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X染色体失活偏移与反复自然流产关系的meta分析

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中国计划生育学杂志 2024年第4期32卷 730-737页

作者：王璐杨梦怡赵璐璐霍正浩王永军首都医科大学附属北京积水潭医院 100096 宁夏医科大学教育部生育力保持省部共建重点实验室

目的:探讨X染色体失活偏移(SXCI)与反复自然流产(RSA)之间的关系。方法:计算机检索PubMed、Medline、Cochraene、CNKI、CBM及万方等数据库,搜集自建库至2023年6月有关SXCI与RSA关系的病例-对照研究文献。采用RevMan 5.3和Stata 16.0软... 详细信息

目的:探讨X染色体失活偏移(SXCI)与反复自然流产(RSA)之间的关系。方法:计算机检索PubMed、Medline、Cochraene、CNKI、CBM及万方等数据库,搜集自建库至2023年6月有关SXCI与RSA关系的病例-对照研究文献。采用RevMan 5.3和Stata 16.0软件对严格筛选后纳入的15项研究中3706例女性(病例组1673例,对照组2033例)相关数据进行meta分析。结果:总体分析中,病例组SXCI比例显著高于对照组(OR=1.68,95%CI 1.29~2.18);不同程度分层分析中,中度SXCI比例在病例组和对照组间的差异无统计学意义(OR=1.11,95%CI 0.56~2.18),高度(OR=2.32,95%CI 1.31~4.11)和极端(OR=4.71,95%CI 1.77~12.52)SXCI比例在病例组均显著增高;不同流产次数分层分析中,流产≥2次(OR=5.06,95%CI 2.46~10.40)和流产≥3次(OR=2.48,95%CI 1.66~3.68)时,病例组高度和极端SXCI比例均显著高于对照组。结论:SXCI,尤其是高度和极端SXCI与RSA的发生风险增大显著关联,且流产次数越多,这种关联性可能越明显。

关键词：反复自然流产 X染色体失活偏移 meta分析

Robust fixed-time flight controller for a dual-system convertible UAV in the cruise mode

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Defence Technology（防务技术） 2024年第9期39卷 53-66页

作者： lulu Chen Zhenbao Liu Qingqing Dang Wen zhao Wenyu Chen School of Civil Aviation Northwestern Polytechnical UniversityXi'an 710072China Shenzhen Research Institute of Northwestern Polytechnical University Shenzhen 518057China Air and Missile Defense College Air Force Engineering UniversityXi'an 710051China

This paper investigates the attitude tracking control problem for the cruise mode of a dual-system convertible unmanned aerial vehicle(UAV)in the presence of parameter uncertainties,unmodeled uncertainties and wind ***,a fixed-time disturbance observer(FXDO)based on the bi-limit homogeneity theory is designed to estimate the lumped disturbance of the convertible UAV ***,a fixed-time integral sliding mode control(FXISMC)is combined with the FXDO to achieve strong robustness and chattering ***-limit homogeneity theory and Lyapunov theory are applied to provide detailed proof of the fixed-time ***,numerical simulation experimental results verify the robustness of the proposed algorithm to model parameter uncertainties and wind *** addition,the proposed algorithm is deployed in a open-source UAV autopilot and its effectiveness is further demonstrated by hardware-in-the-loop experimental results.

关键词： Convertible UAV Flight control Disturbance observer Fixed-time control

Source apportionment and specific-source-site risk of quinolone antibiotics for effluent-receiving urban rivers and groundwater in a city, China

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Journal of Environmental Sciences 2024年第10期144卷 185-198页

作者： Yu zhao Yuanmeng Song lulu Zhang Bo zhao Mengqi Lu Jiansheng Cui Wenzhong Tang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of ScienceBeijing 100085China College of Environment Science and Engineering Hebei University of Science and TechnologyShijiazhuang 050000China University of Chinese Academy of Sciences Beijing 100049China

