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Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 233-243页

作者： Hongmin LU Tiantian GUO Yue ZHANG Dewang LIU lulu hou Chengxue MA Mingwei XING College of Wildlife and Protected Area Northeast Forestry UniversityHarbin 150040China

Microplastics(MPs)have attracted growing attention worldwide as an increasingly prevalent environmental *** addition,chicken meat is currently the most widely consumed kind of poultry in the global *** demand for chicken is on the rise both at home and *** a result,the safety of chicken raising has also received significant *** lungs play an essential role in the physiological activities of chickens,and they are also the most vulnerable *** injury is difficult to repair after the accumulation of contaminants,and the mortality rate is high,which brings huge economic losses to *** research on the toxicity of MPs has mainly focused on the marine ecosystem,while the mechanisms of toxicity and lung damage in chickens have been poorly ***,this study explored the effects of exposure to polystyrene microplastics(PS-MPs)at various concentrations for 42 d on chicken ***-MPs could cause lung pathologies and ultrastructural abnormalities,such as endoplasmic reticulum(ER)swelling,inflammatory cell infiltration,chromatin agglutination,and plasma membrane ***,PS-MPs increased the expression of genes related to the heat shock protein family(Hsp60,Hsp70,and Hsp90),ER stress signaling(activating) transcription factor 6(ATF0),ATF4,protein kinase RNA-like ER kinase(PERK),and eukaryotic translation initiation factor 2 subunitα(eIF2a),pyroptosis-related genes(NOD)-,LRR-and pyrin domain-containing protein 3(NLRP3),apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC),interleukin-1β(IL-1β),cysteinyl aspartate-specific proteinase 1(Caspasel),and gasdermin-D(GSDMD),and the inflammatory signaling pathway(nuclear factor-kB(NF-kB),inducible nitric oxide synthase(iNOS),and cyclooxygenase-2(COX-2).The above results showed that PS-MP exposure could result in lung stress,ER stress,pyroptosis,and inflammation in *** findings provide new scientific clues for further research o

关键词： Polystyrene microplastics Endoplasmic reticulum stress Lung NLRP3 inflammasome Inflammation

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锂渣物化特性及其碱激发制备人造集料实验

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矿产综合利用 2024年第1期45卷 199-206页

作者：邹周宋亮谢晓东侯璐璐高杰新疆农业大学交通与物流工程学院新疆乌鲁木齐830091 新疆大学交通运输工程学院新疆乌鲁木齐830049 新疆交投建设管理有限责任公司新疆乌鲁木齐830099 华东交通大学土木建筑学院江西南昌330013

这是一篇陶瓷及复合材料领域的论文。伴随着我国锂矿冶炼规模增长,锂渣产量逐年增加,其资源化利用的必要性日趋凸显。为探明锂渣的物化性能及其作为胶凝材料制备人造集料的潜力,首先通过实验表征了宜春市锂云母锂渣和澳大利亚锂辉石锂... 详细信息

这是一篇陶瓷及复合材料领域的论文。伴随着我国锂矿冶炼规模增长,锂渣产量逐年增加,其资源化利用的必要性日趋凸显。为探明锂渣的物化性能及其作为胶凝材料制备人造集料的潜力,首先通过实验表征了宜春市锂云母锂渣和澳大利亚锂辉石锂渣的组成和性能,并分析其对碱激发性能的影响。其次,以氢氧化钠为碱激发剂,采用圆盘冷造粒法制备了两种锂渣人造集料,并测试了其抗压强度。最后,通过玻璃电极法、电感耦合等离子体质谱法、离子色谱法和分光光度法等实验论证了人造集料的环境风险。结果表明:锂云母锂渣的物化性质较锂辉石锂渣更适合用于碱激发制备人造集料,所制得的人造集料强度更高,液体浸出物也不具有环境危害性。

