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Robust fixed-time flight controller for a dual-system convertible UAV in the cruise mode

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Defence Technology（防务技术） 2024年第9期39卷 53-66页

作者： lulu chen Zhenbao Liu Qingqing Dang Wen Zhao Wenyu chen School of Civil Aviation Northwestern Polytechnical UniversityXi'an 710072China Shenzhen Research Institute of Northwestern Polytechnical University Shenzhen 518057China Air and Missile Defense College Air Force Engineering UniversityXi'an 710051China

This paper investigates the attitude tracking control problem for the cruise mode of a dual-system convertible unmanned aerial vehicle(UAV)in the presence of parameter uncertainties,unmodeled uncertainties and wind ***,a fixed-time disturbance observer(FXDO)based on the bi-limit homogeneity theory is designed to estimate the lumped disturbance of the convertible UAV ***,a fixed-time integral sliding mode control(FXISMC)is combined with the FXDO to achieve strong robustness and chattering ***-limit homogeneity theory and Lyapunov theory are applied to provide detailed proof of the fixed-time ***,numerical simulation experimental results verify the robustness of the proposed algorithm to model parameter uncertainties and wind *** addition,the proposed algorithm is deployed in a open-source UAV autopilot and its effectiveness is further demonstrated by hardware-in-the-loop experimental results.

关键词： Convertible UAV Flight control Disturbance observer Fixed-time control

Homeostatic regulation of NAD(H)and NADP(H)in cells

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Genes & Diseases 2024年第5期11卷 285-299页

作者： Luojun chen Xiaoke Xing Pingfeng Zhang lulu chen Huadong Pei Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubei 430062China Department of Oncology Georgetown Lombardi Comprehensive Cancer CenterGeorgetown University Medical CenterWashingtonDC 20057USA

Nicotinamide adenine dinucleotide(NAD^(+))/reduced NAD^(+)(NADH)and nicotinamide adenine dinucleotide phosphate(NADP^(+))/reduced NADP^(+)(NADPH)are essential metabolites involved in multiple metabolic pathways and cellular ***^(+)and NADH redox couple plays a vital role in catabolic redox reactions,while NADPH is crucial for cellular anabolism and antioxidant *** NAD(H)and NADP(H)homeostasis is crucial for normal physiological activity and is tightly regulated through various mechanisms,such as biosynthesis,consumption,recycling,and conversion between NAD(H)and NADP(H).The conversions between NAD(H)and NADP(H)are controlled by NAD kinases(NADKs)and NADP(H)phosphatases[specifically,metazoan SpoT homolog-1(MESH1)and nocturnin(NOCT)].NADKs facilitate the synthesis of NADP^(+)from NAD^(+),while MESH1 and NOCT convert NADP(H)into NAD(H).In this review,we summarize the physiological roles of NAD(H)and NADP(H)and discuss the regulatory mechanisms governing NAD(H)and NADP(H)homeostasis in three key aspects:the transcriptional and posttranslational regulation of NADKs,the role of MESH1 and NOCT in maintaining NAD(H)and NADP(H)homeostasis,and the influence of the circadian clock on NAD(H)and NADP(H)*** conclusion,NADKs,MESH1,and NOCT are integral to various cellular processes,regulating NAD(H)and NADP(H)*** of these enzymes results in various human diseases,such as cancers and metabolic ***,strategies aiming to restore NAD(H)and NADP(H)homeostasis hold promise as novel therapeutic approaches for these diseases.

关键词： MESH1 NAD(H) NADK NADP(H) Nocturnin

4-Nitrocatechol as a novel matrix for low-molecular-weight compounds in situ detection and imaging in biological tissues by MALDI-MSI

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Chinese Chemical Letters 2024年第6期35卷 486-490页

作者： Hualei Xu Manman Han Haiqiang Liu Liang Qin lulu chen Hao Hu Ran Wu chenyu Yang Hua Guo Jinrong Li Jinxiang Fu Qichen Hao Yijun Zhou Jinchao Feng Xiaodong Wang Key Laboratory of Mass Spectrometry Imaging and Metabolomics(Minzu University of China) State Ethnic Affairs CommissionBeijing 100081China College of Life and Environmental Sciences Centre for Imaging&Systems BiologyMinzu University of ChinaBeijing 100081China