There is a large surface-groundwater exchange downstream ofwastewater treatment plants(WWTPs),and antibiotics upstream may influence sites downstream of ***,samples from 9 effluent-receiving urban rivers(ERURs)and 12 groundwater sites were collected in Shijiazhuang City in December 2020 and April *** ERURs,8 out of 13 target quinolone antibiotics(QNs)were detected,and the total concentration of QNs in December and April were 100.6-4,398 ng/L and 8.02–2,476 ng/L,*** groundwater,all target QNs were detected,and the total QNs concentration was 1.09–23.03 ng/L for December and 4.54–170.3 ng/L for *** distribution of QNs was dissimilar between ERURs and *** QN concentrations were weakly correlated with land use types in the *** results of a positive matrix factorization model(PMF)indicated four potential sources of QNs in both ERURs and groundwater,and WWTP effluents were the main source of *** December to April,the contribution of WWTP effluents and agricultural emissions increased,while livestock activities *** value decomposition(SVD)results showed that the spatial variation of most QNs was mainly contributed by sites downstream(7.09%-88.86%)of ***,a new method that combined the results of SVD and PMF was developed for a specific-source-site risk quotient(SRQ),and the SRQ for QNs was at high level,especially for the sites downstream of *** temporal variation,the SRQ for WWTP effluents,aquaculture,and agricultural emissions ***,in order to control the antibiotic pollution,more attention should be paid to WWTP effluents,aquaculture,and agricultural emission sources for the benefit of sites downstream of WWTPs.

关键词： Source apportionment Singular value decomposition Positive matrix factorization model Quinolone antibiotics(QNs) Specific-source-site risk quotient(SRQ) WWTP effluents

Knowledge, attitude, and practice toward disease prevention among a high-risk population for chronic obstructive pulmonary disease: A cross-sectional study

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International Journal of Nursing Sciences 2023年第2期10卷 238-244页

作者： lulu zhao Qinghua zhao Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Nursing The People’s Hospital of DazuChongqingChina

Objective This study aimed to describe the current situation of knowledge,attitude,and practice(KAP)of chronic obstructive pulmonary disease(COPD)prevention among a high-risk population for *** A cross-sectional survey was conducted.A total of 241 participants at risk of COPD were selected who visited the respiratory outpatient department of a Class A tertiary hospital in Chongqing,China from January to December 2021.A self-developed COPD prevention KAP assessment was used for evaluation which included knowledge(21 items),attitude(9 items),and practice(9 items)three dimension,39 *** The average overall KAP score was 68.29±12.91,with scores for the knowledge,attitude,and practice dimension was 68.75±18.07,71.13±15.09 and 65.00±20.93,*** the people at risk of COPD,76.8%experienced a moderate level of KAP toward COPD prevention,while 22.0%were at a poor *** differences in the KAP scores were based on gender,educational level,occupation,type of medical insurance,smoking,and passive smoking status(P<0.05).The male COPD high-risk group has better KAP toward COPD prevention than the female group(P<0.05).The knowledge and attitude of COPD prevention present worse in people with a high risk of COPD aged 70 or above,primary school and below educational level,and farmers(P<0.05).Smoking and passive smoking groups have higher recognition of the knowledge but the lower practice of COPD prevention(P<0.05).Conclusion The participants with a high risk of COPD had a moderate level of KAP for COPD prevention,in which the understanding and action on vaccination and lung function test was weak,but an active attitude for *** is necessary to implement tailored health education interventions to their characteristics to reduce the incidence and development of COPD.

关键词： Chronic obstructive pulmonary disease Risk Knowledge Attitudes Practice

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焦化废水处理研究综述

燃料与化工 2024年第5期55卷 1-3,13页

作者：尚彦宏侯冬梅刘原麟赵璐璐辽宁科技大学化工学院鞍山114051 中冶焦耐(大连)工程技术有限公司大连116085 辽宁省低碳焦化专业技术创新中心大连116085

随着我国能源需求的快速增长,焦化废水的产量也随之增高。因焦化废水存在难以降解、污染程度高等问题,一直受到焦化行业广泛关注。通过重点论述和分析焦化废水处理技术的最新研究成果,对焦化废水处理的未来研究方向进行了展望。

关键词：焦化废水处理工艺环境污染

Atomistic insight into ordered defect superstructures at novel grain boundaries in CuO nanosheets: From structures to electronic properties

