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“治上焦如羽”在耳鼻咽喉疾病治疗中的应用

中国医药导报 2022年第15期19卷 133-135页

作者：孙红刘建华闫占峰矫璐璐朱雅静刘莉莉黄小芮张琳婧北京中医药大学东直门医院耳鼻喉科北京100700

温病学家吴鞠通提出“治上焦如羽”,即针对温病邪在上焦的病证,宜从“轻”施治。耳鼻咽喉居于人体头颈部,皆为清窍,位属上焦,非轻不能上达。临床治疗该部位的疾病多选用质地轻清之品,同时配合气味芳香与引经之药,以助药达病所,属“治上... 详细信息

温病学家吴鞠通提出“治上焦如羽”,即针对温病邪在上焦的病证,宜从“轻”施治。耳鼻咽喉居于人体头颈部,皆为清窍,位属上焦,非轻不能上达。临床治疗该部位的疾病多选用质地轻清之品,同时配合气味芳香与引经之药,以助药达病所,属“治上焦如羽”的范畴。本文基于“治上焦如羽”在耳鼻咽喉科常见疾病,尤其对疾病初期治疗中的具体应用展开了论述,以期更好地指导临床治疗。

关键词：治上焦如羽耳鼻咽喉疾病引经药

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刘建华教授治疗梅尼埃病的辨治思路

中国医药导报 2021年第12期18卷 162-165页

作者：朱雅静刘建华闫占峰矫璐璐刘思溟刘莉莉张琳婧王鑫北京中医药大学东直门医院耳鼻喉科北京100700

梅尼埃病是临床常见的耳源性眩晕疾病,因其眩晕易反复发作,导致听力下降,严重影响人们的生活和工作。刘建华教授认为本病的病因病机往往是因肝脾肾虚损,内生风、火、痰饮,以致蒙蔽清窍,发为眩晕。刘建华教授提倡分阶段论治,急则以息风... 详细信息

梅尼埃病是临床常见的耳源性眩晕疾病,因其眩晕易反复发作,导致听力下降,严重影响人们的生活和工作。刘建华教授认为本病的病因病机往往是因肝脾肾虚损,内生风、火、痰饮,以致蒙蔽清窍,发为眩晕。刘建华教授提倡分阶段论治,急则以息风、降火、化痰为主,同时也注重健脾、疏肝;缓则以健脾化饮、滋补肝肾为要。临证中善用药对,增强药效,精简组方。本文总结刘建华教授长期辨证治疗梅尼埃病的心得,并对临床典型案例加以阐述,以期为中医治疗梅尼埃病提供借鉴。

关键词：梅尼埃病眩晕分阶段论治祛风火痰补肝脾肾

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大直径水平受荷单桩的抗力组分分析及其应用

土木工程学报 2024年第8期57卷 72-82页

作者：王舸廖晨聪张璐璐林奖勤叶冠林张泽超上海交通大学海洋工程国家重点实验室上海200240 高新船舶与深海开发装备协同创新中心上海200240 上海市公共建筑和基础设施数字化运维重点实验室上海200240 中国长江三峡集团有限公司北京100038

现有海上风机单桩设计方法的改进主要从修正p-y曲线入手,较少涉及单桩抗力组分的研究。文章将大直径水平受荷单桩的桩-土相互作用分解为桩-土水平抗力p、侧壁摩阻力τz、基底水平摩阻力Fs、基底竖向抗力Fbot,建立含4类抗力弹簧的简化梁... 详细信息

现有海上风机单桩设计方法的改进主要从修正p-y曲线入手,较少涉及单桩抗力组分的研究。文章将大直径水平受荷单桩的桩-土相互作用分解为桩-土水平抗力p、侧壁摩阻力τz、基底水平摩阻力Fs、基底竖向抗力Fbot,建立含4类抗力弹簧的简化梁单元分析模型,通过三维有限元分析对工程试桩验算,提取各抗力弹簧的组分,明确大直径单桩的抗力组成和变化规律。结果表明,小长径比单桩的水平承载力主要由水平抗力(p-y抗力)控制,但侧壁摩阻力τz、基底水平摩阻力Fs不可忽略;大直径单桩变形模式由桩土相对刚度控制,长径比是影响单桩水平承载力组分变化的重要因素。在此基础上提出了p-y抗力组分曲线,并通过案例分析展示了修正单桩水平承载力的步骤和结果。

关键词：海上风电大直径单桩抗力组分桩-土相对刚度承载力修正

调和营卫治疗阻塞性睡眠呼吸暂停低通气综合征的临床思路

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现代中医临床 2019年第6期26卷 39-43页

作者：边芳子刘思溟闫占峰矫璐璐原晶晶郝鹏鹏刘莉莉刘巧平北京中医药大学东直门医院

阻塞性睡眠呼吸暂停低通气综合征是指患者在睡眠期间频繁出现呼吸暂停和低通气,常以鼾声不规律,或自觉明显憋气乃至反复憋醒为主要临床表现的疾病。从菅气、卫气的生成和运行等方面探讨营卫与睡眠的关系;从卫气受邪不入阴,营气亏虚、卫... 详细信息

阻塞性睡眠呼吸暂停低通气综合征是指患者在睡眠期间频繁出现呼吸暂停和低通气,常以鼾声不规律,或自觉明显憋气乃至反复憋醒为主要临床表现的疾病。从菅气、卫气的生成和运行等方面探讨营卫与睡眠的关系;从卫气受邪不入阴,营气亏虚、卫行于外两个角度阐述营卫不和与阻塞性睡眠呼吸暂停低通气综合征的关系。治疗上以调和营卫为主,以益气健脾、利湿祛浊,理气活血化瘀,利咽豁痰、通利鼻窍等为法;在运用中药治疗的基础上,可配合鼻内针刺治疗;并结合临床典型病案加以阐述。