Low-molecular-weight(LMW)compounds are ubiquitous in living organisms and play essential roles in biological *** direct analysis of LMW compounds in biological tissues by matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI)could provide a more comprehensive understanding of their essential ***,we evaluated 4-nitrocatechol(4-NC)as a novel positive-ion matrix for enhancing in situ detection and imaging of LMW compounds from the rat liver,brain,and germinating Chinese-yew seed by *** results showed that the 4-NC possessed remarkable features,including strong ultraviolet absorption,uniform matrix crystal,excellent chemical stability,and fewer matrix-related background *** use of 4-NC led to the successful detection of 232,218,and193 LMW compounds from the three abovementioned tissue sections,***,the use of 4-NC improved the imaging quality of LMW compounds in tissue sections through MALDI-MSI and has the potential as a matrix for MALDI tissue imaging of LMW compounds.

关键词： MALDI-MSI 4-Nitrocatechol LMW compounds In situ detection Tissue imaging

Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli Xu Zhuojun Xin Qiuyu Cao Jiaojiao Huang Xianglin Wu Yanan Huo Qin Wan Yingfen Qin Ruying Hu Lixin Shi Qing Su Xuefeng Yu Li Yan Guijun Qin Xulei Tang Gang chen Min Xu Tiange Wang Zhiyun Zhao Zhengnan Gao Guixia Wang Feixia Shen Zuojie Luo Li chen Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Tao Yang Huacong Deng lulu chen Tianshu Zeng Jiajun Zhao Yiming Mu Shengli Wu Yuhong chen Jieli Lu Weiqing Wang Guang Ning Yu Xu Yufang Bi Mian Li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian Provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong University Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with *** included 104538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life *** isotemporal substitution models,we found that substituting 1 h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD ***-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working *** stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long *** pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active *** U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical *** divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

基于视觉障碍人群需求分析的生活性街道无障碍环境评价——以哈尔滨历史城区为例

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科技导报 2024年第17期42卷 130-143页

作者：戴锏陈心朗陈璐露王春琦哈尔滨工业大学建筑与设计学院哈尔滨150006 自然资源部寒地国土空间规划与生态保护修复重点实验室哈尔滨150006 福建省城乡规划设计研究院福州350003

以视障人群的出行需求为切入点,以出行必经的城市生活性街道无障碍环境为研究对象。首先选取18位视障人群进行半结构化访谈,同时通过开源数据与实地调研获取研究区域的建成环境数据;其次基于扎根理论,将视障人群出行意愿的强烈程度与出... 详细信息

以视障人群的出行需求为切入点,以出行必经的城市生活性街道无障碍环境为研究对象。首先选取18位视障人群进行半结构化访谈,同时通过开源数据与实地调研获取研究区域的建成环境数据;其次基于扎根理论,将视障人群出行意愿的强烈程度与出行需求进行关联,即“可以出行”对应安全性、“方便出行”对应便捷性、“乐意出行”对应舒适性,从安全性、便捷性及舒适性3个维度建构生活性街道无障碍环境评价体系;最后以哈尔滨历史城区道里片区生活性街道为实证对象,对街道无障碍环境进行评价,总结其问题与空间特征,以此提出视障人群的街道无障碍设施类型多样化空间优化策略。

关键词：视觉障碍人群生活性街道扎根理论无障碍环境评价哈尔滨历史城区

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涡旋波超表面研究现状与应用进展

科技导报 2024年第12期42卷 107-124页

作者：司黎明陈璐璐孙厚军吕昕北京理工大学集成电路与电子学院北京100081 毫米波与太赫兹技术北京市重点实验室北京100081 北京理工大学唐山研究院唐山063000

涡旋波超表面以其独特的电磁波操控能力和轨道角动量(OAM)特性,为电磁波的精准调控和应用提供了新的自由度。阐述了涡旋波的基本理论,包括其产生的原理及携带的轨道角动量的特性。介绍了涡旋波超表面的两大类型——反射型和透射型超表面... 详细信息

涡旋波超表面以其独特的电磁波操控能力和轨道角动量(OAM)特性,为电磁波的精准调控和应用提供了新的自由度。阐述了涡旋波的基本理论,包括其产生的原理及携带的轨道角动量的特性。介绍了涡旋波超表面的两大类型——反射型和透射型超表面,总结了涡旋波测量技术,为评估涡旋波超表面的性能提供了科学有效的方法。进而介绍了涡旋波超表面在提高无线通信系统的网络空间安全、数据传输容量、雷达系统的目标探测能力以及全息成像技术的成像质量等方面的应用。对涡旋波超表面的未来发展方向进行了展望,包括高阶多模式OAM波的研究、远距离传输中波束发散问题的解决、可重构涡旋波超表面的设计、OAM隐秘信号传输以及多通道复用技术的开发等,为网络空间安全的建设提供支撑,为无线通信、雷达探测以及光学成像等领域提供更加高效、灵活的技术解决方案。

