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High-level disinfection of gastrointestinal endoscope reprocessing

World Journal of Experimental Medicine 2015年第1期5卷 33-35页

作者： King-Wah Chiu lung-sheng lu Shue-Shian Chiou Division of Gastroenterology and Hepatology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital College of Medicine Chang Gung University

High level disinfection(HLD) of the gastrointestinal(GI)endoscope is not simply a slogan, but rather is a form of experimental monitoring-based medicine. By definition,GI endoscopy is a semicritical medical device. Hence,such medical devices require major quality assurance for disinfection. And because many of these items are temperature sensitive, low-temperature chemical methods, such as liquid chemical germicide, must be used rather than steam sterilization. In summarizing guidelines for infection prevention and control for GI endoscopy, there are three important steps that must be highlighted: manual washing, HLD with automated endoscope reprocessor, and drying. Strict adherence to current guidelines is required because compared to any other medical device, the GI endoscope is associated with more outbreaks linked to inadequate cleaning or disinfecting during HLD. Both experimental evaluation on the surveillance bacterial cultures and in-use clinical results have shown that, the monitoring of the stringent processes to prevent and control infection is an essential component of the broader strategy to ensure the delivery of safe endoscopy services, because endoscope reprocessing is a multistep procedure involving numerous factors that can interfere with its efficacy. Based on our years of experience in the surveillance of culture monitoring of endoscopic reprocessing, we aim in this study to carefully describe what details require attention in the GI endoscopy disinfection and to share our experience so that patients can be provided with high quality and safe medical practices. Quality management encompasses all aspects of pre- and postprocedural care including the efficiency of the endoscopy unit and reprocessing area, as well as the endoscopic procedure itself.

关键词： Automated endoscope reprocessor Bacterial culture Gastrointestinal endoscopy High-level disinfection Liquid chemical germicide

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Swab culture monitoring of automated endoscope reprocessors after high-level disinfection

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World Journal of Gastroenterology 2012年第14期18卷 1660-1663页

作者： lung-sheng lu Yi-Chun Chiu Ming-Tzung Lin Tsung-Hui Hu King-Wah Chiu Division of HepatoGastroenterology Department of Internal MedicineChang Gung Memorial Hospital-Kaohsiung Medical CenterChang Gung University College of Medicine

AIM:To conduct a bacterial culture study for monitoring decontamination of automated endoscope reprocessors(AERs) after high-level disinfection(HLD).METHODS:From February 2006 to January 2011,authors conducted randomized consecutive sampling each month for 7 *** collected a total of 420 swab cultures,including 300 cultures from 5 gastroscope AERs,and 120 cultures from 2 colonoscope *** cultures were obtained from the residual water from the AERs after a full reprocessing *** were cultured to test for aerobic bacteria,anaerobic bacteria,and mycobacterium ***:The positive culture rate of the AERs was 2.0%(6/300) for gastroscope AERs and 0.8%(1/120) for colonoscope *** the positive cultures,including 6 from gastroscope and 1 from colonoscope AERs,showed monofloral *** the gastroscopeAER samples,50%(3/6) were colonized by aerobic bacterial and 50%(3/6) by fungal ***:A full reprocessing cycle of an AER with HLD is adequate for disinfection of the *** culture is a useful method for monitoring AER decontamination after each reprocessing *** contamination of AERs after reprocessing should also be kept in mind.

关键词： Automated endoscope reprocessor Gastrointestinal scope High-level disinfection Swab culture Monitoring Decontamination

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Five-year sequential changes in secondary antibiotic resistance of Helicobacter pylori in Taiwan

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World Journal of Gastroenterology 2015年第37期21卷 10669-10674页

作者： I-Ting Wu Seng-Kee Chuah Chen-Hsiang Lee Chih-Ming Liang lung-sheng lu Yuan-Hung Kuo Yi-Hao Yen Ming-luen Hu Yeh-Pin Chou Shih-Cheng Yang Chung-Mou Kuo Chung-Huang Kuo Chun-Chih Chien Yu-Shao Chiang Shue-Shian Chiou Tsung-Hui Hu Wei-Chen Tai Division of Hepatogastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of Infectious Diseases Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Department of Laboratory Medicine Kaohsiung Chang Gung Memorial Hospital