关键词：陶瓷及复合材料锂云母锂渣锂辉石锂渣碱激发人造集料

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不同剂量艾司氯胺酮对剖宫产术后产妇抑郁及疼痛程度的影响

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中国药业 2024年第7期33卷 88-91页

作者：朱玉昌侯璐璐汤富学王丽高静马健辉青岛大学附属山东省妇幼保健院山东济南250014 青岛大学附属泰安市中心医院山东泰安271000 山东省潍坊市人民医院山东潍坊261000

目的探讨不同剂量艾司氯胺酮对剖宫产术后产妇抑郁及疼痛程度的影响。方法选取青岛大学附属山东省妇幼保健院2021年10月至2022年10月收治的行剖宫产产妇330例,按随机数字表法分为对照组、低剂量组、高剂量组,各110例。剖宫产术毕,行患... 详细信息

目的探讨不同剂量艾司氯胺酮对剖宫产术后产妇抑郁及疼痛程度的影响。方法选取青岛大学附属山东省妇幼保健院2021年10月至2022年10月收治的行剖宫产产妇330例,按随机数字表法分为对照组、低剂量组、高剂量组,各110例。剖宫产术毕,行患者自控镇痛(PCIA)。3组产妇均予舒芬太尼50μg+酒石酸布托啡诺10 mg+昂丹司琼8 mg方案,低剂量组产妇加用艾司氯胺酮0.6 mg/kg,高剂量组产妇加用艾司氯胺酮1.2 mg/kg,均用0.9%氯化钠注射液稀释至100 mL。结果与对照组比较,低剂量组和高剂量组产妇术后3 d和7 d的爱丁堡产后抑郁量表(EPDS)评分均显著降低(P0.05)。结论高剂量艾司氯胺酮可有效降低剖宫产产妇的产后抑郁评分及抑郁发生率,改善剖宫产术后的疼痛程度,且安全性良好。

关键词：艾司氯胺酮剖宫产抑郁症产后镇痛剂量

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Chongqing Reviving

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Beijing Review 2009年第33期52卷 20-21页

作者： Yu Jijun,CuiJia and hou lulu

Chongqing’s economy has withstood the global financial chill and looks to growth Thousands of cargo ships are busy loading and unloading goods in front of Chaotianmen Square Dock,where the Yangtze and Jialingjiang ri... 详细信息

关键词： Chongqing Reviving

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Corrosion Behavior of Graphene Nanosheets Reinforced Magnesium Matrix Composites in Simulated Body Fluids

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 525-536页

作者： Liwen Chen Jianhui Jing lulu Zhang Jing Li Weipeng Chen Limin Li Yuan Zhao Hua hou Yuhong Zhao School of Materials Science and Engineering Collaborative Innovation Center of Ministry of Education and Shanxi Province for High-Performance Al/Mg Alloy MaterialsNorth University of ChinaTaiyuan 030051China Shanxi Key Laboratory of Advanced Manufacturing Technology School of Mechanical EngineeringNorth University of ChinaTaiyuan 030051China School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

Magnesium(Mg)alloy is considered as a promising biodegradable implant material but restricted to rapid ***,the new strategies based on thixomolding process had been explored to utilize the outstanding anti-permeability of graphene nanosheets(GNPs)while inhibit its galvanic corrosion with the matrix,so as to improve the corrosion resistance of *** agglomerate of GNPs with 0.9 wt%content is the main reason for the deterioration of corrosion performance due to the formation of micro-galvanic *** grain refinement of composites with 0.6 wt%content had positive effects on the better corrosion *** process adjusting,the unique distributions of GNPs along grain boundaries play a vital role in improving the corrosion *** can be ascribed to the following mechanisms:(I)The barriers can be established between the Mg matrix and corrosive medium,hence blocking the charge transfer at the interface;(II)The GNPs can effectively promote apatite deposition on the Mg matrix,leading to form dense apatite layers and prevent the further invasion of SBF;(III)The GNPs acting as reinforcements exists in the corrosion layer and apatite layer,impede the apatite layer falling off from the Mg *** findings broaden the horizon for biomedical applications in Mg matrix composites to realize desired performances.

