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Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： lung-yi mak Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai yin Chan Ching lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,P<0.001),compared to *** both acute and post-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,P<0.001;post-acute:IRR:1.24,95%CI:1.14-1.36,P<0.001)and adverse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,P<0.001;post-acute:IRR:1.24,95%CI:1.13-1.35,P<0.001),compared to *** Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma

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Carvedilol Versus Other Nonselective Beta Blockers for Variceal Bleeding Prophylaxis and Death: A Network Meta-analysis

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1143-1149页

作者： Ka-Shing Cheung Chiu-Hang Mok Lok-Ka Lam Xian-Hua Mao lung-yi mak Wai-Kay Seto Man-Fung Yuen Department of Medicine School of Clinical MedicineThe University of Hong KongQueen Mary HospitalHong KongChina Department of Medicine The University of Hong Kong-Shenzhen HospitalShenzhenGuangdongChina School of Clinical Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background and Aims:We aimed to perform a network meta-analysis(NWM)to examine comparative effectiveness of non-selective beta blockers(NSBBs)on prophylaxis of gastroesophageal variceal bleeding(GVB)and mortality ***:MEDLINE(OVID)and EMBASE databases were searched for eligible randomized clinical trials(RCTs)from inception to July 3,*** of interest included primary/secondary prophylaxis of GVB,failure to achieve hepatic venous pressure gradient(HVPG)decremental response,liver-related and all-cause mortality.A Bayesian NWM was performed to derive relative risk(RR)with 95%credible intervals(CrIs).The ranking probability of each NSBB was assessed by surface under cumulative ranking curve(SUCRA).Results:Thirty-three RCTs including 3,188 cirrhosis patients with gastroesophageal varices were *** with placebo,nadolol ranked first for reducing variceal bleeding[RR:0.25,(95%CrI:0.11–0.51);SUCRA:0.898],followed by carvedilol[RR:0.33,(95%CrI:0.11–0.88);SUCRA:0.692]and propranolol[RR:0.52,(95%CrI:0.37–0.75);SUCRA:0.405].Carvedilol was more effective than propranolol in achieving HVPG decremental response[RR:0.43,(95%CrI:0.26–0.69)].Carvedilol ranked first for reducing all-cause mortality[RR:0.32,(95%CrI:0.17–0.57);SUCRA:0.963],followed by nadolol[RR:0.48,(95%CI:0.29–0.77);SUCRA:0.688],and propranolol[RR:0.77,(95%CI:0.58–1.02);SUCRA:0.337].Similar findings were observed for liver-related *** ranked the *** RR of adverse events was 4.38,(95%CrI:0.33–161.4);SUCRA:0.530,followed by propranolol[RR:7.54,(95%CrI:1.90–47.89);SUCRA:0.360],and nadolol[RR:18.24,(95%CrI:91.51–390.90);SUCRA:0.158].Conclusions:Carvedilol is the preferred NSBB with better survival benefit and lower occurrence of adverse events among patients with gastroesophageal varices.

关键词： NSBB Carvedilol Nadolol Propranolol Varices Cirrhosis CPSH

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Epidemiology and natural history of Wilson's disease in the Chinese: A territory-based study in Hong Kong between 2000 and 2016

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World Journal of Gastroenterology 2017年第43期23卷 7716-7726页

作者： Ka-Shing Cheung Wai-Kay Seto James Fung lung-yi mak Ching-lung Lai Man-Fung Yuen Department of Medicine The University of Hong KongQueen Mary Hospital State Key Laboratory for Liver Research The University of Hong Kong