AIM: To determine changes in the antibiotic resistance of Helicobacter pylori(H. pylori) in southern Taiwan after failure of first-line standard triple ***: We analyzed 137 H. pylori-infected isolates from patients who experienced eradication failure after standard first-line triple therapy from January2010 to December 2014. The H. pylori strains were tested for susceptibility to amoxicillin, clarithromycin,levofloxacin, metronidazole and tetracycline using the E-test method. The minimal inhibitory concentration(MIC) was determined by the agar dilution *** values of ≥ 0.5, ≥ 1, ≥ 1, ≥ 4 and ≥ 8 mg/L were considered to be the resistance breakpoints for amoxicillin, clarithromycin, levofloxacin, tetracycline and metronidazole, ***: A high resistance rate was found for clarithromycin(65%-75%) and metronidazole(30%-40%)among patients who failed first-line standard *** resistance levels to amoxicillin and tetracycline remained very low; however, levofloxacin resistance was as high as 37.5% in 2010 but did not increase any further during the past 5 years. The rates of resistance to these antibiotics did not show a statistically significant upward or downward ***: Antibiotic resistance of H. pylori remains a problem for the effective eradication of this pathogen and its associated diseases in Taiwan. High clarithromycin resistance indicated that this antibiotic should not be prescribed as a second-line H. pylori eradication therapy. Moreover, levofloxacin-based second-line therapy should be used cautiously, and the local resistance rates should be carefully monitored.

关键词： Helicobacter pylori Antibiotic resistance Five-yea

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan lu Kang Wang Yuanhong Peng Meng Chen Lin Zhong luji Huang F U Cheng Xindan sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' UTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

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An experimental investigation of one-and two-degree of freedom VIV of cylinders

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Acta Mechanica Sinica 2013年第2期29卷 284-293页

作者： Zhuang Kang lu-sheng Jia College of Shipbuilding Harbin Engineering University CNOOC Research Institute

In the paper,an experiment investigation was conducted for one-and two-degree of freedom vortex-induced vibration（VIV） of a horizontally-oriented cylinder with diameter of 11 cm and length of 120 *** the experiment,the spring constants in the cross-flow and in-line flow directions were regulated to change the natural vibration frequency of the model *** was found that,in the one-degree of freedom VIV experiment,a ＂double peak＂ phenomenon was observed in its amplitude within the range of the reduced velocities tested,moreover,a ＂2T＂ wake appeared in the vicinity of the second *** the two-degree of freedom VIV experiment,the trajectory of cylinder exhibited a reverse ＂C＂ shape,i.e.,a ＂new moon＂ *** analysis of these data,it appears that,besides the non-dimensional in-line and cross-flow natural vibration frequency ratios,the absolute value of the natural vibration frequency of cylinder is also one of the important parameters affecting its VIV behavior.

关键词： One- and two-degree of freedom VIV “2T” wake “New moon” trajectory Natural vibration frequency ratio

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Monitoring nearest neighbor queries with cache strategies

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 529-537页

作者： PAN Peng lu Yan-sheng College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

The problem of continuously monitoring multiple K-nearest neighbor (K-NN) queries with dynamic object and query dataset is valuable for many location-based applications. A practical method is to partition the data space into grid cells, with both object and query table being indexed by this grid structure, while solving the problem by periodically joining cells of objects with queries having their influence regions intersecting the cells. In the worst case, all cells of objects will be accessed once. Object and query cache strategies are proposed to further reduce the I/O cost. With object cache strategy, queries remaining static in current processing cycle seldom need I/O cost, they can be returned quickly. The main I/O cost comes from moving queries, the query cache strategy is used to restrict their search-regions, which uses current results of queries in the main memory buffer. The queries can share not only the accessing of object pages, but also their influence regions. Theoretical analysis of the expected I/O cost is presented, with the I/O cost being about 40% that of the SEA-CNN method in the experiment results.

关键词： K-nearest neighbors (K-NNs) Continuous query Object cache Query cache

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An Explicit Backlund Transformation of Burgers Equation with Applications

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Communications in Theoretical Physics 2005年第6X期44卷 987-989页

作者： lu Zhuo-sheng Key Laboratory of Mathematics Mechanization Academy of Mathematics and Systems Science the Chinese Academy of Sciences Beijing 100080 China

In this paper, an explicit Bgcklund transformation （BT） of the Burgers equation is obtained by using the further extended tanh method [Phys. Lett. A 307 （2003） 269; Chaos, Solitons ＆ Fractals 17 （2003） 669]. Based on the BT and some newly obtained seed solutions, infinite sequences of exact solutions for the Burgers equation are generated. Further more, this BT of the Burgers equation is applied to solve the variant Boussinesq equations and the approximate equations of long water wave.

