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Morphological characteristics and evolution model of slope units along loess gully cross section

Frontiers of Earth Science 2024年第1期18卷 17-29页

作者： lulu LIU Fayuan LI Xue YANG Jianhua cheng School of Geography Nanjing Normal UniversityNanjing 210023China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China Key Laboratory of Virtual Geographic Environment(Ministry of Education) Nanjing Normal UniversityNanjing 210023China

Gully morphology is an important part of loess landform *** with gully development,the variation of its cross section is the most significant,and it can intuitively reflect the characteristics of the lateral widening of the gully ***,in-depth research of the variation of the cross-sectional morphology of the gully is helpful to understanding the development process of the loess *** on the DEMs(Digital Elevation Model)of nine periods of an indoor simulated loess small watershed,this paper studies the evolution model of a complete branch ditch in the watershed using the digital terrain analysis theory and *** show that with the development of the gully,the average gradient of the gully slope continuously decreases,and the slope morphology is mostly a concave slope along the slope *** degree of downward concave first increases and then gradually tends to be *** gully erosion mode is gradually transformed from downward cutting erosion to lateral *** more mature the gully development,the lower the depth of gully bottom cutting is compared with the width of gully ***,the surface cutting depth tends to be stable and the slope is ***,the transformation law of the slope morphology of the gully cross section with the development of the gully is studied,and the prediction model of the transformation of the slope morphology of the gully cross section is established by using the Markov *** Markov model can better reflect the dynamic change of the slope morphology of the gully cross section,which is of great significance to revealing the external performance and internal mechanism of the gully morphology.

关键词： gully cross section slope morphology Markov chain digital elevation model

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基于关联理论隐喻观的汉语儿童隐喻认知理解研究

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天津师范大学学报（社会科学版） 2024年第1期 87-96页

作者：程璐璐余珊珊袁文婷彭玉乐中国石油大学(华东)外国语学院青岛266580 黑龙江大学西语学院哈尔滨150080 佳木斯大学国际教育学院佳木斯154007 黑龙江外国语学院英语系哈尔滨150500 中国海洋大学外国语学院青岛266101

以句子释义考查汉语儿童隐喻理解能力的发展情况。通过隐喻句理解测试、故事理解测试和词义的临时概念采访测试,调查60名不同年龄组汉语儿童对不同隐喻类型的理解程度,考查儿童构建临时概念的能力发展特点,分析儿童构建词义的临时概念... 详细信息

以句子释义考查汉语儿童隐喻理解能力的发展情况。通过隐喻句理解测试、故事理解测试和词义的临时概念采访测试,调查60名不同年龄组汉语儿童对不同隐喻类型的理解程度,考查儿童构建临时概念的能力发展特点,分析儿童构建词义的临时概念能力与隐喻理解的相关性。结果表明,儿童构建临时概念的能力和隐喻理解能力具有相关性,两者均随着年龄的增长而逐渐增强,且随着隐喻类型难度的提升而逐渐减弱。同时,研究还发现语境对儿童构建临时概念进而理解隐喻产生影响。

关键词：汉语儿童隐喻关联理论临时概念语用学

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基于经筋理论探讨膝骨关节炎的分期治疗策略

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江西中医药大学学报 2024年第4期36卷 1-4,8页

作者：程露露余洋洋代建陈朝晖安徽中医药大学合肥230012 武汉体育学院武汉430079

膝骨关节炎是临床上常见的退行性骨关节疾病,其病位主要以其所属骨骼、筋肉、筋膜为主,关节软骨退变是其主要病理变化。膝为筋之府,筋骨相连,骨痹则筋伤,筋伤则束骨无力。现基于经筋的生理功能、病理特点,探讨膝骨关节炎的发病机制以及... 详细信息

膝骨关节炎是临床上常见的退行性骨关节疾病,其病位主要以其所属骨骼、筋肉、筋膜为主,关节软骨退变是其主要病理变化。膝为筋之府,筋骨相连,骨痹则筋伤,筋伤则束骨无力。现基于经筋的生理功能、病理特点,探讨膝骨关节炎的发病机制以及针灸在膝骨关节炎的病程进展中的分期论治应用:瘀沫期活血通脉,消沫利水;筋膜拘挛期松解粘连,提高关节稳定性;筋结病灶期温通散结,骨正筋顺。

关键词：经筋理论膝骨关节炎分期治疗

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Long-term outcomes of endothelial keratoplasty in Chinese eyes at a University Hospital

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Eye and Vision 2014年第1期1卷 51-54页

作者： Alvin L Young Rachel PW Kwok Vishal Jhanji lulu L cheng Srinivas K Rao Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina Darshan Eye Clinic ChennaiIndia.