AIM To investigate the epidemiology and natural history of Wilson's disease in the *** Data were retrieved via electronic search of hospital medical registry of the Hong Kong Hospital Authority,which covers all the public healthcare services. We identified cases of Wilson's disease between 2000 and 2016 by the International Classification of Diseases(ICD)-9 code. We analyzed the incidence rate,prevalence and adverse outcomes of Wilson's *** We identified 211 patients(male cases 104; female cases 107; median age 27.2 years,IQR: 17.1-38.6 years; duration of follow-up 8.0 years,IQR: 5.0-14.0 years). The average annual incidence rate was 1.44 per million person-years while the prevalence was 17.93 per million. Between 2000 and 2016,there was a decrease in the annual incidence rate from 1.65 to 1.23 per million person-years(P = 0.010),whereas there was an increase in the annual prevalence from 7.80 to 25.20 per million(P < 0.001). Among the 176 cases with hepatic involvement,38(21.6%) had cirrhosis,three(1.7%) developed hepatocellular carcinoma,24(13.6%) underwent liver transplantations,and 26(14.8%) died. Seven patients had concomitant chronic viral hepatitis B or C. The 5-year and 10-years rates of overall survival were 92.6% and 89.5%,and for transplant-free survival rates 91.8% and 87.4%,respectively. Cirrhosis and possibly chronic viral hepatitis were associated with poorer overall survival. CONCLUSION There was a significant increase in the prevalence of Wilson's disease in Hong Kong. The prognosis was favorable except for those with cirrhosis or concomitant viral hepatitis.

关键词： Hepaticolenticular 退化肝硬化 Hepatocellular 癌移植

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Prediction of hepatocellular carcinoma development by aminotransferase to platelet ratio index in primary biliary cholangitis

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World Journal of Gastroenterology 2017年第44期23卷 7863-7874页

作者： Ka-Shing Cheung Wai-Kay Seto James Fung lung-yi mak Ching-lung Lai Man-Fung Yuen Department of Medicine The University of Hong Kong Queen Mary Hospital State Key Laboratory for Liver Research The University of Hong Kong

AIM To investigate the usefulness of aspartate aminotransferase to platelet ratio index(APRI) in predicting hepatocellular carcinoma(HCC) risk in primary biliary cholangitis(PBC).METHODS We identified PBC patients between 2000 and 2015 by searching the electronic medical database of a tertiary center. The hazard ratio(HR) of HCC with different risk factors was determined by Cox proportional hazards model. RESULTS One hundred and forty-four PBC patients were recru-ited. Patients were diagnosed at a median age of 57.8 years [interquartile range(IQR): 48.7-71.5 years), and 41(28.5%) patients had cirrhosis at baseline. The median follow-up duration was 6.9 years(range: 1.0-26.3 years). Twelve patients developed HCC, with an incidence rate of 10.6 cases per 1000 patient-years. The overall 5-, 10-and 15-year cumulative incidences of HCC were 2.3% 95%CI: 0%-4.8%), 8.4%(95%CI: 1.8%-14.5%) and 21.6%(6.8%-34.1%), respectively. Older age(HR = 1.07), cirrhosis(HR = 4.38) and APRI at 1 year after treatment(APRI-r1) > 0.54(HR = 3.94) were independent factors for HCC development. APRI-r1, when combined with treatment response, further stratified HCC risk(log rank P < 0.05). The area under receiver operating curve of APRI-r1 in predicting HCC was 0.77(95%CI: 0.64-0.88).CONCLUSION APRI-r1 can be used to predict the development of HCC in PBC patients. Combination of APRI-r1 with treatment response can further stratify the HCC risk.

关键词： Aspartate aminotransferase 血小板比率索引 Hepatocellular 癌主要胆汁的胆管炎 Ursodeoxycholic 酸肝硬化

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Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients

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World Journal of Gastroenterology 2019年第11期25卷 1398-1408页

作者： lung-yi mak Wai-Pan To Danny Ka-Ho Wong James Fung Fen Liu Wai-Kay Seto Ching-lung Lai Man-Fung Yuen Department of Medicine Queen Mary Hospital Department of Medicine The University of Hong Kong State Key Laboratory for Liver Research The University of Hong Kong

BACKGROUND Liver cirrhosis is a major risk factor for hepatocellular carcinoma(HCC)development in chronic hepatitis B(CHB). Serum Mac-2 binding protein glycosylation isomer(M2 BPGi) is a novel serological marker for fibrosis. The role of M2 BPGi in prediction of HCC is *** To examine the role of serum M2 BPGi in predicting HCC development in hepatitis B e antigen(HBeAg)-negative *** Treatment-naive CHB patients with documented spontaneous HBeAg seroconversion were recruited. Serum M2 BPGi was measured at baseline(within3 years from HBeAg seroconversion), at 5 years and 10 years after HBeAg seroconversion and expressed as cut-off index(COI). Multivariate cox regression was performed to identify predictors for HCC development. ROC analysis was used to determine the cut-off value of M2 *** Among 207 patients(57% male, median age at HBeAg seroconversion 40 years old) with median follow-up of 13.1(11.8-15.5) years, the cumulative incidence of HCC at 15 years was 7%. Median M2 BPGi levels were significantly higher in patients with HCC compared to those without HCC(baseline: 1.39 COI vs 0.38 COI, P yielded AUROC of 0.883 with 91.7% sensitivity and 80.8% *** High serum M2 BPGi within 3 years after HBeAg seroconversion was a strong predictor for subsequent HCC development in treatment-naive HBeAg-negative CHB patients.