关键词：阻塞性睡眠呼吸暂停低通气综合征鼾眠调和菅卫鼻内针刺

复发性良性阵发性位置性眩晕的中西医研究概况

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现代中医临床 2019年第2期26卷 72-76页

作者：边芳子矫璐璐闫占峰刘巧平刘思溟郝鹏鹏刘莉莉张琳婧北京中医药大学东直门医院北京100700

良性阵发性位置性眩晕(BPPV)治疗后,仍有一定比例患者症状无好转,或数天后再次发作,复发性BPPV是临床上难以解决的问题。从中西医两个角度探讨这个问题,对复发性BPPV的诊断、可能的发病机制、复发的危险因素和防治方法,以及中医病因病... 详细信息

良性阵发性位置性眩晕(BPPV)治疗后,仍有一定比例患者症状无好转,或数天后再次发作,复发性BPPV是临床上难以解决的问题。从中西医两个角度探讨这个问题,对复发性BPPV的诊断、可能的发病机制、复发的危险因素和防治方法,以及中医病因病机、分型论治和特色治疗等方面,予以系统论述,旨在探索更加有效的思路和方法,降低BPPV的复发率。认为通过综合分析患者体质、临床表现,依据和运用中医理论,对患者进行分型论治,作为手法复位后的辅助手段,采用个体化中西医结合治疗方案进行防治,在减轻眩晕症状,减少复发方面具有独特优势,中医药联合手法复位治疗BPPV有着广泛的应用前景。

关键词：良性阵发性位置性眩晕复发发病机制危险因素治未病

The effects of light illuminance and correlated color temperature on mood and creativity

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Building Simulation 2021年第3期14卷 463-475页

作者： Li Lan Sarra Hadji lulu Xia Zhiwei Lian Department of Architecture School of DesignShanghai Jiao Tong UniversityShanghai200240China

The lighting environment is one of the indoor environmental factors that may influence *** combined effects of illumination(300 lx vs.2000 lx)and color temperature(3000 K vs.6000 K)on mood and creativity were investigated in 24 *** exposure,participants completed questionnaires to assess their mood and lighting perceptions,performed creative and analytical tasks,and collected saliva samples for analysis of melatonin *** interactive effect of illuminance and color temperature on the mood was *** participants performed better on the performance of Flexibility,Fluency and Originality in the verbal creative task when they expressed higher positive mood(at 2000 lx,6000 K and 300 lx,3000 K)and performed better on the performance of Resistance to closure in the figural creative task when they reported the lowest positive mood(at 2000 lx,3000 K).Analytical thinking,including calculation and echoic memory skills,was facilitated at the lighting setting(300 lx,6000 K)that induced the least affective *** significant difference in melatonin concentration was *** evidence implies that the affective state of the occupants was influenced by light and that their creative performance was altered *** findings will help to elaborate a design guideline on the lighting environment according to the specific needs of different tasks.

关键词： lighting color temperature illumination mood creativity productivity

Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli Xu Zhuojun Xin Qiuyu Cao jiaojiao Huang Xianglin Wu Yanan Huo Qin Wan Yingfen Qin Ruying Hu Lixin Shi Qing Su Xuefeng Yu Li Yan Guijun Qin Xulei Tang Gang Chen Min Xu Tiange Wang Zhiyun Zhao Zhengnan Gao Guixia Wang Feixia Shen Zuojie Luo Li Chen Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Tao Yang Huacong Deng lulu Chen Tianshu Zeng Jiajun Zhao Yiming Mu Shengli Wu Yuhong Chen Jieli Lu Weiqing Wang Guang Ning Yu Xu Yufang Bi Mian Li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian Provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong University Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with *** included 104538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life *** isotemporal substitution models,we found that substituting 1 h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD ***-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working *** stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long *** pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active *** U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical *** divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

I3:A Self-organising Learning Workflow for Intuitive Integrative Interpretation of Complex Genetic Data

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Genomics, Proteomics & Bioinformatics 2019年第5期17卷 503-510页

作者： Yun Tan lulu Jiang Kankan Wang Hai Fang State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Bristol Renal School of Clinical SciencesUniversity of BristolBristol BS13NYUK Wellcome Centre for Human Genetics University of OxfordOxford OX37BNUK

We propose a computational workflow(I3)for intuitive integrative interpretation of complex genetic data mainly building on the self-organising *** illustrate the use in interpreting genetics of gene expression and understanding genetic regulators of protein phenotypes,particularly in conjunction with information from human population genetics and/or evolutionary history of human *** reveal that loss-of-function intolerant genes tend to be depleted of tissue-sharing genetics of gene expression in brains,and if highly expressed,have broad effects on the protein phenotypes *** suggest that this workflow presents a general solution to the challenge of complex genetic data interpretation.I3 is available at http://***/***.

关键词： Self-organising Human genetics Interpretation Evolution Machine learning

Bipartite consensus problem on matrix-valued weighted directed networks

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Science China(Information Sciences) 2021年第4期64卷 229-231页

作者： lulu PAN Haibin SHAO Yugeng XI Dewei LI Department of Automation Shanghai Jiao Tong University Key Laboratory of System Control and Information Processing Ministry of Education

Dear editor,Consensus turns out to be an important paradigm in coordination of multi-agent systems [1]. Previous studies largely concentrate on consensus problem over networks where the weights on edges are scalars, which cannot completely characterize the correlation of different dimensions corresponding to the state of an agent in the network.

关键词： Consensus Multi-agent systems Bipartite Consensus Antagonist interactions Networked systems