Background:Endothelial keratoplasty(EK)is used increasingly for the management of cases with endothelial ***-term outcomes of the surgery are not widely reported in the *** report our experience of EK in Chinese eyes at a University teaching ***:Retrospective analysis was performed for all cases of EK performed between 2005 and *** analyzed included indication for surgery,associated surgical procedures,complications,best-corrected visual acuity(BCVA)and overall graft ***:Overall,22 eyes of 21 patients underwent EK(13 males,8 females,mean age 71.8±11.3 years).Pseudophakic bullous keratopathy was the leading indication for surgery(n=12)followed by Fuchs’endothelial dystrophy(n=4),or both(n=3).Other indications for surgery included failed penetrating keratoplasty(n=2)and endothelial decompensation due to multiple surgeries(n=1).Triple procedure was performed in 5(22.7%)*** were noted in the form of postoperative interface hemorrhage(n=2,9%)and graft dislocation(n=1,4.5%).The mean postoperative endothelial cell density was 1069±585.8 cells/*** mean postoperative pachymetry was 675.8±108.5μ*** mean preoperative and postoperative intraocular pressure was 11.3±3.2 and 13.9±4.5 mmHg *** the last follow-up(mean,47.4±13.7 months),BCVA was≥20/70 in 9(40.9%)*** of poor BCVA included primary graft failure(n=4),graft decompensation(n=4),advanced glaucoma(n=2)and irreversible graft rejection(n=2).Graft remained clear in 12(54.5%)cases at the last *** graft survival was 19.7±17.7 months(median 17.5 months).Conclusions:Nearly half of the EK grafts in our study survived over a period of five *** failure,glaucoma and graft rejection were the main causes of poor graft survival.

关键词： Endothelial keratoplasty Keratoplasty Long-term outcomes

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Controllable CPL response driven by achiral UV-photosensitive dichroic dye through cholesteric liquid crystals

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Science China Chemistry 2024年第4期67卷 1250-1255页

作者： Yihan Chen Yang Li Hang Li lulu Li Yiwu Quan Yixiang cheng State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Key Laboratory of High-Performance Polymer Material and Technology of Ministry of Education School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Versatile stimuli-responsive circularly polarized luminescent(CPL)materials have potential applications in information storage,security encryption,and intelligent *** this study,the Z/E isomerization of ultraviolet(UV)-photosensitive achiralα-cyanostilbene derivative was used as an achiral dichroic dye(Switch)to drive the controllable CPL-active response in cholesteric liquid crystals(CLCs).Under irradiation by 365 nm UV light,the resulting CLCs-Z-Switch underwent a Z-to-E configuration isomerization as CLCs-E-Switch,accompanied by a decrease in its dichroic order parameter(SFvalue)from 0.15to *** the quantum yield(QY)of CLCs-E-Switch increased from 8.1%(CLCs-Z-Switch)to 16.8%,the corresponding glumvalues of CPL emission decreased from+0.55/-0.57 to+0.37/-0.39 due to a decrease in the order of helical arrangement of E-Switch in E7 *** study enables photosensitive CLCs-Switch to be applied for optical information storage devices.

关键词： circularly polarized luminescent photosensitive dichroic dye cholesteric liquid crystals chiral induction

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High speed small gauge anterior vitrectomy cutter for scleral fixated intraocular lens implantation

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 77-80页

作者： Yuan Bo Liang Yoly Y.Y. FonG lulu L. cheng Alvin L. Young Clinical and Epidemiological Eye Research Center the Affiliated Eye Hospital School of Optometry and OphthalmologyWenzhou Medical University Wenzhou 325027 ZhejiangProvince China Department of Ophthalmology ＆ Visual Sciences the ChineseUniversity of Hong Kong Prince of Wales Hospital ShatinHong Kong China