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Nano Research 2019年第5期12卷 1099-1104页

作者： lulu zhao Lei Li Huaping Sheng He Zheng Shuangfeng Jia Weiwei Meng Huihui Liu Fan Cao Huayu Peng Jianbo Wang School of Physics and Technology Center for Electron MicroscopyMOE Key Laboratory of Artificial Micro-and Nano-structuresand Institute for Advanced StudiesWuhan UniversityWuhan 430072China Science and Technology on High Strength Structural Materials Laboratory Central South UniversityChangsha 410083China

Determining atomistic structures of grain boundaries (GBs) is essential to understand structure--property interplay in ***,different GB superstructures in CuO nanosheets,including (111) and (114) twinning boundaries (TBs) and (002)/(223) GB,are *** the lower-energy stoichiometric (111) TB,both experimental and first-principles investigations reveal a severe segregation of Cu and O vacancies and a nonstoichiometric property at (114) TB,which may facilitate ionic transportation and provide space for elemental *** importantly,the calculated electronic structures have shown the increased conductivity as well as the unanticipated magnetism in both (114) TB and (002)/(223) *** findings could contribute to the race towards the property-directing structural design by GB engineering.

关键词： grain boundarie satomistic structure electronic property scanning transmission electron microscopy (STEM) first-principles

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民族药三尖杉叶的生药学研究

中药与临床 2024年第4期15卷 24-31页

作者：先蕊李倩卿艳赵璐璐郑雯兰志琼李敏成都中医药大学药学院西南特色中药资源国家重点实验室四川省药品检验研究院国家药品监督管理局中成药质量评价重点实验室

目的：主要开展我国多民族用药三尖杉叶的生药学研究，为其质量标准的建立奠定基础。方法：通过文献考证和实地调研对民族药三尖杉的药用情况和资源分布进行整理；采用性状、显微、薄层色谱鉴别法研究三尖杉叶鉴定特征；采用紫外-可见... 详细信息

目的：主要开展我国多民族用药三尖杉叶的生药学研究，为其质量标准的建立奠定基础。方法：通过文献考证和实地调研对民族药三尖杉的药用情况和资源分布进行整理；采用性状、显微、薄层色谱鉴别法研究三尖杉叶鉴定特征；采用紫外-可见分光光度法（UV-Vis）建立三尖杉总生物碱含量测定方法；采用半数致死量法考察药材急性毒性。结果：三尖杉叶在我国苗族、瑶族、汉族等多个民族均有药用，可收敛止血，主要治疗内脏出血，现代多提纯其生物碱制成注射液用于癌症治疗；其主要鉴别要点为：叶下表面具两条白色气孔带，较绿色边带宽3～5倍；粉末显微多见排列整齐的平轴式气孔；以高三尖杉酯碱为对照品建立的三尖杉叶薄层色谱鉴别法分离度高、斑点清晰，方法可行；UV-Vis测定总生物碱含量的回归方程具有良好的线性关系（r=0.999 6），不同产地样品平均含量为26.82%(n=10)；急毒实验结果表明：10～15g煎汤内服无毒性。结论：通过生药学研究，掌握了三尖杉叶的多民族药用和资源情况，确定了药材性状和显微鉴别特征，建立了薄层色谱鉴别和总生物碱含量测定方法，并通过安全性实验验证了其用法和用量，为保证民族药三尖杉叶临床用药的安全、有效和稳定，以及进一步开发利用提供了科学依据。

关键词：民族药三尖杉叶调研性状和显微鉴定薄层色谱急性毒性

Probing shock geometry via the charge to mass ratio dependence of heavy ion spectra from multiple spacecraft observations of the 2013 November 4 event

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Research in Astronomy and Astrophysics 2016年第12期16卷 101-106页

作者： lulu zhao Gang Li Glenn M. Mason Christina Cohen Richard Mewaldt Mihir Desai Rob Ebert Maher Al-Dayeh Department of Physics and Space Sciences Florida Institute of Technology FL 32901 USA Department of Space Science and CSPAR University of Alabama in Hun-tsville Huntsville Alabama 35801 USA Applied Physics Laboratory Johns Hopkins University Laurel MD 20723 USA California Institute of Technology Pasadena CA 91125 USA Southwest Research Institute San Antonio TX 78228 USA University of Texas at San Antonio San Antonio TX 78249 USA