关键词： Magnesium matrix composite Graphene nanosheets Corrosion resistance

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Accelerating electron transport in Eosin Y by bidentately bridging on BaSnO_(3)for noble-metal-free photocatalytic H 2 production

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Energy Storage and Saving 2023年第1期2卷 328-335页

作者： Jinwen Shi Huaiyu Lu Xing Kang lulu hou Feng Chen Yazhou Zhang Kang Chen Xiao Wang Xiangjiu Guan Lijing Ma International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi’an Jiaotong UniversityXi’an710049China State Key Laboratory for Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China Department of High-Tech Development Weichai Power Co.Ltd.WeifangShandong261061China China Petroleum Pipeline Engineering Co.Ltd. PipeChinaUrumqi830013China Department of New Energy Project Northwest Engineering Co.Ltd.PowerChinaXi’an710065China

The separation and transport of photogenerated carriers is regarded as a curial factor in photocatalytic H_(2)*** known in solar cells and photoelectron-chemistry,to strengthen the electron conduction for effective utilization of carriers,the electron transport material(ETM)is widely ***,inspired by the function of ETM,we adopted barium stannate(BaSnO_(3),labeled as BSO)as an excellent ETM which had the merits of high electron mobility,suitable conduction band position and simple preparation,to adjust the carrier kinetics of dye Eosin Y(EY)-sensitized photocatalytic ***,the photocatalytic system with the spatial sepa-ration sites of photogenerated carriers excitation and water reduction reaction was elaborately constructed,that was,dye EY-sensitized BSO(EY/BSO)for photocatalytic H_(2)*** photocatalytic H_(2)-production rate of EY/BSO(257𝜇mol·h^(−1)·g EY^(−1))in the absence of noble metals was 28.6 times higher than that of single EY(∼9𝜇mol·h^(−1)·g EY^(−1))under visible-light *** systematic and comprehensive characterizations,the formed electron transport channel by the bidentate bridging of EY on BSO could accelerate the transfer of photogenerated electrons from EY to BSO,promoting the effective separation of photogenerated carriers for the enhanced pho-tocatalytic ***,the water reduction reaction for H_(2)production proceeded on the surface of BSO that acted as the H_(2)-evolution cocatalyst,avoiding the use of high-cost noble ***,based on the well-proved ETM-based concept in the EY/BSO system,La-doped BaSnO_(3)(LBSO)with better electron trans-port ability was adopted to construct EY/LBSO system(344𝜇mol·h^(−1)·g EY^(−1))which showed better photocatalytic activity than EY/BSO.

关键词： Electron transport material Photocatalytic hydrogen production Barium stannate Dye sensitization

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Influence of Unconscious Emotional Control Goals Priming on Anticipatory Anxiety and Physiological Activity

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Health 2016年第14期8卷 1589-1602页

作者： lulu hou Xiufeng Yan Qi Jiang Huanzhen Wang Changran Li Institution of Mental Health Education Southwest University Chongqing China Faculty of Psychology Southwest University Chongqing China Organization Department of CPC DaTong Committee Datong China

Individuals frequently generate emotion during the anticipation process and the anticipatory emotion has an important adaptive significance, especially the negative anticipative emotion. Many researches used conscious emotion regulation strategy and successfully reduced negative anticipatory emotion. However, it is costly for our limited cognition. In the present study, we used sentence unscrambling tasks to prime unconscious emotion control goal and investigated its effect on anticipatory anxiety, including experience and physiological activity. The results showed that 1) relative to anticipating neutral images, participations’ anxiety experience and skin conductance level were higher when anticipating negative and unknown images;2) participants who had a unconscious emotion control goal primed achieved the same decrease in skin conductance as those explicitly instructed to reappraise, compared to a control group;3) heart rate was not affected by experiment condition and anticipation type. Together, these findings suggest that unconscious emotion regulation may provide an effective mean of regulating negative anticipatory emotion.