关键词：涡旋波超表面轨道角动量

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燕麦活性物质的研究综述

现代食品 2024年第4期30卷 139-141页

作者：陈露露宜春学院化学与生物工程学院江西宜春336000

相关研究显示,食用燕麦可以降低患高血脂症与糖尿病的风险,燕麦在保健、食品及其他行业中具有广泛的应用前景。因此,本文叙述了燕麦的主要活性成分,阐述了燕麦活性物质的作用,展望了今后燕麦的研究方向,旨在为研发燕麦产品提供相应的参考。

关键词：燕麦活性物质农作物

研究生心理支持体系构建的国内外经验与中国路径

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中国高教研究 2024年第6期 77-84页

作者：邓丽芳陈露露王姝怡北京航空航天大学人文社会科学学院北京100191

解决研究生的心理健康问题,既要看到问题本身,也要看到问题背后的诉求。研究生心理支持体系建设是提升研究生教育质量的必然选择。结合深度访谈、问卷调查和比较分析,从现实样态与国内外实践经验两方面窥见研究生心理支持体系的实然之... 详细信息

解决研究生的心理健康问题,既要看到问题本身,也要看到问题背后的诉求。研究生心理支持体系建设是提升研究生教育质量的必然选择。结合深度访谈、问卷调查和比较分析,从现实样态与国内外实践经验两方面窥见研究生心理支持体系的实然之貌。研究发现,研究生心理支持体系应当包括发展性支持、预防性支持和干预性支持三大核心要素;当前我国研究生对发展性支持和干预性支持满意率良好,但对预防性支持满意率偏低;以法律/政策文件为引导、健全研究生心理支持组织、配齐配强人才队伍和加大研究生心理支持经费投入是国内外研究生心理支持的主要经验。对此,研究生心理支持体系应从“重治轻防”转向“发展为先,重防优治”,同时优化心理支持实施过程和确保各参与主体分工明确。

关键词：研究生心理支持现实样态建设路径

线粒体凋亡在胃癌中的调控机制及中医药干预研究进展

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中国实验方剂学杂志 2024年第14期30卷 259-269页

作者：陈露露陈玉婵宋忠阳赵海宏张茂福张志明甘肃省中医药大学甘肃中医药大学附属医院甘肃省中医院

胃癌（GC）是世界上最常见癌症之一，其症状隐匿不显，发病机制复杂且尚未明确，具有高发病率、高死亡率、预后不良等特点。线粒体凋亡作为经典细胞凋亡途径之一，在GC逃避细胞凋亡中被广泛描述，可通过氧化应激、细胞周期、线粒体膜电... 详细信息

胃癌（GC）是世界上最常见癌症之一，其症状隐匿不显，发病机制复杂且尚未明确，具有高发病率、高死亡率、预后不良等特点。线粒体凋亡作为经典细胞凋亡途径之一，在GC逃避细胞凋亡中被广泛描述，可通过氧化应激、细胞周期、线粒体膜电位、线粒体易位等机制介导线粒体凋亡参与GC增殖、侵袭及转移等过程，同时也是中医药（TCM）干预恢复GC线粒体功能的潜在靶点之一。TCM基于“中医脾-线粒体相关”理论，阐述脾虚失荣、癌毒内结是线粒体凋亡之根本，确立以“健脾复其本、抗癌解毒攻其根”为基本治疗原则，通过抑制氧化应激、促进细胞周期停滞、下调线粒体膜电位等多种途径促进线粒体凋亡，改善GC能量代谢障碍、恢复线粒体结构及功能，有效干预GC的发生发展，具有不良反应小、耐药性低的独特优势。但线粒体凋亡在GC中的作用机制及TCM干预线粒体凋亡治疗GC的作用靶点尚缺乏系统性评述。因此，该文从线粒体凋亡对GC的发生发展的影响及TCM干预线粒体凋亡治疗GC的作用进行系统性整理、归纳，以期为GC的治疗及进一步的研究提供一定的文献及理论参考依据。

关键词：胃癌(GC) 细胞凋亡线粒体中医药研究进展