ones for corresponding linear *** examples are provided to illustrate the applications of our result.

关键词： Liouville Riemann nonlinear

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A Tightly Coupled Dipole Array with Diverse Element Reflection Phases for RCS Reduction

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Chinese Journal of Electronics 2024年第2期33卷 449-455页

作者： Yuewen GOU Yikai CHEN shiwen YANG University of Electronic Science and Technology of China

This paper proposes a novel low scattering tightly coupled dipole array(TCDA), aiming to reduce the radar cross section(RCS) of phased antenna arrays under a certain oblique incident wave. First, we build three types of antenna elements that exhibit similar radiation characteristics but diverse reflection phase differences based on the proposed theoretical analysis. The required reflection phase difference is achieved by using different dielectric superstrates for each antenna element. Then, by arranging the three types of subarrays next to each other, a low scattering TCDA(8 × 9) is designed. Meanwhile, a reference antenna array with a single type of antenna element is also constructed. To demonstrate the effectiveness of the proposed RCS reduction technique, simulated and measured results of the reference and proposed antenna array are compared. Both antenna arrays operate over the 6–18 GHz frequency band and can scan up to ±45° in the E-/H-planes. However, the proposed antenna array achieves a significant monostatic RCS reduction over 8–12 GHz, with a maximum reduction value of 7.55 d B. It indicates that this diverse element reflection phase technique is a good candidate for wideband RCS reduction.

关键词： Antenna measurements Phased arrays Dipole antennas Antenna theory Scattering Reflector antennas Reflection

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Fine-Grained Ship Recognition Based on Visible and Near-Infrared Multimodal Remote Sensing Images: Dataset,Methodology and Evaluation

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Computers, Materials & Continua 2024年第6期79卷 5243-5271页

作者： shiwen Song Rui Zhang Min Hu Feiyao Huang Department of Aerospace Science and Technology Space Engineering UniversityBeijing101416China

Fine-grained recognition of ships based on remote sensing images is crucial to safeguarding maritime rights and interests and maintaining national ***,with the emergence of massive high-resolution multi-modality images,the use of multi-modality images for fine-grained recognition has become a promising ***-grained recognition of multi-modality images imposes higher requirements on the dataset *** key to the problem is how to extract and fuse the complementary features of multi-modality images to obtain more discriminative fusion *** attention mechanism helps the model to pinpoint the key information in the image,resulting in a significant improvement in the model’s *** this paper,a dataset for fine-grained recognition of ships based on visible and near-infrared multi-modality remote sensing images has been proposed first,named Dataset for Multimodal Fine-grained Recognition of Ships(DMFGRS).It includes 1,635 pairs of visible and near-infrared remote sensing images divided into 20 categories,collated from digital orthophotos model provided by commercial remote sensing *** provides two types of annotation format files,as well as segmentation mask images corresponding to the ship ***,a Multimodal Information Cross-Enhancement Network(MICE-Net)fusing features of visible and near-infrared remote sensing images,has been *** the network,a dual-branch feature extraction and fusion module has been designed to obtain more expressive *** Feature Cross Enhancement Module(FCEM)achieves the fusion enhancement of the two modal features by making the channel attention and spatial attention work cross-functionally on the feature map.A benchmark is established by evaluating state-of-the-art object recognition algorithms on ***-Net conducted experiments on DMFGRS,and the precision,recall,mAP0.5 and mAP0.5:0.95 reached 87%,77.1%,83.8%and 63.9%,*** experiments demons

关键词： Multi-modality dataset ship recognition fine-grained recognition attention mechanism

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Facile low-temperature supercritical carbonization method to prepare high-loading nickel single atom catalysts for efficient photodegradation of tetracycline

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Journal of Environmental Sciences 2024年第4期138卷 373-384页

作者： Han Qiao Lirong Zheng shiwen Hu Gang Tang Hongri Suo Chongxuan Liu School of Environment Harbin Institute of TechnologyHarbin 150090China State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China Beijing Synchrotron Radiation Facility(BSRF) Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Environmental photocatalysis is a promising technology for treating antibiotics in *** this study,a supercritical carbonization method was developed to synthesize a single-atom photocatalyst with a high loading of Ni(above 5 wt.%)anchored on a carbonnitrogen-silicate substrate for the efficient photodegradation of a ubiquitous environmental contaminant of tetracycline(TC).The photocatalyst was prepared from an easily obtained metal-biopolymer-inorganic supramolecular hydrogel,followed by supercritical drying and carbonization *** low-temperature(300℃)supercritical ethanol treatment prevents the excessive structural degradation of hydrogel and greatly reduces the metal clustering and aggregation,which contributed to the high Ni *** characterizations confirmed that Ni was present at isolated sites and stabilized by Ni-N and Ni-O bonds in a Ni-(N/O)_(6)-C/SiC configuration.A 5%Ni-C-Si catalyst,which performed the best among the studied catalysts,exhibited a wide visible light response with a narrow bandgap of 1.45 eV that could efficiently and repeatedly catalyze the oxidation of TC with a conversion rate of almost 100% within 40 *** reactive species trapping experiments and electron spin resonance(ESR)tests demonstrated that the h+,and·O_(2)-were mainly responsible for TC *** TC degradation mechanism and possible reaction pathways were provided ***,this study proposed a novel strategy to synthesize a high metal loading singleatom photocatalyst that can efficiently remove TC with high concentrations,and this strategy might be extended for synthesis of other carbon-based single-atom catalysts with valuable properties.