In large Solar Energetic Particle （SEP） events, ions can be accelerated at coronal mass ejection （CME）-driven shocks to very high energies. The spectra of heavy ions in many large SEP events show features such as roll-overs or spectral breaks. In some events when the spectra are plotted in terms of energy/nucleon, they can be shifted relative to each other to make the spectral breaks align. The amount of shift is charge to mass ratio （Q/A） dependent and varies from event to event. This can be understood if the spectra of heavy ions are organized by the diffusion coefficients （Cohen et al. 2005）. In the work of Li et al. （2009）, the Q/A dependence of the scaling is related to shock geometry when the CME-driven shock is close to the Sun. For events where multiple in-situ spacecraft observations exist, one may expect that different spacecraft are connected to different portions of the CME-driven shock that have different shock geometries, therefore yielding different Q/A dependence. In this work, we examine one SEP event which occurred on 2013 November 4. We study the Q/A dependence of the energy scaling for heavy ion spectra using helium, oxygen and iron ions. Observations from STEREO-A, STEREO-B and ACE are examined. We find that the scalings are different for different spacecraft. We suggest that this is because ACE, STEREO- A and STEREO-B are connected to different parts of the shock that have different shock geometries. Our analysis indicates that studying the Q/A scaling of in-situ particle spectra can serve as a powerful tool to remotely examine the shock geometry for large SEP events.

关键词： Sun: particle emission -- acceleration of particles

Dietary methionine deficiency stunts growth and increases fat deposition via suppression of fatty acids transportation and hepatic catabolism in Pekin ducks

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1871-1886页

作者： Yongbao Wu Jing Tang Zhiguo Wen Bo Zhang Junting Cao lulu zhao Zhanbao Guo Ming Xie Zhengkui Zhou Shuisheng Hou State Key Laboratory of Animal Nutrition Key Laboratory of Animal(Poultry)Genetics Breeding and ReproductionMinistry of Agriculture and Rural AffairsInstitute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural Affairs Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China

Background:Although methionine(Met),the first-limiting dietary amino acid,has crucial roles in growth and regulation of lipid metabolism in ducks,mechanisms underlying are not well ***,the objective was to use dietary Met deficiency to investigate the involvement of Met in lipid metabolism and fat accumulation of Pekin ***:A total of 150 male Pekin ducks(15-d-old,558.5±4.4 g)were allocated into 5 groups(6 replicates with 5 birds each)and fed corn and soybean meal-based diets containing 0.28%,0.35%,0.43%,0.50%,and 0.58%Met,respectively,for 4 ***-deficient(Met-D,0.28%Met)and Met-adequate(Met-A,0.43%Met)groups were selected for subsequent molecular ***,liver,and abdominal fat samples were collected to assess the genes and proteins involved in lipid metabolism of Pekin ducks and hepatocytes were cultured in vivo for ***:Dietary Met deficiency caused growth depression and excess fat deposition that were ameliorated by feeding diets with adequate *** triglyceride and non-esterified fatty acid concentrations increased(P<0.05),whereas serum concentrations of total cholesterol,low density lipoprotein cholesterol,total protein,and albumin decreased(P<0.05)in Met-D ducks compared to those in Met-A *** on hepatic proteomics analyses,dietary Met deficiency suppressed expression of key proteins related to fatty acid transport,fatty acid oxidation,tricarboxylic acid cycle,glycolysis/gluconeogenesis,ketogenesis,and electron transport chain;selected key proteins had similar expression patterns verified by qRT-PCR and Western blotting,which indicated these processes were likely *** vitro verification with hepatocyte models confirmed albumin expression was diminished by Met ***,in abdominal fat,dietary Met deficiency increased adipocyte diameter and area(P<0.05),and down-regulated(P<0.05)of lipolytic genes and proteins,suggesting Met deficiency may suppress lipolysis in ***

关键词： Fat deposition Hepatic catabolism Methionine deficiency Pekin duck Proteomics