关键词： Burgers equation Backlund transformation exact solution

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THREE-DIMENSIONAL MODELING FOR THIN PLATE-LIKE STRUCTURES INCluDING SURFACE EFFECTS BY USING STATE SPACE METHOD

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Acta Mechanica Solida Sinica 2010年第3期23卷 260-270页

作者： Hongyu sheng Pin lu Institute of Civil Engineering Hefei University of Technology Hefei 230009 China Institute of Materials Research and Engineering A ^＊STAR (Agency for Science Technology and Research) 3 Research Link Singapore 117602

A three-dimensional （3-D） approach based on the state space method is proposed to study size-dependent mechanical properties of ultra-thin plate-like elastic structures considering surface effects. The structure is modeled as a laminate composed of a bulk bounded with upper and bottom surface layers, which are allowed to have different material properties from the bulk layer. State equations, including the surface properties of the structure, can be established on the basis of 3-D fundamental elasticity to analyze the size-dependent static characteristics of the thin plate-like structure. Compared with two-dimensional plate theories based size-dependent models for thin film structures in literature, the present 3-D approach is exact, which can provide benchmark results to assess the accuracy of 2-D plate theories and various numerical approaches. To show the feasibility of the proposed approach, a 3-D analytical solution for a simply supported plate-like thin structure including surface layers is derived. An algorithm is proposed for the calculation of the state equations obtained to ensure that the numerical results can reveal the surface effects clearly even for extremely thin surface layers. Numerical examples are carried out to exhibit the surface effects and some discussions are provided based on the results obtained.

关键词： micro-structures surface effects size-dependence state equation three-dimensional modeling

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Factorization of radiative leptonic D-meson decay with sub-leading power corrections

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Chinese Physics C 2021年第7期45卷 20-30页

作者： Long-sheng lu School of Physics Nankai University300071 TianjinChina

In this work,we calculate the sub-leading power contributions to radiative leptonic D→γν*** the first time,we provide the analytic expressions of next-to-leading power contributions and the error estimation associated with the power expansion of O(∧_(QCD)/m_(c)).In our calculation,we adopt two different models of the D-meson distribution amplitudesφ^(+)_(D,Ⅰ)andφ^(+)_(DⅡ).Within the framework of QCD factorization as well as the dispersion relation,we evaluate the soft contribution up to the next-to-leading logarithmic accuracy and also consider the higher-twist contribution from the two-particle and three-particle distribution ***,we find that all the sub-leading power contributions are significant atλd(μ0)354 MeV,and the next-to-leading power contributions lead to 143%inφ^(+)_(D,Ⅰ)and 120%inφ^(+)_(DⅡ)corrections to leading power vector form factors with Eγ=0.5 *** the corrections from the higher-twist and local sub-leading power contributions are enhanced with increasing inverse moment,it is difficult to extract an appropriate inverse moment of the D-meson distribution *** predicted branching fractions are(1.88^(+0.36)_(0.29))×10^(-5)forφ^(+)_(D,Ⅰ)and(2.31^(+0.65)_(-0.54))×10^(-5)forφ^(+)_(DⅡ).

关键词： factorization D-meson radiative leptonic decay sub-leading power correction

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Effects of electric parameters on microstructure and properties of MAO coating fabricated on ZK60 Mg alloy in dual electrolyte

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Rare Metals 2012年第2期31卷 172-177页

作者： Chen, Jing Wang, Zexin lu, sheng School of Materials Science and Engineering Jiangsu University of Science and Technology Zhenjiang 212003 China School of Mechanical Engineering Jiangsu University of Science and Technology Zhenjiang 212003 China

Micro-arc oxidation (MAO) process was carried out in a dual electrolyte system of NaAlO 2 and Na 3 PO 4 on ZK60 Mg alloys to explore the effect of electric parameters including current density, frequency, duty cycle and oxidation time on the evolution of coatings and other characteristics. The microstructural characteristics of coatings were observed by scanning electron microscopy (SEM) combined with the analysis of voltage-time responses during MAO process. Test of weight loss was conducted at a 3.5% NaCl solution to assess the resistance to corrosion. The results indicate that the current density and duty cycle play key roles on the coating quality. The peak voltage during MAO process increased with the increase in current density but the coating would be more easily detached when the current density was beyond a critical value. Voltage during MAO and microstructure of the coating were affected remarkably by duty cycle, and corrosion resistance was improved greatly when duty cycle was 40%. By means of single variable experiments, MAO process with optimized electric parameters was developed, which corresponds to the current density of 20 A dm 2 , frequency of 500 Hz, duty cycle of 40% and oxidation time of 15 min.

关键词： magnesium alloys micro-arc oxidation electrical parameters microstructure performance

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