关键词： Carbon-based single-atom catalyst Nickel Photocatalytic degradation Tetracycline Visible light

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放电泵浦ArF准分子激光动力学模拟与参数分析

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强激光与粒子束 2015年第8期27卷 29-34页

作者：罗时文左都罗王新兵华中科技大学武汉光电国家实验室武汉430074

利用一维流体模型研究了放电泵浦ArF准分子激光动力学过程,得到气体放电过程中放电电路的电流电压波形,得到了电子密度、光子密度、电场的时空分布特性,分析了放电参数对激光输出的影响。结果表明,电路参数、工作气压、氟气比例均对激... 详细信息

利用一维流体模型研究了放电泵浦ArF准分子激光动力学过程,得到气体放电过程中放电电路的电流电压波形,得到了电子密度、光子密度、电场的时空分布特性,分析了放电参数对激光输出的影响。结果表明,电路参数、工作气压、氟气比例均对激光输出有显著影响,放电电路中的电感值对输出影响较小,参数范围较广,而电路中较小的峰化电容值有利于获得长脉冲输出,气压太大或太小都会使输出能量降低,同样,氟气比例太大或太小也会使输出能量降低。

关键词： ArF准分子激光流体模型放电电路电子密度光子密度

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Hydroxyl radical production by abiotic oxidation of pyrite under estuarine conditions:The effects of aging,seawater anions and illumination

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Journal of Environmental Sciences 2024年第1期135卷 715-727页

作者： Ruixue Liu Yinshun Dai Yucheng Feng shiwen Sun Xiaodong Zhang Chunjiang An Shan Zhao Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong UniversityQingdao 266237China Department of Building Civil and Environmental EngineeringConcordia UniversityMontrealQC H3G 1M8Canada

Pyrite is widely distributed in estuarine sediments as an inexpensive natural Fenton-like reagent,however,the mechanism on the hydroxyl radical(HO^(·))production by pyrite under estuarine environmental conditions is still poorly *** batch experiments were performed to investigate the effects of estuarine conditions including aging(in air,in water),seawater anions(Cl^(-),Br^(-)and HCO_(3)^(-))and light on the HO^(·)production by pyrite *** one-electron transfer dominated the process from O_(2) to HO^(·)induced by oxidation of *** Fe(oxyhydr)oxide coatings on the surface of pyrite aged in air and water consumed hydrogen peroxide while mediating the electron transfer,and the combined effect of the two resulted in a suppression of HO^(·)production in the early stage of aging and a promotion of HO^(·)production in the later stage of *** of the surface oxide layers by aggressive anions was the main reason for the inhibition of HO^(·)production by Cl^(-)and Br^(-),and the generation of Cl^(·)and Br^(·)may also play a role in the scavenging of HO^(·).HCO_(3)^(-)increased the average rate of HO^(·)production through surface-CO_(2) complexes formed by adsorption on the surface of *** significant enhancement of HO^(·)production under light was attributed to the formation of photoelectrons induced by photochemical reactions on pyrite and its surface oxide *** findings provide new insights into the environmental chemical behavior of pyrite in the estuary and enrich the understanding of natural remediation of estuarine environments.

关键词： Hydroxyl radical Pyrite oxidation Aging Anions Irradiation

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Recent advances and future prospects on Ni_(3)S_(2)-Based electrocatalysts for efficient alkaline water electrolysis

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Green Energy & Environment 2024年第4期9卷 659-683页

作者： shiwen Wang Zhen Geng Songhu Bi Yuwei Wang Zijian Gao Liming Jin Cunman Zhang Clean Energy Automotive Engineering Center School of Automotive StudiesTongji UniversityShanghai201804China

Green hydrogen(H_(2))produced by renewable energy powered alkaline water electrolysis is a promising alternative to fossil fuels due to its high energy density with zero-carbon ***,efficient and economic H_(2) production by alkaline water electrolysis is hindered by the sluggish hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).Therefore,it is imperative to design and fabricate high-active and low-cost non-precious metal catalysts to improve the HER and OER performance,which affects the energy efficiency of alkaline water ***_(3)S_(2) with the heazlewoodite structure is a potential electrocatalyst with near-metal conductivity due to the Ni–Ni metal ***,the review comprehensively presents the recent progress of Ni_(3)S_(2)-based electrocatalysts for alkaline water ***,the HER and OER mechanisms,performance evaluation criteria,preparation methods,and strategies for performance improvement of Ni_(3)S_(2)-based electrocatalysts are *** challenges and perspectives are also analyzed.

关键词： Alkaline water electrolysis Hydrogen Electrocatalysts Ni_(3)S_(2)

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Suppression of cell growth and migration by blocking hedgehog signaling pathway in gastric cancer cells

Suppression of cell growth and migration by blocking hedgeho...

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细胞—生命的基础——中国细胞生物学学会2013年全国学术大会·武汉

作者： Runwei Yan Xiang Peng Xiaogang Yuan Qingtian luo Yong Li Xuan Huang Nonghua Lv shiwen luo Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityKey Laboratory of Digestive Diseases of Jiangxi Province Center for Experimental Medicine The First Affiliated Hospital of Nanchang University

Background Previous studies suggest Hedgehog signaling is essential for gastric cancer,but the precise function of Hedgehog signaling in gastric cancer is still *** aim of this study is to clarify the role of Hedgehog signaling in gastric tumorigenesis. Methods The expressions of Hedgehog signaling key components in clinical samples of gastric

关键词： Hedgehog signaling pathway gastric cancer Glil cDNA microarray analysis

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