关键词： Hepatocellular carcinoma Hepatitis B Liver fibrosis Mac-2 binding protein glycosylation isomer Biomarker

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CD137L,a driver of harmful inflammation in the nervous system

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Neural Regeneration Research 2023年第11期18卷 2387-2388页

作者： Hiu yi Wong Amanda C.Y.Chan Anselm mak Herbert Schwarz Division of Life Science State Key Laboratory of Molecular NeuroscienceMolecular Neuroscience CenterThe Hong Kong University of Science and TechnologyHong Kong Special Administrative RegionChina Hong Kong Center for Neurodegenerative Diseases Hong Kong Special Administrative RegionChina Division of Neurology University Medicine ClusterNational University HospitalSingapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore Division of Rheumatology University Medicine ClusterNational University Health SystemDepartment of MedicineYong Loo Lin School of MedicineNational Univesity of SingaporeSingapore Department of Physiology and Immunology ProgrammeYong Loo Lin School of MedicineNational University of SingaporeSingapore Integrative Sciences and Engineering Programme NUS Graduate SchoolNational University of SingaporeSingapore

CD137 (TNFRSF9,4-1BB) is a member of the tumor necrosis factor (TNF) receptor family and a potent costimulatory *** levels of CD137 are expressed on T cells upon ***137 signaling in T cells,either by cognate interaction with antigen-presenting cells (APC)or by agonistic anti-CD137 antibodies,strongly enhances proliferation,interferon-y secretion,and cytolytic activity of T ***,CD137 signaling is a main driver of cellular,type 1 helper T cells (Th1)and type 1 cytolytic T cells (Tc1) polarised immune responses.

关键词： CD137 CD137L inflammation

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应激与生命意义感的曲线关系:基于意义建构视角

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中国临床心理学杂志 2024年第3期32卷 645-649,638页

作者：阳光耀陈一笛北京林业大学人文社会科学学院心理学系北京100083

目的:考察应激与生命意义感的曲线关系,并从意义建构视角解释其内在机制。方法:选取青少年生活事件量表(T1)、意义建构量表(T1)和生命意义感量表(T2),对236名大学生(男性99人,女性137人)进行间隔1个月的半纵向调查。结果:(1)应激量平方... 详细信息

目的:考察应激与生命意义感的曲线关系,并从意义建构视角解释其内在机制。方法:选取青少年生活事件量表(T1)、意义建构量表(T1)和生命意义感量表(T2),对236名大学生(男性99人,女性137人)进行间隔1个月的半纵向调查。结果:(1)应激量平方项与意义建构、寻求意义感及拥有意义感均显著负相关,意义建构与寻求意义感及拥有意义感均显著正相关。(2)中介效应分析显示,控制应激量一次项时,意义建构在应激量平方项与寻求意义感及拥有意义感之间均起显著中介作用。结论:应激与意义建构、寻求意义感、拥有意义感呈倒“U”形关系,意义建构在应激平方项与寻求意义感和拥有意义感之间发挥中介作用。相对于经历过高或过低累积应激的个体,经历了中等程度应激的个体通过高意义建构策略提升生命意义感。

关键词：应激生命意义感意义建构曲线关系

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Enhanced visible-light-driven heterogeneous photocatalytic CO_(2) methanation using a Cu_(2)O@Cu-MOF-74 thin film

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ChemPhysMater 2023年第2期2卷 126-133页

作者： Hao Wu Wahyu Prasetyo Utomo Yuanmeng Tian Chun Hong mak Hoi ying Chung Hsien-yi Hsu Jin Shang Yun Hau Ng School of Energy and Environment City University of Hong KongHong Kong 999077China Shenzhen Research Institute City University of Hong KongShenzhen 518057China