AIM： To report the outcomes of anterior vitrectomy using high speed cutter for scleral fixated intraocular lens （SFIOL） implantation in patients with posterior capsular rupture .METHODS： Medical records of 51 patients with posterior capsular rupture who received high speed cutter anterior vitrectomy via limbal incision with SFIOL implantation from June 2011 to December 2013 were reviewed retrospectively for visual outcomes and ***： Totally 51 eyes of 51 patients were identified （23 males and 28 females）. Mean age at surgery was 67.2±15y （range 27-91y）, with mean follow-up of 23±8.2mo （range 12-40mo）. The 49 （96.1%） eyes had improvement or unchanged of final postoperative visual acuity. The most common complication was vitreous haemorrhage （5.9%） and transient rise in intraocular pressure （5.9%） which all spontaneously resolved CONCLUSION： High speed cutter anterior vitrectomy via limbal incision is a safe and effective method for those with posterior capsular rupture for SFIOL implantation.

关键词： cataract aphakia posterior capsular rupture intraocular lens scleral fixation

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Electrostatic interaction-mediated 1:1 complexes for high-contrast mitochondrial-targeted phosphorescence bioimaging

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Science China Chemistry 2024年第10期67卷 3406-3413页

作者： Jianshuo cheng Hao Sun lulu Zhou Glib VBaryshnikov Mouwei Liu Shen Shen Hans Ågren Liangliang Zhu State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China Laboratory of Organic Electronics Department of Science and TechnologyLinköping UniversityNorrköping 60174Sweden Department of Physics and Astronomy Uppsala UniversityUppsala SE-75120Sweden

Organelle-targeted imaging can provide information on cellular functions and intracellular interactions,being significant for disease *** use of room-temperature phosphorescence(RTP)in organelle-targeted imaging can fully utilize its unique characteristics of long wavelength and deep ***,this technology has long been plagued by insufficient probe targeting and limited luminous *** this work,we prepared a series of complexes composed of multicationic persulfurated arenes and biomacromolecules via electrostatic interactions in 1:1 stoichiometry for high-contrast mitochondrial-targeted RTP *** an electrostatic interaction design effectively prevented the self-aggregation of the probes,which is not conducive to mitochondrial ***,it suppressed the non-radiative decay to the maximum extent,enabling the probes to exhibit strong RTP signals both in aqueous solution and at the cellular ***,the biomacromolecules can serve as carriers for an electrostatic interaction transfer of the persulfurated arenes to *** leads to high mitochondrial targeting Pearson's correlation coefficients of the probes and high-contrast RTP imaging effects,as well as the independence of the co-incubated probe *** results provide new insights for the development of targeted imaging technologies.

关键词： room-temperature phosphorescence mitochondrial targeting bioimaging complex electrostatic interaction

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高级别浆液性卵巢癌类器官模型的建立及鉴定

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癌症进展 2024年第15期22卷 1634-1636,1722页

作者：黄丽洁程璐璐谢云青林晓为崔好高嫣妮福建医科大学肿瘤临床学院/福建省肿瘤医院肿瘤分子生物学研究室福州3500140 福建医科大学肿瘤临床学院/福建省肿瘤医院检验科福州3500140

目的建立并鉴定高级别浆液性卵巢癌类器官模型。方法选取行卵巢癌细胞减灭术的10例高级别浆液性卵巢癌患者的卵巢癌组织,将卵巢癌组织消化成单细胞,在基质胶中培养7天,构建高级别浆液性卵巢癌类器官模型。比较类器官与原发肿瘤的形态... 详细信息

目的建立并鉴定高级别浆液性卵巢癌类器官模型。方法选取行卵巢癌细胞减灭术的10例高级别浆液性卵巢癌患者的卵巢癌组织,将卵巢癌组织消化成单细胞,在基质胶中培养7天,构建高级别浆液性卵巢癌类器官模型。比较类器官与原发肿瘤的形态学特征、免疫组化特征和苏木精-伊红(HE)染色结果。结果 10例患者的高级别浆液性卵巢癌类器官模型均成功构建。光学显微镜显示类器官数量可观,形态呈类圆形3D立体结构。HE染色显示,在高倍镜下,类器官细胞核异型性明显,局部区域形成微乳头状结构。免疫组化显示黏蛋白16(MUC16)强阳性,p53弥漫性强阳性,类器官与原发肿瘤的免疫组化染色情况一致。结论体外成功构建的高级别浆液性卵巢癌类器官模型具有明显的上皮性特征,与原发肿瘤高度相似,可用于卵巢癌的药物筛选和基础研究建模。