关键词： Anticipatory Anxiety Physiological Activity Unconscious Emotional Control Goals Priming

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3种微藻藻际环境生物多样性及相互作用关系研究进展

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海洋湖沼通报 2022年第4期44卷 154-159页

作者：侯路路李蕾中国海洋大学山东青岛266003 烟台市海洋经济研究院山东烟台264000

藻际环境中,微藻与藻际微生物通过多种胞外产物进行一系列的营养物质交换、信息信号传递以及基因代谢调控。不同藻际环境具有特异性,在生物要素的物质循环、微食物环以及藻-菌(藻、其他生物)相互作用中差异显著。本文综述了3种微藻-小球... 详细信息

藻际环境中,微藻与藻际微生物通过多种胞外产物进行一系列的营养物质交换、信息信号传递以及基因代谢调控。不同藻际环境具有特异性,在生物要素的物质循环、微食物环以及藻-菌(藻、其他生物)相互作用中差异显著。本文综述了3种微藻-小球藻(Chlorella)、杜氏盐藻(Dunaliella)和雨生红球藻(Haematococcus)藻际环境的藻际微生物多样性特征、相互作用机制以及微生态调节等方面的研究,旨在进一步加深对藻际环境生物多样性的理解,为通过藻际环境中的相互作用构建多功能藻-菌生物互作研究平台提供可操作的途径和理论基础。

关键词：藻际环境生物多样性相互作用群体感应信号微食物环

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基于Spark架构的艺术学慕课资源协同过滤推荐算法研究

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现代电子技术 2020年第3期43卷 162-164,168页

作者：侯璐璐宝鸡文理学院

传统资源协同过滤推荐算法MAE值偏高,因此提出基于Spark架构的艺术学慕课资源协同过滤推荐算法。采用分级响应形式,建立用户⁃资源评分关系模型,用户对资源的评分减掉该用户评分平均值,完成资源协同过滤相似度计算的优化,引入集成度高的S... 详细信息

传统资源协同过滤推荐算法MAE值偏高,因此提出基于Spark架构的艺术学慕课资源协同过滤推荐算法。采用分级响应形式,建立用户⁃资源评分关系模型,用户对资源的评分减掉该用户评分平均值,完成资源协同过滤相似度计算的优化,引入集成度高的Spark架构,预测用户对资源的评分并生成推荐列表,实现艺术学慕课资源的精准推荐。经过与两种传统算法的对比实验结果可知,研究的算法在不同比例训练集和测试集的情况下,MAE值均低于两种传统方法,说明基于Spark架构的艺术学慕课资源协同过滤推荐算法推荐精度更高,性能更好。

关键词：协同过滤推荐算法 Spark架构艺术学慕课资源用户评分预测用户⁃资源评分关系模型相似度计算

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领域与地盘:中西方权地观之比较

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地理科学 2019年第7期39卷 1055-1062页

作者：侯璐璐刘云刚中山大学地理科学与规划学院/广东省城市化与地理环境空间模拟重点实验室广东广州510275 华南师范大学地理科学学院广东广州510631

通过对中西权地观中情感属性、权力属性、空间属性对比,提出地盘作为关系的空间投影发挥作用。根据塑造地盘的关系属性的不同,将地盘分为情感型地盘、工具型地盘及混合型地盘3类。地盘体系中讲究人情、信任与求和,通过模糊正规权力的空... 详细信息

通过对中西权地观中情感属性、权力属性、空间属性对比,提出地盘作为关系的空间投影发挥作用。根据塑造地盘的关系属性的不同,将地盘分为情感型地盘、工具型地盘及混合型地盘3类。地盘体系中讲究人情、信任与求和,通过模糊正规权力的空间边界对抗空间阻力,形成缓冲我与非我的圈层结构。

关键词：领域地盘权地观关系政治地理学

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