Cuprous oxide is a potential photocatalyst for the reduction of CO_(2).However,its high rate of charge recombina-tion and low ability to adsorb CO_(2) limit its activity,particularly when gaseous CO_(2) was ***,a Cu-based metal-organic framework(Cu-MOF-74)with high CO_(2) adsorption is coated onto Cu_(2) O nanowires by a topotactic transformation *** optimized Cu_(2) O@Cu-MOF-74 composite thin film showed a CH 4 evolution rate 4.5 times higher than that of bare Cu_(2) O under visible light illumination(>420 nm),with water vapor as the electron *** results of electrochemical impedance spectroscopy,transient photocurrent measurements,and fluorescence spectroscopy collectively suggest that the decoration of Cu_(2) O with Cu-MOF-74 facilitates electron extraction from excited Cu_(2) O,thereby inducing long-lived photocharges for the reduction of CO_(2).This study provides insights into the modification of transition metal oxides for application in photocatalysis by coating the surface with metal-organic frameworks.

关键词： Metal-organic framework Photocatalysis CO_(2)conversion Metal oxide Charge transport

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多元嵌入乡村振兴:少数民族务工人员返乡创业社会支持体系构建

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北方民族大学学报（哲学社会科学版） 2024年第4期 5-13页

作者：马伟华张亦弛南开大学社会学院天津300350

少数民族务工人员的返乡回流,对于乡村振兴具有一定的推动作用。作为一种经济行为,该群体的返乡创业具有明显的社会嵌入特征,其创业行为包括创业意愿、创业决策、创业激情和创业模式在内,深受既有政策、文化环境及社会关系结构的影响。... 详细信息

少数民族务工人员的返乡回流,对于乡村振兴具有一定的推动作用。作为一种经济行为,该群体的返乡创业具有明显的社会嵌入特征,其创业行为包括创业意愿、创业决策、创业激情和创业模式在内,深受既有政策、文化环境及社会关系结构的影响。在此基础上,需要有针对性地构建一套更为全面的少数民族务工人员返乡创业的社会支持系统:以政府为供给主体的正式社会支持,以乡村社区为供给主体的准正式社会支持和以社会组织、家庭亲友等社会关系网络为供给主体的非正式社会支持。这三种社会支持各有所长,缺一不可,共同构成一套以多元主体协同推进为特色的少数民族务工人员返乡创业的社会支持体系。在此社会支持体系的助推下,少数民族务工人员的返乡创业之路更为顺畅,民族地区乡村产业振兴更具蓬勃发展之机。

关键词：乡村振兴社会嵌入返乡创业社会支持

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基于NSGA-II的电动汽车复合制动多目标优化控制

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机械设计与制造 2024年第5期399卷 185-189页

作者：邓璘张俊峰黄炳义马来西亚雪兰莪大学工程与生命科学学院雪兰莪州431002 重庆电子工程职业学院智能制造与汽车学院重庆401331

为了提高电动汽车制动效果,设计了一种基于NSGA-II的电动汽车复合制动多目标优化控制策略。按照多目标优化的方式实现复合制动转矩分配并建立Pareto解集,利用改造后的理想解法实施决策确定最佳输出参数,获得与制动需求相符的转矩分配结... 详细信息

为了提高电动汽车制动效果,设计了一种基于NSGA-II的电动汽车复合制动多目标优化控制策略。按照多目标优化的方式实现复合制动转矩分配并建立Pareto解集,利用改造后的理想解法实施决策确定最佳输出参数,获得与制动需求相符的转矩分配结果。设计了模糊PID控制器,并开展了控制策略转矩分配仿真分析。研究结果表明:提升制动稳定性,形成更接近I曲线的结果。进行决策分析时,考虑车辆制动过程造成的干扰,决策获得最优参数,从而完成对转矩进行分配的过程。利用这里控制策略能够回收更高比例的制动能量,促进制动回收性能的明显提升,在较低强度制动下获得更优的制动能量回收效果,相对单独的模糊控制策略具备更优综合性能,完成预期制动力的分配。该研究对提高电动汽车复合制动效率具有很好的理论支撑价值,也可以推广到其他的车辆领域。

关键词：电动汽车复合制动多目标优化模糊控制决策联合仿真

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