关键词：类器官高级别浆液性卵巢癌模型药物筛选

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Genetic variant in a BaP-activated super-enhancer increases prostate cancer risk by promoting AhR-mediated FAM227A expression

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Journal of Biomedical Research 2024年第2期38卷 149-162,I0001-I0010页

作者： lulu Fan Hao Wang Shuai Ben Yifei cheng Silu Chen Zhutao Ding Lingyan Zhao Shuwei Li Meilin Wang Gong cheng Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Urology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China

Genetic variants in super-enhancers(SEs)are increasingly implicated as a disease risk-driving *** studies have reported an associations between benzo[a]pyrene(BaP)exposure and some malignant tumor ***,it is unclear whether BaP is involved in the effect of genetic variants in SEs on prostate cancer risk,nor the associated intrinsic molecular *** the current study,by using logistic regression analysis,we found that rs5750581T>C in 22q-SE was significantly associated with prostate cancer risk(odds ratio=1.26,P=7.61×10^(-5)).We also have found that the rs6001092T>G,in a high linkage disequilibrium with rs5750581T>C(r^(2)=0.98),is located in a regulatory aryl hydrocarbon receptor(AhR)motif and may interact with the FAM227A promoter in further bioinformatics *** then performed a series of functional and BaP acute exposure experiments to assess biological function of the genetic variant and the target ***,the rs6001092-G allele strengthened the transcription factor binding affinity to AhR,thereby upregulating FAM227A,especially upon exposure to BaP,which induced the malignant phenotypes of prostate *** current study highlights that AhR acts as an environmental sensor of BaP and is involved in the SE-mediated prostate cancer risk,which may provide new insights into the etiology of prostate cancer associated with the inherited SE variants under environmental carcinogen stressors.

关键词： super-enhancer prostate cancer genetic variants AhR BaP FAM227A

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理筋正骨手法联合双氯芬酸二乙胺乳胶剂治疗肱骨外上髁炎29例临床观察

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甘肃中医药大学学报 2024年第2期41卷 75-80页

作者：余洋洋金祥雨李冬静程露露张文娣林永艳陈朝晖安徽中医药大学研究生院安徽合肥230012 安徽三联学院护理学院安徽合肥231200 安徽中医药大学第一附属医院针灸康复科安徽合肥230601 安徽中医药大学针灸推拿学院安徽合肥230012

目的观察理筋正骨手法联合双氯芬酸二乙胺乳胶剂治疗肱骨外上髁炎的临床疗效。方法将60例肱骨外上髁炎患者采用随机数字表法分为对照组和治疗组,各30例。由于在治疗过程中2组各有1例患者脱离研究,最终各纳入29例。对照组给予体外冲击波... 详细信息

目的观察理筋正骨手法联合双氯芬酸二乙胺乳胶剂治疗肱骨外上髁炎的临床疗效。方法将60例肱骨外上髁炎患者采用随机数字表法分为对照组和治疗组,各30例。由于在治疗过程中2组各有1例患者脱离研究,最终各纳入29例。对照组给予体外冲击波联合双氯芬酸二乙胺乳胶剂涂抹治疗,治疗组采用理筋正骨手法联合双氯芬酸二乙胺乳胶剂涂抹治疗。比较2组的临床疗效及治疗前后视觉模拟评分法(VAS)评分、压痛阈值、改良Mayo肘关节功能评分(MEPS)、桡侧腕伸肌群中位频率(MF)及积分肌电(iEMG)值。结果治疗组总有效率为96.55%(28/29),对照组为72.41%(21/29),2组比较差异有统计学意义(P<0.05);治疗后2组VAS评分均明显降低,肘关节疼痛、运动功能、稳定性、日常生活活动能力(ADL)评分及MEPS总分,压痛阈值,桡侧腕伸肌群iEMG及MF值均明显升高,与同组治疗前比较差异有统计学意义(P<0.05或P<0.01),且治疗组各项指标改善更明显,与对照组治疗后比较差异均有统计学意义(P<0.05或P<0.01)。结论理筋正骨手法联合双氯芬酸二乙胺乳胶剂临床疗效显著,可有效缓解肱骨外上髁炎患者疼痛及肌肉疲劳度,降低肘关节周围肌群张力,改善肘关节功能,值得临床推广应用。

关键词：肱骨外上髁炎理筋正骨手法体外冲击波双氯芬酸二乙胺乳胶剂临床疗效

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